DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5404 and SLC26A5

DIOPT Version :9

Sequence 1:	NP_650482.1	Gene:	CG5404 / 41901	FlyBaseID:	FBgn0038354	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_945350.1	Gene:	SLC26A5 / 375611	HGNCID:	9359	Length:	744	Species:	Homo sapiens

Alignment Length:	659	Identity:	163/659 - (24%)
Similarity:	295/659 - (44%)	Gaps:	119/659 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 YPQLETEAEALEKATARALLPGAISKPASEAGK-APRMNKWKRRLHRHVPVFQWLPLYS-TEWGI 64
            :|.|:......:|      :|.:|:....:|.. .|:  |.:..::..:|:.:|||.|. .|:.:
Human    25 HPVLQERLHTKDK------VPDSIADKLKQAFTCTPK--KIRNIIYMFLPITKWLPAYKFKEYVL 81

  Fly    65 DDFIAGITLGLTIIPESMACALLAGLPARYGLCSAFIGPLIYMVFGSIDKVIIGPTSLVALV--- 126
            .|.::||:.|:..:|:.:|.|:||.:|..:||.|:|...::|...|:...:.|||.::::|:
Human    82 GDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGG 146

  Fly   127 --------------SVQFTVGRP------IEFAFLLTFLSGIVQIIMGTMRMGFIFEFISMPVIK 171
                          .|..|.|..      ::.|..:|.||||:|..:|..|.||:..:::.|:::
Human   147 VAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVR 211

  Fly   172 AFSSATAILVIESQLKVLLGIKY-----LVAGLMNSVGMLSSRIEESNMADLIMGVCAIVFLLLL 231
            .|::|.|:.|..|.||.|.|:|.     :.:.:.::|.:|.: ::..|:..|  ||..:||.|||
Human   212 GFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQN-VKNLNVCSL--GVGLMVFGLLL 273

  Fly   232 ELLDRVANNEKRNKI-----LRIFCRYLSTSRNTLIVLIAAIVSFIWIQKCGQVPYALSKNALST 291
            .  .:..|...:.|:     |..|                |:|....|.....:..:.:.:.:.|
Human   274 G--GKEFNERFKEKLPAPIPLEFF----------------AVVMGTGISAGFNLKESYNVDVVGT 320

  Fly   292 LPNFTVPSFHIETAERNYSIWEVLKELNIGIIVIPIVGILTNISIGK-LTPKG--LVDTNQELLT 353
            ||...:|..:.:|     |::.:   :.:..|.|.|||....||:.| |..|.  .||.||||:.
Human   321 LPLGLLPPANPDT-----SLFHL---VYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIA 377

  Fly   354 VGLCNMFGSCVQAMPSSGAFTRYAISTACGLRTPMANLYLGIIVLLALSYLSPYFNYIPEATLAA 418
            :||||..||..|....|.:.:|..:....|.:|.:|.....:::||.:......|..:|:|.|:|
Human   378 LGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSA 442

  Fly   419 ILICSI------FTLLDFKLPMRLWRDSKRDFATWLLCFCVSVLFGVEVGLFVSIVVTALHLLF- 476
            |:|.::      |:.|.|     .||.||.:...||..|..|:..|::.||..::::..|.:::
Human   443 IVIVNLKGMFMQFSDLPF-----FWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYR 502

  Fly   477 --------LWARPEIRVKI-----EQLDEMQYIRVTPSNGIYFPAINYLRERVLKACEQADFRIT 528
                    |...||..|.|     |::.|:..|::...|...:.|.:.|....||  .:......
Human   503 TQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSNALK--RKTGVNPA 565

  Fly   529 VVIDGQRISGMDYTAAQGISKLSSDLCRQADASSS-----------------TLLILFRFPEHLQ 576
            |::..:|.:...|....|.:.:::....:|||...                 .::|...|||.:|
Human   566 VIMGARRKAMRKYAKEVGNANMANATVVKADAEVDGEDATKPEEEDGEVKYPPIVIKSTFPEEMQ 630

  Fly   577 RLIDNTDNL 585
            |.:...||:
Human   631 RFMPPGDNV 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5404	NP_650482.1	sulP	50..557	CDD:273284	144/563 (26%)
CG5404	NP_650482.1	STAS_SulP_like_sulfate_transporter	498..>554	CDD:132913	9/55 (16%)
SLC26A5	NP_945350.1	sulP	66..709	CDD:273284	155/610 (25%)
		STAS_SulP_like_sulfate_transporter	526..694	CDD:132913	23/116 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..744
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810