Protein Alignment CG5404 and SLC26A3

DIOPT Version :10

• Sequence 1: NP_650482.1
• Gene: CG5404 / 41901
• FlyBaseID: FBgn0038354
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: NP_000102.1
• Gene: SLC26A3 / 1811
• HGNCID: 3018
• Length: 764
• Species: Homo sapiens
• Alignment Length: 650
• Identity: 161/650 - (24%)
• Similarity: 277/650 - (42%)
• Gaps: 132/650 - (20%)

  Fly    40 KWKRRLHRHVPVFQWLPLYS-TEWGIDDFIAGITLGLTIIPESMACALLAGLPARYGLCSAFIGP 103
            |.||.:....|:..|||.|. .||.:.|.::||:.|:..:.:.:|.|||..:|..|||.::|...
Human    49 KAKRIVLSLFPIASWLPAYRLKEWLLSDIVSGISTGIVAVLQGLAFALLVDIPPVYGLYASFFPA 113

  Fly   104 LIYMVFGSIDKVIIGPTSLVALV-------SVQ--------FTVGRP---------------IEF 138
            :||:.||:...:.:||..:::::       :|.        .|:|.|               :..
Human   114 IIYLFFGTSRHISVGPFPILSMMVGLAVSGAVSKAVPDRNATTLGLPNNSNNSSLLDDERVRVAA 178

  Fly   139 AFLLTFLSGIVQIIMGTMRMGFIFEFISMPVIKAFSSATAILVIESQLKVLLGIKYLVAGLMNSV 203
            |..:|.||||:|:..|.:|:||:..::|..:|..|::|.|:.|:.||||.:  .:..|....:.|
Human   179 AASVTVLSGIIQLAFGILRIGFVVIYLSESLISGFTTAAAVHVLVSQLKFI--FQLTVPSHTDPV 241

  Fly   204 GMLS------SRIEESNMADLIMGVCAIVFLLLLELLDRVANNEKRNKILRIFCRYLSTSRNTLI 262
            .:..      |:||::|:|||   |.|::.||::.::..:....|....:.|...::.|
Human   242 SIFKVLYSVFSQIEKTNIADL---VTALIVLLVVSIVKEINQRFKDKLPVPIPIEFIMT------ 297

  Fly   263 VLIAAIVSFIWIQKCGQVPYALSKNALSTL------PNFTVP-SFHIETAERNYSIWEVLKELNI 320
             :|||.||:    .|.      .||.....      |.|..| :..:||.:......       .
Human   298 -VIAAGVSY----GCD------FKNRFKVAVVGDMNPGFQPPITPDVETFQNTVGDC-------F 344

  Fly   321 GIIVIPIVGILTNISIGKLTPKGLVDTNQELLTVGLCNMFGSCVQAMPSSGAFTRYAISTACGLR 385
            ||.::......:..|:..|.....:|.||||:.:||.|:.....:....|.|.:|.|:..:.|.:
Human   345 GIAMVAFAVAFSVASVYSLKYDYPLDGNQELIALGLGNIVCGVFRGFAGSTALSRSAVQESTGGK 409

  Fly   386 TPMANLYLGIIVL---LALSY-LSPYFNYIPEATLAAILICSI-FTLLDFKLPMRLWRDSKRDFA 445
            |.:|.|...||||   ||:.: |:|    :.::.|||:.:.:: ..|:.|....||||..|.|..
Human   410 TQIAGLIGAIIVLIVVLAIGFLLAP----LQKSVLAALALGNLKGMLMQFAEIGRLWRKDKYDCL 470

  Fly   446 TWLLCFCVSVLFGVEVGLFVSIVVTALHLLFLWARPEI-------RVKIEQLDEMQYIRVTPS-- 501
            .|::.|..:::.|:.:||..|:....|.::|....|:.       |..|.:..:..|....|.
Human   471 IWIMTFIFTIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANIGRTNIYKNKKDYYDMYEPEGV 535

  Fly   502 ------NGIYFPAINYLRERVLKACEQADFRITVVIDGQRISGMDYTAAQGISKLSSDLCRQADA 560
                  :.|||..|.:.|.:::.|         |.....||......|.:.|.||..
Human   536 KIFRCPSPIYFANIGFFRRKLIDA---------VGFSPLRILRKRNKALRKIRKLQK-------- 583

  Fly   561 SSSTLLILFRFPEHLQRLIDNTDNLVFCESENKVKEFLTQESLRNGYINLKEHIRASIDLGYKID 625
                           |.|:..|.....| :.:.:|:  :.|.|.|..|.:.:....:.||.:.||
Human   584 ---------------QGLLQVTPKGFIC-TVDTIKD--SDEELDNNQIEVLDQPINTTDLPFHID 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5404	NP_650482.1	PRK11660	50..557	CDD:481320	145/570 (25%)
SLC26A3	NP_000102.1	Sulfate_transp	73..475	CDD:459995	113/434 (26%)
		STAS_SulP_like_sulfate_transporter	526..712	CDD:132913	27/139 (19%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:22627094	761..764