DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX4 and aox1

DIOPT Version :9

Sequence 1:	NP_650478.1	Gene:	AOX4 / 41897	FlyBaseID:	FBgn0038350	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_012825683.2	Gene:	aox1 / 100495429	-ID:	-	Length:	1323	Species:	Xenopus tropicalis

Alignment Length:	1367	Identity:	399/1367 - (29%)
Similarity:	646/1367 - (47%)	Gaps:	191/1367 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FTINGQPYAVNLTDLPPDITLNTFIREHAQLTATKFMCLEGGCGACVCAVSD----GKST--WTV 63
            |.:||:.......|  |:..|..::|:...||.||:.|..||||||...||.    .|..  ::.
Frog    12 FFVNGRKIVEENAD--PEELLLPYLRKKLLLTGTKYGCGGGGCGACTVMVSTIHPVSKKILHFSA 74

  Fly    64 NSCLKLLNTCAQLEIITCEGLGNQVTGYHPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQHGGRV 128
            |:||..:.:.....:.|.||:|:..|..||:|:|:||.:|:|||||:||.||::|.|:..| ...
Frog    75 NACLLPICSMHGAAVTTIEGIGSTTTKLHPVQERIAKAHGSQCGFCTPGMVMSVYSLLRNH-PEP 138

  Fly   129 TMEEVENSFGGNICRCTGYRPILDAMKSF---------------------AVDS----------- 161
            |||::..|.|||:|||||||||:|..::|                     .||:
Frog   139 TMEQIYESLGGNLCRCTGYRPIVDGCRTFCNKTDCCQVKENGMEKISTPDTVDNILTGLFKEEQF 203

  Fly   162 -TVEVSEESVDIEDLNLKARNCPRSGKVCKGTCRQSKLIYEDGSQ-WYWPSTLAEIFEALENVGD 224
             .::.::|.:...:|.|..:.            ::.|||::.|.. |..||:|.|:   |:....
Frog   204 LPLDPTQELIFPPELLLMDKE------------KKEKLIFQGGRMTWISPSSLQEL---LQLKAT 253

  Fly   225 SEEFMLVGGNTAHGVYRRSPDIKH--FIDVNGVEDLHQYSSDKEKLTLGASLSLTETMEIIQSTS 287
            ..:..||.|||..|...:...|.|  .|..:.:.:|:......:.:|:||:.|||...|.::...
Frog   254 YPKAPLVVGNTIVGPEMKFRGIFHPVIISPSRIPELNFVIHKDDGITVGAACSLTVLKEALKEVV 318

  Fly   288 KQSGFE---YLEVLWHHIDLVANVPVRNSGTLAGNICTKKEHPEFPSDIFISFEALDVKVVAMKG 349
            .|...|   ....|...::.:....:||:.:|.|||.::.     |:.......|....::.:..
Frog   319 TQQPEEKTKLFHALLQQLETLGGPQIRNTASLGGNIISRS-----PTSDLNPVLAAGNCILTVAA 378

  Fly   350 IDDEKEMTLEE--FLGDTDRKMLLKAFILPRYPKDMYIYDSFKIMPRAQNAHAYVNAGFLLELDG 412
            ||..::|.|:|  |......:.:|.:..|| |.|....|..|:...|.:||...|.||..::.:.
Frog   379 IDGTRQMPLDEAFFAHSLKAEEVLVSVHLP-YSKKGDHYSVFRQAQRRENALPIVTAGMKVQFEE 442

  Fly   413 NS-MVKSARICFGGIRPDFIHATDIEQLMVGHSPYESNLVEQTFNKLESLVKPDEVLPDASPAYR 476
            |: ::|..||.:||:.|..:.|....|.::| ..::.:::.:....:...:......|.....||
Frog   443 NTDIIKVIRIFYGGVGPTTVFAKTTCQDLIG-KHWDDHMLSEACRLMVHEITLSPSAPGGMVEYR 506

  Fly   477 SKLACGLLYKFLLK----------HAPDAEVSGKFKSGGELLQRPLSSGLQLFQ--TNKQTY--P 527
            |.|.....:||.|:          |..|......|::       ..:..:||:|  :::|:.  |
Frog   507 STLTISFFFKFYLEVLQRLNHMGTHYSDVSALNSFET-------LCNENVQLYQDVSSRQSVQDP 564

  Fly   528 VTQGVQKLEGMIQCSGEATYMNDVLTTSNSVYCAFVGATKVGATIDQIDATEALQHPGVVAFYTA 592
            :.:.:....|:...:|||.|.:|:......::..||.:||..|.|..:|.:|||..||||...|.
Frog   565 IGRPIMHYSGIKHATGEAVYCDDMPCVDGELFLYFVTSTKAHAKIVSLDFSEALAQPGVVDVVTT 629

  Fly   593 KDIPGTNTFCEPSFGYEAE-------EIFCSGMVRHSEQPVGVIVALTADQAQRATKLVKISYSS 650
            :|.|||   |:..| .|.|       ::.|.|.:      :..::|.|..:|::|...||:.|.:
Frog   630 EDCPGT---CKSMF-EEGEVPLLAKDKVLCVGQI------ICAVLADTPARAKKAAAAVKVVYEN 684

  Fly   651 PSSNFKLMPSLKDVFSSETPDTSRIIPLVISKLKEVKFSD--KPDLEV----------------R 697
                                    :.|::::..:.::.:.  ||..::                .
Frog   685 ------------------------LEPVILTIQEAIEHNSFFKPQRKLENGNVEEAFKSADQIQE 725

  Fly   698 GIFEMGLQYHFTMEPQTTIIIP-FED-GLKVFSATQWIDQTQSVIAHTLQMKAKDVQLEVRRLGG 760
            |...:|.|.||.||.|:..::| .|| .:.|:.:||.....|::||..|.:.:..:...|:|:||
Frog   726 GEIYIGGQEHFYMETQSIRVLPKGEDKEMDVYVSTQDPTYIQNLIATILNVPSNRITCHVKRVGG 790

  Fly   761 GYGCKISRGNQVACAAALAAHKLNRPVRFVQSLESMMDCNGKRWACRSEYQCHVKTSGRIVGLSN 825
            .:|.|.::...:|...|:||:|..|.||.|......|...|.|.....:|:......|.|..:..
Frog   791 AFGGKTTKTGNIAAITAVAANKTRRAVRCVFERGDDMLITGGRHPFLGKYKVGFMNDGHITAVDV 855

  Fly   826 DFYEDAGWNTNESP-VQGHSTFTAANCYEFTDSNFKLSGHAVLTDAPSSTWCRAPGSVEGIAMME 889
            .::.:||...::|. |...:.....:.|..  .|.:.:|.|..|:.||:|..|..|..:...:.|
Frog   856 AYFSNAGCTPDDSVLVVEIALMNMDSAYRL--PNVRCTGTACKTNLPSNTAFRGFGYPQAAFVTE 918

  Fly   890 NIIEHVAFEIQKDPAEVRLANISK------------KSKMATVFPEFLKTREYYSRKKEIEAFNA 942
            ..|..||.:.:..|.:||..|:.|            ...:...:.|.::...|.||:..||.||.
Frog   919 TWISEVAIKCRIPPEKVREMNLYKDISQTHFRQEILARTLGMCWNECMEKSSYNSRRLAIENFNK 983

  Fly   943 NNRWKKRGLGLSLMNFPI----IYIGQFPATVTIYHVDGTVVVTHGGIEMGQGMNTKIAQVAAYT 1003
            :|.|||:||.:..|.|||    .:.||..|.|.|| :||:|:|||||||||||::|||.|:|:..
Frog   984 DNYWKKKGLAIIPMKFPIGSLAKFFGQAAALVHIY-LDGSVLVTHGGIEMGQGVHTKIMQIASRE 1047

  Fly  1004 LGIDLSYVKVESSTSINGANSMVTGYAIGSESVCYAVRKICETLNARLKPVR--KAKATWVETVE 1066
            |||.|||:.:..:.:.:..|:.|:|.::|::....||:..||.|..||.|:|  ..|::|.|.|.
Frog  1048 LGIPLSYIHICETNTSSVPNTQVSGGSLGTDVNGMAVKNACEILMQRLLPIRSKNPKSSWKEWVT 1112

  Fly  1067 AANAQLINLIASD---------HYKTGDMQ--NYHVLGLALSEVEIDVLTGNILIRRVDILEDAG 1120
            .|..|.::|.|:.         :::||:..  :|.|.|:|.||||||.|||:....|.||:.|.|
Frog  1113 EAYMQSVSLSATGFCRSFDRELNWETGEGNPVHYCVYGVACSEVEIDCLTGDHKNLRTDIVIDFG 1177

  Fly  1121 ESLSPWIDVGQVEGAFVMGLGYWLSELLIYEGDNGRLLTNRTWNYKPLGAKDIPIDFRVELVHNP 1185
            .|::|.:|:||:|||||.|||.:..|.|.: ..||.|.|.....||....:|||..|.|.|:.|.
Frog  1178 CSINPAVDIGQIEGAFVQGLGLFTIEELKF-SPNGVLYTRGPAQYKIPSVRDIPEQFNVSLLSNV 1241

  Fly  1186 RPSSSGFMGSKATGEPPCCLAVSVIFALQQALQSARQDAGLPREWLRLGAPTTPETLLLNAGHQV 1250
             |:|.....||..|||...|..|:.||::.|:.|||::.|: .|...|.:|.|||.:.:..|.|.
Frog  1242 -PNSCAIYSSKGVGEPALFLGSSIYFAIKDAVLSARRERGM-SELFTLNSPATPEKIRMACGDQF 1304

  Fly  1251 SE 1252
            ::
Frog  1305 TD 1306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX4	NP_650478.1	PLN02906	24..1240	CDD:215491	390/1334 (29%)
		Fer2_2	80..153	CDD:280048	40/72 (56%)
		FAD_binding_5	203..378	CDD:279309	43/182 (24%)
		CO_deh_flav_C	388..489	CDD:281449	24/101 (24%)
		Ald_Xan_dh_C	542..648	CDD:214971	36/112 (32%)
		Ald_Xan_dh_C2	690..1174	CDD:280834	176/533 (33%)
aox1	XP_012825683.2	mam_aldehyde_ox	10..1323	CDD:132014	399/1367 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920