back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX3 and Aox4

DIOPT Version :9

Sequence 1:	NP_001303439.1	Gene:	AOX3 / 41896	FlyBaseID:	FBgn0038349	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_076120.2	Gene:	Aox4 / 71872	MGIID:	1919122	Length:	1336	Species:	Mus musculus

Alignment Length:	1353	Identity:	398/1353 - (29%)
Similarity:	626/1353 - (46%)	Gaps:	173/1353 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FSINGLPYAVNLTNLPPDITLNTFIREHAQLTATKFMCQEGGCGAC-ICVVRDGKRS-----WAV 63
            |.:||  ..|...|..|:..|..:.|:...||.||:.|..|||||| :.|.|...::     :..
Mouse    12 FFVNG--KKVIEKNPDPEKNLLFYTRKVLNLTGTKYSCGTGGCGACTVMVSRYNPKTRKIHHYPA 74

  Fly    64 NSCLTLLNTCAQLEIVTAEGLGNQRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQNEGKV 128
            .:||..:.......|.|.||:|:.:...:|:|:||||.:||||||||||.||::|.|: :|..:.
Mouse    75 TACLVPICWLHGAAITTVEGVGSIKKRVHPVQERLAKCHGTQCGFCSPGMVMSIYTLL-RNHPEP 138

  Fly   129 TMAEVENSFGGNICRCTGYRPILDAMKSFAVDSNIAIPAECGDIEDLKPRNCPKTGQAC---SGS 190
            |..::..:.|||:|||||||||:::.|:|:..|.:.              ....:|:.|   ...
Mouse   139 TPDQITEALGGNLCRCTGYRPIVESGKTFSQKSTVC--------------QMKGSGKCCMDPDEK 189

  Fly   191 CLPS------TLVY-EDGVQ----------------------------------WHWPKSLSELF 214
            ||.|      |.:| ||..|                                  |..|.:|::|.
Mouse   190 CLESREKKMCTKLYNEDEFQPFDPSQEPIFPPELIRMAEDPNKRRLTFQGKRTTWIIPVTLNDLL 254

  Fly   215 DALDKVKDS-EEFMLVAGNTAHGVYRRSTDIKH--FIDVQGVEELHQHSSEGQQLKLGANLSLTQ 276
            :    :|.| .|..||.|||..|...:..|..:  ||...||.||:...:....:.:||..||.|
Mouse   255 E----LKASYPEAPLVMGNTTVGPGIKFNDEFYPVFISPLGVPELNLMDTTNNGVTIGAGYSLAQ 315

  Fly   277 ---TMEIIRTTSKQPGFEYLDVLWNHIDLIANVPVRNSGTLAGNISIKKQNPEFPSDIFISFEAL 338
               |::.:.:...:...:....|..|:..:|...:||..||.|:.:   ..|.| ||:.....|.
Mouse   316 LKDTLDFLVSEQPKEKTKTFHALQKHLRTLAGPQIRNMATLGGHTA---SRPNF-SDLNPILAAG 376

  Fly   339 NVKVVALKNAADEKEMSL----AEYLGTNDKK---LVLKTFVLPAYPKDKYIYESYKIMPRAQNA 396
            |..:..:.....::::.|    .|.|...|.|   ::|..|:  .|..........::..|.:||
Mouse   377 NATINVVSREGKDRQLPLNGPFLEKLPEADLKPEEVILSIFI--PYTAQWQFVSGLRLAQRQENA 439

  Fly   397 HAYVNAAFLLEL-EADNKVKSARICFGGIRPDFIHASAIEKLLVGQNPYESSLVEQTFTKLEDLI 460
            .|.|||...:|. |..|.:|..::.||.:.|..:.||...|.|:|:...:..|.:.....|:::.
Mouse   440 FAIVNAGMSVEFEEGTNTIKDLKMFFGSVAPTVVSASQTCKQLIGRQWDDQMLSDACQLVLQEIR 504

  Fly   461 KPDEVLPDASPA---YRSKLACGLFYKFLLK---------HAPVAEVGEKFRSGGQILQRPLSSG 513
            .|    |||...   ||..|...|.:||.||         .....::..||.|...........|
Mouse   505 IP----PDAEGGMVEYRRTLIISLLFKFYLKVQRWLNEMDPQKFPDIPGKFVSALDDFPIETPQG 565

  Fly   514 LQVFQ----TQKKNYPVTQAVEKVEGMIQCSGEATYMNDVLTTSNTLHCAFVGATKVGSTIDSID 574
            :|:||    .|.:..||...:....|:...:|||.:::|:......|..|.|.:|:..:.|.|:|
Mouse   566 IQMFQCVDPKQPQKDPVGHPIMHQSGIKHATGEAIFIDDMPPIDQELCLAVVTSTRAHAKITSLD 630

  Fly   575 ASEALKQPGVIAFYSAKDIPGTNTFCEPSFGFEVEEIFCSGLVRHSEQPAGVIVALTAD---QAH 636
            .||||..|||:...:|:|:||.|.. .....:...|:.|.|         .:|..:.||   .|.
Mouse   631 VSEALACPGVVDVITAEDVPGENDH-NGEILYAQSEVICVG---------QIICTVAADTYIHAK 685

  Fly   637 RAAKLVRISYSNPSSDFKLQPSLGDVFASPTPDSSRIVPASKSTSKKIKFS-EQPDKEVRGIFQM 700
            .|||.|:|:|.:      ::|::..: ......:|.:.|..|.....:.:: :..|:.|.|...:
Mouse   686 EAAKRVKIAYDD------IEPTIITI-EEALEHNSFLSPEKKIEQGNVDYAFKHVDQIVEGEIHV 743

  Fly   701 GLQYHFTMEPQTTVAIP-FED-GLKIFSATQWMDQTQSVIAHMLQVKAKDVQLQVRRLGGGYGSK 763
            ..|.||.||.||.:||| .|| .:.:...||:....|..::..|.|....:...::|.||.:|.|
Mouse   744 EGQEHFYMETQTILAIPQTEDKEMVLHLGTQFPTHVQEFVSAALNVPRSRIACHMKRAGGAFGGK 808

  Fly   764 ITRGNQVACAASLVAYKLNRPVRFVQSLESMMDCNGKRWACRSDYKCHIKDNGKIVGLTNDFYED 828
            :|:...:....::.|.|..||:||:......|.....|......||....:||:|.....::|.:
Mouse   809 VTKPALLGAVCAVAANKTGRPIRFILERSDDMLITAGRHPLLGKYKIGFMNNGEIRAADVEYYTN 873

  Fly   829 AGWSPNESP--IEGHSTFTAVNCYDLNGDNFKNNGNAVLTDAPSSTWCRAPGSVEGIAMIENIIE 891
            .|.:|:||.  || .....:.|.|.:  .||:..|.|..|:.||:|..|..|..:...::|..|.
Mouse   874 GGCTPDESELVIE-FVVLKSENTYHI--PNFRCRGRACKTNLPSNTAFRGFGFPQATVVVEAYIA 935

  Fly   892 HVAFEVQKDPAEVRLANIAAGNKISELLPQF------------LESREYAQRKKEIESHNAKNRW 944
            .||.:....|.|||..|:......:.....|            ||...:..|||..|..|..|.|
Mouse   936 AVASKCNLLPEEVREINMYKKTSKTAYKQTFNPEPLRRCWKECLEKSSFFARKKAAEEFNGNNYW 1000

  Fly   945 TKRGLGLAVMDY----PIFYFGQYPATVAIYHVDGTVVVTHGGIEMGQGMNTKVAQVAAYTLGID 1005
            .||||.:..|.:    ||.::.|..|.|.|: :||:|::||||.|:|||::||:.|||:..|.:.
Mouse  1001 KKRGLAVVPMKFSVAVPIAFYNQAAALVHIF-LDGSVLLTHGGCELGQGLHTKMIQVASRELNVP 1064

  Fly  1006 LSFIKVESSDTINGANSMVTGGAVGSESLCYAVRKACETLNSRLEPVKKKD--ASWIETVEAAYG 1068
            .|::....:.|....||..|.|::|::....||:.||:.|..||.|:.:|:  ..|.|.::.|:.
Mouse  1065 KSYVHFSETSTTTVPNSAFTAGSMGADINGKAVQNACQILMDRLRPIIRKNPKGKWEEWIKMAFE 1129

  Fly  1069 KSINLIASDHYK-----------KGDMQNYHIYGLALTEVELDVLTGNSQIKRVDILEDAGESLS 1122
            :||:|.|:.::|           :||...|::||.|.:|||:|.|||..::.|.||..||..|::
Mouse  1130 ESISLSATGYFKGYQTNMDWKKEEGDPYPYYVYGAACSEVEVDCLTGAHKLLRTDIFVDAAFSIN 1194

  Fly  1123 PWIDIGQIEGAFVMCLGYWMSEQLVYDRETGRLLTNRTWNYKPPGAKDIPIDFRIELIQKPNPSG 1187
            |.:||||:||||:..:|::.:|:|.|..: |.|.:....:||.|...:||.:|.:.|:...||
Mouse  1195 PALDIGQVEGAFIQGMGFYTTEELKYSPK-GVLYSRGPEDYKIPTITEIPEEFYVTLVHSRNP-- 1256

  Fly  1188 AGFMRSKATGEPPCCLAVSVVFALRQALDSARHDAGLPREWVRLGAPTTPETL 1240
            .....||..||....|..||:||:..|:.:||.:.|| .:...|.:|.|||.:
Mouse  1257 IAIYSSKGLGEAGMFLGSSVLFAIYDAVTTARKERGL-SDIFPLNSPATPEVI 1308

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.