back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX4 and Aox4

DIOPT Version :9

Sequence 1:	NP_650478.1	Gene:	AOX4 / 41897	FlyBaseID:	FBgn0038350	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001008523.2	Gene:	Aox4 / 316424	RGDID:	1311975	Length:	1333	Species:	Rattus norvegicus

Alignment Length:	1380	Identity:	410/1380 - (29%)
Similarity:	649/1380 - (47%)	Gaps:	206/1380 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FTINGQPYAVNLTDLPPDITLNTFIREHAQLTATKFMCLEGGCGACVCAVS----DGKST--WTV 63
            |.:||:  .|...:..|::.|..::|:...||.||:.|..||||||...:|    :.|..  :..
  Rat    10 FFVNGK--KVIEKNPVPEMNLLFYVRKVLHLTGTKYSCGGGGCGACTVMISRYNPESKKIYHYPA 72

  Fly    64 NSCLKLLNTCAQLEIITCEGLGNQVTGYHPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQHGGRV 128
            .:||..:.:.....:.|.||:|:.....||:|:||||.:||||||||||.||::|.|:..| ...
  Rat    73 TACLVPVCSLHGAAVTTVEGVGSIKRRIHPVQERLAKCHGTQCGFCSPGMVMSIYTLLRNH-PEP 136

  Fly   129 TMEEVENSFGGNICRCTGYRPILDAMKSFAVDSTVEVSEESVDIEDLNLKARNCPRSGKVCKGT- 192
            |.:::..:.|||:|||||||||:::.|:|:.:|:|           ..:|.     |||.|...
  Rat   137 TPDQITEALGGNLCRCTGYRPIVESGKTFSPESSV-----------CQMKG-----SGKCCMDLD 185

  Fly   193 --CRQS-------KLIYEDGSQ----------------------------------WYWPSTLAE 214
              |.:|       ||..||..|                                  |..|.||.:
  Rat   186 EGCSESTKERMCTKLYNEDEFQPLDPSQEPIFPPELIRMAEDPHKRRLTFQGERTIWIMPVTLND 250

  Fly   215 IFEALENVGDSEEFMLVGGNTAHGVYRRSPDIKH-------FIDVNGVEDLHQYSSDKEKLTLGA 272
            :   ||......|..||.||||.|     |.:|.       ||...|:.:|:...:....:|:||
  Rat   251 L---LELKASYPEAPLVMGNTAVG-----PGMKFNNEFHPVFISPLGLPELNLVDTANSGVTIGA 307

  Fly   273 SLSLTETMEIIQSTSKQSGFEYL---EVLWHHIDLVANVPVRNSGTLAGNICTKKEHPEFPSDI- 333
            ..||.:..:|:.|.:.:...|..   :.|..|:..:|...:||..||.|::.::   |:| ||:
  Rat   308 RHSLAQMKDILHSLTLEQPKEKTKTHQALLKHLRTLAGPQIRNMATLGGHVVSR---PDF-SDLN 368

  Fly   334 -FISFEALDVKVVAMKGIDDEKEMTLE----EFLGDTDRK---MLLKAFILPRYPKDMYIYDSFK 390
             .::.....:.|::.:|   ::::.|.    |.|.:...|   :.|..|| |...:..|: ...:
  Rat   369 PILAAGNATINVISKEG---QRQIPLNGPFLERLPEASLKPEEVALSVFI-PYSGQWQYV-SGLR 428

  Fly   391 IMPRAQNAHAYVNAGFLLEL-DGNSMVKSARICFGGIRPDFIHATDIEQLMVGHSPYESNLVEQT 454
            :..|.:||.|.||||..:|. :|.:.:|..::.||.:.|..:.|:...:.::|....:..|.:..
  Rat   429 LAQRQENAFAIVNAGMSVEFEEGTNTIKDLQMLFGSVAPTVVSASQTCKQLIGRQWDDQMLSDAC 493

  Fly   455 FNKLESLVKPDEVLPDASPA---YRSKLACGLLYKFLLK-----------HAPDAEVSGKFKSGG 505
            ...||.:..|    |||...   ||..|...||:||.||           ..||  :..||.|..
  Rat   494 QLVLEEIRIP----PDAEGGMVEYRRTLIISLLFKFYLKVRRWLSEMDPQKFPD--IPEKFVSAL 552

  Fly   506 ELLQRPLSSGLQLFQ----TNKQTYPVTQGVQKLEGMIQCSGEATYMNDVLTTSNSVYCAFVGAT 566
            :.|......|:|:||    ...:..||...:....|:...:|||.:::|:...:..:....|.:|
  Rat   553 DDLPIETPQGIQMFQCVDPNQPEQDPVGHPIMHQSGIKHATGEAKFVDDMPRINQELCLTVVTST 617

  Fly   567 KVGATIDQIDATEALQHPGVVAFYTAKDIPGTNTFCEPSFGYEAEEIFCSGMVRHSEQPVGVIVA 631
            :..|.|..||.:|||.:||||...||:|:||.|......| |...|:.|.|.:      :..:.|
  Rat   618 RAHAKITSIDVSEALAYPGVVDVITAEDVPGDNNHSGEIF-YAQNEVICVGQI------ICTVAA 675

  Fly   632 LTADQAQRATKLVKISYSSPSSNFKLMPSL---------KDVFSSETPDTSRIIPLVISKLKE-- 685
            .|...|:.|.|.|||:|..      :.|::         ....|||            .|:::
  Rat   676 DTYIHAKEAAKRVKITYDD------IEPAIITIEQALEHNSFLSSE------------KKIEQGN 722

  Fly   686 VKFSDK-PDLEVRGIFEMGLQYHFTMEPQTTIIIP-FEDGLKVFS-ATQWIDQTQSVIAHTLQMK 747
            |.::.| .|..:.|...:..|.||.||.||.:.|| .||...|.. .||:....|..::..|::.
  Rat   723 VDYAFKHVDHIIEGEIHVEGQEHFYMETQTILAIPQTEDKEMVLHVGTQFPTHVQEYVSAALKVP 787

  Fly   748 AKDVQLEVRRLGGGYGCKISRGNQVACAAALAAHKLNRPVRFVQSLESMMDCNGKRWACRSEYQC 812
            ...:..:::|.||.:|.|:::...:....|:||||..||:||:....:.|.....|.....:|:.
  Rat   788 RNRIACQMKRTGGAFGGKVTKPALLGAVCAVAAHKTGRPIRFILDRSNDMLITAGRHPLLGKYKI 852

  Fly   813 HVKTSGRIVGLSNDFYEDAGWNTNESP-VQGHSTFTAANCYEFTDSNFKLSGHAVLTDAPSSTWC 876
            ....:|:|.....::|.:.|...:||. |.......:.|.|..  .||:..|.|..|:.||:|..
  Rat   853 GFMNNGKIKAADVEYYTNGGCTPDESEMVIEFIVLKSENAYHI--PNFRCRGRACKTNLPSNTAF 915

  Fly   877 RAPGSVEGIAMMENIIEHVAFEIQKDPAEVRLAN----ISKKSKMATVFP--------EFLKTRE 929
            |..|..:...::|..|..||.:....|.|:|..|    |||.:...|..|        |.|:...
  Rat   916 RGFGFPQATVVVEAYIAAVASKCNLLPEEIREINMYKQISKTAYKQTFNPEPLRRCWKECLQKSS 980

  Fly   930 YYSRKKEIEAFNANNRWKKRGLGLSLMNF----PIIYIGQFPATVTIYHVDGTVVVTHGGIEMGQ 990
            :::||:..|.||.||.|||:||.:..|.|    |:.:..|..|.|.|: :||:|::||||.|:||
  Rat   981 FFARKQAAEEFNKNNYWKKKGLAVVPMKFSVAVPMAFYNQAAALVHIF-LDGSVLLTHGGCELGQ 1044

  Fly   991 GMNTKIAQVAAYTLGIDLSYVKVESSTSINGANSMVTGYAIGSESVCYAVRKICETLNARLKPV- 1054
            |::||:.|||:..|.|..|||.:..::::...|::.|..::|::....||:..|:||..||:|:
  Rat  1045 GLHTKMIQVASRELNIPKSYVHLVETSTVTVPNAVFTAGSMGADINGKAVQNACQTLLDRLQPII 1109

  Fly  1055 -RKAKATWVETVEAANAQLINLIASDHYK-----------TGDMQNYHVLGLALSEVEIDVLTGN 1107
             :..|..|.|.|:.|..:.|:|.|:.::|           .||...|:|.|.|.||||:|.|||.
  Rat  1110 KKNPKGKWEEWVKKAFEESISLSATGYFKGYQTNMDWEKEEGDPYPYYVYGAACSEVEVDCLTGA 1174

  Fly  1108 ILIRRVDILEDAGESLSPWIDVGQVEGAFVMGLGYWLSELLIYEGDNGRLLTNRTWNYKPLGAKD 1172
            ..:.|.||..||..|::|.:|:|||||||:.|:|::..|.|.| ...|.|.:....:||.....:
  Rat  1175 HKLLRTDIFMDAAFSINPALDIGQVEGAFIQGMGFYTIEELKY-SPKGVLYSRGPDDYKIPTVTE 1238

  Fly  1173 IPIDFRVELVHNPRPSSSGFMGSKATGEPPCCLAVSVIFALQQALQSARQDAGLPREWLRLGAPT 1237
            ||.:|.|.:|.:..|.:  ...||..||....|..||:||:..|:.:||::.|| .:...|.:|.
  Rat  1239 IPEEFYVTMVRSRNPIA--IYSSKGLGEAGMFLGSSVLFAIYDAVTTARKERGL-SDIFPLNSPA 1300

  Fly  1238 TPETLLLNAGHQVSE 1252
            |||.:.:....|.::
  Rat  1301 TPEVIRMACKDQFTD 1315

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.