DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX3 and AO1

DIOPT Version :9

Sequence 1:	NP_001303439.1	Gene:	AOX3 / 41896	FlyBaseID:	FBgn0038349	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_568407.2	Gene:	AO1 / 832221	AraportID:	AT5G20960	Length:	1368	Species:	Arabidopsis thaliana

Alignment Length:	1330	Identity:	431/1330 - (32%)
Similarity:	659/1330 - (49%)	Gaps:	150/1330 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FSINGLPYAVNLTNLPPDITLNTFIREHAQLTATKFMCQEGGCGACICVVR------DGKRSWAV 63
            |:|||..:.:.|:::.|..||..|:|......:.|..|.|||||||:.::.      :....:.:
plant    23 FAINGQRFELELSSIDPSTTLVDFLRNKTPFKSVKLGCGEGGCGACVVLLSKYDPLLEKVDEFTI 87

  Fly    64 NSCLTLLNTCAQLEIVTAEGLGNQRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMYGLM------- 121
            :||||||.:.....|.|::||||.|.|::.:.:|:|..:.||||||:||..::|:..:
plant    88 SSCLTLLCSIDGCSITTSDGLGNSRVGFHAVHERIAGFHATQCGFCTPGMSVSMFSALLNADKSH 152

  Fly   122 ---EQNEGKVTMAEVENSFGGNICRCTGYRPILDAMKSFAVD---SNIAIPAEC--GDIEDLKPR 178
               ......:|..|.|.:..||:||||||||::||.||||.|   .::...|.|  |:..|...|
plant   153 PPPRSGFSNLTAVEAEKAVSGNLCRCTGYRPLVDACKSFAADVDIEDLGFNAFCKKGENRDEVLR 217

  Fly   179 NCPKTGQACSGSC-LPSTL---------VYEDGVQWHWPKSLSELFDALDKVKDSEEFMLVAGNT 233
            ..|......|..| .|..|         ::....:|..|.|:||| ..|.:|::.....||||||
plant   218 RLPCYDHTSSHVCTFPEFLKKEIKNDMSLHSRKYRWSSPVSVSEL-QGLLEVENGLSVKLVAGNT 281

  Fly   234 AHGVYRRSTDIKH--FIDVQGVEELHQHSSEGQQLKLGANLSLTQTMEIIRTTSKQPGFEYLDVL 296
            :.|.|:...:.|:  |||::.:.|.....|:.:.::|||.:::::.:|::|   ::.....|..:
plant   282 STGYYKEEKERKYERFIDIRKIPEFTMVRSDEKGVELGACVTISKAIEVLR---EEKNVSVLAKI 343

  Fly   297 WNHIDLIANVPVRNSGTLAGNISIKKQNPEFPSDIFISFEALNVKVVALKNAADEKEMSLAEYLG 361
            ..|::.|||..|||:||:.||| :..|..:||||:.....|....|..:.:::.:::.:|.|:|.
plant   344 ATHMEKIANRFVRNTGTIGGNI-MMAQRKQFPSDLATILVAAQATVKIMTSSSSQEQFTLEEFLQ 407

  Fly   362 TN--DKKLVLKTFVLPAYPKDK---------YIYESYKIMPR-AQNAHAYVNAAFLLEL-EADN- 412
            ..  |.|.:|.:..:|::...|         .::|:|:..|| ..||.|::||||..|: ||.:
plant   408 QPPLDAKSLLLSLEIPSWHSAKKNGSSEDSILLFETYRAAPRPLGNALAFLNAAFSAEVTEALDG 472

  Fly   413 -KVKSARICFGGIRPDFIH-ASAIEKLLVGQNPYESSLVEQTFTKLEDLIKPDEVLPD---ASPA 472
             .|...::.||.......| |..:|:.|.|:...:..|:|..     .|:| ||::||   ::|.
plant   473 IVVNDCQLVFGAYGTKHAHRAKKVEEFLTGKVISDEVLMEAI-----SLLK-DEIVPDKGTSNPG 531

  Fly   473 YRSKLACGLFYKFL----LKHAPVA---------EVGEKFRSGGQIL--QRPLSSGLQVFQTQKK 522
            |||.||....::|.    .|:|...         |:|  |....:.|  :..|||..|:.:.|:.
plant   532 YRSSLAVTFLFEFFGSLTKKNAKTTNGWLNGGCKEIG--FDQNVESLKPEAMLSSAQQIVENQEH 594

  Fly   523 NYPVTQAVEKVEGMIQCSGEATYMNDVLTTSNTLHCAFVGATKVGSTIDSIDASEALKQPGVIAF 587
            : ||.:.:.|....:|.||||.|::|:....|.|:.||:.:|...:.|..|...:.....||:..
plant   595 S-PVGKGITKAGACLQASGEAVYVDDIPAPENCLYGAFIYSTMPLARIKGIRFKQNRVPEGVLGI 658

  Fly   588 YSAKDIP------GTNTFCEPSFGFEVEEIFCSGLVRHSEQPAGVIVALTAD-QAHR--AAKLVR 643
            .:.||||      |||.|......|..|...|:|         .:|..|.|| |.|.  ||.||.
plant   659 ITYKDIPKGGQNIGTNGFFTSDLLFAEEVTHCAG---------QIIAFLVADSQKHADIAANLVV 714

  Fly   644 ISYSNPSSDFK-----LQPSLGDVFASPTPDSSRIVPASKSTSKKIKFSEQPDKEVRGI-FQMGL 702
            |.|.  :.|.|     |:.::.:......|...|..|....|    |..::.:.::.|. ...|.
plant   715 IDYD--TKDLKPPILSLEEAVENFSLFEVPPPLRGYPVGDIT----KGMDEAEHKILGSKISFGS 773

  Fly   703 QYHFTMEPQTTVAIPFEDG-LKIFSATQWMDQTQSVIAHMLQVKAKDVQLQVRRLGGGYGSKITR 766
            ||.|.||.||.:|:|.||. :.::|:||..:.....||..|.|...:|::..||:|||:|.|..:
plant   774 QYFFYMETQTALAVPDEDNCMVVYSSTQTPEFVHQTIAGCLGVPENNVRVITRRVGGGFGGKAVK 838

  Fly   767 GNQVACAASLVAYKLNRPVRFVQSLESMMDCNGKRWACRSDYKCHIKDNGKIVGLTNDFYEDAGW 831
            ...||.|.:|.|.|:.||||...:.::.|...|.|...:..|....|.||||..|..:...|||.
plant   839 SMPVAAACALAASKMQRPVRTYVNRKTDMITTGGRHPMKVTYSVGFKSNGKITALDVEVLLDAGL 903

  Fly   832 SPNESPIEGHSTFTAVNCYDLNGDNFKNNGNAVLTDAPSSTWCRAPGSVEGIAMIENIIEHVAFE 896
            :.:.||:.......|:..||....:|  |.....|:..|.|..||||.|:|..:.|.|||.||..
plant   904 TEDISPLMPKGIQGALMKYDWGALSF--NVKVCKTNTVSRTALRAPGDVQGSYIGEAIIEKVASY 966

  Fly   897 VQKDPAEVRLANI-----------AAGNKISELLPQFLESR--EYA---QRKKEIESHNAKNRWT 945
            :..|..|:|..|:           |...:.||.....|..|  |::   :|:|.:|..||.|:|.
plant   967 LSVDVDEIRKVNLHTYESLRLFHSAKAGEFSEYTLPLLWDRIDEFSGFNKRRKVVEEFNASNKWR 1031

  Fly   946 KRGLGLAVMDYPIFYFGQYPATVAIYHVDGTVVVTHGGIEMGQGMNTKVAQVAAYTLGID----- 1005
            |||:......|.: .....|..|::.. ||::||...|||:|||:.|||.|:|||:||:.
plant  1032 KRGISRVPAVYAV-NMRSTPGRVSVLG-DGSIVVEVQGIEIGQGLWTKVKQMAAYSLGLIQCGTT 1094

  Fly  1006 ----LSFIKVESSDTINGANSMVTGGAVGSESLCYAVRKACETLNSRLEPVKKK-------DASW 1059
                |..|:|..|||::.....:|.|:..||:...|||..|:.|..||.|||..       ..:|
plant  1095 SDELLKKIRVIQSDTLSMVQGSMTAGSTTSEASSEAVRICCDGLVERLLPVKTALVEQTGGPVTW 1159

  Fly  1060 IETVEAAYGKSINLIASDHYKKGDMQNYHIYGLALTEVELDVLTGNSQIKRVDILEDAGESLSPW 1124
            ...:..||.:|||:..|..|.......|..||:|.:|||::||||.:.|.|.||:.|.|:||:|.
plant  1160 DSLISQAYQQSINMSVSSKYMPDSTGEYLNYGIAASEVEVNVLTGETTILRTDIIYDCGKSLNPA 1224

  Fly  1125 IDIGQIEGAFVMCLGYWMSEQLVYDRETGRLLTNRTWNYKPPGAKDIPIDFRIELIQKPNPSGAG 1189
            :|:||||||||..||::|.|:.:.:.: |.::|:.||.||.|....||..|.:|::........
plant  1225 VDLGQIEGAFVQGLGFFMLEEFLMNSD-GLVVTDSTWTYKIPTVDTIPRQFNVEILNSGQHKNR- 1287

  Fly  1190 FMRSKATGEPPCCLAVSVVFALRQALDSAR 1219
            .:.|||:||||..||.||..|:|.|:..||
plant  1288 VLSSKASGEPPLLLAASVHCAVRAAVKEAR 1317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX3	NP_001303439.1	PLN02906	24..1238	CDD:215491	425/1311 (32%)
		Fer2_2	80..153	CDD:280048	31/82 (38%)
		FAD_binding_4	201..360	CDD:303082	49/160 (31%)
		CO_deh_flav_C	386..487	CDD:281449	36/112 (32%)
		Ald_Xan_dh_C	540..646	CDD:214971	38/114 (33%)
		Ald_Xan_dh_C2	688..1172	CDD:280834	183/517 (35%)
AO1	NP_568407.2	PLN00192	16..1364	CDD:215096	431/1330 (32%)
		Fer2_2	104..188	CDD:280048	32/83 (39%)
		FAD_binding_5	249..425	CDD:279309	54/180 (30%)
		CO_deh_flav_C	443..545	CDD:281449	35/107 (33%)
		Ald_Xan_dh_C	611..721	CDD:279635	39/120 (33%)
		Ald_Xan_dh_C2	750..1271	CDD:280834	185/529 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	83	1.000	Domainoid score	I2880
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H98597
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720