DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX4 and aox6

DIOPT Version :9

Sequence 1:	NP_650478.1	Gene:	AOX4 / 41897	FlyBaseID:	FBgn0038350	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001265746.1	Gene:	aox6 / 570457	ZFINID:	ZDB-GENE-050208-742	Length:	1338	Species:	Danio rerio

Alignment Length:	1380	Identity:	420/1380 - (30%)
Similarity:	637/1380 - (46%)	Gaps:	223/1380 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FTINGQPYAVNLTDLPPDITLNTFIREHAQLTATKFMCLEGGCGACVCAVS------DGKSTWTV 63
            |.:||:.......|  |:..|..::|:..:||.||:.|..||||||...||      ...|..:|
Zfish    12 FYVNGKKIVEKNPD--PETMLLPYLRKKLRLTGTKYSCGGGGCGACTIMVSRYDPQTKSISHLSV 74

  Fly    64 NSCLKLLNTCAQLEIITCEGLGNQVTGYHPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQHGGRV 128
            |.||..:.......:.|.||:||..|..||:|:|:||.:|:|||||:||.||:||.|: ::....
Zfish    75 NGCLFPICHLHGAAVTTVEGIGNTKTKLHPVQERIAKAHGSQCGFCTPGMVMSMYTLL-RNNPHP 138

  Fly   129 TMEEVENSFGGNICRCTGYRPILDAMKSFAVDSTVEVSEESVDIEDLNLKARN-CPRSGKVC--- 189
            |::::.....||:|||||||||:|..::|.                   ::.| |..:|..|
Zfish   139 TLDDITECLAGNLCRCTGYRPIIDGYRTFC-------------------ESENCCLLNGSTCNVL 184

  Fly   190 --KGTCRQ------SK-----------LIY--------EDGSQ-----------WYWPSTLAEIF 216
              .|:...      ||           ||:        ||..|           |..|.:|.|:
Zfish   185 NGNGSAENGHAELFSKDDLLPLDPSQDLIFPPELMRMAEDKDQSIQRFCGERMTWISPGSLDEL- 248

  Fly   217 EALENVGDSEEFMLVGGNTAHGVYRRSPDIKH--FIDVNGVEDLHQYSSDKEKLTLGASLSLTET 279
              |:...|..:..||.|||..|:..:...|.|  .|....|.:|.:.:...|.:.:||..|:::.
Zfish   249 --LQLKADYPQAPLVMGNTTIGLDMKFKGIFHPIIISPTRVPELFKVNHRSEGVCVGAGCSMSDL 311

  Fly   280 MEIIQSTSKQ---SGFEYLEVLWHHIDLVANVPVRNSGTLAGNICTKKEHPEFP-SDIFISFEAL 340
            ..:::.|...   ........|...|:||....:||..||.|||.:     .:| ||:.....|.
Zfish   312 KSVLEKTINDFPPENTHTFRALLQQINLVGGQQIRNVATLGGNIAS-----AYPNSDLTPVLAAG 371

  Fly   341 DVKVVAMKGIDDEKEMTLEE--FLGDT-----DRKMLLKAFILPRYPKDMYIYDSFKIMPRAQNA 398
            ...:||:.. |..:.:.:::  |||..     ..::||..|| |...::..:: :|:.:||.:||
Zfish   372 RCTLVALSK-DGRRRLPIDKDFFLGFAKTILKPEEILLSVFI-PATRQNEIVH-AFRHVPRKENA 433

  Fly   399 HAYVNAGFLLELDGNS-MVKSARICFGGIRPDFIHATDIEQLMVGHSPYESNLVEQTFNKLESLV 462
            .|.:|||..:.|:.|| :||...|.:||:....:.|....|.:||. |:|...:...::.|...|
Zfish   434 LATLNAGMRVWLNDNSNVVKEISIYYGGVGATILSADHACQKIVGR-PWEEATLNDAYSALFDDV 497

  Fly   463 KPDEVLPDASPAYRSKLACGLLYKFLL--------KHAPDAEVSGKFKSGGELLQRPLSSGLQLF 519
            |.|...|.....:|..|...||:||.|        |.....||..:.:|..:.|.:.:..|.|.|
Zfish   498 KLDPAAPGGKVDFRRSLTLSLLFKFHLLILQYLKEKDVIQMEVPQEMQSAIQPLPKRILPGYQEF 562

  Fly   520 QTNKQTYPVTQGVQKLEG--------MIQCSGEATYMNDVLTTSNSVYCAFVGATKVGATIDQID 576
            |...:    .|..|.|.|        :.|.:|||.|.:|:..|...:..|.|.::|..|.|..||
Zfish   563 QNVLE----DQSAQDLVGRPMMHRSALSQATGEAVYCDDLPYTDGELVLAIVTSSKAHAKITHID 623

  Fly   577 ATEALQHPGVVAFYTAKDIPGT--NTFCEPSFGYEAE-----EIFCSGMVRHSEQPVGVIVALTA 634
            .:|||:.||||...|||||||.  .||.    ||:.|     |:.|.|      |.:..:||.:.
Zfish   624 FSEALKLPGVVDVITAKDIPGKKFRTFT----GYDEELLAEDEVSCVG------QMICAVVADSK 678

  Fly   635 DQAQRATKLVKISYSSPSSNFKLMPSLKD-VFSSETPDTSRIIPLVISKLKEVKFSDKPDLEVRG 698
            ..|:|....||:||.          .|:| :|:.|.           :..||..|..:..:| ||
Zfish   679 AHAKRGAAAVKVSYE----------DLQDCIFTLEE-----------AIEKESFFLPRRQIE-RG 721

  Fly   699 IFEMGL---------------QYHFTMEPQTTIIIPF--EDGLKVFSATQWIDQTQSVIAHTLQM 746
            ..|.||               |.||.||.|:.:::|.  |..:||:.:||....||..:|.||.:
Zfish   722 DVEKGLRDAEQVYEGEIRIGGQEHFYMETQSFLVVPVGEEKEMKVYLSTQHPTYTQEAVAETLGI 786

  Fly   747 KAKDVQLEVRRLGGGYGCKISRGNQVACAAALAAHKLNRPVRFVQSLESMMDCNGKRWACRSEYQ 811
            .:..|...|:||||.:|.|:::...:|...|.||.|...|||.|......|...|.|.....:|:
Zfish   787 PSNRVTCHVKRLGGAFGGKVTKTAILASITAAAAWKTGLPVRCVLERGEDMLITGGRHPVWGKYK 851

  Fly   812 CHVKTSGRIVGLSNDFYEDAGWNTNESPVQGHSTFT-AANCYEFTDSNFKLSGHAVLTDAPSSTW 875
            .....:|||......:|.::|...:||.:....... ..|.|..  .|.:....|..|:.||:|.
Zfish   852 VGFMKNGRITAADFQYYANSGNKVDESVLVAEKILLHLDNAYNI--PNLRGRSAACRTNLPSNTA 914

  Fly   876 CRAPGSVEGIAMMENIIEHVAFEIQKDPAEVRLANISKK------------SKMATVFPEFLKTR 928
            .|..|..:.:.::|::|:.||.::.:.|.|:|..|:.|:            ..:...:.|.::..
Zfish   915 FRGFGVPQCMLVIESMIDDVALQLGRLPEEIREMNMYKQVSLTHYKMEFDPENLVRCWKECMEKS 979

  Fly   929 EYYSRKKEIEAFNANNRWKKRGLGLSLMNFPIIY--------IGQFPATVTIYHVDGTVVVTHGG 985
            ::..|:|.|:.||..|::||||:.:    .||.|        :.|..|.|.||. ||:|:|:|||
Zfish   980 DFSHRRKAIDLFNQQNQFKKRGISI----IPIKYGIGFAEGFLNQAAALVHIYK-DGSVLVSHGG 1039

  Fly   986 IEMGQGMNTKIAQVAAYTLGIDLSYVKVESSTSINGANSMVTGYAIGSESVCYAVRKICETLNAR 1050
            .|||||::|||.|||:..|.|..|.:.:..:::....|:..:..:.|:::...||:..|:.|..|
Zfish  1040 AEMGQGLHTKIQQVASRELNIPASLIHISETSTQCVPNTCPSAASFGTDANGMAVQDACQILYNR 1104

  Fly  1051 LKPVRK--AKATWVETVEAANAQLINLIASDHYKTGDMQ-----------NYHVLGLALSEVEID 1102
            |:||||  .|.||...:..|..:.|:|.|:.:|:..|:.           .|....:..||||:|
Zfish  1105 LEPVRKKDPKGTWQNWIMKAFLEKISLSATGYYRGHDLDMDWEKQEGRPYAYFTYAVCCSEVELD 1169

  Fly  1103 VLTGNILIRRVDILEDAGESLSPWIDVGQVEGAFVMGLGYWLSELLIYEGDNGRLLTNRTWNYKP 1167
            .|||.....|.||:.|.|.|::|.||:||:||||..|||.:..|.|.| ..:|.|.|.....||.
Zfish  1170 CLTGEYRTLRTDIVVDIGRSINPSIDIGQIEGAFTQGLGLYTMEELKY-SPSGVLYTRGPGQYKI 1233

  Fly  1168 LGAKDIPIDFRVELV---HNPRPSSSGFMGSKATGEPPCCLAVSVIFALQQALQSARQDAGLPRE 1229
            ....|:|::|.|.|:   .||.    ....||..|||...|..||.||::.|:.:||:||||...
Zfish  1234 PAVCDVPLNFNVYLLAGSSNPH----AIYSSKGIGEPTLFLGSSVFFAIKDAVTAARKDAGLTGP 1294

  Fly  1230 WLRLGAPTTPETLLL 1244
            : :|.:|.|||...|
Zfish  1295 F-QLNSPATPERACL 1308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX4	NP_650478.1	PLN02906	24..1240	CDD:215491	412/1355 (30%)
		Fer2_2	80..153	CDD:280048	37/72 (51%)
		FAD_binding_5	203..378	CDD:279309	48/198 (24%)
		CO_deh_flav_C	388..489	CDD:281449	34/101 (34%)
		Ald_Xan_dh_C	542..648	CDD:214971	42/112 (38%)
		Ald_Xan_dh_C2	690..1174	CDD:280834	167/534 (31%)
aox6	NP_001265746.1	mam_aldehyde_ox	10..1338	CDD:132014	420/1380 (30%)
		Fer2_2	91..162	CDD:280048	37/71 (52%)
		FAD_binding_5	235..414	CDD:279309	47/188 (25%)
		CO_deh_flav_C	422..524	CDD:281449	34/103 (33%)
		Ald_Xan_dh_C	589..695	CDD:214971	44/125 (35%)
		Ald_Xan_dh_C2	708..1240	CDD:280834	170/540 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720