DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX4 and gad-3

DIOPT Version :9

Sequence 1:	NP_650478.1	Gene:	AOX4 / 41897	FlyBaseID:	FBgn0038350	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001294662.1	Gene:	gad-3 / 24104108	WormBaseID:	WBGene00015057	Length:	1257	Species:	Caenorhabditis elegans

Alignment Length:	1355	Identity:	354/1355 - (26%)
Similarity:	596/1355 - (43%)	Gaps:	229/1355 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FTINGQPYAVNLTDLPPDITLNTFIREHAQLTATKFMCLEGGCGACVCAVSDGKSTW-------- 61
            |.:||:.  ||..::.|::||..::|....|..||..|.||.||:|...:    .||
Worm     8 FNVNGKD--VNEENVDPELTLAYYLRNKLGLRGTKLGCEEGVCGSCTVVL----GTWDDCQNKAV 66

  Fly    62 --TVNSCLKLLNTCAQLEIITCEGLGNQVTGYHPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQH 124
              .||:||..|....:..:||.||:|:: ...||||.|:|:.:..|||||||||||:.|.|....
Worm    67 YRAVNACLVPLFHVHKTFVITVEGVGSR-DKIHPIQDRMARGHALQCGFCSPGFVMSAYALFSNQ 130

  Fly   125 GGRVTMEEVENSFGGNICRCTGYRPILDAMKSFAVDSTVEVSEESVDIEDLNLKARNCPRSGKVC 189
             ...|::::..:...|:||||||||||:|:.||:.:|                  ..|....|..
Worm   131 -PNPTIQQINAAIRANLCRCTGYRPILEALYSFSSES------------------GGCCGGNKTG 176

  Fly   190 KGTCRQSKLIYEDG------------------------------SQWYWPSTL-AEIFEAL--EN 221
            .|.|:......|||                              |....|.|| .:..|.|  :|
Worm   177 GGCCKDKSSSDEDGGYDEKLLSFNDFPKYDPTQEIIFPPSLRVFSDSETPVTLKGDRIELLLPKN 241

  Fly   222 VGDSEEF-----MLVGGNTAHGVYRRSPDIKHF----IDVNGVEDLHQYSSDKEKLTLGASLSLT 277
            :...::|     ::..|.....|..|:|  |.|    |....|::.::.:.:|:.:.:||:|::.
Worm   242 IDQFKKFKKDRTVISSGLITRFVSTRNP--KEFSQKWISTKYVKEFNEITVNKDSVVVGAALNIQ 304

  Fly   278 ETMEIIQST-SKQSGFEYLEVLWHHIDLVANVPVRNSGTLAGNICTKKEHPEFPSDIFISFEALD 341
            :..:.:.|: |...|.|    :...|...::..:.|..|..|.|.:..:.....||:.|.|..||
Worm   305 KMADTLTSSLSINIGKE----IDSFIQKFSSPQIANFATWTGAIISGAKSSLSVSDLLILFNVLD 365

  Fly   342 VKVVAMKGIDDEKEMTLEEFLGDTDRKMLLKAFILPRYPKDMYIYDSFKIMPRAQNAHAYVNA-- 404
            .|:..:....:..::.:|||   .::|:..                          .|..|||
Worm   366 AKLTLLNNSGELTQVAIEEF---AEKKLFA--------------------------THTIVNAIF 401

  Fly   405 -----GFL--LELDGNSMVKSARICFGGIRPDFIHATDIEQLMV--GHSPYESNLVEQTFNKLES 460
                 |||  |:|...|...|....|..     :....:.::.|  |..|.....:|...:.|:.
Worm   402 SRSLTGFLFCLKLGETSEQDSTNFNFAA-----LVGNQVSRIFVGLGGQPKRLTSLEVHIDALKG 461

  Fly   461 LVKPDEVLPDASPAYRS-KLACGLLYKFLLKHAPDAEVSGKFKSGGELLQRPLSSGLQLF--QTN 522
            |...|.........|:: |:|......|:.......|:.|             .:.||.|  :||
Worm   462 LSVSDLCQTTEMSDYKNVKIALTRFSDFMNHKEKTEEIEG-------------INYLQYFKPKTN 513

  Fly   523 KQT-YPVTQGVQKLEGMIQCSGEATYMNDVLTTSNSVYCAFVGATKVGATIDQIDATEALQHPGV 586
            :.. .|:.....:.    ..:|||.|:||: ...|:|:..||.:|...|.|.:||.:||||..||
Worm   514 ESAGRPIANYFNER----AITGEAFYVNDI-QAYNAVHLGFVLSTVPHAEITKIDVSEALQLEGV 573

  Fly   587 VAFYTAKDIPGTNTFCEPSFGY------EAEEIFCSGMVRHSEQPVGVIVALTADQAQRATKLVK 645
            ..::...|:||.||   |....      :...||....|....|.:|||.|.....|:||.||||
Worm   574 AGYFGVSDVPGNNT---PGLQISNMNFPDDTTIFADKKVESVGQVIGVIAANDVVLARRAAKLVK 635

  Fly   646 ISYSSPSSNFKLMPSL---KDVFSSETPDTSRIIPLVISKLKEVKFSDKPD------LE-----V 696
            :.|       |.:|||   |:...::            |.|.:|:...|.:      ||     :
Worm   636 VEY-------KELPSLVNFKEAIEAK------------SLLGDVQHFGKDENLVKESLENSSKVL 681

  Fly   697 RGIFEMGLQYHFTMEPQTTIIIPFE-DGLKVFSATQWIDQTQSVIAHTLQMKAKDVQLEVRRLGG 760
            .|..::|.|.|:.:|.|::::||.| |.|.|..:||....||.::|.|:::.|..:.::.:||||
Worm   682 EGECDIGGQEHYYLETQSSLVIPGEGDELIVNCSTQGTSFTQLMVAETMKIPAHKIIVKTKRLGG 746

  Fly   761 GYGCKISRGNQVACAAALAAHKLNRPVRFVQSLESMMDCNGKRWACRSEYQCHVKTSGRIVGLSN 825
            |:|.|::..:.:||..|:.|.|||||.....|....:...|||....::|:..:...|:|.|:..
Worm   747 GFGGKVNNASWIACMCAIVAKKLNRPTYGFLSRADDLAITGKRHEVHAKYRVGINFDGKIEGIHY 811

  Fly   826 DFYEDAGWNTNESP----VQGHSTFTAANCYEFTDSNFKLSGHAVLTDAPSSTWCRAPGSVEGIA 886
            ..:.:.||:.:.|.    |.|.......|.     ...:..|:.|.|::.|:|..|..|:.:...
Worm   812 QAWLNGGWSKDHSEGVTMVMGLMVDDVYNM-----GTIRFDGYPVKTNSNSNTALRGYGNPQSKL 871

  Fly   887 MMENIIEHVAFEIQKDPAEVRLANIS------------KKSKMATVFPEFLKTREYYSRKKEIEA 939
            :.|.::..:|.::.|...|::..|.:            ....:...:....|..|:.:|:..|:.
Worm   872 INEGVMRRIARDVGKSTEEIKRINFALEGGRRYLGGKIHNDALVECWEYCKKWSEFENRQSGIKQ 936

  Fly   940 FNANNRWKKRGLGLSLMNFPIIYIGQFPATVT--IYHVDGTVVVTHGGIEMGQGMNTKIAQVAAY 1002
            ||.|:...|||:.:|.:.|.:.:.|.....:.  :.::||:|.::.||.|||||:|.|:.||.:.
Worm   937 FNKNSTAVKRGIAMSSVRFGLPHPGPTGHGIASLLINLDGSVQLSIGGTEMGQGLNQKMLQVCSE 1001

  Fly  1003 TLGIDLSYVKVESSTSINGANSMVTGYAIGSESVCYAVRKICETLNARLKP-VRKAKATWVETVE 1066
            .|...:..:.:...::....|:..||.:..:::...||...|:.:.:||:| :.|....|.:::.
Worm  1002 ALKRPIDTITIVDCSTDKVTNAPETGGSQNADTNGLAVLACCKKIMSRLQPIIDKNDGEWEKSIR 1066

  Fly  1067 AANAQLINLIASDH-------YKTGDMQN-YHVLGLALSEVEIDVLTGNILIRRVDILEDAGESL 1123
            .|....:.|..:::       :..|:|:: |:..|....|:|||.|||...:.||||:.|.||||
Worm  1067 EAYGAYVPLQCTEYGTVERAKFGVGEMESPYNTTGACAVEMEIDTLTGYNRVIRVDIVMDVGESL 1131

  Fly  1124 SPWIDVGQVEGAFVMGLGYWLSELLIYEGDNGRLLTNRTWNYKPLGAKDIPIDFRVELVHNPRPS 1188
            :|.:|:||:||||:.|.|....|.:.:....|:|..|....||...|.|:|.||||:|:.....:
Worm  1132 NPALDIGQIEGAFIQGYGLVTCEKITFNKTTGQLDQNTAGKYKIPKASDVPKDFRVKLLGINNAN 1196

  Fly  1189 SSGFMGSKATGEPPCCLAVSVIF-ALQQALQSARQDAGLPREWLRLGAPTTPETL 1242
            .:....||..||||..::...:. ::...:.:.|.:.|: .|::...:|.:.|.:
Worm  1197 GAQVYSSKGIGEPPLMMSCGAVHSSIMNCIDNWRNENGI-HEFVDTISPLSAEKI 1250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX4	NP_650478.1	PLN02906	24..1240	CDD:215491	347/1332 (26%)
		Fer2_2	80..153	CDD:280048	35/72 (49%)
		FAD_binding_5	203..378	CDD:279309	41/217 (19%)
		CO_deh_flav_C	388..489	CDD:281449	23/112 (21%)
		Ald_Xan_dh_C	542..648	CDD:214971	42/111 (38%)
		Ald_Xan_dh_C2	690..1174	CDD:280834	143/522 (27%)
gad-3	NP_001294662.1	fer2	6..77	CDD:238126	24/74 (32%)
		PLN02906	23..1255	CDD:215491	348/1338 (26%)
		Fer2_2	87..158	CDD:280048	35/72 (49%)
		FAD_binding_4	<277..385	CDD:303082	23/111 (21%)
		Ald_Xan_dh_C	530..642	CDD:279635	44/122 (36%)
		Ald_Xan_dh_C2	661..1182	CDD:280834	143/525 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163372
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.650