DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9590 and Fam114a1l1

DIOPT Version :9

Sequence 1:	NP_650488.1	Gene:	CG9590 / 41907	FlyBaseID:	FBgn0038360	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	XP_237514.6	Gene:	Fam114a1l1 / 316729	RGDID:	1309701	Length:	566	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	131/568 - (23%)
Similarity:	210/568 - (36%)	Gaps:	140/568 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EEDGGNDWAQ------------------SDEDDNWDDWGDDDDKFVHVEKEQQP-----QEKVSS 49
            :..||.|.|:                  |:|....|..|:..:.......|..|     |.|.|
  Rat    10 DNGGGEDAAEMPNSPAEDAEVQCGPAMTSNEPAPADHTGEQSEVSAAACAEVTPTGLLDQSKAS- 73

  Fly    50 RNDAKGTAENQEKLETPRISAPATAS-----------------ATSSS--------WGLWG-GKL 88
              ||..|..|.|..|...:....:.|                 |..||        ||.|| ..|
  Rat    74 --DADETPLNGEVTEDTLVECIDSVSLEGDTGSEIPLKEQNDVAVDSSPPAGRWAGWGSWGKSLL 136

  Fly    89 SSVLTTATEGLGTITTQ---------VNQGLNQIIGVPDPEELARINVAEKAEKAA--KAPPEEN 142
            ||...|...||..:..:         ||.|..: ..:.|.|.....||....:.|.  ..||...
  Rat   137 SSASATVGHGLTAVKEKAGATLRIHSVNSGSPE-GALTDAENRISQNVTPDQDPAGGPHTPPPPG 200

  Fly   143 VDDEKESSAAFGLDFVTNLGSKVLNTGLDTLEGIGKKT--MTILQDNDPKLMNKRKLLGLEANSP 205
            ....:...:|. .:.|.|.|..:|..|||.||.|||.:  |.:|.::||.....:.|:   ....
  Rat   201 TAGSRGVLSAL-TNAVQNTGKSILTGGLDALEFIGKNSSAMNVLAESDPGFKRTKTLM---ERMV 261

  Fly   206 NLSAVLLEAKKEADQMEQSLQQLQLKRQKAQLRFEILFENYCGLVHFEALEILSKESRLKLDTLL 270
            :||.:|.|||::  :.::..|||..:|   ...:.:||..|.||.|   |||||.||..|:.:.|
  Rat   262 SLSQMLREAKEK--EKQRLAQQLTAER---TAHYGMLFNEYQGLSH---LEILSNESESKVQSFL 318

  Fly   271 DAVSGNARAELQETINEVKELIELEDLDVESEGDYE-----------AEELSERLAATIKDAELG 324
            .::.|. :.||.:     .:||.::|:.|..|.:.|           .||.:..|...:.:..:.
  Rat   319 ASLDGE-KLELLK-----NDLISIKDIFVAKESENEENPEEQGLEESGEEFARMLTELLFELHVA 377

  Fly   325 IQFDDIANHWTQSLSWLTSEEAT----------------------------------AADLEQAY 355
            ...|.:.....::..|:..:::.                                  |..:|..|
  Rat   378 ATPDKLNKAMKKAHDWVEEDQSVVSIDVAKGSEEEEKKEGKEEKAEEPEEDKAGGKGAKTVEVVY 442

  Fly   356 AKSIHALSEACALEMCKLHKIAELLL-----VKPHHSTANEVDGVVNLCQQFNGHLQGLSHRFAA 415
            ..||.:|:|..|..:.:|||:|||:|     .||....|..   ::.|.......:..||.:|..
  Rat   443 MLSIESLAEVTARCIEQLHKVAELILHGQEEEKPAQDQAKV---LIRLTTAMCNEVAALSKKFTN 504

  Fly   416 VLS---GKSETEESKGRVSTFFSEMLSAVQFIEKAYKLFTPILQMGAV 460
            ||:   ...:.|.....:::...|..::..:::.|.:|..|:||:..:
  Rat   505 VLTTVGSNKKAEVLNPMINSVLLEGCNSTTYVQDALQLLLPVLQVSHI 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9590	NP_650488.1	DUF719	80..249	CDD:283086	52/190 (27%)
Fam114a1l1	XP_237514.6	DUF719	124..300	CDD:283086	51/185 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338270
Domainoid	1	1.000	69	1.000	Domainoid score	I9379
eggNOG	1	0.900	-	-		E1_2C2HB
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	117	1.000	Inparanoid score	I4711
OMA	1	1.010	-	-		QHG49595
OrthoDB	1	1.010	-	-		D403298at33208
OrthoFinder	1	1.000	-	-		FOG0003527
OrthoInspector	1	1.000	-	-		otm45934
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12842
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.870