DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX3 and XDH2

DIOPT Version :9

Sequence 1:	NP_001303439.1	Gene:	AOX3 / 41896	FlyBaseID:	FBgn0038349	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_195216.2	Gene:	XDH2 / 829642	AraportID:	AT4G34900	Length:	1353	Species:	Arabidopsis thaliana

Alignment Length:	1382	Identity:	414/1382 - (29%)
Similarity:	645/1382 - (46%)	Gaps:	206/1382 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 INGLPYAVNLTNLPPD----ITLNTFIREHAQLTATKFMCQEGGCGACICVV----RDGKR--SW 61
            :..:.|...:..:.||    :||..::|: ..||.||..|.|||||:|..:|    |:.|.  .:
plant     7 MEAIMYVNGVRRVLPDGLAHMTLLEYLRD-LGLTGTKLGCGEGGCGSCTVMVSSYDRESKTCVHY 70

  Fly    62 AVNSCLTLLNTCAQLEIVTAEGLGNQRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQNEG 126
            |||:||..|.:...:.:::.||:|:::.|.:|:|:.||..:|:|||||:|||||:||.|:..::.
plant    71 AVNACLAPLYSVEGMHVISIEGVGHRKLGLHPLQESLASSHGSQCGFCTPGFVMSMYALLRSSKN 135

  Fly   127 KVTMAEVENSFGGNICRCTGYRPILDAMKSFAVDSNIAIPAECGDIEDLKPRN-CPKTGQACS-G 189
            ..:..|:|....||:|||||||||:||.:.|| .|:.|:.:....:......| ||.||:.|| |
plant   136 SPSEEEIEECLAGNLCRCTGYRPIIDAFRVFA-KSDDALYSGLSSLSLQDGSNICPSTGKPCSCG 199

  Fly   190 SCLPS-----------TLVYED-------------------------------GVQWHWPKSLSE 212
            |...|           ::.|.|                               |:.|:.|.||..
plant   200 SKTTSEAATCNEDRFQSISYSDIDGAKYTDKELIFPPELLLRKLAPLKLGGNEGITWYRPVSLQN 264

  Fly   213 LFDALDKVKDSEEFMLVAGNTAHGVYRRSTDIKH--FIDVQGVEELHQHSSEGQQLKLGANLSLT 275
            |.:......|::   |:.|||..|:..|...:::  .|....|.||:..:.....:::|:.|.|:
plant   265 LLELKANFPDAK---LLVGNTEVGIEMRLKRLQYPVLISAAQVPELNALNVNDNGIEVGSALRLS 326

  Fly   276 QTMEIIRTTSKQ-PGFE------YLDVL-WNHIDLIANVPVRNSGTLAGNI----SIKKQNP--- 325
            :.:.:.|...|: |..|      :::.| |     .|...:||...:.|||    .|...||
plant   327 ELLRLFRKVVKERPAHETSACKAFIEQLKW-----FAGTQIRNVACIGGNICTASPISDLNPLWM 386

  Fly   326 ----EF-------------PSDIFISFEALNVKVVALKNAADEKEMSLAEYLGTNDKKLVLKTFV 373
                ||             ..|.|:.:..::                    :|:|:   :|.:..
plant   387 ASRAEFRIINCNGDVRSIPAKDFFLGYRKVD--------------------MGSNE---ILLSVF 428

  Fly   374 LPAYPKDKYIYESYKIMPRAQNAHAYVNAAFLLELEADNK---VKSARICFGGIRPDFIHASAIE 435
            ||.....:|:.| :|...|..:..|.||....:.||...:   |..|.|.:||:.|..:.|...|
plant   429 LPWTRPLEYVKE-FKQAHRRDDDIAIVNGGMRVFLEEKGQQLFVSDASIVYGGVAPLSLRARNTE 492

  Fly   436 KLLVGQNPYESSLVEQTFTKLEDLIKPDEVLPDASPAYRSKLACGLFYKFLL---KHA----PVA 493
            :||:|:| :...|::.....::..:...|..|.....:|..|....|:||.|   .|.    |..
plant   493 ELLIGKN-WNKCLLQDALKVIQSDVLIKEGAPGGMVEFRKSLTLSFFFKFFLWVTHHVNNVNPTI 556

  Fly   494 EV-GEKFRSGGQILQRPLSSGLQVFQTQKKNYPVTQAVEKVEGMIQCSGEATYMNDVLTTSNTLH 557
            |. .....|..|::.|....|.|.::|.|:...|......:...:|.:|||.|.:|......|||
plant   557 ETFPPSHMSAVQLVPRFSRIGKQDYETVKQGTSVGLPEVHLSARMQVTGEAEYTDDTPLPPCTLH 621

  Fly   558 CAFVGATKVGSTIDSIDASEALKQPGVIAFYSAKDIPGTNTFCEPSFGFEV--EEIFCSGLVRHS 620
            .|.|.:....:.|.|:|.|.|....|.:..:.|||:||.|     ..|..|  ||:|.:.:|...
plant   622 AALVLSKVPHARILSVDDSAAKSSSGFVGLFLAKDVPGNN-----MIGPIVADEELFATDVVTCV 681

  Fly   621 EQPAGVIVALTADQAHRAAKLVRISYSNPSSDFKLQPSLGDVFASPTPDSSRIVPASKSTSKKIK 685
            .|..||:||.|.:.|..||:.|.:.|....:...::.::......|            :|.::::
plant   682 GQVIGVLVADTHENAKTAARKVDVRYQELPAILSIKEAINAKSFHP------------NTERRLR 734

  Fly   686 --------FSEQPDKEVRGIFQMGLQYHFTMEPQTTVAIPFEDG--LKIFSATQWMDQTQSVIAH 740
                    .|.|.|:.:.|..|||.|.||.:||..::....:.|  :.:.|:||...|.|..::|
plant   735 KGDVELCFQSGQCDRIIEGEVQMGGQEHFYLEPNGSLVWTIDGGNEVHMISSTQAPQQHQKYVSH 799

  Fly   741 MLQVKAKDVQLQVRRLGGGYGSKITRGNQVACAASLVAYKLNRPVRFVQSLESMMDCNGKRWACR 805
            :|.:....|..:.:|||||:|.|.||...:|.|||:.:|.|||||:.:...:..|...|.|.:..
plant   800 VLGLPMSKVVCKTKRLGGGFGGKETRSAFIAAAASVPSYLLNRPVKLILDRDVDMMITGHRHSFV 864

  Fly   806 SDYKCHIKDNGKIVGLTNDFYEDAGWSP--NESPIEGHSTFTAVNCYDLNGDNFKNNGNAVLTDA 868
            ..||....:.|||:.|..:.|.:.|.|.  :.|.:| .:.|.:.|.|::  .:.:..||...|:.
plant   865 GKYKVGFTNEGKILALDLEIYNNGGNSMDLSLSNLE-RAMFHSDNVYEI--PHVRIVGNVCFTNF 926

  Fly   869 PSSTWCRAPGSVEGIAMIENIIEHVAFEVQKDPAEVRLANIAAGNKIS------------ELLPQ 921
            ||:|..|..|..:|:.:.||.|:.:|.|:.|.|.|::..|......|:            :|..:
plant   927 PSNTAFRGFGGPQGMLITENWIQRIAAELDKIPEEIKEMNFQVEGSITHYFQSLQHCTLHQLWKE 991

  Fly   922 FLESREYAQRKKEIESHNAKNRWTKRGLGLAVMDYPIF----YFGQYPATVAIYHVDGTVVVTHG 982
            ...|..:.:.::|.:..|:.|||.|||:.:....:.|.    :..|..|.|.:| .||||:||||
plant   992 LKVSSNFLKTRREADEFNSHNRWKKRGVAMVPTKFGISFTTKFMNQAGALVHVY-TDGTVLVTHG 1055

  Fly   983 GIEMGQGMNTKVAQVAAYTLGIDLSFIKVESSDTINGANSMVTGGAVGSESLCYAVRKACETLNS 1047
            |:|||||::||||||||....|.||.:.|..:.|....|:..|..:..|:....||..|||.:.:
plant  1056 GVEMGQGLHTKVAQVAATAFNILLSSVFVSETSTDKVPNASPTAASASSDMYGAAVLDACEQIIA 1120

  Fly  1048 RLEPVKKKD--ASWIETVEAAYGKSINLIASDHY-----------KKGDMQNYHIYGLALTEVEL 1099
            |:|||..|.  .::.|...|.|.:.|:|.|...:           .||:...|:.||.|..|||:
plant  1121 RMEPVASKHNFNTFSELASACYFQRIDLSAHGFHIVPELEFDWVSGKGNAYRYYTYGAAFAEVEI 1185

  Fly  1100 DVLTGNSQIKRVDILEDAGESLSPWIDIGQIEGAFVMCLGYWMSEQLVYDR------ETGRLLTN 1158
            |.|||:...::.||:.|.|.||:|.|||||||||||..||:...|:|.:..      :.|.|||.
plant  1186 DTLTGDFHTRKADIMLDLGYSLNPTIDIGQIEGAFVQGLGWVALEELKWGDAAHKWIKPGSLLTC 1250

  Fly  1159 RTWNYKPPGAKDIPIDFRIELIQKPNPSGAGFMRSKATGEPPCCLAVSVVFALRQALDSARHDAG 1223
            ...:||.|...|:|....:.|: |.||:......|||.||||..||.|..||:::|:.:||.:.|
plant  1251 GPGSYKIPSINDMPFQLNVSLL-KGNPNAKAIHSSKAVGEPPFFLAASAFFAIKEAIKAARSEVG 1314

  Fly  1224 LPREWVRLGAPTTPETL 1240
            | ..|..|..|.|||.:
plant  1315 L-TNWFPLETPATPERI 1330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX3	NP_001303439.1	PLN02906	24..1238	CDD:215491	409/1357 (30%)
		Fer2_2	80..153	CDD:280048	35/72 (49%)
		FAD_binding_4	201..360	CDD:303082	39/192 (20%)
		CO_deh_flav_C	386..487	CDD:281449	27/103 (26%)
		Ald_Xan_dh_C	540..646	CDD:214971	38/107 (36%)
		Ald_Xan_dh_C2	688..1172	CDD:280834	179/522 (34%)
XDH2	NP_195216.2	PLN02906	26..1344	CDD:215491	411/1363 (30%)
		Fer2_2	90..162	CDD:280048	35/71 (49%)
		FAD_binding_5	252..431	CDD:279309	43/209 (21%)
		CO_deh_flav_C	441..545	CDD:281449	28/104 (27%)
		Ald_Xan_dh_C	604..711	CDD:214971	39/111 (35%)
		Ald_Xan_dh_C2	730..1264	CDD:280834	180/537 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720