Protein Alignment AOX4 and Aox4

DIOPT Version :10

• Sequence 1: NP_650478.1
• Gene: AOX4 / 41897
• FlyBaseID: FBgn0038350
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_076120.2
• Gene: Aox4 / 71872
• MGIID: 1919122
• Length: 1336
• Species: Mus musculus
• Alignment Length: 1365
• Identity: 418/1365 - (30%)
• Similarity: 638/1365 - (46%)
• Gaps: 175/1365 - (12%)

  Fly     5 FTINGQPYAVNLTDLPPDITLNTFIREHAQLTATKFMCLEGGCGACVCAVS--DGKST----WTV 63
            |.:||:.......|  |:..|..:.|:...||.||:.|..||||||...||  :.|:.    :..
Mouse    12 FFVNGKKVIEKNPD--PEKNLLFYTRKVLNLTGTKYSCGTGGCGACTVMVSRYNPKTRKIHHYPA 74

  Fly    64 NSCLKLLNTCAQLEIITCEGLGNQVTGYHPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQHGGRV 128
            .:||..:.......|.|.||:|:.....||:|:||||.:||||||||||.||::|.|:..| ...
Mouse    75 TACLVPICWLHGAAITTVEGVGSIKKRVHPVQERLAKCHGTQCGFCSPGMVMSIYTLLRNH-PEP 138

  Fly   129 TMEEVENSFGGNICRCTGYRPILDAMKSFAVDSTVEVSEES----VDIEDLNLKARNCPRSGKVC 189
            |.:::..:.|||:|||||||||:::.|:|:..|||...:.|    :|.::..|::    |..|:|
Mouse   139 TPDQITEALGGNLCRCTGYRPIVESGKTFSQKSTVCQMKGSGKCCMDPDEKCLES----REKKMC 199

  Fly   190 KGTCRQSKLIYEDGSQ----------------------------------WYWPSTLAEIFEALE 220
                  :||..||..|                                  |..|.||.::   ||
Mouse   200 ------TKLYNEDEFQPFDPSQEPIFPPELIRMAEDPNKRRLTFQGKRTTWIIPVTLNDL---LE 255

  Fly   221 NVGDSEEFMLVGGNTAHGVYRRSPDIKH-------FIDVNGVEDLHQYSSDKEKLTLGASLSLT- 277
            ......|..||.|||..|     |.||.       ||...||.:|:...:....:|:||..||.
Mouse   256 LKASYPEAPLVMGNTTVG-----PGIKFNDEFYPVFISPLGVPELNLMDTTNNGVTIGAGYSLAQ 315

  Fly   278 --ETMEIIQSTSKQSGFEYLEVLWHHIDLVANVPVRNSGTLAGNICTKKEHPEFPSDI--FISFE 338
              :|::.:.|...:...:....|..|:..:|...:||..||.|:..::   |.| ||:  .::..
Mouse   316 LKDTLDFLVSEQPKEKTKTFHALQKHLRTLAGPQIRNMATLGGHTASR---PNF-SDLNPILAAG 376

  Fly   339 ALDVKVVAMKGIDDEKEMTLE----EFLGDTDRK---MLLKAFILPRYPKDMYIYDSFKIMPRAQ 396
            ...:.||:.:|.|  :::.|.    |.|.:.|.|   ::|..||  .|..........::..|.:
Mouse   377 NATINVVSREGKD--RQLPLNGPFLEKLPEADLKPEEVILSIFI--PYTAQWQFVSGLRLAQRQE 437

  Fly   397 NAHAYVNAGFLLEL-DGNSMVKSARICFGGIRPDFIHATDIEQLMVGHSPYESNLVEQTFNKLES 460
            ||.|.||||..:|. :|.:.:|..::.||.:.|..:.|:...:.::|....:..|.:.....|:.
Mouse   438 NAFAIVNAGMSVEFEEGTNTIKDLKMFFGSVAPTVVSASQTCKQLIGRQWDDQMLSDACQLVLQE 502

  Fly   461 LVKPDEVLPDASPA---YRSKLACGLLYKFLLK-----------HAPDAEVSGKFKSGGELLQRP 511
            :..|    |||...   ||..|...||:||.||           ..||  :.|||.|..:.....
Mouse   503 IRIP----PDAEGGMVEYRRTLIISLLFKFYLKVQRWLNEMDPQKFPD--IPGKFVSALDDFPIE 561

  Fly   512 LSSGLQLFQ----TNKQTYPVTQGVQKLEGMIQCSGEATYMNDVLTTSNSVYCAFVGATKVGATI 572
            ...|:|:||    ...|..||...:....|:...:|||.:::|:......:..|.|.:|:..|.|
Mouse   562 TPQGIQMFQCVDPKQPQKDPVGHPIMHQSGIKHATGEAIFIDDMPPIDQELCLAVVTSTRAHAKI 626

  Fly   573 DQIDATEALQHPGVVAFYTAKDIPGTNTFCEPSFGYEAEEIFCSGMVRHSEQPVGVIVALTADQA 637
            ..:|.:|||..||||...||:|:||.|.. .....|...|:.|.|.:      :..:.|.|...|
Mouse   627 TSLDVSEALACPGVVDVITAEDVPGENDH-NGEILYAQSEVICVGQI------ICTVAADTYIHA 684

  Fly   638 QRATKLVKISYSSPSSNFKLMPSLKDVFSSETPDTSRIIPLVISKLKE--VKFSDK-PDLEVRGI 699
            :.|.|.|||:|.........:....:..|..:|:         .|:::  |.::.| .|..|.|.
Mouse   685 KEAAKRVKIAYDDIEPTIITIEEALEHNSFLSPE---------KKIEQGNVDYAFKHVDQIVEGE 740

  Fly   700 FEMGLQYHFTMEPQTTIIIP-FEDGLKVFS-ATQWIDQTQSVIAHTLQMKAKDVQLEVRRLGGGY 762
            ..:..|.||.||.||.:.|| .||...|.. .||:....|..::..|.:....:...::|.||.:
Mouse   741 IHVEGQEHFYMETQTILAIPQTEDKEMVLHLGTQFPTHVQEFVSAALNVPRSRIACHMKRAGGAF 805

  Fly   763 GCKISRGNQVACAAALAAHKLNRPVRFVQSLESMMDCNGKRWACRSEYQCHVKTSGRIVGLSNDF 827
            |.|:::...:....|:||:|..||:||:......|.....|.....:|:.....:|.|.....::
Mouse   806 GGKVTKPALLGAVCAVAANKTGRPIRFILERSDDMLITAGRHPLLGKYKIGFMNNGEIRAADVEY 870

  Fly   828 YEDAGWNTNESP-VQGHSTFTAANCYEFTDSNFKLSGHAVLTDAPSSTWCRAPGSVEGIAMMENI 891
            |.:.|...:||. |.......:.|.|..  .||:..|.|..|:.||:|..|..|..:...::|..
Mouse   871 YTNGGCTPDESELVIEFVVLKSENTYHI--PNFRCRGRACKTNLPSNTAFRGFGFPQATVVVEAY 933

  Fly   892 IEHVAFEIQKDPAEVRLANISKK-SKMA---TVFP--------EFLKTREYYSRKKEIEAFNANN 944
            |..||.:....|.|||..|:.|| ||.|   |..|        |.|:...:::|||..|.||.||
Mouse   934 IAAVASKCNLLPEEVREINMYKKTSKTAYKQTFNPEPLRRCWKECLEKSSFFARKKAAEEFNGNN 998

  Fly   945 RWKKRGLGLSLMNF----PIIYIGQFPATVTIYHVDGTVVVTHGGIEMGQGMNTKIAQVAAYTLG 1005
            .||||||.:..|.|    ||.:..|..|.|.|: :||:|::||||.|:|||::||:.|||:..|.
Mouse   999 YWKKRGLAVVPMKFSVAVPIAFYNQAAALVHIF-LDGSVLLTHGGCELGQGLHTKMIQVASRELN 1062

  Fly  1006 IDLSYVKVESSTSINGANSMVTGYAIGSESVCYAVRKICETLNARLKPV--RKAKATWVETVEAA 1068
            :..|||....:::....||..|..::|::....||:..|:.|..||:|:  :..|..|.|.::.|
Mouse  1063 VPKSYVHFSETSTTTVPNSAFTAGSMGADINGKAVQNACQILMDRLRPIIRKNPKGKWEEWIKMA 1127

  Fly  1069 NAQLINLIASDHYK-----------TGDMQNYHVLGLALSEVEIDVLTGNILIRRVDILEDAGES 1122
            ..:.|:|.|:.::|           .||...|:|.|.|.||||:|.|||...:.|.||..||..|
Mouse  1128 FEESISLSATGYFKGYQTNMDWKKEEGDPYPYYVYGAACSEVEVDCLTGAHKLLRTDIFVDAAFS 1192

  Fly  1123 LSPWIDVGQVEGAFVMGLGYWLSELLIYEGDNGRLLTNRTWNYKPLGAKDIPIDFRVELVHNPRP 1187
            ::|.:|:|||||||:.|:|::.:|.|.| ...|.|.:....:||.....:||.:|.|.|||:..|
Mouse  1193 INPALDIGQVEGAFIQGMGFYTTEELKY-SPKGVLYSRGPEDYKIPTITEIPEEFYVTLVHSRNP 1256

  Fly  1188 SSSGFMGSKATGEPPCCLAVSVIFALQQALQSARQDAGLPREWLRLGAPTTPETLLLNAGHQVSE 1252
            .:  ...||..||....|..||:||:..|:.:||::.|| .:...|.:|.|||.:.:....|.:|
Mouse  1257 IA--IYSSKGLGEAGMFLGSSVLFAIYDAVTTARKERGL-SDIFPLNSPATPEVIRMACTDQFTE 1318

  Fly  1253  1252
            Mouse  1319  1318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AOX4	NP_650478.1	PLN02906	24..1240	CDD:215491	409/1332 (31%)
Aox4	NP_076120.2	mam_aldehyde_ox	9..1335	CDD:132014	418/1365 (31%)