DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX3 and XDH1

DIOPT Version :9

Sequence 1:	NP_001303439.1	Gene:	AOX3 / 41896	FlyBaseID:	FBgn0038349	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_195215.2	Gene:	XDH1 / 829641	AraportID:	AT4G34890	Length:	1361	Species:	Arabidopsis thaliana

Alignment Length:	1385	Identity:	416/1385 - (30%)
Similarity:	649/1385 - (46%)	Gaps:	218/1385 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LPYAVNLTNLPPD----ITLNTFIREHAQLTATKFMCQEGGCGACICVV----RDGKRS--WAVN 64
            |.|...:..:.||    :||..::|: ..||.||..|.|||||||..:|    |..|.|  :|||
plant    18 LLYVNGVRRVLPDGLAHMTLLEYLRD-LGLTGTKLGCGEGGCGACTVMVSSYDRKSKTSVHYAVN 81

  Fly    65 SCLTLLNTCAQLEIVTAEGLGNQRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQNEGKVT 129
            :||..|.:...:.:::.||||:::.|.:|:|:.||..:|:|||||:|||:|:||.|:..::...:
plant    82 ACLAPLYSVEGMHVISIEGLGHRKLGLHPVQESLASSHGSQCGFCTPGFIMSMYSLLRSSKNSPS 146

  Fly   130 MAEVENSFGGNICRCTGYRPILDAMKSFAVDSNIAIPAECGDIEDLKPRN----CPKTGQACS-- 188
            ..|:|....||:|||||||||:||.:.||...:...   || :..|..::    ||.||:.||
plant   147 EEEIEECLAGNLCRCTGYRPIVDAFRVFAKSDDALY---CG-VSSLSLQDGSTICPSTGKPCSCG 207

  Fly   189 -------GSCLP---STLVYED-------------------------------GVQWHWPKSLSE 212
                   .||..   .::.|.|                               |:.|:.|..|..
plant   208 SKTTNEVASCNEDRFQSISYSDIDGAKYTDKELIFPPELLLRKLTPLKLRGNGGITWYRPVCLQN 272

  Fly   213 LFDALDKVKDSEEFMLVAGNTAHGVYRRSTDIKH--FIDVQGVEELHQHSSEGQQLKLGANLSLT 275
            |.:......|::   |:.|||..|:..|...:::  .|.|..|.||:..:.....:::|:.|.|:
plant   273 LLELKANYPDAK---LLVGNTEVGIEMRLKRLQYQVLISVAQVPELNALNVNDNGIEVGSALRLS 334

  Fly   276 QTMEIIRTTSKQ-PGFE------YLDVL-WNHIDLIANVPVRNSGTLAGNI----SIKKQNP--- 325
            :.:.:.|...|: |..|      :::.| |     .|...:||...:.|||    .|...||
plant   335 ELLRLFRKIVKERPAHETSACKAFIEQLKW-----FAGTQIRNVACIGGNICTASPISDLNPLWM 394

  Fly   326 ----EF-------------PSDIFISFEALNVKVVALKNAADEKEMSLAEYLGTNDKKLVLKTFV 373
                ||             ..|.|:.:..::                    :|:|:   :|.:..
plant   395 ASRAEFRITNCNGDVRSIPAKDFFLGYRKVD--------------------MGSNE---ILLSVF 436

  Fly   374 LPAYPKDKYIYESYKIMPRAQNAHAYVNAAFLLELEADNK---VKSARICFGGIRPDFIHASAIE 435
            ||.....:|:.| :|...|..:..|.||....:.||...:   |..|.|.:||:.|..:.|...|
plant   437 LPWTRPLEYVKE-FKQAHRRDDDIAIVNGGMRVFLEDKGQQLFVSDASIAYGGVAPLSLCARKTE 500

  Fly   436 KLLVGQNPYESSLVEQTFTKLEDLIKPDEVLPDASPA----YRSKLACGLFYKFLL--------K 488
            :.|:|:| :...|::...    .:|:.|.|:.:.:|.    :|..|....|:||.|        .
plant   501 EFLIGKN-WNKDLLQDAL----KVIQSDVVIKEDAPGGMVEFRKSLTLSFFFKFFLWVSHNVNNA 560

  Fly   489 HAPVAEVGEKFRSGGQILQRPLSSGLQVFQTQKKNYPVTQAVEKVEGMIQCSGEATYMNDVLTTS 553
            ::.:........|..|.:.|....|.|.::|.|:...|..:...:...:|.:|||.|.:|.....
plant   561 NSAIETFPPSHMSAVQPVPRLSRIGKQDYETVKQGTSVGSSEVHLSARMQVTGEAEYTDDTPVPP 625

  Fly   554 NTLHCAFVGATKVGSTIDSIDASEALKQPGVIAFYSAKDIPGTNTF--CEPSFGFEVEEIFCSGL 616
            ||||.|||.:....:.|.|||.|.|....|.:..:.||||||.|..  ..|.     ||:|.:.:
plant   626 NTLHAAFVLSKVPHARILSIDDSAAKSSSGFVGLFLAKDIPGDNMIGPIVPD-----EELFATDV 685

  Fly   617 VRHSEQPAGVIVALTADQAHRAAKLVRISYSNPSSDFKLQPSLGDVFASPTPDSSRIVPASKSTS 681
            |....|..||:||.|.:.|..||..|.:.|....:...::.::......|            :|.
plant   686 VTCVGQVIGVVVADTHENAKTAAGKVDVRYEELPAILSIKEAINAKSFHP------------NTE 738

  Fly   682 KKIK--------FSEQPDKEVRGIFQMGLQYHFTMEPQTTVAIPFEDGLKI--FSATQWMDQTQS 736
            |:::        .|.|.|:.:.|..|||.|.||.:||..::....:.|.::  .|:||...:.|.
plant   739 KRLRKGDVELCFQSGQCDRVIEGEVQMGGQEHFYLEPNGSLVWTVDGGSEVHMISSTQAPQKHQK 803

  Fly   737 VIAHMLQVKAKDVQLQVRRLGGGYGSKITRGNQVACAASLVAYKLNRPVRFVQSLESMMDCNGKR 801
            .::|:|.:....|..:.:|:|||:|.|.||...:|.|||:.:|.|||||:.:...:..|...|.|
plant   804 YVSHVLGLPMSKVVCKTKRIGGGFGGKETRSAFIAAAASVPSYLLNRPVKLILDRDVDMMITGHR 868

  Fly   802 WACRSDYKCHIKDNGKIVGLTNDFYEDAGWSPNES-PIEGHSTFTAVNCYDLNGDNFKNNGNAVL 865
            .:....||....:.|||:.|..:.|.:.|.|.:.| .:...:.|.:.|.|::  .:.:..||...
plant   869 HSFLGKYKVGFTNEGKILALDLEIYNNGGNSLDLSLSVLERAMFHSDNVYEI--PHVRIVGNVCF 931

  Fly   866 TDAPSSTWCRAPGSVEGIAMIENIIEHVAFEVQKDPAEVRLANIAAGNKIS------------EL 918
            |:.||:|..|..|..:|:.:.||.|:.:|.|:.|.|.|::..|......::            :|
plant   932 TNFPSNTAFRGFGGPQGMLITENWIQRIAAELNKSPEEIKEMNFQVEGSVTHYCQTLQHCTLHQL 996

  Fly   919 LPQFLESREYAQRKKEIESHNAKNRWTKRGLGLAVMDYPIF----YFGQYPATVAIYHVDGTVVV 979
            ..:...|..:.:.::|.:..|:.|||.|||:.:....:.|.    :..|..|.|.:| .||||:|
plant   997 WKELKVSCNFLKARREADEFNSHNRWKKRGVAMVPTKFGISFTTKFMNQAGALVHVY-TDGTVLV 1060

  Fly   980 THGGIEMGQGMNTKVAQVAAYTLGIDLSFIKVESSDTINGANSMVTGGAVGSESLCYAVRKACET 1044
            ||||:|||||::||||||||....|.||.:.|..:.|....|:..|..:..|:....||..|||.
plant  1061 THGGVEMGQGLHTKVAQVAASAFNIPLSSVFVSETSTDKVPNASPTAASASSDMYGAAVLDACEQ 1125

  Fly  1045 LNSRLEPVKKKD--ASWIETVEAAYGKSINLIASDHY-----------KKGDMQNYHIYGLALTE 1096
            :.:|:|||..|.  .::.|.|.|.|.:.|:|.|...:           .||:...|:.||.|..|
plant  1126 IIARMEPVASKHNFNTFTELVSACYFQRIDLSAHGFHIVPDLGFDWISGKGNAFRYYTYGAAFAE 1190

  Fly  1097 VELDVLTGNSQIKRVDILEDAGESLSPWIDIGQIEGAFVMCLGYWMSEQLVYDR------ETGRL 1155
            ||:|.|||:...:..||:.|.|.||:|.||:||||||||..||:...|:|.:..      :.|.|
plant  1191 VEIDTLTGDFHTRAADIMLDLGYSLNPAIDVGQIEGAFVQGLGWVALEELKWGDAAHKWIKPGSL 1255

  Fly  1156 LTNRTWNYKPPGAKDIPIDFRIELIQKPNPSGAGFMRSKATGEPPCCLAVSVVFALRQALDSARH 1220
            ||....|||.|...|:|.:..:.|: |.||:......|||.||||..||.||.||:::|:.:||.
plant  1256 LTCGPGNYKIPSINDMPFNLNVSLL-KGNPNTKAIHSSKAVGEPPFFLASSVFFAIKEAIKAART 1319

  Fly  1221 DAGLPREWVRLGAPTTPETL 1240
            :.|| .:|..|.:|.|||.:
plant  1320 EVGL-TDWFPLESPATPERI 1338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX3	NP_001303439.1	PLN02906	24..1238	CDD:215491	410/1363 (30%)
		Fer2_2	80..153	CDD:280048	35/72 (49%)
		FAD_binding_4	201..360	CDD:303082	39/192 (20%)
		CO_deh_flav_C	386..487	CDD:281449	28/107 (26%)
		Ald_Xan_dh_C	540..646	CDD:214971	41/107 (38%)
		Ald_Xan_dh_C2	688..1172	CDD:280834	176/521 (34%)
XDH1	NP_195215.2	PLN02906	34..1352	CDD:215491	412/1369 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720