DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX4 and Xdh

DIOPT Version :9

Sequence 1:	NP_650478.1	Gene:	AOX4 / 41897	FlyBaseID:	FBgn0038350	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_058850.2	Gene:	Xdh / 497811	RGDID:	62043	Length:	1331	Species:	Rattus norvegicus

Alignment Length:	1356	Identity:	416/1356 - (30%)
Similarity:	641/1356 - (47%)	Gaps:	177/1356 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FTINGQPYAVNLTDLPPDITLNTFIREHAQLTATKFMCLEGGCGACVCAVS-----DGKST-WTV 63
            |.:||:.......|  |:.||..::|....|..||..|.|||||||...:|     ..|.. ::|
  Rat     8 FFVNGKKVVEKNAD--PETTLLVYLRRKLGLCGTKLGCGEGGCGACTVMISKYDRLQNKIVHFSV 70

  Fly    64 NSCLKLLNTCAQLEIITCEGLGNQVTGYHPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQHGGRV 128
            |:||..:.:...:.:.|.||:|| ....||:|:|:|:.:|:|||||:||.||:||.|: ::....
  Rat    71 NACLAPICSLHHVAVTTVEGIGN-TQKLHPVQERIARSHGSQCGFCTPGIVMSMYTLL-RNQPEP 133

  Fly   129 TMEEVENSFGGNICRCTGYRPILDAMKSFA--------------------VDSTVEVSEESVDIE 173
            |:||:||:|.||:||||||||||...::||                    .|.||.:|....:.|
  Rat   134 TVEEIENAFQGNLCRCTGYRPILQGFRTFAKDGGCCGGSGNNPNCCMNQTKDQTVSLSPSLFNPE 198

  Fly   174 DLN--------------LKARNCPRSGKVCKGTCRQSKLIYE-DGSQWYWPSTLAEIFEALENVG 223
            |..              |:.::.|           |.||.:| :...|...||:.|:.:......
  Rat   199 DFKPLDPTQEPIFPPELLRLKDTP-----------QKKLRFEGERVTWIQASTMEELLDLKAQHP 252

  Fly   224 DSEEFMLVGGNTAHGVYRRSPDIKHFIDV--NGVEDLHQYSSDKEKLTLGAS--LSLTETM---E 281
            |::   ||.|||..|:..:..::...:.|  ..:.:|:......|.::.|||  |||.|::   |
  Rat   253 DAK---LVVGNTEIGIEMKFKNMLFPLIVCPAWIPELNSVVHGPEGISFGASCPLSLVESVLAEE 314

  Fly   282 IIQSTSKQSGFEYLEVLWHHIDLVANVPVRNSGTLAGNICTKKEHPEFP-SDIFISFEALDVKV- 344
            |.:...:::  |....:...:...|...|::..::.|||.|..     | ||:...|.|...|:
  Rat   315 IAKLPEQKT--EVFRGVMEQLRWFAGKQVKSVASIGGNIITAS-----PISDLNPVFMASGAKLT 372

  Fly   345 VAMKGIDDEKEMTLEEFLGDTDRKMLLK------AFILPRYPKDMYIYDSFKIMPRAQNAHAYVN 403
            :..:|......|....|.|  .||.||:      :..:| |.|:...:.:||...|.::..|.|.
  Rat   373 LVSRGTRRTVRMDHTFFPG--YRKTLLRPEEILLSIEIP-YSKEGEFFSAFKQASRREDDIAKVT 434

  Fly   404 AGF-LLELDGNSMVKSARICFGGIRPDFIHATDIEQLMVGHSPYESNLVEQTFNKLESL-VKPDE 466
            :|. :|...|...|:...:||||:....|.|.......:..|..|..|........|.| :.||
  Rat   435 SGMRVLFKPGTIEVQELSLCFGGMADRTISALKTTPKQLSKSWNEELLQSVCAGLAEELHLAPD- 498

  Fly   467 VLPDASPAYRSKLACGLLYKFLLK------HAPDAEVSGK----FKSGGELLQRPLSSGLQLFQT 521
             .|.....:|..|.....:||.|.      .|...::.||    |.|...|.|:...:.:|||
  Rat   499 -APGGMVEFRRTLTLSFFFKFYLTVLQKLGRADLEDMCGKLDPTFASATLLFQKDPPANVQLF-- 560

  Fly   522 NKQTYPVTQGVQKLEGM--------IQCSGEATYMNDVLTTSNSVYCAFVGATKVGATIDQIDAT 578
              |..|..|..:.:.|.        :|.||||.|.:|:....|.:....|.:|:..|.|..||.:
  Rat   561 --QEVPKDQSEEDMVGRPLPHLAANMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKITSIDTS 623

  Fly   579 EALQHPGVVAFYTAKDIPGTNT---FCEPSFGYEAEEIFCSGMVRHSEQPVGVIVALTADQAQRA 640
            ||.:.||.|.|.||:|:|.:|.   |.:.:. :..:|:.|.|.:      :|.:||.|.:.||||
  Rat   624 EAKKVPGFVCFLTAEDVPNSNATGLFNDETV-FAKDEVTCVGHI------IGAVVADTPEHAQRA 681

  Fly   641 TKLVKISYSSPSSNFKLMPSLKD--VFSSETPDTSRIIPLVISKLKEVKFSDKPDLEVRGIFEMG 703
            .:.|||:|....:...:..::.:  .:.||         :.|.|....|...:.|..|.|...:|
  Rat   682 ARGVKITYEDLPAIITIQDAINNNSFYGSE---------IKIEKGDLKKGFSEADNVVSGELYIG 737

  Fly   704 LQYHFTMEPQTTIIIPFEDG--LKVFSATQWIDQTQSVIAHTLQMKAKDVQLEVRRLGGGYGCKI 766
            .|.||.:|...||.:|..:.  :::|.:||...:|||.:|..|.:....:.:.|:|:|||:|.|.
  Rat   738 GQEHFYLETNCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPDNRIVVRVKRMGGGFGGKE 802

  Fly   767 SRGNQVACAAALAAHKLNRPVRFVQSLESMMDCNGKRWACRSEYQCHVKTSGRIVGLSNDFYEDA 831
            :|...|:.|.||||||..||||.:...:..|...|.|....::|:.....:|.:|.|....:.:.
  Rat   803 TRSTVVSTAVALAAHKTGRPVRCMLDRDEDMLITGGRHPFLAKYKVGFMKTGTVVALEVAHFSNG 867

  Fly   832 GWNTNE--SPVQGHSTFTAANCYEFTDSNFKLSGHAVLTDAPSSTWCRAPGSVEGIAMMENIIEH 894
            | ||.:  ..:...:.|...|.|:.  .|.:.:|....|:.||:|..|..|..:|:.:.|..:..
  Rat   868 G-NTEDLSRSIMERALFHMDNAYKI--PNIRGTGRICKTNLPSNTAFRGFGGPQGMLIAEYWMSE 929

  Fly   895 VAFEIQKDPAEVRLANISKKSKMA------------TVFPEFLKTREYYSRKKEIEAFNANNRWK 947
            ||........|||..|:.|:..:.            ..:.|.:.:.:|.:||:|:|.||..|.||
  Rat   930 VAITCGLPAEEVRRKNMYKEGDLTHFNQKLEGFTLPRCWDECIASSQYLARKREVEKFNRENCWK 994

  Fly   948 KRGL-------GLSLMNFPIIYIGQFPATVTIYHVDGTVVVTHGGIEMGQGMNTKIAQVAAYTLG 1005
            ||||       |:|   |.:.::.|..|.|.:| .||:|::||||.|||||::||:.|||:..|.
  Rat   995 KRGLCIIPTKFGIS---FTLPFLNQGGALVHVY-TDGSVLLTHGGTEMGQGLHTKMVQVASRALK 1055

  Fly  1006 IDLSYVKVESSTSINGANSMVTGYAIGSESVCYAVRKICETLNARLKPVRKAK--ATWVETVEAA 1068
            |..|.:.:..:::....|:..|..:..::....||.:.|:|:..||:|.:|.|  ..|...|..|
  Rat  1056 IPTSKIHISETSTNTVPNTSPTAASASADLNGQAVYEACQTILKRLEPFKKKKPNGPWEAWVMDA 1120

  Fly  1069 NAQLINLIASDHYKT-----------GDMQNYHVLGLALSEVEIDVLTGNILIRRVDILEDAGES 1122
            ....::|.|:..|||           |:..:|...|:|.||||||.|||:....|.||:.|.|.|
  Rat  1121 YTSAVSLSATGFYKTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSS 1185

  Fly  1123 LSPWIDVGQVEGAFVMGLGYWLSELLIYEGDNGRLLTNRTWNYKPLGAKDIPIDFRVELVHNPRP 1187
            |:|.||:||||||||.|||.:..|.|.|..: |.|.|.....||......|||:|||.|:.: .|
  Rat  1186 LNPAIDIGQVEGAFVQGLGLFTMEELHYSPE-GSLHTRGPSTYKIPAFGSIPIEFRVSLLRD-CP 1248

  Fly  1188 SSSGFMGSKATGEPPCCLAVSVIFALQQALQSAR-QDAGLPREWLRLGAPTTPETL 1242
            :......|||.||||..||.|:.||::.|:::|| |.....::..:|.:|.|||.:
  Rat  1249 NKRAIYASKAVGEPPLFLASSIFFAIKDAIRAARAQHGDNAKQLFQLDSPATPEKI 1304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX4	NP_650478.1	PLN02906	24..1240	CDD:215491	409/1333 (31%)
		Fer2_2	80..153	CDD:280048	41/72 (57%)
		FAD_binding_5	203..378	CDD:279309	44/189 (23%)
		CO_deh_flav_C	388..489	CDD:281449	27/102 (26%)
		Ald_Xan_dh_C	542..648	CDD:214971	39/108 (36%)
		Ald_Xan_dh_C2	690..1174	CDD:280834	172/519 (33%)
Xdh	NP_058850.2	PLN02906	23..1317	CDD:215491	411/1339 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720