DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX4 and Aox2

DIOPT Version :9

Sequence 1:	NP_650478.1	Gene:	AOX4 / 41897	FlyBaseID:	FBgn0038350	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_038939552.1	Gene:	Aox2 / 316421	RGDID:	1359668	Length:	1347	Species:	Rattus norvegicus

Alignment Length:	1359	Identity:	406/1359 - (29%)
Similarity:	641/1359 - (47%)	Gaps:	177/1359 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FTINGQPYAVNLTDLPPDITLNTFIREH--AQLTATKFMCLEGGCGACVCAVSDG----KST--W 61
            |.:||:  .|...::.|::||..|:|::  ..||.||:.|..|.||||...||..    |.|  :
  Rat    13 FFVNGK--KVTEKNVDPEVTLLAFLRKNWTLCLTGTKYACGTGSCGACTVMVSQHDPVCKKTRHF 75

  Fly    62 TVNSCLKLLNTCAQLEIITCEGLGNQVTGYHPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQHGG 126
            :|.:||..|.:.....:.|.||:|:..|..||:|:||||.:||||||||||.||:||.|:..| .
  Rat    76 SVMACLVPLCSLHGAAVTTVEGVGSIKTRLHPVQERLAKSHGTQCGFCSPGMVMSMYALLRNH-P 139

  Fly   127 RVTMEEVENSFGGNICRCTGYRPILDAMKSFAVDS-------TVEVSEESVDIEDLNLKARNC-- 182
            :.:.|::..:.|||:||||||||||::.::|.::|       |.:...:..:.:....|:..|
  Rat   140 QPSEEQLLEALGGNLCRCTGYRPILESGRTFCMESDGCLQKGTGQCCLDQKEGDSSGSKSDICTE 204

  Fly   183 -------------------PRSGKVCKGTCRQSKLIYEDGSQWYWPSTLAEIFEALENVGDSEEF 228
                               |...::.:...:|:...|.:...|..|.||.|:   |.......|.
  Rat   205 LFVKDEFQPLDPTQELIFPPELLRMAENPEKQTLTFYGERITWIAPGTLQEL---LVLKAKYPEA 266

  Fly   229 MLVGGNTAHGVYRRSPDIKHFIDV----NGVEDLHQYSSDKEKLTLGASLSLTETMEII-QSTSK 288
            .|:.||||.|...:|..  ||..|    ..:.||...:.....||:||..||.:..::: :|.|:
  Rat   267 PLISGNTALGPAMKSQG--HFYPVLLSPARIPDLRMVTKTSGGLTIGACCSLAQVKDVLAESISE 329

  Fly   289 --QSGFEYLEVLWHHIDLVANVPVRNSGTLAGNICTKKEHPEFPSDI--FISFEALDVKVVAMKG 349
              :...:....|..|:..:|...:||..:|.|::.::    .:.||:  .:|.....:.:::.:|
  Rat   330 LPEEKTQTYRALLKHLRSLAGQQIRNMASLGGHVISR----HYYSDLNPILSVGNATLNLLSEEG 390

  Fly   350 IDDEKEMTLE-EFLG-----DTDRKMLLKAFILPRYPKDMYIYDSFKIMPRAQNAHAYVNAGF-L 407
            :   :::.|. .||.     |...:.:|.:..:|...|..:: .:|:.....|||...||||. :
  Rat   391 L---RQIPLNGHFLAGLANEDLKPEEILGSVYIPHSQKREFV-SAFRQAQCHQNALPDVNAGMRV 451

  Fly   408 LELDGNSMVKSARICFGGIRPDFIHATDIEQLMVGHSPYESNLVEQTFNKLESLVKPDEV-LPDA 471
            |..:|..:::...|.:||:.|..:.|....|.::|.. :.:.|:::....|     .||| ||.:
  Rat   452 LFKEGTDIIEELSIAYGGVGPTTVSAHRSCQQLLGRR-WNALLLDEACRLL-----LDEVSLPGS 510

  Fly   472 SPA----YRSKLACGLLYKF-------------LLKHAPDAE-----VSGKFKSGGELLQRPLSS 514
            :..    :|..|.....:||             ||..:.|::     ..|...|.|: .|..|..
  Rat   511 AVGGKVEFRRTLIVSFFFKFYLEVLQELKADKRLLPESTDSQRYPEIADGSRSSLGD-FQVTLPQ 574

  Fly   515 GLQLFQ--TNKQTY--PVTQGVQKLEGMIQCSGEATYMNDVLTTSNSVYCAFVGATKVGATIDQI 575
            |:|.:|  .:.|..  ||.:.:..|.|:...:|||.:.:|:......::.|.|.:|:..|.|..|
  Rat   575 GVQTYQRVNSHQPLQDPVGRPIMHLSGLKHATGEAVFCDDIPRVDKELFMALVTSTRAHARIISI 639

  Fly   576 DATEALQHPGVVAFYTAKDIPGTNTFCEPSFGYE------AEEIFCSGMVRHSEQPVGVIVALTA 634
            |::|.|..||||...||:||||.|       |.|      .:::.|.|.|      |..:||.|.
  Rat   640 DSSEVLDLPGVVDVITAEDIPGNN-------GEEDDKLLAVDKVLCVGQV------VCAVVAETD 691

  Fly   635 DQAQRATKLVKISYSSPSSNFKLMPSLKDVFSSETPDTSRIIPLVISKLKEVKFS---DKPDLEV 696
            .||:||||.:||:|..      |.|.|   |:.|.............||::....   :..|..|
  Rat   692 VQAKRATKKIKITYED------LKPVL---FTIEDAIQHNSFLCPEKKLEQGNMEEAFENVDQIV 747

  Fly   697 RGIFEMGLQYHFTMEPQTTIIIP-FED-GLKVFSATQWIDQTQSVIAHTLQMKAKDVQLEVRRLG 759
            .|...:|.|.||.||.|..::|| .|| .|.::.:||.....|..::..|.:....:...|:|:|
  Rat   748 EGKVHVGGQEHFYMETQRVLVIPKTEDKELDMYVSTQDPAHVQKTVSSALNIPLSRITCHVKRVG 812

  Fly   760 GGYGCKISRGNQVACAAALAAHKLNRPVRFVQSLESMMDCNGKRWACRSEYQCHVKTSGRIVGLS 824
            ||:|.|:.|.......||:.|.|..||:|.|...|..|...|.|....::|:.....||||..|.
  Rat   813 GGFGGKVGRPAVFGAIAAVGAVKTGRPIRLVLDREDDMLITGGRHPLFAKYKVGFMNSGRIKALD 877

  Fly   825 NDFYEDAGWNTNESP-VQGHSTFTAANCYEFTDSNFKLSGHAVLTDAPSSTWCRAPGSVEGIAMM 888
            .:.|.:.|...::|. |.........|.|:.  .|.:|.|.|.:|:.||:|..|..|..:|..:.
  Rat   878 IECYINGGCTLDDSELVTEFLVLKLENAYKI--RNLRLRGRACMTNLPSNTAFRGFGFPQGALVT 940

  Fly   889 ENIIEHVAFEIQKDPAEVRLANISK------------KSKMATVFPEFLKTREYYSRKKEIEAFN 941
            |:.|..||.:....|.::|..|:.|            ...:...:.|.|....:..|:..::.||
  Rat   941 ESCITAVAAKCGLPPEKIREKNMYKTVDKTIYKQAFNPEPLIRCWNECLDKSSFAIRRTRVDEFN 1005

  Fly   942 ANNRWKKRGLGLSLMNFPIIYIG----QFPATVTIYHVDGTVVVTHGGIEMGQGMNTKIAQVAAY 1002
            ..:.|:|||:.:..|.|.:.:..    |..|.|.|| .||:|:|.|||.|:|||::||:.|||:.
  Rat  1006 KKSYWRKRGIAVVPMKFSVGFAATSYHQAAALVHIY-TDGSVLVAHGGNELGQGIHTKMLQVASR 1069

  Fly  1003 TLGIDLSYVKVESSTSINGANSMVTGYAIGSESVCYAVRKICETLNARLKPV--RKAKATWVETV 1065
            .|.|.:||:....:.:....|::.|..::|::....||:..|:.|..||:||  :..:.||.:.:
  Rat  1070 ELKIPMSYLHTSETCTAAVPNTIATAASVGADVNGRAVQNACQILLKRLEPVIKKNPEGTWRDWI 1134

  Fly  1066 EAANAQLINLIASDHYK-----------TGDMQNYHVLGLALSEVEIDVLTGNILIRRVDILEDA 1119
            |||..|.|:|.|:.:::           .||...|:|.|.|.||||||.|||.....|.||:.||
  Rat  1135 EAAFEQRISLSATGYFRGYKAFMDWEKGEGDPFPYYVYGAACSEVEIDCLTGAHKKMRTDIVMDA 1199

  Fly  1120 GESLSPWIDVGQVEGAFVMGLGYWLSELLIYEGDNGRLLTNRTWNYKPLGAKDIPIDFRVELVHN 1184
            ..||:|.|||||:||||:.|:|.:.:|.|.|..: |.|.:.....||.....|:|..|.|.|:
  Rat  1200 CCSLNPAIDVGQIEGAFIQGMGLYTTEELHYSPE-GVLYSRSPDKYKIPTVTDVPEQFNVSLL-- 1261

  Fly  1185 PRPSSS---GFMGSKATGEPPCCLAVSVIFALQQALQSARQDAGLPREWLRLGAPTTPE 1240
              |||.   ....||..||....|..||.||:..|:.:||:...:..:: .:.:|.|||
  Rat  1262 --PSSQTPLTIYSSKGLGESGMFLGSSVFFAIADAVAAARRQRDIAEDF-TVKSPATPE 1317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX4	NP_650478.1	PLN02906	24..1240	CDD:215491	399/1338 (30%)
		Fer2_2	80..153	CDD:280048	42/72 (58%)
		FAD_binding_5	203..378	CDD:279309	43/189 (23%)
		CO_deh_flav_C	388..489	CDD:281449	28/119 (24%)
		Ald_Xan_dh_C	542..648	CDD:214971	41/111 (37%)
		Ald_Xan_dh_C2	690..1174	CDD:280834	168/515 (33%)
Aox2	XP_038939552.1	mam_aldehyde_ox	10..1346	CDD:132014	406/1359 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720