DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5404 and Slc26a4

DIOPT Version :9

Sequence 1:	NP_650482.1	Gene:	CG5404 / 41901	FlyBaseID:	FBgn0038354	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_062087.1	Gene:	Slc26a4 / 29440	RGDID:	3293	Length:	780	Species:	Rattus norvegicus

Alignment Length:	631	Identity:	158/631 - (25%)
Similarity:	270/631 - (42%)	Gaps:	156/631 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QLETEAEALEKATARALLPGAISKPASEAGKAPRMNKWKRRLHRHVPVFQWLPLYST-EWGIDDF 67
            |.:.|....|:.|.|..|..:.|.....|..|         |...:|:..|||.|.. ||.:.|.
  Rat    33 QQQRERRLPERRTLRDSLARSCSCSRKRAFGA---------LKALLPILDWLPKYRVKEWLLSDI 88

  Fly    68 IAGITLGLTIIPESMACALLAGLPARYGLCSAFIGPLIYMVFGSIDKVIIGPTSLVALV--SVQF 130
            |:|::.||....:.||.||||.:|.:|||.|||...|.|.|||:...:.:||..:|:|:  ||..
  Rat    89 ISGVSTGLVGTLQGMAYALLAAVPVQYGLYSAFFPILTYFVFGTSRHISVGPFPVVSLMVGSVVL 153

  Fly   131 TVGRPIEF---------------------------AFLLTFLSGIVQIIMGTMRMGFIFEFISMP 168
            ::.....|                           |..||.|.||:|::.|.:::|||..:::.|
  Rat   154 SMAPDDHFLVPSGNGSTLNTTTLDTGTRDAARVLLASTLTLLVGIIQLVFGGLQIGFIVRYLADP 218

  Fly   169 VIKAFSSATAILVIESQLKVLLGIKYLVAGLMNSVGMLS---------SRIEESNMADLIMGVCA 224
            ::..|::|.|..|:.||||::|.:     ...|..|:||         ..|.::|:||.|.|:..
  Rat   219 LVGGFTTAAAFQVLVSQLKIVLNV-----STKNYNGVLSIIYTLIEIFQNIGDTNIADFIAGLLT 278

  Fly   225 IVFLLLLELLDRVANNEKRNKILRIFCRYLSTSRNTLIVLIAAIVSFIWIQKCGQVPYALSKNAL 289
            |:..:.::.|    |:..::||             .:.:.|..||:.|        ..|:|..|
  Rat   279 IIVCMAVKEL----NDRFKHKI-------------PVPIPIEVIVTII--------ATAISYGA- 317

  Fly   290 STLPNFTVPSFHIETAERNYSIWEVLKELNIGII--VIPIVGILTN----------------ISI 336
                          ..|.||:. .::|.:..|.:  |:|.||:.::                :|:
  Rat   318 --------------NLEANYNA-GIVKSIPSGFLPPVLPSVGLFSDMLAASFSIAVVAYAIAVSV 367

  Fly   337 GKLTPKG---LVDTNQELLTVGLCNMFGSCVQAMPSSGAFTRYAISTACGLRTPMANLYLGIIVL 398
            ||:....   ::|.|||.:..|:.|:|........::.|.:|.|:..:.|.:|.:|.|...:||:
  Rat   368 GKVYATKHDYIIDGNQEFIAFGISNVFSGFFSCFVATTALSRTAVQESTGGKTQVAGLISAVIVM 432

  Fly   399 LALSYLSPYFNYIPEATLAAILICSI----FTLLDFKLPMRLWRDSKRDFATWLLCFCVSVLFGV 459
            :|:..|......:.::.|||::|.::    ..:.|  :| |||:.:|.|...|:....:|::.|:
  Rat   433 VAIVALGKLLEPLQKSVLAAVVIANLKGMFMQVCD--VP-RLWKQNKTDAVIWVFTCIMSIILGL 494

  Fly   460 EVGLFVSIVVTALHLLFLWARPEIRVKIEQLDEMQYIRVTPSNGIYFPAINY--LRE----RVL- 517
            ::||...::...|.::       :||   |......:...||..||....:|  |.|    ::|
  Rat   495 DLGLLAGLLFGLLTVV-------LRV---QFPSWNGLGSVPSTDIYKSITHYKNLEEPEGVKILR 549

  Fly   518 -------------KACEQADFRITVVIDGQRISGMDYTAAQGISKL 550
                         |.|.::    ||..|..|:......|.:.|.||
  Rat   550 FSSPIFYGNVDGFKKCVKS----TVGFDAIRVYNKRLKALRRIQKL 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5404	NP_650482.1	sulP	50..557	CDD:273284	148/585 (25%)
CG5404	NP_650482.1	STAS_SulP_like_sulfate_transporter	498..>554	CDD:132913	18/73 (25%)
Slc26a4	NP_062087.1	sulP	70..725	CDD:273284	148/585 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910