DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5404 and Slc26a6

DIOPT Version :9

Sequence 1:	NP_650482.1	Gene:	CG5404 / 41901	FlyBaseID:	FBgn0038354	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001137289.1	Gene:	Slc26a6 / 301010	RGDID:	1310197	Length:	758	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	147/554 - (26%)
Similarity:	256/554 - (46%)	Gaps:	92/554 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ETEAEALEKATARALLPGAISKPASEAGKAPRMNKW-----------KRRLHRHVPVFQWLPLYS 59
            |.|.|..:....|.||.....:.....|...:.:.|           |..|.:||||..|||.|.
  Rat    23 EMELERRDYHVERPLLNQEQLEDLGHWGPVSKTHPWRTWFRCSRARAKSLLIQHVPVLGWLPRYP 87

  Fly    60 T-EWGIDDFIAGITLGLTIIPESMACALLAGLPARYGLCSAFIGPLIYMVFGSIDKVIIGPTSLV 123
            . ||.:.|.::|:::.:..:|:.:|.|||||||..:||.|:|....:|.:||:...:.:|..:::
  Rat    88 VREWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPMFGLYSSFYPVFVYFLFGTSRHISVGTFAVM 152

  Fly   124 ALV----------------SVQFTV-GRPIEFAFLLTFLSGIVQIIMGTMRMGFIFEFISMPVIK 171
            :::                |:..|| |..::.|:.|:||.|:.|:.:|.:..||:..::|.|:::
  Rat   153 SVMVGGVTESLTADEAFVQSLNTTVDGARVQVAYTLSFLVGLFQVGLGLVHFGFVVTYLSEPLVR 217

  Fly   172 AFSSATAILVIESQLKVLLGIKYLVAGLMNSVGMLS---------SRIEESNMADLIMGVCAIVF 227
            ::::|.::.|:.||||.:.|||     |.:..|.||         :::.::....::..:.|.|.
  Rat   218 SYTTAASVQVLVSQLKYVFGIK-----LNSHSGPLSVIYTVLEVCAQLPKTVPGTVVTAIVAGVV 277

  Fly   228 LLLLELLDRVANNEKRNKILRIFCRYLSTSRNTLIVLIAAIVSFIWIQKCGQVPYALSKN---AL 289
            |:|::||     |||..:.|.:      .....|:.||.|..          :.|.:..|   .:
  Rat   278 LVLVKLL-----NEKLRRRLPL------PIPGELLTLIGATA----------ISYGVKLNDRFKV 321

  Fly   290 STLPNFT---VPSFHIETAERNYSIWEVLKELNIGIIVIPIVGILTNISIGK---LTPKGLVDTN 348
            ..:.|.|   :|....:|        |:...|......|.:||....||:||   |.....||:|
  Rat   322 DVVGNITTGLIPPVAPKT--------ELFATLVGNAFAIAVVGFAIAISLGKIFALRHGYRVDSN 378

  Fly   349 QELLTVGLCNMFGSCVQAMPSSGAFTRYAISTACGLRTPMANLYLGIIVLLALSYLSPYFNYIPE 413
            |||:.:||.|:.|...|..|.|.:.:|..:..:.|..|.:|.....:.:||.:..|...|..:|:
  Rat   379 QELVALGLSNLIGGFFQCFPVSCSMSRSLVQESTGGNTQIAGAVSSLFILLIIVKLGELFRDLPK 443

  Fly   414 ATLAAILICSIFTLL-DFKLPMRLWRDSKRDFATWLLCFCVSVLFGVEVGLFVSIVVTALHLLFL 477
            |.|||::|.::..:: .|.....||:.::.|...||:.|..::|..:::||.||||.:.|.::
  Rat   444 AVLAAVIIVNLKGMMKQFSDICSLWKANRVDLLIWLVTFVATILLNLDIGLAVSIVFSLLLVV-- 506

  Fly   478 WARPEIRVKIEQLDEMQYIRVTPSNGIYFPAINY 511
                 ||:   ||.....:...|...||.....|
  Rat   507 -----IRM---QLPHYSVLGQVPDTDIYRDVAEY 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5404	NP_650482.1	sulP	50..557	CDD:273284	135/499 (27%)
CG5404	NP_650482.1	STAS_SulP_like_sulfate_transporter	498..>554	CDD:132913	4/14 (29%)
Slc26a6	NP_001137289.1	sulP	78..737	CDD:273284	135/499 (27%)
		HCO3_cotransp	<369..452	CDD:304903	27/82 (33%)
		STAS_SulP_like_sulfate_transporter	<653..734	CDD:132913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810