DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5404 and SLC26A11

DIOPT Version :9

Sequence 1:	NP_650482.1	Gene:	CG5404 / 41901	FlyBaseID:	FBgn0038354	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_016879994.1	Gene:	SLC26A11 / 284129	HGNCID:	14471	Length:	696	Species:	Homo sapiens

Alignment Length:	599	Identity:	195/599 - (32%)
Similarity:	315/599 - (52%)	Gaps:	67/599 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PQLETEAEALEKATARALLPG-----AISKPASEAGKAPRMNKWKRRLHRHVPVFQWLPLYSTEW 62
            |.:|..:.......||:..||     ....||:              |.|.:|:..|||.||.:|
Human    63 PTVEMPSSVTALGQARSSGPGMAPSACCCSPAA--------------LQRRLPILAWLPSYSLQW 113

  Fly    63 GIDDFIAGITLGLTIIPESMACALLAGLPARYGLCSAFIGPLIYMVFGSIDKVIIGPTSLVALVS 127
            ...||:||:::|||.||:::|.|.:||||.:|||.|||:|..:|...|:...|.:|||::::|:.
Human   114 LKMDFVAGLSVGLTAIPQALAYAEVAGLPPQYGLYSAFMGCFVYFFLGTSRDVTLGPTAIMSLLV 178

  Fly   128 VQFTVGRPIEFAFLLTFLSGIVQIIMGTMRM------------------------GFIFEFISMP 168
            ..:|...| .:|.||.||||.:|:.||.:|:                        ||:.:|||.|
Human   179 SFYTFHEP-AYAVLLAFLSGCIQLAMGVLRLAHISPHPLGLGGAGTSSMSPLGWPGFLLDFISYP 242

  Fly   169 VIKAFSSATAILVIESQLKVLLGIKYLVAGLMNSVGMLSSRIEESNMADLIMGVCAIVFLLLLEL 233
            |||.|:||.|:.:...|:|.|||::.:.......|.....||.|:.:.|.::|:..::.||:|:|
Human   243 VIKGFTSAAAVTIGFGQIKNLLGLQNIPRPFFLQVYHTFLRIAETRVGDAVLGLVCMLLLLVLKL 307

  Fly   234 L-DRVANNEKRN----KILRIFCRYLSTSRNTLIVLIAAIVSFIWIQKCGQVPYALSKNALSTLP 293
            : |.|.......    ::.|......:|:||.|:|..||:|::.: :..|..|:.|:......||
Human   308 MRDHVPPVHPEMPPGVRLSRGLVWAATTARNALVVSFAALVAYSF-EVTGYQPFILTGETAEGLP 371

  Fly   294 NFTVPSFHIETAERNYSIWEVLKELNIGIIVIPIVGILTNISIGKLTPKG---LVDTNQELLTVG 355
            ...:|.|.:.||....|..|:::::..|:.|:|::|:|.:|::.|.....   .:|.|||||.:|
Human   372 PVRIPPFSVTTANGTISFTEMVQDMGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELLAIG 436

  Fly   356 LCNMFGSCVQAMPSSGAFTRYAISTACGLRTPMANLYLGIIVLLALSYLSPYFNYIPEATLAAIL 420
            |.||.||.|.:.|.:|:|.|.|::...|:.||...|..|::|||:|.||:..|.|||::.|||::
Human   437 LTNMLGSLVSSYPVTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALAAVI 501

  Fly   421 ICSIFTLLDFKLPMRLWRDSKRDF----ATWLLCFCVSVLFGVEVGLFVSIVVTALHLLFLWARP 481
            |.::..|.|.|:...|||..:.|.    .|:||||     :.|:.|:....:|:.|.||...|||
Human   502 IMAVAPLFDTKIFRTLWRVKRLDLLPLCVTFLLCF-----WEVQYGILAGALVSLLMLLHSAARP 561

  Fly   482 EIRVKIEQLDEMQYIRVTPSNGIYFPAINYLRERVLKACEQADFRITVVIDGQRISGMDYTAAQG 546
            |.:|     .|...:.:.|::|:.|||:..|||.:|....:......:|::...:..:|||...|
Human   562 ETKV-----SEGPVLVLQPASGLSFPAMEALREEILSRALEVSPPRCLVLECTHVCSIDYTVVLG 621

  Fly   547 ISKLSSDLCRQADA 560
            :.:|..|..:|..|
Human   622 LGELLQDFQKQGVA 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5404	NP_650482.1	sulP	50..557	CDD:273284	183/542 (34%)
CG5404	NP_650482.1	STAS_SulP_like_sulfate_transporter	498..>554	CDD:132913	15/55 (27%)
SLC26A11	XP_016879994.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141497
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55446
OrthoDB	1	1.010	-	-		D289441at2759
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.820