DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX4 and xdh-1

DIOPT Version :9

Sequence 1:	NP_650478.1	Gene:	AOX4 / 41897	FlyBaseID:	FBgn0038350	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_502747.1	Gene:	xdh-1 / 178381	WormBaseID:	WBGene00010083	Length:	1358	Species:	Caenorhabditis elegans

Alignment Length:	1352	Identity:	405/1352 - (29%)
Similarity:	648/1352 - (47%)	Gaps:	153/1352 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FTINGQPYAVNLTDLPPDITLNTFIREHAQLTATKFMCLEGGCGACVCAVS---DGK-STWTVNS 65
            |.:||:  .|...|:.|.:||.|::|:..:||.||..|.|||||||...:|   :|: ..::.||
Worm    18 FYVNGK--RVEEKDVDPKMTLATYLRDKLKLTGTKIGCNEGGCGACTIMISHIENGEIKHFSANS 80

  Fly    66 CLKLLNTCAQL--EIITCEGLGNQVTG-YHPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQHGGR 127
            |  |:..|...  .:.|.||:|:.... .||:|:||||.:|:|||||:|||||.||.|: ::...
Worm    81 C--LMPVCGVFGKAVTTVEGIGSVAKNRLHPVQERLAKAHGSQCGFCTPGFVMAMYALL-RNNPN 142

  Fly   128 VTMEEVENSFGGNICRCTGYRPILDAMKSFAVD--STVEVSEES---VDIEDLNLKARNC----- 182
            .|:.::.....||:||||||||||:|..|||||  .|::|:||:   :......:|...|
Worm   143 PTISDINLGLQGNLCRCTGYRPILEAFYSFAVDESGTLKVTEENGCGMGENCCKVKKTACGGSDE 207

  Fly   183 --------PRSGKV-------CKGTCRQSKLI---------YEDGS--------QWYWPSTLAEI 215
                    .|..|:       ||......:||         ||..|        :||.|.:..::
Worm   208 TTPGYTGGERKRKIQLSDMSDCKPYDPTQELIFPPELKLHGYESMSFAYDHHHTKWYQPVSYDDL 272

  Fly   216 FEALENVGDSEEFMLVGGNT--AHGVYRRSPDIKHFIDVNGVEDLHQYSSDKEKLTLGASLSLTE 278
            ......:..:.   |:.||:  |..:..|..|:...|:...|:.||:...:.:.:.:|..:|||:
Worm   273 LSLKRELPHAR---LISGNSELAIELKFRFIDLPAVINPRQVKVLHEKHLENDGVYMGTGMSLTD 334

  Fly   279 TMEIIQSTSKQSGFEYLEVLWHHIDLV---ANVPVRNSGTLAGNICTKKEHPEFPSDIFISFEAL 340
            .........|....|...||.|..:::   |.:.|||..::||||.|.....:. :.|:::..||
Worm   335 MDNYSVQLMKDLPREQTAVLKHVHEMLHWFAGIHVRNVASVAGNIATASPISDL-NPIWMASNAL 398

  Fly   341 DVKVVAMKGIDDEKEMTLEE--FLGDTDRKM------LLKAFILPRYPKDMYIYDSFKIMPRAQN 397
            .|.....:|   ||.:.::|  |||  .||.      ::||.|:|...::.: :.::|...|.::
Worm   399 VVLDSEARG---EKRVHIDEKFFLG--YRKTVIQQDEIIKAVIVPLLEENEH-FAAYKQAQRRED 457

  Fly   398 AHAYVNAGFLLELDGNSM-VKSARICFGGIRPDFIHATDIEQLMVGHSPYESNLVEQTFNKLESL 461
            ..|.|...||::||..:: |:..||.:||:.|....|....:.::|.. :....:::....|...
Worm   458 DIAIVTGAFLVKLDPKTLVVEKIRISYGGMAPTTKLALTTMEKLIGEK-WSQTFLDKALGLLSDE 521

  Fly   462 VKPDEVLPDASPAYRSKLACGLLYKFLLKHAPDAE------VSGKFKSGGELLQRPLSSGLQLFQ 520
            :|....:|.....||..||....:||.|..:...|      |....|.|..:.:...::  ||:|
Worm   522 LKLPAGVPGGMSQYRLSLALSFFFKFFLGVSKKLELTEIKYVDADVKIGQNVPETLYAT--QLYQ 584

  Fly   521 TNKQTY----PVTQGVQKLEGMIQCSGEATYMNDVLTTSNSVYCAFVGATKVGATIDQIDATEAL 581
            ..|...    |:.:.::.:.|....:|||.|.:|: ..::..:.|||.:.....|::.||.|.||
Worm   585 EVKANQPAHDPLGRPIKHVSGDKHTTGEAVYCDDI-NVADCNHIAFVLSPIAHGTLNSIDYTAAL 648

  Fly   582 QHPGVVAFYTAKDIPGTNTFCEPSFGYEAE-EIFCSGMVRHSEQPVGVIVALTADQAQRATKLVK 645
            :..|||....|.|:.     .....|:.:: .:|....:....||:..|||...:.|::|..|||
Worm   649 EIDGVVGTIDASDVT-----TGAQMGHHSDTPVFVKETITFHGQPIAAIVATDHEIARKAASLVK 708

  Fly   646 ISYSSPSSNFKLMPSLKD--------VFSSETPDTSRIIPLVISKLKEVKFSDKPDLEVRGIFEM 702
            :.||.......:..:|:.        |..|...|..::|....||...:         |.|..:|
Worm   709 LDYSVEKPIVTIKQALEAESFVFKHFVIHSSLNDNEQVIKSDWSKYDRI---------VEGSIDM 764

  Fly   703 GLQYHFTMEPQTTIIIPFEDG-LKVFSATQWIDQTQSVIAHTLQMKAKDVQLEVRRLGGGYGCKI 766
            |.|.||.:|.|..|:||.||. |::..:.|.::..|..:|..|.|....:..:|:|:|||:|.|.
Worm   765 GGQEHFYLETQQCIVIPHEDDELEIIISNQCVNDVQIEVAKCLGMAQHKISTKVKRIGGGFGGKE 829

  Fly   767 SRGNQVACAAALAAHKLNRPVRFVQSLESMMDCNGKRWACRSEYQCHVKTSGRIVGLSNDFYEDA 831
            |.|..:|..|:|||.|..||::|.......|...|.|.....:|:..|..:|:.:.|......::
Worm   830 STGAILAVPASLAAKKFGRPMKFKFERFDDMAITGTRHPFTLQYKLAVDENGKFLDLDYTALSNS 894

  Fly   832 GWNTNES-PVQGHSTFTAANCYEFTDSNFKLSGHAVLTDAPSSTWCRAPGSVEGIAMMENIIEHV 895
            |...:.| .|...:...|.|.|:|  .|..::|....|:..|:|..|..|..:|:...|.:::||
Worm   895 GHTIDLSMGVMQRAMVHADNVYKF--ENADITGKMCKTNLASNTAFRGFGGPQGMFGTEIMVKHV 957

  Fly   896 AFEIQKDPAEVRLANISKKS------------KMATVFPEFLKTREYYSRKKEIEAFNANNRWKK 948
            |.:...:..|||:.|..|:.            .:...:.|..|..:|.:|.:|::.||.:|:::|
Worm   958 AEKFGFNHDEVRVKNFYKEGDCTPFGMHLNQCNVTRTWDECRKNSDYDNRLEEVKKFNDSNKFRK 1022

  Fly   949 RGLGLSLMNFPIIY----IGQFPATVTIYHVDGTVVVTHGGIEMGQGMNTKIAQVAAYTLGIDLS 1009
            ||:.|:...|.|.:    :.|..|.|.:| .||:|:|:|||:|||||::|||.|:||..|.|.:.
Worm  1023 RGIYLTPTRFGIGFGLKQLNQAGALVLVY-TDGSVLVSHGGMEMGQGLHTKILQIAARCLEIPIE 1086

  Fly  1010 YVKVESSTSINGANSMVTGYAIGSESVCYAVRKICETLNARLKPVRK--AKATWVETVEAANAQL 1072
            .:.:..:::....|:..|..::||:....||:..|..:|.||:..:|  ...||.:.|:||....
Worm  1087 RIHIHDTSTDKVPNASATAASVGSDMNGLAVQDACRQINERLERFKKLDPNGTWDDWVKAAYVDR 1151

  Fly  1073 INLIASD----HYKTGDMQN--------YHVLGLALSEVEIDVLTGNILIRRVDILEDAGESLSP 1125
            ::|.||.    |::..|..|        |.|.|.|..|||||.|||:..:.|.||:.|.||||:|
Worm  1152 VSLSASGFGIIHHEPVDFFNGKGAELFGYSVYGTACCEVEIDCLTGDHHLLRTDIVMDVGESLNP 1216

  Fly  1126 WIDVGQVEGAFVMGLGYWLSELLIYEGDNGRLLTNRTWNYKPLGAKDIPIDFRVELVHNPRPSSS 1190
            .||:||:||||:.|.|.:..|.:....| |..||....|||...|.|.|..|.|.|:.| ..:..
Worm  1217 AIDIGQIEGAFIQGYGLFTMEEIKIRPD-GIRLTRGPGNYKIPSADDAPRHFNVSLLGN-SSNKM 1279

  Fly  1191 GFMGSKATGEPPCCLAVSVIFALQQALQSARQDAGLPREWLRLGAPTTPETL 1242
            |...|||.||||..|.....||:::|:::.|...| ..::....:|.|||.:
Worm  1280 GIFSSKAIGEPPLFLGSCAFFAIREAVRAYRIQNG-NADYFVFHSPATPERI 1330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX4	NP_650478.1	PLN02906	24..1240	CDD:215491	397/1329 (30%)
		Fer2_2	80..153	CDD:280048	38/73 (52%)
		FAD_binding_5	203..378	CDD:279309	48/195 (25%)
		CO_deh_flav_C	388..489	CDD:281449	25/101 (25%)
		Ald_Xan_dh_C	542..648	CDD:214971	31/106 (29%)
		Ald_Xan_dh_C2	690..1174	CDD:280834	170/515 (33%)
xdh-1	NP_502747.1	Fer2	18..86	CDD:278537	28/71 (39%)
		PLN02906	34..1340	CDD:215491	399/1334 (30%)
		Fer2_2	95..168	CDD:280048	38/73 (52%)
		FAD_binding_5	260..440	CDD:279309	48/188 (26%)
		CO_deh_flav_C	447..549	CDD:281449	25/102 (25%)
		Ald_Xan_dh_C	610..715	CDD:279635	33/110 (30%)
		Ald_Xan_dh_C2	755..1264	CDD:280834	170/521 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720