DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX4 and Aox3

DIOPT Version :9

Sequence 1:	NP_650478.1	Gene:	AOX4 / 41897	FlyBaseID:	FBgn0038350	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_076106.2	Gene:	Aox3 / 71724	MGIID:	1918974	Length:	1335	Species:	Mus musculus

Alignment Length:	1347	Identity:	403/1347 - (29%)
Similarity:	640/1347 - (47%)	Gaps:	160/1347 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FTINGQPYAVNLTDLPPDITLNTFIREHAQLTATKFMCLEGGCGACVC------AVSDGKSTWTV 63
            |.:||:.......|  |::.|..::|:..:||.||:.|..|.||||..      .:|...|.::.
Mouse    12 FFVNGKKVTERNAD--PEVNLLFYLRKVIRLTGTKYGCGGGDCGACTVMISRYDPISKRISHFSA 74

  Fly    64 NSCLKLLNTCAQLEIITCEGLGNQVTGYHPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQHGGRV 128
            .:||..:.:.....:.|.||:|:..|..||:|:|:||.:|||||||:||.||::|.|:..|....
Mouse    75 TACLVPICSLHGAAVTTVEGIGSTKTRIHPVQERIAKGHGTQCGFCTPGMVMSIYTLLRNHPEPS 139

  Fly   129 TMEEVENSFGGNICRCTGYRPILDAMKSFAVDST-VEVSEESVDIEDLNLKARNCP-RSGKVCKG 191
            | |::..:.|||:|||||||||:::.|||...|| .:::.|.....|   :.:|.| |...||..
Mouse   140 T-EQIMETLGGNLCRCTGYRPIVESAKSFCPSSTCCQMNGEGKCCLD---EEKNEPERKNSVCTK 200

  Fly   192 TCRQSKLIYEDGSQ----------------------------WYWPSTLAEIFEALENVGDSEEF 228
            ...:.:....|.:|                            |..|.||.::.| |:....|..
Mouse   201 LYEKKEFQPLDPTQELIFPPELMRMAEESQNTVLTFRGERTTWIAPGTLNDLLE-LKMKHPSAP- 263

  Fly   229 MLVGGNTAHGVYRRSPDIKHFIDVN--GVEDLHQYSSDKEKLTLGASLSLTETMEIIQSTSKQSG 291
             ||.|||..|::.:..|:.:.|.::  .:.:|...::.|:.|||||.||||:...::.....:..
Mouse   264 -LVIGNTYLGLHMKFTDVSYPIIISPARILELFVVTNTKQGLTLGAGLSLTQVKNVLSDVVSRLP 327

  Fly   292 FEYLEV---LWHHIDLVANVPVRNSGTLAGNICTKKEHPEFPSDIFISFEALDVKVVAMKGIDDE 353
            .|..::   |...:..:|...:||..:|.|:|.::.  |....:..:......:.|.:.:||
Mouse   328 KEKTQIYCALLKQLKTLAGQQIRNVASLGGHIISRL--PTSDLNPILGIGNCILNVASTEGI--- 387

  Fly   354 KEMTL-EEFL-GDTD-----RKMLLKAFILPRYPKDMYIYDSFKIMPRAQNAHAYVNAGF--LLE 409
            :::.| :.|| |..|     .::|:..|: ||..|..:: .:|:..||.|||.|.||||.  :.:
Mouse   388 QQIPLNDHFLAGVPDAILKPEQVLISVFV-PRSSKWEFV-SAFRQAPRQQNAFATVNAGMKVVFK 450

  Fly   410 LDGNSMVKSARICFGGIRPDFIHATDIEQLMVGHSPYESNLVEQTFNKLESLVKPDEVLPDASPA 474
            .|.|: :....|.:|||....|.|....:.::|.. ::..:::.....:...|......|.....
Mouse   451 EDTNT-ITDLGILYGGIGATVISADKSCRQLIGRC-WDEEMLDDAGKMICEEVSLLMAAPGGMEE 513

  Fly   475 YRSKLACGLLYKFLL----------KHA-PDAEVSGKFKSGGELLQRPLSSGLQLFQ----TNKQ 524
            ||..||...|:.|.|          .|. ||  :|.|.....|.....:..|:|.||    ....
Mouse   514 YRKTLAISFLFMFYLDVLKQLKTRDPHKYPD--ISQKLLHILEDFPLTMPYGMQSFQDVDFQQPL 576

  Fly   525 TYPVTQGVQKLEGMIQCSGEATYMNDVLTTSNSVYCAFVGATKVGATIDQIDATEALQHPGVVAF 589
            ..|:.:.:....|:...:|||.:.:|:......::.|.|.::|..|.|..:||:|||...|||..
Mouse   577 QDPIGRPIMHQSGIKHATGEAVFCDDMSVLPGELFLAVVTSSKSHAKIISLDASEALASLGVVDV 641

  Fly   590 YTAKDIPGTNTFCEPSFGYEAEEIFCSGMVRHSEQPVGVIVALTAD---QAQRATKLVKISYSSP 651
            .||:|:||.|...|.|. |..:|:.|.|.         ::.|:.||   .||:|.|.|||.|...
Mouse   642 VTARDVPGDNGREEESL-YAQDEVICVGQ---------IVCAVAADSYAHAQQAAKKVKIVYQDI 696

  Fly   652 SSNFKLMPSLKDVFSSET---PDTSRIIPLVISKLKEVKFSDK---PDLEVRGIFEMGLQYHFTM 710
            .   .::.:::|....|:   |:         .||::....:.   .|..:.|...:|.|.||.|
Mouse   697 E---PMIVTVQDALQYESFIGPE---------RKLEQGNVEEAFQCADQILEGEVHLGGQEHFYM 749

  Fly   711 EPQTTIIIP-FED-GLKVFSATQWIDQTQSVIAHTLQMKAKDVQLEVRRLGGGYGCKISRGNQVA 773
            |.|:..::| .|| .:.::.::|....||.::|.||.:....:...|:|:||.:|.|.|:...:|
Mouse   750 ETQSVRVVPKGEDKEMDIYVSSQDAAFTQEMVARTLGIPKNRINCHVKRVGGAFGGKASKPGLLA 814

  Fly   774 CAAALAAHKLNRPVRFVQSLESMMDCNGKRWACRSEYQCHVKTSGRIVGLSNDFYEDAGWNTNES 838
            ..||:||.|..||:||:......|...|.|.....:|:.....:|:|.......|.:.|...::|
Mouse   815 SVAAVAAQKTGRPIRFILERRDDMLITGGRHPLLGKYKIGFMNNGKIKAADIQLYINGGCTPDDS 879

  Fly   839 P-VQGHSTFTAANCYEFTDSNFKLSGHAVLTDAPSSTWCRAPGSVEGIAMMENIIEHVAFEIQKD 902
            . |..::.....|.|:.  .|.::.|....|:.||:|..|..|..:|..:.|..:..||.:.:..
Mouse   880 ELVIEYALLKLENAYKI--PNLRVRGRVCKTNLPSNTAFRGFGFPQGAFVTETCMSAVAAKCRLP 942

  Fly   903 PAEVRLANISKKSKMATVFPEF------------LKTREYYSRKKEIEAFNANNRWKKRGLGLSL 955
            |.:||..|:.:.........||            ::...||:|||.::.||....|||||:.:..
Mouse   943 PEKVRELNMYRTIDRTIHNQEFDPTNLLQCWEACVENSSYYNRKKAVDEFNQQRFWKKRGIAIIP 1007

  Fly   956 M----NFPIIYIGQFPATVTIYHVDGTVVVTHGGIEMGQGMNTKIAQVAAYTLGIDLSYVKVESS 1016
            |    .||..:..|..|.|.|| .||:|:|.|||:|:|||:|||:.|||:..|.|.:||:.::..
Mouse  1008 MKFSVGFPKTFYYQAAALVQIY-TDGSVLVAHGGVELGQGINTKMIQVASRELKIPMSYIHLDEM 1071

  Fly  1017 TSINGANSMVTGYAIGSESVCYAVRKICETLNARLKPVRK--AKATWVETVEAANAQLINLIASD 1079
            :::...|::.||.:.|::....||:..|:.|..||:|:.|  ...||.|.|:.|..|.|:|.|:.
Mouse  1072 STVTVPNTVTTGASTGADVNGRAVQNACQILMKRLEPIIKQNPSGTWEEWVKEAFVQSISLSATG 1136

  Fly  1080 HYK-----------TGDMQNYHVLGLALSEVEIDVLTG---NILIRRVDILEDAGESLSPWIDVG 1130
            :::           .||:..|.|.|.|.||||||.|||   ||   |.||:.|...|::|.:|:|
Mouse  1137 YFRGYQADMDWEKGEGDIFPYFVFGAACSEVEIDCLTGAHKNI---RTDIVMDGSFSINPAVDIG 1198

  Fly  1131 QVEGAFVMGLGYWLSELLIYEGDNGRLLTNRTWNYKPLGAKDIPIDFRVELVHNPRPSSSGFMGS 1195
            |:|||||.|||.:..|.|.|..: |.|.|.....||.....|||.:|.|.|: .|.|:......|
Mouse  1199 QIEGAFVQGLGLYTLEELKYSPE-GVLYTRGPHQYKIASVTDIPEEFHVSLL-TPTPNPKAIYSS 1261

  Fly  1196 KATGEPPCCLAVSVIFALQQALQSARQDAGLPREWLRLGAPTTPETL 1242
            |..||....|..||.||:..|:.:||::.||...| .:.:|.|.|.:
Mouse  1262 KGLGEAGTFLGCSVFFAIAAAVAAAREERGLSPIW-AINSPATAEVI 1307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX4	NP_650478.1	PLN02906	24..1240	CDD:215491	397/1324 (30%)
		Fer2_2	80..153	CDD:280048	39/72 (54%)
		FAD_binding_5	203..378	CDD:279309	46/214 (21%)
		CO_deh_flav_C	388..489	CDD:281449	28/102 (27%)
		Ald_Xan_dh_C	542..648	CDD:214971	39/108 (36%)
		Ald_Xan_dh_C2	690..1174	CDD:280834	170/521 (33%)
Aox3	NP_076106.2	mam_aldehyde_ox	9..1334	CDD:132014	403/1347 (30%)
		Fer2_2	91..162	CDD:280048	39/71 (55%)
		FAD_binding_5	239..419	CDD:279309	46/188 (24%)
		CO_deh_flav_C	426..530	CDD:281449	29/105 (28%)
		Ald_Xan_dh_C	594..697	CDD:214971	40/112 (36%)
		Ald_Xan_dh_C2	709..1241	CDD:280834	174/547 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720