DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9590 and fam114a2

DIOPT Version :9

Sequence 1:	NP_650488.1	Gene:	CG9590 / 41907	FlyBaseID:	FBgn0038360	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001186864.1	Gene:	fam114a2 / 100380147	XenbaseID:	XB-GENE-6046311	Length:	489	Species:	Xenopus tropicalis

Alignment Length:	471	Identity:	134/471 - (28%)
Similarity:	222/471 - (47%)	Gaps:	65/471 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KEQ-----QPQEKVSSRNDAKGTAE--NQEKLETPRISAPATASATSSSWGLWGGKLSSVLTTAT 96
            |||     :|......|.:||.::|  .||:.:||......:.:.:.|.||.||....|:::||:
Frog    31 KEQKRAVSEPVAITRKRPEAKSSSEAAEQEEQKTPEKHDLDSEAKSPSGWGYWGNWGKSLISTAS 95

  Fly    97 EGLGTITTQVNQGLNQI---IGVPDPEELARINVAEKAEKAAKAPPEENVDDEKESSAAFG-LDF 157
            ..:.|:...:...:.:.   :|||.|.||: |...|:.|:.|.:....:..:.:.||...| |.|
Frog    96 ATVATVGHGITSAIEKAESSLGVPSPVELS-IRSQEETEEGADSVQSADAKENESSSPITGALGF 159

  Fly   158 VTNL-------GSKVLNTGLDTLEGIGKKTMTILQDNDPKLMNKRKLLGLEANSPNLSAVLLEAK 215
            ::::       |..||..|||.||.||||||.::.:.||..   :|..|:...:..||.||.||
Frog   160 LSSISTAVQSTGKTVLTGGLDALEFIGKKTMDVIAEGDPGF---KKTKGIINRNSTLSQVLREA- 220

  Fly   216 KEADQMEQSLQQLQLKRQKAQLRFEILFENYCGLVHFEALEILSKESRLKLDTLLDAVSGNARAE 280
            ||.:::..|........|||  .:.:||:.|.||.|.||||:|||||..|...:|.::||...||
Frog   221 KEQEELRVSSDFNAETEQKA--HYGLLFDEYQGLAHLEALELLSKESDAKTKAILSSLSGEELAE 283

  Fly   281 LQETINEVKELIELEDLDVESEGDYEAEELSERLAATIKDAELGIQFDDIANHWTQSLSWLT--- 342
            ::..:..:||...||:.|.|.|.:...||.::.:.....:..:..:...:......:..|:.
Frog   284 VKAELEPLKEAFSLEEFDDEEELEKGDEEFTQEVTTLFDELHISARPLKLTKARIDAYKWMADVE 348

  Fly   343 -------SEEATAAD--------LEQAYAKSIHALSE--ACALEMCKLHKIAELLL--VKPHHST 388
                   .|:|...|        :|..:..:|.:|:|  ||::||  .||.|.|:|  ..|..:.
Frog   349 EDGKKKKEEQAEPEDAEVQGKTSVEDIHEFAIRSLAELTACSMEM--FHKAATLILHGESPVPAA 411

  Fly   389 ANEVDG------VVNLCQQFNGHLQGLSHRFAAVL--SGKSETEESKGRVST-FFSEMLSAVQFI 444
            |.   |      .:.||::    |..||.|...:|  :|.||..:....:.| .|.|..::..:|
Frog   412 AR---GRALSQMTILLCKE----LTQLSKRITTLLTITGASEKSDVLNPLITGVFLEASNSASYI 469

  Fly   445 EKAYKLFTPILQMGAV 460
            :.|::|..|:|::..:
Frog   470 QDAFQLLLPVLEISHI 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9590	NP_650488.1	DUF719	80..249	CDD:283086	56/179 (31%)
fam114a2	NP_001186864.1	DUF2413	2..>98	CDD:287302	20/66 (30%)
fam114a2	NP_001186864.1	DUF719	79..251	CDD:283086	56/178 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I8908
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10270
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4348
OMA	1	1.010	-	-		QHG49595
OrthoDB	1	1.010	-	-		D403298at33208
OrthoFinder	1	1.000	-	-		FOG0003527
OrthoInspector	1	1.000	-	-		otm49021
Panther	1	1.100	-	-	LDO	PTHR12842
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2406
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.080