Protein Alignment AOX4 and Aox1

DIOPT Version :10

• Sequence 1: NP_650478.1
• Gene: AOX4 / 41897
• FlyBaseID: FBgn0038350
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_033806.2
• Gene: Aox1 / 11761
• MGIID: 88035
• Length: 1333
• Species: Mus musculus
• Alignment Length: 1364
• Identity: 398/1364 - (29%)
• Similarity: 642/1364 - (47%)
• Gaps: 191/1364 - (14%)

  Fly     5 FTINGQPYAVNLTDLPPDITLNTFIREHAQLTATKFMCLEGGCGACVCAVSD-GKST-----WTV 63
            |.:|||.......|  |::.|..::|::.:||.||:.|..||||||...:|. ..||     ..|
Mouse     8 FYVNGQKVVEKNVD--PEMMLLPYLRKNLRLTGTKYGCGGGGCGACTVMISRYNPSTKAIRHHPV 70

  Fly    64 NSCLKLLNTCAQLEIITCEGLGNQVTGYHPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQHGGRV 128
            |:||..:.:.....:.|.|||||..|..||||:|:||.:|||||||:||.||:||.|:..| ...
Mouse    71 NACLTPICSLHGTAVTTVEGLGNTRTRLHPIQERIAKCHGTQCGFCTPGMVMSMYALLRNH-PEP 134

  Fly   129 TMEEVENSFGGNICRCTGYRPILDAMKSFA-------------------VDSTVEVSEESVDIED 174
            |::::.::.|||:|||||||||:||.|:|.                   ::...|..||.....:
Mouse   135 TLDQLTDALGGNLCRCTGYRPIIDACKTFCKASGCCQSKENGVCCLDQEINGLAESQEEDKTSPE 199

  Fly   175 LNLKARNCPRSG-----------KVCKGTCRQSKLIYEDGSQWYWPSTLAEIFEALENVGDSEEF 228
            |..:....|...           ::.:....::::.|.:...|..|.||.|:.||......:.
Mouse   200 LFSEEEFLPLDPTQELIFPPELMRIAEKQPPKTRVFYGERVTWISPVTLKELVEAKFKYPQAP-- 262

  Fly   229 MLVGGNTAHGVYRRSPDIKH-------FIDVNGVEDLHQYSSDKEKLTLGASLSLTET----MEI 282
             :|.|.|:.|     |::|.       .|..:.:|:|...|..::.|||||.|||.:.    .:|
Mouse   263 -IVMGYTSVG-----PEVKFKGVFHPIIISPDRIEELGVISQARDGLTLGAGLSLDQVKDILADI 321

  Fly   283 IQSTSKQSGFEYLEVLWHHIDLVANVPVRNSGTLAGNICTKKEHPEFPSDIFISFEALDVKVVAM 347
            :|...::....| ..|..|:..:|...:||..:|.|:|.::  |.:...:..::.....:.:::.
Mouse   322 VQKLPEEKTQTY-RALLKHLRTLAGSQIRNMASLGGHIVSR--HLDSDLNPLLAVGNCTLNLLSK 383

  Fly   348 KGIDDEKEMTL-EEFL-----GDTDRKMLLKAFILPRYPKDMYIYDSFKIMPRAQNAHAYVNAGF 406
               |.|:.:.| ||||     .|...:.:|.:..:| :.:......:|:...|.|||.|.||:|.
Mouse   384 ---DGERRIPLSEEFLRKCPEADLKPQEVLVSVNIP-WSRKWEFVSAFRQAQRQQNALAIVNSGM 444

  Fly   407 -LLELDGNSMVKSARICFGGIRPDFIHATDIEQLMVGHSPYESNLVEQTFNKLESLVKPDEVLPD 470
             :|..:|..:::...|.:||:....|.|.:..|.::|. |:...:::....    ||..:..|..
Mouse   445 RVLFREGGGVIEELSILYGGVGSTIISAKNSCQRLIGR-PWNEGMLDTACR----LVLDEVTLAA 504

  Fly   471 ASPA----YRSKLACGLLYKFLLK-----------HAPDAEVSGKFKSGGELLQ-----RPLS-- 513
            ::|.    ::..|....|:||.|:           |:|  .::|..:|..:.|.     |.|:
Mouse   505 SAPGGKVEFKRTLIISFLFKFYLEVSQGLKREDPGHSP--SLAGNHESALDDLHSKHPWRTLTHQ 567

  Fly   514 --SGLQLFQTNKQTYPVTQGVQKLEGMIQCSGEATYMNDVLTTSNSVYCAFVGATKVGATIDQID 576
              ...||.|.     |:.:.:..|.|:...:|||.|.:|:......::..||.:::..|.|..||
Mouse   568 NVDPAQLPQD-----PIGRPIMHLSGIKHATGEAIYCDDMPAVDRELFLTFVTSSRAHAKIVSID 627

  Fly   577 ATEALQHPGVVAFYTAKDIPGTNTFCEPSFGYEAEEIFCSGMVRHSEQPVGVIVALTADQAQRAT 641
            .:|||..||||...||..:...|||...:| ...:|:.|.|.:      |..::|.:..:|::|.
Mouse   628 LSEALSLPGVVDIITADHLQEANTFGTETF-LATDEVHCVGHL------VCAVIADSETRAKQAA 685

  Fly   642 KLVKISYSSPSSNFKLMPSL---------KDVFSSE-------TPDTSRIIPLVISKLKEVKFSD 690
            |.||:.|..      |.|.:         |..|.||       ..:..:|:
Mouse   686 KQVKVVYQD------LAPLILTIEEAIQHKSFFKSERKLECGNVDEAFKIV-------------- 730

  Fly   691 KPDLEVRGIFEMGLQYHFTMEPQTTIIIP-FEDG-LKVFSATQWIDQTQSVIAHTLQMKAKDVQL 753
              |..:.|...:|.|.||.||.|:.:::| .||| :.::.:||:....|.::|.||::.|..|..
Mouse   731 --DQILEGEIHIGGQEHFYMETQSMLVVPKGEDGEIDIYVSTQFPKYIQDIVAATLKLSANKVMC 793

  Fly   754 EVRRLGGGYGCKISRGNQVACAAALAAHKLNRPVRFVQSLESMMDCNGKRWACRSEYQCHVKTSG 818
            .|||:||.:|.|:.:.:.:|...|.||.|..|.||.:......|...|.|.....:|:......|
Mouse   794 HVRRVGGAFGGKVGKTSILAAITAFAASKHGRAVRCILERGEDMLITGGRHPYLGKYKAGFMNDG 858

  Fly   819 RIVGLSNDFYEDAGWNTNESP-VQGHSTFTAANCYEFTDSNFKLSGHAVLTDAPSSTWCRAPGSV 882
            ||:.|..:.|.:.|.:.:||. |.........|.|:|  .|.:..|.|..|:.||:|..|..|..
Mouse   859 RILALDVEHYCNGGCSLDESLWVIEMGLLKLDNAYKF--PNLRCRGWACRTNLPSNTALRGFGFP 921

  Fly   883 EGIAMMENIIEHVAFEIQKDPAEVRLANISK------------KSKMATVFPEFLKTREYYSRKK 935
            :...:.|..|..||.:....|.:||..|:.|            ...::..:.|.:....|:.||.
Mouse   922 QAGLVTEACITEVAIKCGLSPEQVRTINMYKHVDTTHYKQEFSAKALSECWRECMAKCSYFERKA 986

  Fly   936 EIEAFNANNRWKKRGLGLSLMNFPI----IYIGQFPATVTIYHVDGTVVVTHGGIEMGQGMNTKI 996
            .|..|||.|.|||||:.:..:.||:    :.:||..|.|.|| :||:.:|:|||||||||::||:
Mouse   987 AIGKFNAENSWKKRGMAVIPLKFPVGIGSVAMGQAAALVHIY-LDGSALVSHGGIEMGQGVHTKM 1050

  Fly   997 AQVAAYTLGIDLSYVKVESSTSINGANSMVTGYAIGSESVCYAVRKICETLNARLKPV--RKAKA 1059
            .||.:..|.:.:|.|.:..:::....|:..:|.::.::....||:..|:||..||:|:  :..:.
Mouse  1051 IQVVSRELRMPMSSVHLRGTSTETVPNTNASGGSVVADLNGLAVKDACQTLLKRLEPIISKNPQG 1115

  Fly  1060 TWVETVEAANAQLINLIASDHYK-----------TGDMQNYHVLGLALSEVEIDVLTGNILIRRV 1113
            ||.:..:.|..|.|:|.|..:::           .|....|.|.|.|.||||||.|||:....|.
Mouse  1116 TWKDWAQTAFDQSISLSAVGYFRGYESNIDWEKGEGHPFEYFVFGAACSEVEIDCLTGDHKNIRT 1180

  Fly  1114 DILEDAGESLSPWIDVGQVEGAFVMGLGYWLSELLIYEGDNGRLLTNRTWNYKPLGAKDIPIDFR 1178
            :|:.|.|.|::|.:|:|||||||:.|:|.:..|.|.| ...|.|.:.....||.....|||.:..
Mouse  1181 NIVMDVGHSINPALDIGQVEGAFIQGMGLYTIEELSY-SPQGTLYSRGPNQYKIPAICDIPTEMH 1244

  Fly  1179 VELVHNPRPSSSGFMGSKATGEPPCCLAVSVIFALQQALQSARQDAGLPREWLRLGAPTTPETL 1242
            :..: .|...|:....||..||....|..||.||:..|:::|||:.|:...| :|.:|.|||.:
Mouse  1245 ISFL-PPSEHSNTLYSSKGLGESGVFLGCSVFFAIHDAVKAARQERGISGPW-KLNSPLTPEKI 1306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AOX4	NP_650478.1	PLN02906	24..1240	CDD:215491	390/1341 (29%)
Aox1	NP_033806.2	mam_aldehyde_ox	5..1333	CDD:132014	398/1364 (29%)