DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5404 and slc26a3.1

DIOPT Version :9

Sequence 1:	NP_650482.1	Gene:	CG5404 / 41901	FlyBaseID:	FBgn0038354	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001129155.1	Gene:	slc26a3.1 / 563962	ZFINID:	ZDB-GENE-041210-180	Length:	745	Species:	Danio rerio

Alignment Length:	722	Identity:	170/722 - (23%)
Similarity:	303/722 - (41%)	Gaps:	180/722 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SEAGKAPRMNKWKRRLHRHV-------------------------------PVFQWLPLYS-TEW 62
            |.|.:..|:|:.::.|..|:                               |...|:..|. .||
Zfish    19 SFAEQHERINRKRKTLRHHLKDYFSGVSFSKLCLCCSCDAKRAKNAALSLFPFIGWMKDYKIKEW 83

  Fly    63 GIDDFIAGITLGLTIIPESMACALLAGLPARYGLCSAFIGPLIYMVFGSIDKVIIGPTSLVALV- 126
            .:.|.::||:.||..:.:.:|.:|||.||..|||.:||...:||...|:...:.:|...:::|:
Zfish    84 LLGDIVSGISTGLVAVLQGLAFSLLASLPPGYGLYTAFFPAIIYFFLGTSRHLSVGAFPILSLMV 148

  Fly   127 -----------SVQFTV----GRPIE-----FAFLLTFLSGIVQIIMGTMRMGFIFEFISMPVIK 171
                       ...|.:    |..:|     .|..:|||.|..|::||.:::|||..::|..::.
Zfish   149 GAVVTRLVPDEGPSFNITGFEGLSLEQQRVLVASSVTFLMGAFQLVMGLLQVGFIVMYLSETLVS 213

  Fly   172 AFSSATAILVIESQLKVLLGIKYLVAGLMNSVGML------SSRIEESNMADLIMGVCAIVFLLL 230
            .|::|.|:.::.|||:.:||:.:  .|:...:.::      .|||..:|:|||:..:..:..:|:
Zfish   214 GFTTAAAVHILVSQLRFVLGLDF--PGINGPLAIIYTLVEVFSRITSTNVADLVTSIAIMALVLI 276

  Fly   231 L-ELLDRVANNEKRNKILRIFCRYLSTSRNTLIVLIAAIVSFIWIQKCGQVPYALSKNALSTLPN 294
            : |:.||.                  .|:..:.:.|..|::.|   .|| |.||.         |
Zfish   277 VKEINDRF------------------KSKLPVPIPIEVIMTVI---ACG-VSYAF---------N 310

  Fly   295 FTVPSFHIETAERNYSI-----------------WEVLKELNIGIIVIPIVGILTNISIGK---L 339
            |          |..:.:                 .||::|..:....:.|||.....|:.|   :
Zfish   311 F----------EERFDVVIVGEMVNGYESPVAPNLEVIEETAVEAFPMAIVGFAVAFSVAKVYSV 365

  Fly   340 TPKGLVDTNQELLTVGLCNMFGSCVQAMPSSGAFTRYAISTACGLRTPMANLYLGIIVLLALSYL 404
            .....:|.||||:..|:.||||:..::..:|.|.:|.||..:.|.:|.:|.:...::||:.:..:
Zfish   366 KHDYTIDGNQELIAFGVSNMFGASFRSFAASTALSRTAIQESTGGKTQIAGILSAMMVLIVIVGV 430

  Fly   405 SPYFNYIPEATLAAILICSI-FTLLDF-KLPMRLWRDSKRDFATWLLCFCVSVLFGVEVGLFVSI 467
            ......:|.:.|.|::|.:: ..|:.| :||. |||:.:.||.||::.|..|:..|:::||.|.|
Zfish   431 GFLLEPLPRSVLGALVIVNLKGMLMQFSELPF-LWRNDRPDFVTWMVTFMASLFLGLDLGLAVGI 494

  Fly   468 VVTALHLLFLWARPEIRVKIE------QLDEMQYIRVTPSNG---------IYFPAINYLRE--- 514
            ......:::....|...|...      ..|...|..:...:|         |:|..|::.|:
Zfish   495 GAELFTVVYRTQFPRCSVLANISGTDLYRDRKDYTSIYEPDGVKIFKIPSPIFFANIDFFRDKLV 559

  Fly   515 --------RVLKACEQADFRI-TVVIDGQ----------RISGMDYTAAQGISKLS-----SDLC 555
                    ||||...:|..:| .::.:|:          |...:| |:...:..|.     |||.
Zfish   560 QEVGFNPMRVLKKRNKALRKIRKMLCNGELEVSDRGPVLRQPSVD-TSEGSMEDLDQPIDFSDLP 623

  Fly   556 RQADASSSTLLILFRFPEHLQRLIDNTDNLVFCESENKVKEFLTQESLRNGYINLKEHIRASIDL 620
            .|.:.:|.....:...|.::..||     |.||     ...|:...:|:.....|||.||..:|:
Zfish   624 IQVNWNSQLPANISVPPVNIHSLI-----LDFC-----AVSFIDVSALKGLKATLKEFIRIEVDV 678

  Fly   621 GYKIDID 627
             |.:..|
Zfish   679 -YIVSCD 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5404	NP_650482.1	sulP	50..557	CDD:273284	146/599 (24%)
CG5404	NP_650482.1	STAS_SulP_like_sulfate_transporter	498..>554	CDD:132913	17/91 (19%)
slc26a3.1	NP_001129155.1	sulP	70..713	CDD:273284	164/671 (24%)
slc26a3.1	NP_001129155.1	STAS_SulP_like_sulfate_transporter	528..707	CDD:132913	38/169 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810