DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX3 and AAO2

DIOPT Version :9

Sequence 1:	NP_001303439.1	Gene:	AOX3 / 41896	FlyBaseID:	FBgn0038349	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_189946.1	Gene:	AAO2 / 823457	AraportID:	AT3G43600	Length:	1321	Species:	Arabidopsis thaliana

Alignment Length:	1316	Identity:	432/1316 - (32%)
Similarity:	655/1316 - (49%)	Gaps:	143/1316 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTKFSINGLPYAVNLTNLPPDITLNTFIREHAQLTATKFMCQEGGCGACICV------VRDGKR 59
            |:..|:|||..:.:.|:::.|..||..|:|......:.|..|.|||||||:.:      |.....
plant     1 MSLVFAINGQRFELELSSVDPSTTLLEFLRYQTSFKSVKLSCGEGGCGACVVLLSKFDPVLQKVE 65

  Fly    60 SWAVNSCLTLLNTCAQLEIVTAEGLGNQRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMY-GLMEQ 123
            .:.|:||||||.:.....|.|:|||||.|.|::||.|||:..:.:|||||:||..:::: .|::.
plant    66 DFTVSSCLTLLCSVNHCNITTSEGLGNSRDGFHPIHKRLSGFHASQCGFCTPGMSVSLFSALLDA 130

  Fly   124 NEGK---VTMAEVENSFGGNICRCTGYRPILDAMKSFAVDSNIAIPAECGDIEDLKPRNCPKTGQ 185
            ::.:   :|:.|.|.:..||:|||||||||:||.||||.|.         |||||...:..:.|.
plant   131 DKSQYSDLTVVEAEKAVSGNLCRCTGYRPIVDACKSFASDV---------DIEDLGLNSFCRKGD 186

  Fly   186 ACSGS----------C-LPSTLVYE----DGVQWHW--PKSLSELFDALDKVK---DSEEFMLVA 230
            ..|.|          | .|..|..|    |...:.|  |.|:.||...|:..|   ::....|||
plant   187 KDSSSLTRFDSEKRICTFPEFLKDEIKSVDSGMYRWCSPASVEELSSLLEACKANSNTVSMKLVA 251

  Fly   231 GNTAHGVYR--RSTDIKHFIDVQGVEELHQHSSEGQQLKLGANLSLTQTMEIIRTTSKQPGFEYL 293
            |||:.|.|:  |..:...:||:..:..|.:.......:::|:.:::::.:..::.....||.|.:
plant   252 GNTSMGYYKDEREQNYDKYIDITRIPHLKEIRENQNGVEIGSVVTISKVIAALKEIRVSPGVEKI 316

  Fly   294 -DVLWNHIDLIANVPVRNSGTLAGNISIKKQNPEFPSDIFISFEALNVKVVALKNAADEKEMSLA 357
             ..|..|:::||...:||.|::.||: :..|..:||||:.....|....|..:.::...::::|.
plant   317 FGKLATHMEMIAARFIRNFGSIGGNL-VMAQRKQFPSDMATILLAAGAFVNIMSSSRGLEKLTLE 380

  Fly   358 EYLGTNDKK---LVLKTFVLPAYPKD---KYIYESYKIMPRAQ-NAHAYVNAAFLLELEADNKVK 415
            |:|..:..:   ||| :..:|.:..:   :..:|:|:..||.. :|.||:|||||.|:: |..|.
plant   381 EFLERSPLEAHDLVL-SIEIPFWHSETNSELFFETYRAAPRPHGSALAYLNAAFLAEVK-DTMVV 443

  Fly   416 SARICFGGI-RPDFIHASAIEKLLVGQNPYESSLVEQTFTKLEDLIKPDEVLPDASPAYRSKLAC 479
            :.|:.||.. ....|....||:.|.|:...:..|.| ..|.|.:::.|::  ..::|||||.||.
plant   444 NCRLAFGAYGTKHAIRCKEIEEFLSGKVITDKVLYE-AITLLGNVVVPED--GTSNPAYRSSLAP 505

  Fly   480 GLFYKFLLKHAPVAEVGEKFRSGGQILQRP-----LSSGLQVFQTQKKNYPVTQAVEKVEGMIQC 539
            |..:|||  |..:........|.|..|..|     |||...|....:.| ||.|.|.||...:|.
plant   506 GFLFKFL--HTLMTHPTTDKPSNGYHLDPPKPLPMLSSSQNVPINNEYN-PVGQPVTKVGASLQA 567

  Fly   540 SGEATYMNDVLTTSNTLHCAFVGATKVGSTIDSIDASEALKQPGVIAFYSAKDIPGTNTFCEPSF 604
            ||||.|::|:.:.:|.|:.||:.:.|..:.|..|...:.|...||:|..|.||:|..........
plant   568 SGEAVYVDDIPSPTNCLYGAFIYSKKPFARIKGIHFKDDLVPTGVVAVISRKDVPKGGKNIGMKI 632

  Fly   605 GFEVEEIFCSGLVRHSEQPAGVIVALTADQAHRAAKLVRISYSNPS--------SDFKLQPSLGD 661
            |...:::|.........:....:||.|...|..|..|..:.|....        .|...:.||.|
plant   633 GLGSDQLFAEDFTTSVGECIAFVVADTQRHADAAVNLAVVEYETEDLEPPILSVEDAVKKSSLFD 697

  Fly   662 VFASPTPDSSRIVPASKSTSK---KIKFSEQPDKEVRGIFQMGLQYHFTMEPQTTVAIPFEDG-L 722
            :.....|  .::...||..::   :|..||         .::|.||.|.||.||.:|:..||. :
plant   698 IIPFLYP--QQVGDTSKGMAEADHQILSSE---------IRLGSQYVFYMETQTALAVGDEDNCI 751

  Fly   723 KIFSATQWMDQTQSVIAHMLQVKAKDVQLQVRRLGGGYGSKITRGNQVACAASLVAYKLNRPVRF 787
            .::|:||.....||.:|..|.:...::::..||:|||:|.|..:...||.|.:|.|.||.||||.
plant   752 VVYSSTQTPQYVQSSVAACLGIPENNIRVITRRVGGGFGGKSVKSMPVATACALAAKKLQRPVRT 816

  Fly   788 VQSLESMMDCNGKRWACRSDYKCHIKDNGKIVGLTNDFYEDAGWSPNESPIEGHSTFTAVNCYDL 852
            ..:.::.|...|.|...:..|....|..|||..|..:...|||.|      .|.|.|...|   |
plant   817 YVNRKTDMIMTGGRHPMKITYSVGFKSTGKITALELEILIDAGAS------YGFSMFIPSN---L 872

  Fly   853 NGDNFKNNGNAV-------LTDAPSSTWCRAPGSVEGIAMIENIIEHVAFEVQKDPAEVRLANI- 909
            .|...|.|..|:       .|:..|....|:||.|:|..:.|.|||::|..:..:...:|..|:
plant   873 IGSLKKYNWGALSFDIKLCKTNLLSRAIMRSPGDVQGTYIAEAIIENIASSLSLEVDTIRKINLH 937

  Fly   910 -----------AAGN----KISELLPQFLESREYAQRKKEIESHNAKNRWTKRGLGLAVMDYPIF 959
                       .||.    .:|.:..:...|.::.:|...:...|..|.|.|||:....:.|.:.
plant   938 THESLALFYKDGAGEPHEYTLSSMWDKVGVSSKFEERVSVVREFNESNMWRKRGISRVPIIYEVL 1002

  Fly   960 YFGQYPATVAIYHVDGTVVVTHGGIEMGQGMNTKVAQVAAYTLGI---D-----LSFIKVESSDT 1016
            .|.. |..|::.. |||:||..||||:|||:.|||.|:.:|.||:   |     |..|:|..||:
plant  1003 LFAT-PGRVSVLS-DGTIVVEIGGIELGQGLWTKVKQMTSYALGMLQCDGTEELLEKIRVIQSDS 1065

  Fly  1017 INGANSMVTGGAVGSESLCYAVRKACETLNSRLEPVKKKD---ASWIETVEAAYGKSINLIASDH 1078
            ::......|||:..||..|.|||..||||..||:|:.::.   .:|.|.:..||.:|:||.|||.
plant  1066 LSMVQGNFTGGSTTSEGSCAAVRLCCETLVERLKPLMERSDGPITWNELISQAYAQSVNLSASDL 1130

  Fly  1079 YKKGD--MQNYHIYGLALTEVELDVLTGNSQIKRVDILEDAGESLSPWIDIGQIEGAFVMCLGYW 1141
            |...|  || |..||.|::|||:|::||.:.:.:.|||.|.|:||:|.:|:|||||:||..||::
plant  1131 YTPKDTPMQ-YLNYGTAVSEVEVDLVTGQTTVLQTDILYDCGKSLNPAVDLGQIEGSFVQGLGFF 1194

  Fly  1142 MSEQLVYDRETGRLLTNRTWNYKPPGAKDIPIDFRIELIQKPNPSGAGFMR---SKATGEPPCCL 1203
            |.|:.:.|.| |.|||:.||.||.|....||..|.:|::.    .|....|   |||:||||..|
plant  1195 MLEEYIEDPE-GLLLTDSTWTYKIPTVDTIPKQFNVEILN----GGCHEKRVLSSKASGEPPLLL 1254

  Fly  1204 AVSVVFALRQALDSAR 1219
            |.||..|.|||:..||
plant  1255 AASVHCATRQAVKEAR 1270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX3	NP_001303439.1	PLN02906	24..1238	CDD:215491	425/1293 (33%)
		Fer2_2	80..153	CDD:280048	35/76 (46%)
		FAD_binding_4	201..360	CDD:303082	41/166 (25%)
		CO_deh_flav_C	386..487	CDD:281449	37/102 (36%)
		Ald_Xan_dh_C	540..646	CDD:214971	29/105 (28%)
		Ald_Xan_dh_C2	688..1172	CDD:280834	184/520 (35%)
AAO2	NP_189946.1	PLN00192	1..1317	CDD:215096	432/1316 (33%)
		fer2	3..78	CDD:238126	27/74 (36%)
		Fer2_2	86..164	CDD:280048	36/77 (47%)
		FAD_binding_5	218..402	CDD:279309	46/185 (25%)
		CO_deh_flav_C	414..515	CDD:281449	39/106 (37%)
		Ald_Xan_dh_C	568..678	CDD:279635	30/109 (28%)
		Ald_Xan_dh_C2	699..1224	CDD:280834	189/548 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	83	1.000	Domainoid score	I2880
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H98597
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720