DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX4 and aox1

DIOPT Version :9

Sequence 1:	NP_650478.1	Gene:	AOX4 / 41897	FlyBaseID:	FBgn0038350	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_017953036.2	Gene:	aox1 / 100379890	XenbaseID:	XB-GENE-6045207	Length:	1322	Species:	Xenopus tropicalis

Alignment Length:	1350	Identity:	412/1350 - (30%)
Similarity:	646/1350 - (47%)	Gaps:	181/1350 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FTINGQPYAVNLTDLPPDITLNTFIREHAQLTATKFMCLEGGCGACVCAVSDGKSTWTVNSCLK- 68
            |.:||:.......| |.|:.| .::|.:..||.||:.|..||||||...:|      ||:...|
Frog    13 FYVNGRKVVEKNPD-PEDMLL-PYLRRNLHLTGTKYGCGGGGCGACTVMIS------TVHPVSKK 69

  Fly    69 ---------LLNTCAQL--EIITCEGLGNQVTGYHPIQKRLAKMNGTQCGFCSPGFVMNMYGLME 122
                     ||..|:..  .:.|.||:||..|..||:|:|:||.:|:|||||:||.||::|.|:.
Frog    70 IIHYPALACLLPICSLYGNAVTTTEGIGNSTTKLHPVQERIAKAHGSQCGFCTPGMVMSIYTLLR 134

  Fly   123 QHGGRVTMEEVENSFGGNICRCTGYRPILDAMKSFAVDSTVEVSEESVDIEDLNLKARNCPRSGK 187
            .| ...|||::.::..||:|||||||||||..|:|:.|..:...:|. .:|::    ::.|
Frog   135 NH-PEPTMEQILSALSGNLCRCTGYRPILDGCKTFSKDCCLNEKKEH-RLEEV----KSFP---- 189

  Fly   188 VCKGTCRQSKLIYE------DGSQ---------------------------WYWPSTLAEIFEAL 219
                     ||.||      |.:|                           ||.||||.||.|..
Frog   190 ---------KLFYEKDFLPLDPTQDLIFPPELMMMFNSQKKMNVFLGERITWYSPSTLDEILELK 245

  Fly   220 ENVGDSEEFMLVGGNTAHGVYRRSPDIKHFIDVNGVE--DLHQYSSDKEKLTLGASLSLTETMEI 282
            .....:.   ||.||||.|...:...:.|.:.::.|.  ||:..|.:...:::||:.||::..||
Frog   246 TKYPSAP---LVVGNTALGPQMKFQGVIHPVLISPVRVMDLYNVSLNDMGISIGAACSLSQVKEI 307

  Fly   283 I---QSTSKQSGFEYLEVLWHHIDLVANVPVRNSGTLAGNICTKKEHPEFPSDIFISFEALDVKV 344
            :   .|..::...:....|..|:..:|...:|:..::.|:|.:|:...:....:......|:
Frog   308 LCENISAIQEDKAKIFHALLQHLGTLAGEQIRSMASIGGHIISKRTISDLNPILAAGGAILN--- 369

  Fly   345 VAMKGIDDEKEMTLEE--FLGDTDRK---MLLKAFILPRYPKDMYIYDSFKIMPRAQNAHAYVNA 404
            .|.||  :.:::.|.|  |.|.:.:|   :||..|| |...||.:: .:|:...|.:||:|.|||
Frog   370 FASKG--ETRQVELNELFFTGSSPQKSEEVLLSVFI-PYSKKDEFV-SAFRQAQRDENANAIVNA 430

  Fly   405 GFLLELDGNS-MVKSARICFGGIRPDFIHATDIEQLMVGHSPYESNLVEQTFNKLESLVKPDEVL 468
            |..:..:.:: :||...|.:|.:.|..::|.:..|.::|.     :..|:..|:...|:..:..|
Frog   431 GMKVHFEEDTDIVKEMAIYYGCMGPSTVYAKNTSQALIGR-----HWDEEMLNEACKLILEEITL 490

  Fly   469 PDASPA----YRSKLACGLLYKFLL-------KHAPDAEVSGKFKSGGELLQRPLSSGLQLFQTN 522
            ..::|.    ||..|.....:||.|       |....:.|:..:.|..:..:......||:||..
Frog   491 SPSAPGGKVQYRRALTISFFFKFYLQVLQCLKKTIKSSSVASDYISAIKDFEINTPKTLQIFQET 555

  Fly   523 KQTYPVTQGV----QKLEGMIQCSGEATYMNDVLTTSNSVYCAFVGATKVGATIDQIDATEALQH 583
            :|..|:...|    ....|:.|.:|||.|::|:.|....::.|||.:.:..|.|..|||:|||..
Frog   556 EQEQPIDDPVGHPIVHTSGIKQATGEAIYVDDMPTVDQELFIAFVTSKRAHAKILSIDASEALAL 620

  Fly   584 PGVVAFYTAKDIPGTNTFCEPSFGYEAEEIFCSGMVRHSEQPVGVIVALTADQAQRATKLVKISY 648
            |||.....|:||||.|.....:..:..:::.|.|.:      :..:||.|...|::|...|||.|
Frog   621 PGVCDIIRAEDIPGKNELDGLNHLFSEDKVECVGQI------ICAVVADTPKHAKQAAAKVKIDY 679

  Fly   649 SSPSSNFKLMP---SLKDVFSSET---PDTSRIIPLVISKLKEVKFSDKPDLEVRGIFEMGLQYH 707
            .:      |.|   :::|...:.:   |:..     :|....|..|. ..|..:.|...:|.|..
Frog   680 QN------LEPVILTMEDAIKNNSFFEPEKK-----IIHGNAEEAFK-SADHILEGEVHIGGQEQ 732

  Fly   708 FTMEPQTTIIIP--FEDGLKVFSATQWIDQTQSVIAHTLQMKAKDVQLEVRRLGGGYGCKISRGN 770
            |.||..|.:::|  .|:.|.::.:||.....|..:|..|.:.:..|...|:|:||.:|.||::.:
Frog   733 FYMETNTVLVVPKGEENELDIYVSTQDPTGVQLAVAACLNVPSNRVMCHVKRVGGAFGGKITKPS 797

  Fly   771 QVACAAALAAHKLNRPVRFVQSLESMMDCNGKRWACRSEYQCHVKTSGRIVGLSNDFYEDAGWNT 835
            ..|||:|:||||..||||.|......|.....|.....:|:......||||||...||.:||.:|
Frog   798 IFACASAVAAHKTKRPVRCVLERGEDMLITAGRHPFFGKYKVGFMNDGRIVGLDVSFYTNAGCST 862

  Fly   836 NES-PVQGHSTFTAANCYEFTDSNFKLSGHAVLTDAPSSTWCRAPGSVEGIAMMENIIEHVAFEI 899
            :|| .|...:.....|.|.|  .|...:..|..|:.||:|..|..|..:...:.|.|::.||.:.
Frog   863 DESILVLVVALIKMDNAYHF--PNLTCTATACKTNLPSNTAFRGFGFPQTGLVTETIMDAVAVKC 925

  Fly   900 QKDPAEVRLAN----ISK--------KSKMATVFPEFLKTREYYSRKKEIEAFNANNRWKKRGLG 952
            ...|.:||..|    |.|        .:.:...:.|.::...|.||:..|:.||..|.|||:|:.
Frog   926 GLQPHQVREKNMYTGIGKTHYNQEFDSTNLMRCWNECMQKSSYQSRRDAIQEFNKENYWKKKGIA 990

  Fly   953 LSLMNFPIIYI----GQFPATVTIYHVDGTVVVTHGGIEMGQGMNTKIAQVAAYTLGIDLSYVKV 1013
            :..:.|.:.::    .|..|.|.||. ||.|:|:|.|:|||||:.|||.||.:..|.|.:||:.:
Frog   991 IIPLKFTVGFVEKTYHQAAALVHIYR-DGYVLVSHSGVEMGQGLYTKIVQVVSRELKIPMSYIYI 1054

  Fly  1014 ESSTSINGANSMVTGYAIGSESVCYAVRKICETLNARLKPV--RKAKATWVETVEAANAQLINLI 1076
            ..::::...||:.:|.:||::....||:..|:.|..||:|:  |.....|.|.|..|..|.|:|.
Frog  1055 CETSTVTVPNSIASGGSIGTDITGIAVKNACDILQQRLEPIISRNPNGKWEEWVSEAFEQRISLS 1119

  Fly  1077 ASDHYK-----------TGDMQNYHVLGLALSEVEIDVLTGNILIRRVDILEDAGESLSPWIDVG 1130
            ::.:|:           .|....|::.|.|.||:|:|.|||.....|.||:.|.|:|::|.||:|
Frog  1120 STGYYRGYDTYMDWEKGEGHAGPYYIFGAACSEIELDCLTGKYNNLRTDIVMDLGQSINPGIDIG 1184

  Fly  1131 QVEGAFVMGLGYWLSELLIYEGDNGRLLTNRTWNYKPLGAKDIPIDFRVELV---HNPRPSSSGF 1192
            ||||||..|.|.:.:|.|.| ...|.|.|.....|......|||.:|.|.|:   :||....|
Frog  1185 QVEGAFTQGFGLYTTEELQY-SPFGSLYTLGPDKYIMPAVCDIPREFNVYLLASSNNPYTIYS-- 1246

  Fly  1193 MGSKATGEPPCCLAVSVIFALQQALQSARQDAGLPREWLRLGAPTTPETL 1242
              ||..||....|..||.||::.|:.|||.:.||.::: .|.:|..||.:
Frog  1247 --SKGVGETALFLGCSVFFAIKDAIDSARAERGLSKDF-TLNSPAGPERI 1293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX4	NP_650478.1	PLN02906	24..1240	CDD:215491	404/1327 (30%)
		Fer2_2	80..153	CDD:280048	40/72 (56%)
		FAD_binding_5	203..378	CDD:279309	49/211 (23%)
		CO_deh_flav_C	388..489	CDD:281449	27/105 (26%)
		Ald_Xan_dh_C	542..648	CDD:214971	36/105 (34%)
		Ald_Xan_dh_C2	690..1174	CDD:280834	171/515 (33%)
aox1	XP_017953036.2	mam_aldehyde_ox	11..1320	CDD:132014	412/1349 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010