DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX4 and xdh

DIOPT Version :9

Sequence 1:	NP_650478.1	Gene:	AOX4 / 41897	FlyBaseID:	FBgn0038350	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_688983.3	Gene:	xdh / 560486	ZFINID:	ZDB-GENE-070719-9	Length:	1351	Species:	Danio rerio

Alignment Length:	1352	Identity:	411/1352 - (30%)
Similarity:	653/1352 - (48%)	Gaps:	162/1352 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FTINGQPYAVNLTDLPPDITLNTFIREHAQLTATKFMCLEGGCGACVCAVSDGKST------WTV 63
            |.:||:.......|  |:|||.|::|....||.||..|.|||||||...||.....      :.:
Zfish    21 FFVNGKKITEKNAD--PEITLLTYLRRSLGLTGTKLGCAEGGCGACTVMVSKYHPNQNRIIHYAI 83

  Fly    64 NSCLKLLNTCAQLEIITCEGLGNQVTGYHPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQHGGRV 128
            |:||..|.:.....:.|.||:|:..:..||:|:|:||.:|:|||||:||.||:||.|: ::..:.
Zfish    84 NACLAPLCSLHHCAVTTVEGIGSVASKLHPVQERIAKAHGSQCGFCTPGIVMSMYALL-RNNPQP 147

  Fly   129 TMEEVENSFGGNICRCTGYRPILDAMKSFAVD------------------STVEVSEESVDIEDL 175
            ||.:::.:|.||:||||||||||:..::|..|                  :|.|....:..::.|
Zfish   148 TMHDIQEAFQGNLCRCTGYRPILEGYRTFTKDGGCCGGKSQTNGCCMTNGNTQEHENSAHPVQHL 212

  Fly   176 NLKARNCPRSG-----------KVCKGTCRQSKLIYEDGSQWYWPSTLAEIFEALENVGDSEEFM 229
            ..::...|...           .:.|.|.|:.:.:.| ...|..|.:|.|:.|......:::
Zfish   213 YDQSEFMPLDPTQEIIFPPELVSLSKQTQREMRFVGE-RVLWIQPCSLKELLELKATYPNAK--- 273

  Fly   230 LVGGNTAHGVYRRSPDIKH--FIDVNGVEDLHQYSSDKEKLTLGASLSLTETMEIIQSTSKQ--- 289
            ||.|||..|:..:..::.:  .:....:.:|:.....::.:.:|||::||...:::||..|:
Zfish   274 LVVGNTEVGIEMKFKNLLYPVILAPAYIPELNIIQHTQDGIEVGASVTLTVLGDVLQSAVKKLPA 338

  Fly   290 SGFEYLEVLWHHIDLVANVPVRNSGTLAGNICTKKEHPEFP-SDIFISFEALDVKVVAM-KGIDD 352
            ...|..:.:...:...|...:||...:.|||.|..     | ||:...|.|...|:..| ||...
Zfish   339 YQTEVFKAVLEQLRWFAGQQIRNVAAVGGNIMTAS-----PISDLNPVFMAAGCKLTVMSKGEKR 398

  Fly   353 EKEMTLEEFLGDTDRKMLLK------AFILPRYPKDMYIYDSFKIMPRAQNAHAYVNAGFLLEL- 410
            ..||..:.|.|  .||..||      :..:|...|..| :.:||..||.::..:.|..|..:..
Zfish   399 VLEMDDKFFTG--YRKTALKPEEILLSIEIPYTKKGQY-FSAFKQSPRKEDDISIVTCGMNVYFK 460

  Fly   411 DGNSMVKSARICFGGIRPDFIHATDIEQLMVGHSPYESNLVEQTFNKLESLVKPDEVLPDASPAY 475
            :.::.|:|.||.:||:.|..:.||.....::... :..:|:|:..:.|...:......|.....|
Zfish   461 EQSNTVQSIRISYGGMAPVTVLATATCNKLLNRQ-WNEDLLEEACSSLAEEMSLSPSAPGGMVTY 524

  Fly   476 RSKLACGLLYKFLL----KHAPDAEVSG--------KFKSGGELLQRPLSSGLQLFQT----NKQ 524
            |..|...|.|||.|    |.|...::.|        :|.:..||.|....|.:||:|.    ..:
Zfish   525 RRTLTISLFYKFFLTVQHKLAVSLQMEGVTVEDIQPEFSTATELFQVDTPSSVQLYQEVPPGQNE 589

  Fly   525 TYPVTQGVQKLEGMIQCSGEATYMNDVLTTSNSVYCAFVGATKVGATIDQIDATEALQHPGVVAF 589
            ...|...:..|..:.|.:|||.|.:|:....|.::.|.|.:||..|.|..||.:.|:..||||||
Zfish   590 DDVVGHPIIHLSALKQATGEAVYCDDMPCYENELHLALVTSTKAHALIKSIDTSSAMSVPGVVAF 654

  Fly   590 YTAKDIPGTN-----TFCEPSFGYEAEEIFCSGMVRHSEQPVGVIVALTADQAQRATKLVKISYS 649
            .:||||||:|     .:.|..|.  .:::.|.|.:      ||.|||.|...||||.|:|||||.
Zfish   655 ISAKDIPGSNMTGPVVYDETVFA--DDKVTCVGHI------VGAIVADTQAHAQRAAKVVKISYE 711

  Fly   650 SPSSNFKLMP---SLKDVFSSETPDTSRIIPLVISKLKEVKFSDKPDLE---------VRGIFEM 702
                  :|.|   :::|..:::            |..:.|:..:|.|:.         :.|...:
Zfish   712 ------ELKPVIVTIQDAINNK------------SFFEPVRTIEKGDVAQGFKDSDHILHGEMHI 758

  Fly   703 GLQYHFTMEPQTTIIIP-FEDG-LKVFSATQWIDQTQSVIAHTLQMKAKDVQLEVRRLGGGYGCK 765
            |.|..|.:|...|:.:| .||| :::|.:||...:||:::|..|.:.|..|...|:|:|||:|.|
Zfish   759 GGQEQFYLETNCTLAVPRGEDGEMELFVSTQSASKTQALVAKALGVPANRVVCRVKRMGGGFGGK 823

  Fly   766 ISRGNQVACAAALAAHKLNRPVRFVQSLESMMDCNGKRWACRSEYQCHVKTSGRIVGLSNDFYED 830
            .||...::...|:||.|:..|||.:...:..|...|.|.....:|:.....:||::.|....|.:
Zfish   824 ESRSTILSTVVAVAAQKVKCPVRCMLDRDEDMLVTGGRHPFFGQYKVGFMKNGRVMALEVTLYSN 888

  Fly   831 AGWNTNES-PVQGHSTFTAANCYEFTDSNFKLSGHAVLTDAPSSTWCRAPGSVEGIAMMENIIEH 894
            ||.:.:.| .:...:.|...|.|..  .|...:|:...|:.||::..|..|..:|:.:.|:.:..
Zfish   889 AGNSLDLSLSILERALFHMDNSYNI--PNICGTGYMCKTNLPSNSAFRGFGGPQGMMIAESWMSD 951

  Fly   895 VAFEIQKDPAEVRLANISKKSKM------------ATVFPEFLKTREYYSRKKEIEAFNANNRWK 947
            ||........|||..|:..:..:            |..:.|.::..::..||..:|.:|..:||.
Zfish   952 VALSCGLPAEEVRRMNMYNEGDLTHFNQRLDQFTIARCWEECMQLSDFNKRKDAVEKYNRQHRWT 1016

  Fly   948 KRGLGLSLMNFPI----IYIGQFPATVTIYHVDGTVVVTHGGIEMGQGMNTKIAQVAAYTLGIDL 1008
            ||||.:....|.|    :::.|..|.|.:|. ||:|::||||.|||||::||:.|||:.||.|..
Zfish  1017 KRGLSIIPTKFGISFTAVFLNQAGALVHVYS-DGSVLLTHGGTEMGQGLHTKMVQVASKTLEIPC 1080

  Fly  1009 SYVKVESSTSINGANSMVTGYAIGSESVCYAVRKICETLNARLKPVRK--AKATWVETVEAANAQ 1071
            :.:.:..:::....|:..|..:..|:....||...|:|:..||:|.::  .|..|.:.|.||...
Zfish  1081 TKIHITETSTSTVPNTSPTAASASSDLNGMAVYNACQTILQRLQPFKEKNPKGCWEDWVTAAYFD 1145

  Fly  1072 LINLIASDHYKTGDMQ-----------NYHVLGLALSEVEIDVLTGNILIRRVDILEDAGESLSP 1125
            .:||.|:..|||.|:.           ||...|:|:||||||.|||:.......|:.|.|:||:|
Zfish  1146 RVNLSANGFYKTPDLGYDFDTNSGRPFNYFSYGVAVSEVEIDCLTGSHKNLHTSIVMDVGKSLNP 1210

  Fly  1126 WIDVGQVEGAFVMGLGYWLSELLIYEGDNGRLLTNRTWNYKPLGAKDIPIDFRVELVHNPRPSSS 1190
            .:|:|||||.|:.|||.:..|.|.|..| |.|.|.....||.....|||.:.:|.|:.: .|:..
Zfish  1211 ALDIGQVEGGFMQGLGLFTLEELRYSPD-GYLYTRGPGMYKIPAFGDIPSELKVSLLRD-APNDK 1273

  Fly  1191 GFMGSKATGEPPCCLAVSVIFALQQALQSARQDAGLPREWLRLGAPTTPETL 1242
            ....|||.||||..||.||.:|::.|:.:||.::||...: ||.:|.|||.:
Zfish  1274 AIFSSKAVGEPPLFLAASVFYAIKDAITAARAESGLTGPF-RLDSPATPERI 1324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX4	NP_650478.1	PLN02906	24..1240	CDD:215491	403/1329 (30%)
		Fer2_2	80..153	CDD:280048	38/72 (53%)
		FAD_binding_5	203..378	CDD:279309	45/187 (24%)
		CO_deh_flav_C	388..489	CDD:281449	26/101 (26%)
		Ald_Xan_dh_C	542..648	CDD:214971	46/110 (42%)
		Ald_Xan_dh_C2	690..1174	CDD:280834	165/524 (31%)
xdh	XP_688983.3	fer2	20..92	CDD:238126	28/72 (39%)
		PLN02906	36..1336	CDD:215491	406/1335 (30%)
		Fer2_2	100..171	CDD:280048	37/71 (52%)
		FAD_binding_5	253..428	CDD:279309	45/184 (24%)
		CO_deh_flav_C	436..540	CDD:281449	27/104 (26%)
		Ald_Xan_dh_C	607..714	CDD:279635	48/120 (40%)
		Ald_Xan_dh_C2	734..1258	CDD:280834	165/527 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720