Protein Alignment CG4520 and TOMM40L

DIOPT Version :10

• Sequence 1: NP_650483.1
• Gene: CG4520 / 41902
• FlyBaseID: FBgn0038355
• Length: 320
• Species: Drosophila melanogaster
• Sequence 2: NP_115550.2
• Gene: TOMM40L / 84134
• HGNCID: 25756
• Length: 308
• Species: Homo sapiens
• Alignment Length: 289
• Identity: 71/289 - (24%)
• Similarity: 124/289 - (42%)
• Gaps: 27/289 - (9%)

  Fly    33 NPGNVQNLHILAHRVMPKFYDGIELDYLHRLAPNKYITAAWVLSH-IRPS-----GFRFGGLYTF 91
            |||:...||.|...|.|...:|:      :|..||.:::.:.::| |..|     |:.....|..
Human    26 NPGSFDELHRLCKDVFPAQMEGV------KLVVNKVLSSHFQVAHTIHMSALGLPGYHLHAAYAG 84

  Fly    92 RVQ-DDTMYTPTIMGDIHPTSLAANLNILYYPFQSLRMEAVLQKAREAAVESQYTIEWTRPCDTW 155
            ..| ..|...||::||: .:|.:.|..:|....:.||.:||.|..:...:..|:..|:..  |.:
Human    85 DWQLSPTEVFPTVVGDM-DSSGSLNAQVLLLLAERLRAKAVFQTQQAKFLTWQFDGEYRG--DDY 146

  Fly   156 TANFY----NVRNESGRCTMSVMRSVSAHWALGGELLLEWNDPQKLTPDLALAARYSHYNYSLAA 216
            ||...    ::..||.......::|::....|||||:.. ..|.:....|.||.:||..::....
Human   147 TATLTLGNPDLIGESVIMVAHFLQSLTHRLVLGGELVYH-RRPGEEGAILTLAGKYSAVHWVATL 210

  Fly   217 TASRQGLDVTYWQRIHPHIQMANLLAWNRNTRKTIATICYQWNFW----NSAVHGMFDSDASVGF 277
            .....|...:|:.|.:..:|:.  :.:..|||....|..:.::..    |....|:.||:..||.
Human   211 NVGSGGAHASYYHRANEQVQVG--VEFEANTRLQDTTFSFGYHLTLPQANMVFRGLVDSNWCVGA 273

  Fly   278 MWTKYLTHLPLQMGFSVVMNLPTDRFAFG 306
            :..|.:..||:.:.....:|...:||..|
Human   274 VLEKKMPPLPVTLALGAFLNHWRNRFHCG 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4520	NP_650483.1	Porin3_Tom40	33..312	CDD:132766	71/289 (25%)
TOMM40L	NP_115550.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		2/2 (100%)
		Porin3_Tom40	24..308	CDD:132766	71/289 (25%)
		Required for mitochondrial targeting. /evidence=ECO:0000250	281..308		6/22 (27%)