Protein Alignment AOX4 and Aox1

DIOPT Version :10

• Sequence 1: NP_650478.1
• Gene: AOX4 / 41897
• FlyBaseID: FBgn0038350
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_062236.3
• Gene: Aox1 / 54349
• RGDID: 620528
• Length: 1333
• Species: Rattus norvegicus
• Alignment Length: 1362
• Identity: 403/1362 - (29%)
• Similarity: 647/1362 - (47%)
• Gaps: 187/1362 - (13%)

  Fly     5 FTINGQPYAVNLTDLPPDITLNTFIREHAQLTATKFMCLEGGCGACVCAVSD-GKSTWT-----V 63
            |.:|||....|..|  |::.|..::|::.:||.||:.|..||||||...:|. ..||.:     |
  Rat     8 FYVNGQKVVENNVD--PEMMLLPYLRKNLRLTGTKYGCGGGGCGACTVMISRYNPSTKSIRHHPV 70

  Fly    64 NSCLKLLNTCAQLEIITCEGLGNQVTGYHPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQHGGRV 128
            |:||..:.:.....:.|.||:||..|..||:|:|:||.:|||||||:||.||:||.|:..| ...
  Rat    71 NACLTPICSLYGTAVTTVEGIGNTRTRLHPVQERIAKCHGTQCGFCTPGMVMSMYALLRNH-PEP 134

  Fly   129 TMEEVENSFGGNICRCTGYRPILDAMKSF-------------------AVDSTVE---------- 164
            :::::.::.|||:|||||||||:||.|:|                   .::.:.|
  Rat   135 SLDQLTDALGGNLCRCTGYRPIIDACKTFCRASGCCESKENGVCCLDQGINGSAEFQEGDETSPE 199

  Fly   165 -VSEESVDIEDLNLKARNCPRSGKVCKGTCRQSKLIYEDGSQWYWPSTLAEIFEALENVGDSEEF 228
             .||:.....|...:....|...::.:....::::.|.:...|..|.||.|:.||        :|
  Rat   200 LFSEKEFQPLDPTQELIFPPELMRIAEKQPPKTRVFYSNRMTWISPVTLEELVEA--------KF 256

  Fly   229 MLVGGNTAHGVYRRSPDIKH-------FIDVNGVEDLHQYSSDKEKLTLGASLSLTETMEI---- 282
            ...|.....|.....|::|.       .|..:.:|:|...:...:.|||||.|||.:..:|
  Rat   257 KYPGAPIVMGYTSVGPEVKFKGVFHPIIISPDRIEELSIINQTGDGLTLGAGLSLDQVKDILTDV 321

  Fly   283 IQSTSKQSGFEYLEVLWHHIDLVANVPVRNSGTLAGNICTKKEHPEFPSDIFISFEALDVKVVAM 347
            :|...:::...| ..|..|:..:|...:||..:|.|:|.::  |.:...:..::.....:.:::.
  Rat   322 VQKLPEETTQTY-RALLKHLRTLAGSQIRNMASLGGHIVSR--HLDSDLNPLLAVGNCTLNLLSK 383

  Fly   348 KGIDDEKEMTL-EEFL---GDTDRK--MLLKAFILPRYPKDMYIYDSFKIMPRAQNAHAYVNAGF 406
               |.::::.| |:||   .|:|.|  .:|.:..:|...|..:: .:|:...|.|||.|.||:|.
  Rat   384 ---DGKRQIPLSEQFLRKCPDSDLKPQEVLVSVNIPCSRKWEFV-SAFRQAQRQQNALAIVNSGM 444

  Fly   407 -LLELDGNSMVKSARICFGGIRPDFIHATDIEQLMVGHSPYESNLVEQTFNKLESLVKPDEVLPD 470
             :|..:|..::|...|.:||:.|..|.|.:..|.::|. |:...:::....    ||..:..|..
  Rat   445 RVLFREGGGVIKELSILYGGVGPTTIGAKNSCQKLIGR-PWNEEMLDTACR----LVLDEVTLAG 504

  Fly   471 ASPA----YRSKLACGLLYKFLLK-----------HAPDAEVSGKFKSGGELLQ-----RPLS-- 513
            ::|.    ::..|....|:||.|:           |.|  .::..::|..|.|.     |.|:
  Rat   505 SAPGGKVEFKRTLIISFLFKFYLEVLQGLKREDPGHYP--SLTNNYESALEDLHSKHHWRTLTHQ 567

  Fly   514 --SGLQLFQTNKQTYPVTQGVQKLEGMIQCSGEATYMNDVLTTSNSVYCAFVGATKVGATIDQID 576
              ..:||.|.     |:.:.:..|.|:...:|||.|.:|:......::..||.:::..|.|..||
  Rat   568 NVDSMQLPQD-----PIGRPIMHLSGIKHATGEAIYCDDMPAVDRELFLTFVTSSRAHAKIVSID 627

  Fly   577 ATEALQHPGVVAFYTAKDIPGTNTFCEPSFGYE----AEEIFCSGMVRHSEQPVGVIVALTADQA 637
            .:|||..||||...||..:..|.|     ||.|    .:::.|.|      |.|..::|.:..:|
  Rat   628 LSEALSLPGVVDIITADHLQDTTT-----FGTETLLATDKVHCVG------QLVCAVIADSETRA 681

  Fly   638 QRATKLVKISYSSPSSNFKLMPSL---------KDVFSSETPDTSRIIPLVISKLKEV-KFSDKP 692
            ::|.|.||:.|..      |.|.:         |..|.||.       .|....:.|. |.:|:
  Rat   682 KQAAKHVKVVYRD------LEPLILTIEEAIQHKSFFESER-------KLECGNVDEAFKIADQ- 732

  Fly   693 DLEVRGIFEMGLQYHFTMEPQTTIIIP-FEDG-LKVFSATQWIDQTQSVIAHTLQMKAKDVQLEV 755
              .:.|...:|.|.||.||.|:.:::| .||| :.::.:||:....|.::|.||::....|...|
  Rat   733 --ILEGEIHIGGQEHFYMETQSMLVVPKGEDGEIDIYVSTQFPKHIQDIVAATLKLSVNKVMCHV 795

  Fly   756 RRLGGGYGCKISRGNQVACAAALAAHKLNRPVRFVQSLESMMDCNGKRWACRSEYQCHVKTSGRI 820
            ||:||.:|.|:.:.:.:|...|.||.|..|.||........|...|.|.....:|:......|||
  Rat   796 RRVGGAFGGKVGKTSIMAAITAFAASKHGRAVRCTLERGEDMLITGGRHPYLGKYKVGFMRDGRI 860

  Fly   821 VGLSNDFYEDAGWNTNESP-VQGHSTFTAANCYEFTDSNFKLSGHAVLTDAPSSTWCRAPGSVEG 884
            |.|..:.|.:.|.:.:||. |.........|.|:|  .|.:..|.|..|:.||:|..|..|..:.
  Rat   861 VALDVEHYCNGGSSLDESLWVIEMGLLKMDNAYKF--PNLRCRGWACRTNLPSNTALRGFGFPQA 923

  Fly   885 IAMMENIIEHVAFEIQKDPAEVRLANISKKSKMATVFPEF-LKT-----RE------YYSRKKEI 937
            ..:.|..:..||......|.:||..|:.|:........|| .||     ||      |..||..:
  Rat   924 GLVTEACVTEVAIRCGLSPEQVRTINMYKQIDNTHYKQEFSAKTLFECWRECMAKCSYSERKTAV 988

  Fly   938 EAFNANNRWKKRGLGLSLMNFPI----IYIGQFPATVTIYHVDGTVVVTHGGIEMGQGMNTKIAQ 998
            ..|||.|.|||||:.:..:.||:    :.:||..|.|.|| :||:.:|:|||||||||::||:.|
  Rat   989 GKFNAENSWKKRGMAVIPLKFPVGVGSVAMGQAAALVHIY-LDGSALVSHGGIEMGQGVHTKMIQ 1052

  Fly   999 VAAYTLGIDLSYVKVESSTSINGANSMVTGYAIGSESVCYAVRKICETLNARLKPV--RKAKATW 1061
            |.:..|.:.:|.|.:..:::....|:..:|.::.::....||:..|:||..||:|:  :..:.||
  Rat  1053 VVSRELKMPMSSVHLRGTSTETVPNTNASGGSVVADLNGLAVKDACQTLLKRLEPIISKNPQGTW 1117

  Fly  1062 VETVEAANAQLINLIASDHYK-----------TGDMQNYHVLGLALSEVEIDVLTGNILIRRVDI 1115
            .:..:.|..|.::|.|..:::           .|....|.|.|.|.||||||.|||:....|.||
  Rat  1118 KDWAQTAFDQSVSLSAVGYFRGYESNINWEKGEGHPFEYFVYGAACSEVEIDCLTGDHKNIRTDI 1182

  Fly  1116 LEDAGESLSPWIDVGQVEGAFVMGLGYWLSELLIYEGDNGRLLTNRTWNYKPLGAKDIPIDFRVE 1180
            :.|.|.|::|.:|:|||||||:.|:|.:..|.|.| ...|.|.:.....||.....|||.:..:.
  Rat  1183 VMDVGHSINPALDIGQVEGAFIQGMGLYTIEELSY-SPQGILYSRGPNQYKIPAICDIPTEMHIS 1246

  Fly  1181 LVHNPRPSSSGFMGSKATGEPPCCLAVSVIFALQQALQSARQDAGLPREWLRLGAPTTPETL 1242
            .: .|...|:....||..||....|..||.||:..|:::|||:.|:...| :|.:|.|||.:
  Rat  1247 FL-PPSEHSNTLYSSKGLGESGVFLGCSVFFAIHDAVRAARQERGISGPW-KLTSPLTPEKI 1306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AOX4	NP_650478.1	PLN02906	24..1240	CDD:215491	394/1339 (29%)
Aox1	NP_062236.3	mam_aldehyde_ox	4..1333	CDD:132014	403/1362 (30%)