Protein Alignment AOX4 and Aox3

DIOPT Version :10

• Sequence 1: NP_650478.1
• Gene: AOX4 / 41897
• FlyBaseID: FBgn0038350
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_001008527.2
• Gene: Aox3 / 493909
• RGDID: 1359328
• Length: 1334
• Species: Rattus norvegicus
• Alignment Length: 1355
• Identity: 404/1355 - (29%)
• Similarity: 640/1355 - (47%)
• Gaps: 177/1355 - (13%)

  Fly     5 FTINGQPYAVNLTDLPPDITLNTFIREHAQLTATKFMCLEGGCGACVCAVSDGK------STWTV 63
            |.:||:.......|  |::.|..::|:..|||.||:.|..|.||||...:|...      |.::.
  Rat    12 FFVNGKKVIERNAD--PEVNLLFYLRKIIQLTGTKYGCGGGDCGACTVMISRYNPISKKISHFSA 74

  Fly    64 NSCLKLLNTCAQLEIITCEGLGNQVTGYHPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQHGGRV 128
            .:||..:.:.....:.|.||:|:..|..||:|:|:||.:|||||||:||.||::|.|:..|....
  Rat    75 AACLVPICSLHGAAVTTVEGIGSTKTRIHPVQERIAKGHGTQCGFCTPGMVMSIYTLLRNHPEPS 139

  Fly   129 TMEEVENSFGGNICRCTGYRPILDAMKSFAVDSTVEVSEESVDIEDLNLKARNCPRSGK------ 187
            | |::..:.|||:|||||||||:::.:||:.:|.         ...:|.|.:.|...||
  Rat   140 T-EQIMETLGGNLCRCTGYRPIVESARSFSPNSA---------CCPMNEKWKCCLDEGKNEPERK 194

  Fly   188 --VCKGTCRQ---------SKLIY--------EDG-----------SQWYWPSTLAEIFEALENV 222
              ||.....:         .:||:        ||.           :.|..|.||.::.|.....
  Rat   195 NSVCTKLYEKEEFQPLDPTQELIFPPELMRMAEDSPNTVLTFRGERTTWIAPGTLNDLLELKMEY 259

  Fly   223 GDSEEFMLVGGNTAHGVYRRSPDIKHFIDVN--GVEDLHQYSSDKEKLTLGASLSLTETMEIIQ- 284
            ..:.   ||.|||..|:..:..|:.:.|.::  .:.:|...::..|.|||||.||||:...|:.
  Rat   260 PSAP---LVIGNTCLGLDMKFKDVSYPIIISPARILELFVVTNTNEGLTLGAGLSLTQVKNILSD 321

  Fly   285 --STSKQSGFEYLEVLWHHIDLVANVPVRNSGTLAGNICTKKEHPEFP-SDIFISFEALDVK--V 344
              |...:...:....|..|:..:|...:||..:|.|:|.::     .| ||:...|...:.|  |
  Rat   322 VVSRLPKERTQTYRALLKHLRTLAGQQIRNVASLGGHIISR-----LPTSDLNPIFGVGNCKLNV 381

  Fly   345 VAMKGIDDEKEMTL-EEFLGDT------DRKMLLKAFILPRYPKDMYIYDSFKIMPRAQNAHAYV 402
            .:.:|   .:::.| :.||...      ..::|:..|: |...|..:: .:|:..||.|||.|.|
  Rat   382 ASTEG---TQQIPLNDHFLAGVPEAILKPEQVLISVFV-PLSRKWEFV-SAFRQAPRQQNAFAIV 441

  Fly   403 NAGFLLEL-DGNSMVKSARICFGGIRPDFIHATDIEQLMVGHSPYESNLVEQTFNKLESLVKPDE 466
            |||..:.. :..:.:....|.:|||....:.|...:|| :|.. ::..:::.....:...|....
  Rat   442 NAGMRVAFKEDTNTITDLSILYGGIGATVVSAKSCQQL-IGRC-WDEEMLDDAGRMIREEVSLLT 504

  Fly   467 VLPDASPAYRSKLACGLLYKFLL-----------KHAPDAEVSGKFKSGGELLQRPLSSGLQLFQ 520
            ..|.....||..||...|:||.|           ...||  :|.|.....|.....:..|.|.|:
  Rat   505 AAPGGMVEYRKTLAISFLFKFYLDVLKQLKRRNPHRCPD--ISQKLLQVLEDFPLTMPHGTQSFK 567

  Fly   521 --TNKQTY--PVTQGVQKLEGMIQCSGEATYMNDVLTTSNSVYCAFVGATKVGATIDQIDATEAL 581
              .::|..  ||.:.:....|:...:|||.:.:|:...:..::.|.|.::|..|.|..:||:|||
  Rat   568 DVDSQQPLQDPVGRPIMHQSGIKHATGEAVFCDDMSVLAGELFLAVVTSSKPHARIISLDASEAL 632

  Fly   582 QHPGVVAFYTAKDIPGTNTFCEPSFGYEAEEIFCSGMVRHSEQPVGVIVALTAD---QAQRATKL 643
            ..||||...||:|:||.|...|.|. |..:|:.|.|.         ::.|:.||   :|::|||.
  Rat   633 ASPGVVDVITAQDVPGDNGREEESL-YAQDEVICVGQ---------IVCAVAADSYARAKQATKK 687

  Fly   644 VKISYSSPSSNFKLMPSLKDVFSSET---PDTSRIIPLVISKLKE--VKFS-DKPDLEVRGIFEM 702
            |||.|....   .::.:::|....|:   |:         .||::  |:.: ...|..:.|...:
  Rat   688 VKIVYEDME---PMIVTVQDALQHESFIGPE---------KKLEQGNVQLAFQSADQILEGEVHL 740

  Fly   703 GLQYHFTMEPQTTIIIPFEDGLK--VFSATQWIDQTQSVIAHTLQMKAKDVQLEVRRLGGGYGCK 765
            |.|.||.||.|:..:||..:.::  ::.::|....||.::|.||.:....:...|:|:||.:|.|
  Rat   741 GGQEHFYMETQSVRVIPKGEDMEMDIYVSSQDAAFTQEMVARTLGIPKNRITCHVKRVGGAFGGK 805

  Fly   766 ISRGNQVACAAALAAHKLNRPVRFVQSLESMMDCNGKRWACRSEYQCHVKTSGRIVGLSNDFYED 830
            .|:...:|..||:||.|..||:||:......|...|.|.....:|:.....:|:|.......|.:
  Rat   806 TSKPGLLASVAAVAAQKTGRPIRFILERGDDMLITGGRHPLLGKYRVGFMNNGKIKAADIQLYIN 870

  Fly   831 AGWNTNESP-VQGHSTFTAANCYEFTDSNFKLSGHAVLTDAPSSTWCRAPGSVEGIAMMENIIEH 894
            .|...::|. |..::.....|.|:.  .|.::.|....|:.||:|..|..|..:|..:.|..:..
  Rat   871 GGCTPDDSELVIEYALLKLENAYKI--PNLRVRGRVCKTNLPSNTAFRGFGFPQGAFVTETWVSA 933

  Fly   895 VAFEIQKDPAEVRLANISKKSKMATVFPEF------------LKTREYYSRKKEIEAFNANNRWK 947
            ||.:....|.:||..|:.|.........||            ::...||||||.::.||..:.||
  Rat   934 VAAKCHLPPEKVRELNMYKTIDRTIHKQEFDPTNLIKCWETCMENSSYYSRKKAVDEFNQQSFWK 998

  Fly   948 KRGLGLSLM----NFPIIYIGQFPATVTIYHVDGTVVVTHGGIEMGQGMNTKIAQVAAYTLGIDL 1008
            |||:.:..|    .||..:..|..|.|.|| .||:|:|.|||:|:|||:|||:.|||:..|.|.:
  Rat   999 KRGIAIIPMKFSVGFPKTFYHQAAALVQIY-TDGSVLVAHGGVELGQGINTKMIQVASRELKIPM 1062

  Fly  1009 SYVKVESSTSINGANSMVTGYAIGSESVCYAVRKICETLNARLKPV--RKAKATWVETVEAANAQ 1071
            ||:.::...::...|::.||.:.|::....||:..|:.|..||:|:  :.....|.|.:..|..|
  Rat  1063 SYIHLDEMNTMTVPNTITTGGSTGADVNGRAVQNACQILMKRLEPIISQNPNGDWEEWINEAFIQ 1127

  Fly  1072 LINLIASDHYK-----------TGDMQNYHVLGLALSEVEIDVLTG---NILIRRVDILEDAGES 1122
            .|:|.|:.:::           .||:..|.|.|.|.||||||.|||   ||   |.||:.|...|
  Rat  1128 SISLSATGYFRGYQADMDWEKGEGDIYPYFVFGAACSEVEIDCLTGAHKNI---RTDIVMDGSFS 1189

  Fly  1123 LSPWIDVGQVEGAFVMGLGYWLSELLIYEGDNGRLLTNRTWNYKPLGAKDIPIDFRVELVHNPRP 1187
            ::|.:|:||:|||||.|||.:..|.|.|..: |.|.|.....||.....|||.:|.|.|: .|..
  Rat  1190 INPAVDIGQIEGAFVQGLGLYTLEELKYSPE-GVLYTRGPHQYKIASVSDIPEEFHVSLL-TPTQ 1252

  Fly  1188 SSSGFMGSKATGEPPCCLAVSVIFALQQALQSARQDAGLPREWLRLGAPTTPETL 1242
            :......||..||....|..||.||:..|:.:||::.|||. .|.:.:|.|.|.:
  Rat  1253 NPKAIYSSKGLGEAGMFLGSSVFFAIAAAVAAARKERGLPL-ILAINSPATAEVI 1306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AOX4	NP_650478.1	PLN02906	24..1240	CDD:215491	398/1332 (30%)
Aox3	NP_001008527.2	mam_aldehyde_ox	9..1333	CDD:132014	404/1355 (30%)