DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX4 and AO4

DIOPT Version :9

Sequence 1:	NP_650478.1	Gene:	AOX4 / 41897	FlyBaseID:	FBgn0038350	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_563711.1	Gene:	AO4 / 839488	AraportID:	AT1G04580	Length:	1337	Species:	Arabidopsis thaliana

Alignment Length:	1348	Identity:	409/1348 - (30%)
Similarity:	657/1348 - (48%)	Gaps:	198/1348 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FTINGQPYAVNLTDLPPDITLNTFIREHAQLTATKFMCLEGGCGACVCAVS------DGKSTWTV 63
            |.:||:.:.|  ..:.|..||..|:|.:....:.|..|.|||||||:..:|      |....:::
plant     8 FAVNGEKFEV--LSVNPSTTLLEFLRSNTCFKSVKLSCGEGGCGACIVILSKYDPVLDQVEEYSI 70

  Fly    64 NSCLKLLNTCAQLEIITCEGLGNQVTGYHPIQKRLAKMNGTQCGFCSPGFVMNMY-GLMEQHGGR 127
            ||||.||.:.....|.|.:||||...|:|||.||.|..:.:|||||:||..:::| .|.:.|..:
plant    71 NSCLTLLCSLNGCSITTSDGLGNTEKGFHPIHKRFAGFHASQCGFCTPGMCISLYSALSKAHNSQ 135

  Fly   128 -----VTMEEVENSFGGNICRCTGYRPILDAMKSFAVDSTVEVSEESVDIEDL------------ 175
                 :|....|.|..||:|||||||||.||.||||.|         ||||||
plant   136 SSPDYLTALAAEKSIAGNLCRCTGYRPIADACKSFASD---------VDIEDLGFNSFWRKGESR 191

  Fly   176 -----NLKARNCPRSGKVC-------KGTCRQSKLIYEDGSQWYW--PSTLAEIFEALENVGDSE 226
                 .|...| |....:.       |..|:.:.|   |.::::|  |.::||:.|.|......:
plant   192 EEMLKKLPPYN-PEKDLITFPDFLKEKIKCQHNVL---DQTRYHWSTPGSVAELQEILATTNPGK 252

  Fly   227 E---FMLVGGNTAHGVYRRSPDIKHFIDVNGVEDLHQYSSDKEKLTLGASLSLTETME-IIQSTS 287
            :   ..||.|||..|.|:.......:||::.:.::.....|..::.:||.:::::.:: :::..:
plant   253 DRGLIKLVVGNTGTGYYKEEKQYGRYIDISHIPEMSMIKKDDREIEIGAVVTISKVIDALMEENT 317

  Fly   288 KQSGFEYLEVLWHHIDLVANVPVRNSGTLAGNICTKKEHPEFPSDIFISFEALDVKVVAMKGIDD 352
            ....|:.:.|   |::.|||..:||||::.||: ...:...|||||.....|.|..|..:.....
plant   318 SAYVFKKIGV---HMEKVANHFIRNSGSIGGNL-VMAQSKSFPSDITTLLLAADASVHMINAGRH 378

  Fly   353 EKEMTLEEFLGD---TDRKMLLKAFILPRYPKDM---YIYDSFKIMPR-AQNAHAYVNAGFL--L 408
            || :.:.|:|..   .|.|.:|....:||:....   .::::::...| ..:|..|:||.||  :
plant   379 EK-LRMGEYLVSPPILDTKTVLLKVHIPRWIASSTTGLLFETYRAALRPIGSALPYINAAFLAVV 442

  Fly   409 ELDGNS---MVKSARICF---GGIRPDFIHATDIEQLMVGHSPYESNLVEQTFNKLESLVKPDEV 467
            ..|.:|   :|...|:.|   ||...  |.|.::|..:.|.....|.|.| ....|:.::.|.
plant   443 SHDASSSGIIVDKCRLAFGSYGGYHS--IRAREVEDFLTGKILSHSVLYE-AVRLLKGIIVPS-- 502

  Fly   468 LPDASPAYRSKLACGLLYKFLLKHAPDAEVSGKFKSGGELLQRP---------LSSGLQLFQTNK 523
            :..:...|:..||.|.|:.||.   |..| ||.:.|.|:.:...         |||..|:|: :|
plant   503 IDTSYSEYKKSLAVGFLFDFLY---PLIE-SGSWDSEGKHIDGHIDPTICLPLLSSAQQVFE-SK 562

  Fly   524 QTYPVTQGVQKLEGMIQCSGEATYMNDVLTTSNSVYCAFVGATKVGATIDQIDATEALQHPGVVA 588
            :.:||.:.:.|....:|.||||.|::|:.:..:.::.||:.:||..|.|..:..:..:...||:|
plant   563 EYHPVGEAIIKFGAEMQASGEAVYVDDIPSLPHCLHGAFIYSTKPLAWIKSVGFSGNVTPIGVLA 627

  Fly   589 FYTAKDIP--GTNTFCEPSFGYEAEEIFCSGMVRHSE------QPVGVIVALTADQAQRATKLVK 645
            ..|.||||  |.|      .||..  :|.:|::...|      |.:.::||.|...|..|..|..
plant   628 VITFKDIPEVGQN------IGYIT--MFGTGLLFADEVTISAGQIIALVVADTQKHADMAAHLAV 684

  Fly   646 ISYSSPSSNFKLMPSLKDVFSSETPDTSRIIPLVISKLKEV--KFSDKP-----------DLEVR 697
            :.|.|.:....:: |::|....             |.|.||  ::..:|           |.::|
plant   685 VEYDSRNIGTPVL-SVEDAVKR-------------SSLFEVPPEYQPEPVGDISKGMAEADRKIR 735

  Fly   698 GI-FEMGLQYHFTMEPQTTIIIPFEDG-LKVFSATQWIDQTQSVIAHTLQMKAKDVQLEVRRLGG 760
            .: ..:|.||.|.||.||.:.:|.||. |.|:|:||..:.||:|||..|.:...:|::..||:||
plant   736 SVELRLGSQYFFYMETQTALALPDEDNCLVVYSSTQAPEFTQTVIATCLGIPEHNVRVITRRVGG 800

  Fly   761 GYGCKISRGNQVACAAALAAHKLNRPVRFVQSLESMMDCNGKRWACRSEYQCHVKTSGRIVGLSN 825
            |:|.|..:...||.|.||||.|:.||||...:.::.|...|.|...:..|....::.|::..|..
plant   801 GFGGKAIKSMPVATACALAAKKMQRPVRIYVNRKTDMIMAGGRHPLKITYSVGFRSDGKLTALDL 865

  Fly   826 DFYEDAGWNTNESPVQGHSTFTAANCYEFTDSNFKLSGHAVLTDAPSSTWCRAPGSVEGIAMMEN 890
            :.:.|||.:.:.|.|...:...:...|::...:|.:.  ...|:.||.|..||||.|:|..:.|:
plant   866 NLFIDAGSDVDVSLVMPQNIMNSLRKYDWGALSFDIK--VCKTNLPSRTSLRAPGEVQGSYIAES 928

  Fly   891 IIEHVAFEIQKDPAEVRLANISKKSKMATVFPEFLKTREYYS----------------RKKEIEA 939
            |||:||..::.|...||..|:.....:...:.:.....:.|:                |.:.::.
plant   929 IIENVASSLKMDVDVVRRINLHTYESLRKFYKQAAGEPDEYTLPLLWDKLEVSADFRRRAESVKE 993

  Fly   940 FNANNRWKKRGLGLSLMNFPIIYI---GQFPATVTIYHVDGTVVVTHGGIEMGQGMNTKIAQVAA 1001
            ||..|.|:|||:.    ..|||::   ...|..|:|.: ||:|.|...|||:|||:.||:.|:.|
plant   994 FNRCNIWRKRGIS----RVPIIHLVIHRPTPGKVSILN-DGSVAVEVAGIEVGQGLWTKVQQMVA 1053

  Fly  1002 YTLGID--------LSYVKVESSTSINGANSMVTGYAIGSESVCYAVRKICETLNARLKP----- 1053
            |.||:.        |..:::..:.:::.:.|..|..:..||:.|.|||..|..|..||:|
plant  1054 YGLGMIKCEGSDDLLERIRLLQTDTLSMSQSSYTAGSTTSENCCEAVRLCCGILVERLRPTMNQI 1118

  Fly  1054 VRKAKA-TWVETVEAANAQLINLIASDHYK----TGDMQNYHVLGLALSEVEIDVLTGNILIRRV 1113
            :..|:: ||...::.||||.::|.|...||    :.:..||   |:..||||:|::||...|.|.
plant  1119 LENARSVTWDMLIQQANAQSVDLSARTFYKPESSSAEYLNY---GVGASEVEVDLVTGRTEIIRS 1180

  Fly  1114 DILEDAGESLSPWIDVGQVEGAFVMGLGYWLSELLIYE----GDNGRLLTNRTWNYKPLGAKDIP 1174
            ||:.|.|:||:|.:|:||:|||||.|:|:::     ||    .:||.:....||:||......||
plant  1181 DIIYDCGKSLNPAVDLGQIEGAFVQGIGFFM-----YEEYTTNENGLVNEEGTWDYKIPTIDTIP 1240

  Fly  1175 IDFRVELVHNPRPSSSGFMGSKATGEPPCCLAVSVIFALQQALQSARQ 1222
            ..|.|::: |.....:..:.|||:||||..:|.||..|.:.|::.||:
plant  1241 KQFNVQIL-NSGHHKNRVLSSKASGEPPLLVAASVHCATRSAIREARK 1287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX4	NP_650478.1	PLN02906	24..1240	CDD:215491	404/1329 (30%)
		Fer2_2	80..153	CDD:280048	36/78 (46%)
		FAD_binding_5	203..378	CDD:279309	45/183 (25%)
		CO_deh_flav_C	388..489	CDD:281449	29/109 (27%)
		Ald_Xan_dh_C	542..648	CDD:214971	34/113 (30%)
		Ald_Xan_dh_C2	690..1174	CDD:280834	172/537 (32%)
AO4	NP_563711.1	PLN00192	1..1337	CDD:215096	409/1348 (30%)
		fer2	6..86	CDD:238126	26/79 (33%)
		Fer2_2	87..167	CDD:280048	37/79 (47%)
		FAD_binding_5	229..407	CDD:279309	46/182 (25%)
		CO_deh_flav_C	419..526	CDD:281449	30/114 (26%)
		Ald_Xan_dh_C	581..691	CDD:279635	36/117 (31%)
		Ald_Xan_dh_C2	720..1240	CDD:280834	171/534 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	83	1.000	Domainoid score	I2880
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H98597
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720