DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AOX4 and XDH

DIOPT Version :9

Sequence 1:NP_650478.1 Gene:AOX4 / 41897 FlyBaseID:FBgn0038350 Length:1256 Species:Drosophila melanogaster
Sequence 2:NP_000370.2 Gene:XDH / 7498 HGNCID:12805 Length:1333 Species:Homo sapiens


Alignment Length:1370 Identity:410/1370 - (29%)
Similarity:642/1370 - (46%) Gaps:203/1370 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 FTINGQPYAVNLTDLPPDITLNTFIREHAQLTATKFMCLEGGCGACVCAVS-----DGKST-WTV 63
            |.:||:.......|  |:.||..::|....|:.||..|.|||||||...:|     ..|.. ::.
Human     8 FFVNGRKVVEKNAD--PETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHFSA 70

  Fly    64 NSCLKLLNTCAQLEIITCEGLGNQVTGYHPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQHGGRV 128
            |:||..:.:...:.:.|.||:|:..|..||:|:|:||.:|:|||||:||.||:||.|: ::....
Human    71 NACLAPICSLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLL-RNQPEP 134

  Fly   129 TMEEVENSFGGNICRCTGYRPILDAMKSFA--------------------VDSTVEVS------E 167
            ||||:||:|.||:||||||||||...::||                    .|.:|.:|      |
Human   135 TMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNCCMNQKKDHSVSLSPSLFKPE 199

  Fly   168 ESVDIEDLN--------LKARNCPRSGKVCKGTCRQSKLIYEDGSQ--WYWPSTLAEIFEALENV 222
            |...::...        |:.::.||            |.:..:|.:  |...|||.|:.:.....
Human   200 EFTPLDPTQEPIFPPELLRLKDTPR------------KQLRFEGERVTWIQASTLKELLDLKAQH 252

  Fly   223 GDSEEFMLVGGNTAHGVYRRSPDI--KHFIDVNGVEDLHQYSSDKEKLTLGASLSLTETMEIIQS 285
            .|::   ||.|||..|:..:..::  ...:....:.:|:......:.::.||:..|:    |::.
Human   253 PDAK---LVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLS----IVEK 310

  Fly   286 TSKQSGFEYLEVLWHHIDLVANVP---------------------VRNSGTLAGNICTKKEHPEF 329
            |.              :|.||.:|                     |::..::.|||.|..     
Human   311 TL--------------VDAVAKLPAQKTEVFRGVLEQLRWFAGKQVKSVASVGGNIITAS----- 356

  Fly   330 P-SDIFISFEALDVKV-VAMKGIDDEKEMTLEEFLGDTDRKMLLK------AFILPRYPKDMYIY 386
            | ||:...|.|...|: :..:|.....:|....|.|  .||.||.      :..:| |.::...:
Human   357 PISDLNPVFMASGAKLTLVSRGTRRTVQMDHTFFPG--YRKTLLSPEEILLSIEIP-YSREGEYF 418

  Fly   387 DSFKIMPRAQNAHAYVNAGF-LLELDGNSMVKSARICFGGIRPDFIHATDIEQLMVGHSPYESNL 450
            .:||...|.::..|.|.:|. :|...|.:.|:...:|:||:....|.|....|..:.....|..|
Human   419 SAFKQASRREDDIAKVTSGMRVLFKPGTTEVQELALCYGGMANRTISALKTTQRQLSKLWKEELL 483

  Fly   451 VEQTFNKLESLVKPDEVLPDASPAYRSKLACGLLYKFLL--------KHAPD--AEVSGKFKSGG 505
            .:......|.|..|.:. |.....:|..|.....:||.|        ::..|  .::...|.|..
Human   484 QDVCAGLAEELHLPPDA-PGGMVDFRCTLTLSFFFKFYLTVLQKLGQENLEDKCGKLDPTFASAT 547

  Fly   506 ELLQRPLSSGLQLFQTNKQTYPVTQGVQKLEGM--------IQCSGEATYMNDVLTTSNSVYCAF 562
            .|.|:...:.:|||    |..|..|..:.:.|.        :|.||||.|.:|:....|.:....
Human   548 LLFQKDPPADVQLF----QEVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDDIPRYENELSLRL 608

  Fly   563 VGATKVGATIDQIDATEALQHPGVVAFYTAKDIPGTNT--FCEPSFGYEAEEIFCSGMVRHSEQP 625
            |.:|:..|.|..||.:||.:.||.|.|.:|.|:||:|.  .|.....:..:::.|.|.:      
Human   609 VTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSNITGICNDETVFAKDKVTCVGHI------ 667

  Fly   626 VGVIVALTADQAQRATKLVKISYSSPSSNFKLMPSLKDVFSSETPDTSRIIPLVISKLKEVKFSD 690
            :|.:||.|.:..|||.:.|||:|....:...:..::|: .|...|:      |.|.|....|...
Human   668 IGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKN-NSFYGPE------LKIEKGDLKKGFS 725

  Fly   691 KPDLEVRGIFEMGLQYHFTMEPQTTIIIPFEDG--LKVFSATQWIDQTQSVIAHTLQMKAKDVQL 753
            :.|..|.|...:|.|.||.:|...||.:|..:.  :::|.:||...:|||.:|..|.:.|..:.:
Human   726 EADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVV 790

  Fly   754 EVRRLGGGYGCKISRGNQVACAAALAAHKLNRPVRFVQSLESMMDCNGKRWACRSEYQCHVKTSG 818
            .|:|:|||:|.|.:|...|:.|.||||:|..||||.:...:..|...|.|....:.|:.....:|
Human   791 RVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTG 855

  Fly   819 RIVGLSNDFYEDAGWNTNE--SPVQGHSTFTAANCYEFTDSNFKLSGHAVLTDAPSSTWCRAPGS 881
            .:|.|..|.:.:.| ||.:  ..:...:.|...|||:.  .|.:.:|....|:.||:|..|..|.
Human   856 TVVALEVDHFSNVG-NTQDLSQSIMERALFHMDNCYKI--PNIRGTGRLCKTNLPSNTAFRGFGG 917

  Fly   882 VEGIAMMENIIEHVAFEIQKDPAEVRLANISKKSKMA------------TVFPEFLKTREYYSRK 934
            .:|:.:.|..:..||........|||..|:.|:..:.            ..:.|.|.:.:|::||
Human   918 PQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKLEGFTLPRCWEECLASSQYHARK 982

  Fly   935 KEIEAFNANNRWKKRGL-------GLSLMNFPIIYIGQFPATVTIYHVDGTVVVTHGGIEMGQGM 992
            .|::.||..|.||||||       |:|   |.:.::.|..|.:.:| .||:|::||||.|||||:
Human   983 SEVDKFNKENCWKKRGLCIIPTKFGIS---FTVPFLNQAGALLHVY-TDGSVLLTHGGTEMGQGL 1043

  Fly   993 NTKIAQVAAYTLGIDLSYVKVESSTSINGANSMVTGYAIGSESVCYAVRKICETLNARLKPVRK- 1056
            :||:.|||:..|.|..|.:.:..:::....|:..|..::.::....||...|:|:..||:|.:| 
Human  1044 HTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAASVSADLNGQAVYAACQTILKRLEPYKKK 1108

  Fly  1057 -AKATWVETVEAANAQLINLIASDHYKT-----------GDMQNYHVLGLALSEVEIDVLTGNIL 1109
             ...:|.:.|.||....::|.|:..|:|           |:..:|...|:|.||||||.|||:..
Human  1109 NPSGSWEDWVTAAYMDTVSLSATGFYRTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHK 1173

  Fly  1110 IRRVDILEDAGESLSPWIDVGQVEGAFVMGLGYWLSELLIYEGDNGRLLTNRTWNYKPLGAKDIP 1174
            ..|.||:.|.|.||:|.||:||||||||.|||.:..|.|.|..: |.|.|.....||......||
Human  1174 NLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPE-GSLHTRGPSTYKIPAFGSIP 1237

  Fly  1175 IDFRVELVHNPRPSSSGFMGSKATGEPPCCLAVSVIFALQQALQSAR-QDAG-LPREWLRLGAPT 1237
            |:|||.|:.: .|:......|||.||||..||.|:.||::.|:::|| |..| ..:|..||.:|.
Human  1238 IEFRVSLLRD-CPNKKAIYASKAVGEPPLFLAASIFFAIKDAIRAARAQHTGNNVKELFRLDSPA 1301

  Fly  1238 TPETL 1242
            |||.:
Human  1302 TPEKI 1306

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AOX4NP_650478.1 PLN02906 24..1240 CDD:215491 403/1347 (30%)
Fer2_2 80..153 CDD:280048 43/72 (60%)
FAD_binding_5 203..378 CDD:279309 42/207 (20%)
CO_deh_flav_C 388..489 CDD:281449 25/101 (25%)
Ald_Xan_dh_C 542..648 CDD:214971 37/107 (35%)
Ald_Xan_dh_C2 690..1174 CDD:280834 172/519 (33%)
XDHNP_000370.2 PLN02906 23..1319 CDD:215491 405/1353 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG4631
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D48717at2759
OrthoFinder 1 1.000 - - FOG0000201
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100184
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.720

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