DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX4 and AOX1

DIOPT Version :9

Sequence 1:	NP_650478.1	Gene:	AOX4 / 41897	FlyBaseID:	FBgn0038350	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_011509364.1	Gene:	AOX1 / 316	HGNCID:	553	Length:	1350	Species:	Homo sapiens

Alignment Length:	1391	Identity:	408/1391 - (29%)
Similarity:	647/1391 - (46%)	Gaps:	241/1391 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FTINGQPYAVNLTDLPPDITLNTFIREHAQLTATKFMCLEGGCGACVCAVSDGKST------WTV 63
            |.:||:.......|  |:..|..::|:..:||.||:.|..||||||...:|.....      ...
Human     9 FYVNGRKVIEKNVD--PETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNPITKRIRHHPA 71

  Fly    64 NSCLKLLNTCAQLEIITCEGLGNQVTGYHPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQHGGRV 128
            |:||..:.:.....:.|.||:|:..|..||:|:|:||.:|||||||:||.||::|.|:..| ...
Human    72 NACLIPICSLYGAAVTTVEGIGSTHTRIHPVQERIAKCHGTQCGFCTPGMVMSIYTLLRNH-PEP 135

  Fly   129 TMEEVENSFGGNICRCTGYRPILDAMKSFAVDSTVEVSEESVDIEDLNLKARNCPRSGKVC---- 189
            |::::.::.|||:|||||||||:||.|:|...|....|:|                :|..|
Human   136 TLDQLTDALGGNLCRCTGYRPIIDACKTFCKTSGCCQSKE----------------NGVCCLDQG 184

  Fly   190 --------KGTCRQSKLIYED-------------------------------GSQ---WYWPSTL 212
                    :|:....||..|:                               ||:   |:.|.||
Human   185 INGLPEFEEGSKTSPKLFAEEEFLPLDPTQELIFPPELMIMAEKQSQRTRVFGSERMMWFSPVTL 249

  Fly   213 AEIFEALENVGDSEEFMLVGGNTAHGVYRRSPDIKH-------FIDVNGVEDL----HQYSSDKE 266
            .|:.|.......:...|   |||:.|     |::|.       .|..:.:|:|    |.|:.
Human   250 KELLEFKFKYPQAPVIM---GNTSVG-----PEVKFKGVFHPVIISPDRIEELSVVNHAYNG--- 303

  Fly   267 KLTLGASLSLTETMEIIQSTSKQSGFEYLEV---LWHHIDLVANVPVRNSGTLAGNICTKKEHPE 328
             |||||.|||.:..:|:....::...|..::   |..|:..:|...:||..:|.|:|.::  ||:
Human   304 -LTLGAGLSLAQVKDILADVVQKLPEEKTQMYHALLKHLGTLAGSQIRNMASLGGHIISR--HPD 365

  Fly   329 FPSDIFISFEALDVKVVAMKGIDDEKEMTL-EEFL-----GDTDRKMLLKAFILPRYPKDMYIYD 387
            ...:..::.....:.:::.:|   ::::.| |:||     .|...:.:|.:..:| |.:......
Human   366 SDLNPILAVGNCTLNLLSKEG---KRQIPLNEQFLSKCPNADLKPQEILVSVNIP-YSRKWEFVS 426

  Fly   388 SFKIMPRAQNAHAYVNAGFLLEL-DGNSMVKSARICFGGIRPDFIHATDIEQLMVGHSPYESNLV 451
            :|:...|.:||.|.||:|..:.. :|:.:::...|.:||:.|..|.|.:..|.::|.     :..
Human   427 AFRQAQRQENALAIVNSGMRVFFGEGDGIIRELCISYGGVGPATICAKNSCQKLIGR-----HWN 486

  Fly   452 EQTFNKLESLVKPDEVLPDASPA----YRSKLACGLLYKFLLK-----------HAPDAEVSGKF 501
            ||..:....|:..:..|..::|.    ::..|....|:||.|:           |.|  .::.|:
Human   487 EQMLDIACRLILNEVSLLGSAPGGKVEFKRTLIISFLFKFYLEVSQILKKMDPVHYP--SLADKY 549

  Fly   502 KSGGELLQRPLSSGLQLFQT--NKQ--TYPVTQGVQKLEGMIQCSGEATYMNDVLTTSNSVYCAF 562
            :|..|.|..........:|.  .||  ..|:...:..|.|:...:|||.|.:|:......::..|
Human   550 ESALEDLHSKHHCSTLKYQNIGPKQHPEDPIGHPIMHLSGVKHATGEAIYCDDMPLVDQELFLTF 614

  Fly   563 VGATKVGATIDQIDATEALQHPGVVAFYTAKDIPGTNTFCEPSFGYEAE------EIFCSGMVRH 621
            |.:::..|.|..||.:|||..||||...||:.:...|:||   |..|||      ::||.|.
Human   615 VTSSRAHAKIVSIDLSEALSMPGVVDIMTAEHLSDVNSFC---FFTEAEKFLATDKVFCVGQ--- 673

  Fly   622 SEQPVGVIVALTAD---QAQRATKLVKISYSSPSSNFKLMPSLKDVFSSETPDTSRIIPLVISKL 683
                  ::.|:.||   ||:||.|.|||.|..                        :.||:::..
Human   674 ------LVCAVLADSEVQAKRAAKRVKIVYQD------------------------LEPLILTIE 708

  Fly   684 KEVKF--SDKPD--LE--------------VRGIFEMGLQYHFTMEPQTTIIIP--FEDGLKVFS 728
            :.::.  |.||:  ||              :.|...||.|.||.||.|:.:::|  .:..:.|:.
Human   709 ESIQHNSSFKPERKLEYGNVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYV 773

  Fly   729 ATQWIDQTQSVIAHTLQMKAKDVQLEVRRLGGGYGCKISRGNQVACAAALAAHKLNRPVRFVQSL 793
            :||:....|.::|.||::.|..|...|||:||.:|.|:.:...:|...|.||:|..|.||.|...
Human   774 STQFPKYIQDIVASTLKLPANKVMCHVRRVGGAFGGKVLKTGIIAAVTAFAANKHGRAVRCVLER 838

  Fly   794 ESMMDCNGKRWACRSEYQCHVKTSGRIVGLSNDFYEDAGWNTNESP-VQGHSTFTAANCYEFTDS 857
            ...|...|.|.....:|:......|||:.|..:.|.:||.:.:||. |.........|.|:|  .
Human   839 GEDMLITGGRHPYLGKYKAGFMNDGRILALDMEHYSNAGASLDESLFVIEMGLLKMDNAYKF--P 901

  Fly   858 NFKLSGHAVLTDAPSSTWCRAPGSVEGIAMMENIIEHVAFEIQKDPAEVRLANISKK-------- 914
            |.:..|.|..|:.||:|..|..|..:...:.|:.|..||.:....|.:||:.|:.|:
Human   902 NLRCRGWACRTNLPSNTAFRGFGFPQAALITESCITEVAAKCGLSPEKVRIINMYKEIDQTPYKQ 966

  Fly   915 ----SKMATVFPEFLKTREYYSRKKEIEAFNANNRWKKRGLGLSLMNFPI----IYIGQFPATVT 971
                ..:...:.|.:....|..||..:|.|||.|.|||:||.:..:.||:    ...||..|.|.
Human   967 EINAKNLIQCWRECMAMSSYSLRKVAVEKFNAENYWKKKGLAMVPLKFPVGLGSRAAGQAAALVH 1031

  Fly   972 IYHVDGTVVVTHGGIEMGQGMNTKIAQVAAYTLGIDLSYVKVESSTSINGANSMVTGYAIGSESV 1036
            || :||:|:|||||||||||::||:.||.:..|.:.:|.|.:..:::....|:.::|.::.::..
Human  1032 IY-LDGSVLVTHGGIEMGQGVHTKMIQVVSRELRMPMSNVHLRGTSTETVPNANISGGSVVADLN 1095

  Fly  1037 CYAVRKICETLNARLKPV--RKAKATWVETVEAANAQLINLIASDHYK--TGDMQ---------N 1088
            ..||:..|:||..||:|:  :..|.||.:..:.|..:.|||.|..:::  ..||.         .
Human  1096 GLAVKDACQTLLKRLEPIISKNPKGTWKDWAQTAFDESINLSAVGYFRGYESDMNWEKGEGQPFE 1160

  Fly  1089 YHVLGLALSEVEIDVLTGNILIRRVDILEDAGESLSPWIDVGQVEGAFVMGLGYWLSELLIYEGD 1153
            |.|.|.|.||||||.|||:....|.||:.|.|.|::|.||:||:||||:.|:|.:..|.|.| ..
Human  1161 YFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGCSINPAIDIGQIEGAFIQGMGLYTIEELNY-SP 1224

  Fly  1154 NGRLLTNRTWNYKPLGAKDIPIDFRVELVHNPRPSSSGFMGSKATGEPPCCLAVSVIFALQQALQ 1218
            .|.|.|.....||.....|:|.:..:.|: .|..:|:....||..||....|..||.||:..|:.
Human  1225 QGILHTRGPDQYKIPAICDMPTELHIALL-PPSQNSNTLYSSKGLGESGVFLGCSVFFAIHDAVS 1288

  Fly  1219 SARQDAGL--PREWLRLGAPTTPETL 1242
            :|||:.||  |   |.|.:|.|||.:
Human  1289 AARQERGLHGP---LTLNSPLTPEKI 1311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX4	NP_650478.1	PLN02906	24..1240	CDD:215491	401/1368 (29%)
		Fer2_2	80..153	CDD:280048	38/72 (53%)
		FAD_binding_5	203..378	CDD:279309	47/197 (24%)
		CO_deh_flav_C	388..489	CDD:281449	26/105 (25%)
		Ald_Xan_dh_C	542..648	CDD:214971	41/114 (36%)
		Ald_Xan_dh_C2	690..1174	CDD:280834	176/531 (33%)
AOX1	XP_011509364.1	mam_aldehyde_ox	5..1328	CDD:132014	408/1391 (29%)
		Fer2_2	88..161	CDD:280048	39/73 (53%)
		FAD_binding_5	239..419	CDD:279309	46/197 (23%)
		CO_deh_flav_C	426..530	CDD:281449	27/108 (25%)
		Ald_Xan_dh_C	594..701	CDD:214971	42/142 (30%)
		Ald_Xan_dh_C2	720..1245	CDD:280834	174/528 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720