DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4520 and TOMM40

DIOPT Version :9

Sequence 1:	NP_001287340.1	Gene:	CG4520 / 41902	FlyBaseID:	FBgn0038355	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_001122388.1	Gene:	TOMM40 / 10452	HGNCID:	18001	Length:	361	Species:	Homo sapiens

Alignment Length:	282	Identity:	68/282 - (24%)
Similarity:	116/282 - (41%)	Gaps:	9/282 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NPGNVQNLHILAHRVMPKFYDGIELDYLHRLAPNKYITAAWVLSHIRPSGFRFGGLYTFRVQ-DD 96
            |||..:..|.....:.|...:|::|.....|:.:..:.....||.|..|.:.||..|....| ..
Human    79 NPGTFEECHRKCKELFPIQMEGVKLTVNKGLSNHFQVNHTVALSTIGESNYHFGVTYVGTKQLSP 143

  Fly    97 TMYTPTIMGDIHPTSLAANLNILYYPFQSLRMEAVLQKAREAAVESQYTIEWTRPCDTWTANFYN 161
            |...|.::||: ..|.:.|..:::.....||.:..:|..:...|..|...|:.....|......|
Human   144 TEAFPVLVGDM-DNSGSLNAQVIHQLGPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGN 207

  Fly   162 --VRNESGRCTMSVMRSVSAHWALGGELLLEWNDPQKLTPDLALAARYSHYNYSLAATASRQGLD 224
              |...||......::|::...||||||:......::.|. ::||.:|:..|:....|..:.|:.
Human   208 PDVLVGSGILVAHYLQSITPCLALGGELVYHRRPGEEGTV-MSLAGKYTLNNWLATVTLGQAGMH 271

  Fly   225 VTYWQRIHPHIQMANLLAWNRNTRKTIATICYQWNF--WNSAVHGMFDSDASVGFMWTKYLTHLP 287
            .||:.:....:|:......:...:.|..:..||.:.  .|....|..||:..||....|.|..||
Human   272 ATYYHKASDQLQVGVEFEASTRMQDTSVSFGYQLDLPKANLLFKGSVDSNWIVGATLEKKLPPLP 336

  Fly   288 LQMGFSVVMNLPTDRF--AFGM 307
            |.:.....:|...::|  .||:
Human   337 LTLALGAFLNHRKNKFQCGFGL 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4520	NP_001287340.1	Porin3_Tom40	33..312	CDD:132766	68/282 (24%)
TOMM40	NP_001122388.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71
TOMM40	NP_001122388.1	Porin3_Tom40	77..361	CDD:132766	68/282 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3296
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1946
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1346842at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.830