DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9590 and FAM114A2

DIOPT Version :9

Sequence 1:	NP_650488.1	Gene:	CG9590 / 41907	FlyBaseID:	FBgn0038360	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001304922.1	Gene:	FAM114A2 / 10827	HGNCID:	1333	Length:	505	Species:	Homo sapiens

Alignment Length:	507	Identity:	132/507 - (26%)
Similarity:	236/507 - (46%)	Gaps:	96/507 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EDGGNDWAQSDEDDNWDDWGDDDDKFVHVEKEQQPQEKVSSRNDAKGTAENQEKLETPR---ISA 70
            |||..:.|::.|         ..|:....|.:.:|......|.:.|.:::    |||.:   |..
Human    20 EDGNCEPAKNSE---------SVDQGAKPESKSEPVVSTRKRPETKPSSD----LETSKVLPIQD 71

  Fly    71 PATASATSSSWGLWGGKLSSVLTTATEGLGTITTQVNQGLNQII-------GVPDPEELARINVA 128
            ..:.....:.||.||....|:|::|:   .|:.| |.||::.:|       |:|.|.|::    .
Human    72 NVSKDVPQTRWGYWGSWGKSILSSAS---ATVAT-VGQGISNVIEKAETSLGIPGPSEIS----T 128

  Fly   129 EKAEKAAKAPPEENVDDEKESSAAFGL-----DFVTNLGSKVLNTGLDTLEGIGKKTMTILQDND 188
            |....|.:...:|| ::....:.|||:     ..|.:.|..|::.|||.||.||||||.::.:.|
Human   129 EVKYVAGETNAKEN-ENSSPVAGAFGVFSTISTAVQSTGKSVISGGLDALEFIGKKTMDVIAEGD 192

  Fly   189 PKLMNKRKLLGLEANSPNLSAVLLEAKKEADQMEQSLQQLQLKRQKAQLRFEILFENYCGLVHFE 253
            |..   ::..||...:..||.||.|| ||.:::..| .::.::..| :..:.:||:.:.||.|.|
Human   193 PGF---KRTKGLMNRNATLSQVLREA-KEKEEIRTS-NEVTVETDK-KTHYGLLFDEFQGLSHLE 251

  Fly   254 ALEILSKESRLKLDTLLDAVSGNARAELQETINEVKELIEL----EDLDVESEGD----YEAEEL 310
            |||:||:||.:|:.::|:::||.....|:..:.::||...|    |:.:.|.:||    .:..||
Human   252 ALEMLSQESEIKVKSILNSLSGEELETLKVELEQLKETFSLAEFCEEEEEEKKGDEDFTKDITEL 316

  Fly   311 SERLAATIKDAELGIQFDDIANHWTQSLSWLT-----------------SEEATAADLEQAYAKS 358
            ..:|..:.|..:|. :..:.|:.|.:..  ||                 :|:.....:|..:|.:
Human   317 FSQLHVSSKPEKLA-RARNTAHEWIRKS--LTKPLAENEEGEKQSEAENTEQVNKNSIEDIHAFA 378

  Fly   359 IHALSE--ACALEMCKLHKIAELLLVKPHHSTANEVDGV----------VNLCQQFNGHLQGLSH 411
            |.:|:|  ||::|:  .||.|.|:|    |....||..:          :.||::    |..||.
Human   379 IRSLAELTACSIEL--FHKTAALVL----HGRKQEVTAIERSQTLSQMTIVLCKE----LSSLSK 433

  Fly   412 RFAAVLSG---KSETEESKGRVSTFFSEMLSAVQFIEKAYKLFTPILQMGAV 460
            .|...|:.   |...:.....::..|.|..::..:|:.|::|..|:|::..:
Human   434 EFTTCLTTAGVKEMADVLNPLITAVFLEASNSASYIQDAFQLLLPVLEISLI 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9590	NP_650488.1	DUF719	80..249	CDD:283086	54/180 (30%)
FAM114A2	NP_001304922.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65		13/57 (23%)
		DUF719	80..247	CDD:310144	54/181 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..366		3/25 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144567
Domainoid	1	1.000	68	1.000	Domainoid score	I9734
eggNOG	1	0.900	-	-		E1_2C2HB
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10270
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4693
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49595
OrthoDB	1	1.010	-	-		D403298at33208
OrthoFinder	1	1.000	-	-		FOG0003527
OrthoInspector	1	1.000	-	-		otm41794
orthoMCL	1	0.900	-	-		OOG6_107690
Panther	1	1.100	-	-	LDO	PTHR12842
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5405
SonicParanoid	1	1.000	-	-		X2406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800