DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX3 and Aox3

DIOPT Version :9

Sequence 1:	NP_001303439.1	Gene:	AOX3 / 41896	FlyBaseID:	FBgn0038349	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_076106.2	Gene:	Aox3 / 71724	MGIID:	1918974	Length:	1335	Species:	Mus musculus

Alignment Length:	1340	Identity:	397/1340 - (29%)
Similarity:	644/1340 - (48%)	Gaps:	148/1340 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FSINGLPYAVNLTNLPPDITLNTFIREHAQLTATKFMCQEGGCGACICVVRD----GKR--SWAV 63
            |.:||  ..|...|..|::.|..::|:..:||.||:.|..|.||||..::..    .||  .::.
Mouse    12 FFVNG--KKVTERNADPEVNLLFYLRKVIRLTGTKYGCGGGDCGACTVMISRYDPISKRISHFSA 74

  Fly    64 NSCLTLLNTCAQLEIVTAEGLGNQRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQNEGKV 128
            .:||..:.:.....:.|.||:|:.:|..:|:|:|:||.:|||||||:||.||::|.|: :|..:.
Mouse    75 TACLVPICSLHGAAVTTVEGIGSTKTRIHPVQERIAKGHGTQCGFCTPGMVMSIYTLL-RNHPEP 138

  Fly   129 TMAEVENSFGGNICRCTGYRPILDAMKSFAVDSNIA-IPAE---CGDIEDLKPRN----CPKTGQ 185
            :..::..:.|||:|||||||||:::.|||...|... :..|   |.|.|..:|..    |.|..:
Mouse   139 STEQIMETLGGNLCRCTGYRPIVESAKSFCPSSTCCQMNGEGKCCLDEEKNEPERKNSVCTKLYE 203

  Fly   186 ACSGSCLPST--LVYE-------------------DGVQWHWPKSLSELFDALDKVKDSEEFMLV 229
            ......|..|  |::.                   :...|..|.:|::|.:.  |:|.... .||
Mouse   204 KKEFQPLDPTQELIFPPELMRMAEESQNTVLTFRGERTTWIAPGTLNDLLEL--KMKHPSA-PLV 265

  Fly   230 AGNTAHGVYRRSTDIKH--FIDVQGVEELHQHSSEGQQLKLGANLSLTQTMEIIRTTSKQPGFEY 292
            .|||..|::.:.||:.:  .|....:.||...::..|.|.|||.|||||...::.....:...|.
Mouse   266 IGNTYLGLHMKFTDVSYPIIISPARILELFVVTNTKQGLTLGAGLSLTQVKNVLSDVVSRLPKEK 330

  Fly   293 LDV---LWNHIDLIANVPVRNSGTLAGNISIKKQNPEFPSDIFISFEALNVKVVALKNAADE--K 352
            ..:   |...:..:|...:||..:|.|:|..:....:....:.|....|||       |:.|  :
Mouse   331 TQIYCALLKQLKTLAGQQIRNVASLGGHIISRLPTSDLNPILGIGNCILNV-------ASTEGIQ 388

  Fly   353 EMSLAEYL--GTND-----KKLVLKTFVLPAYPKDKYIYESYKIMPRAQNAHAYVNAAFLLELEA 410
            ::.|.::.  |..|     :::::..|| |...|.::: .:::..||.|||.|.|||...:..:.
Mouse   389 QIPLNDHFLAGVPDAILKPEQVLISVFV-PRSSKWEFV-SAFRQAPRQQNAFATVNAGMKVVFKE 451

  Fly   411 D-NKVKSARICFGGIRPDFIHASAIEKLLVGQNPYESSLVEQTFTKLEDLIKPDEVLPDASPAYR 474
            | |.:....|.:|||....|.|....:.|:|: .::..:::.....:.:.:......|.....||
Mouse   452 DTNTITDLGILYGGIGATVISADKSCRQLIGR-CWDEEMLDDAGKMICEEVSLLMAAPGGMEEYR 515

  Fly   475 SKLACG---LFYKFLLKHAPV------AEVGEKFRSGGQILQR-PLSS--GLQVFQ----TQKKN 523
            ..||..   :||..:||....      .::.:|..   .||:. ||:.  |:|.||    .|...
Mouse   516 KTLAISFLFMFYLDVLKQLKTRDPHKYPDISQKLL---HILEDFPLTMPYGMQSFQDVDFQQPLQ 577

  Fly   524 YPVTQAVEKVEGMIQCSGEATYMNDVLTTSNTLHCAFVGATKVGSTIDSIDASEALKQPGVIAFY 588
            .|:.:.:....|:...:|||.:.:|:......|..|.|.::|..:.|.|:||||||...||:...
Mouse   578 DPIGRPIMHQSGIKHATGEAVFCDDMSVLPGELFLAVVTSSKSHAKIISLDASEALASLGVVDVV 642

  Fly   589 SAKDIPGTNTFCEPSFGFEVEEIFCSGLVRHSEQPAGVIVALTAD---QAHRAAKLVRISYSNPS 650
            :|:|:||.|...|.|. :..:|:.|.|         .::.|:.||   .|.:|||.|:|.|.:
Mouse   643 TARDVPGDNGREEESL-YAQDEVICVG---------QIVCAVAADSYAHAQQAAKKVKIVYQD-- 695

  Fly   651 SDFKLQPSLGDVFASPTPDSSRIVPASKSTSKKIKFSEQ-PDKEVRGIFQMGLQYHFTMEPQTTV 714
                ::|.:..| .......|.|.|..|.....::.:.| .|:.:.|...:|.|.||.||.|:..
Mouse   696 ----IEPMIVTV-QDALQYESFIGPERKLEQGNVEEAFQCADQILEGEVHLGGQEHFYMETQSVR 755

  Fly   715 AIP-FED-GLKIFSATQWMDQTQSVIAHMLQVKAKDVQLQVRRLGGGYGSKITRGNQVACAASLV 777
            .:| .|| .:.|:.::|....||.::|..|.:....:...|:|:||.:|.|.::...:|..|::.
Mouse   756 VVPKGEDKEMDIYVSSQDAAFTQEMVARTLGIPKNRINCHVKRVGGAFGGKASKPGLLASVAAVA 820

  Fly   778 AYKLNRPVRFVQSLESMMDCNGKRWACRSDYKCHIKDNGKIVGLTNDFYEDAGWSPNESP--IEG 840
            |.|..||:||:......|...|.|......||....:||||.......|.:.|.:|::|.  ||
Mouse   821 AQKTGRPIRFILERRDDMLITGGRHPLLGKYKIGFMNNGKIKAADIQLYINGGCTPDDSELVIE- 884

  Fly   841 HSTFTAVNCYDLNGDNFKNNGNAVLTDAPSSTWCRAPGSVEGIAMIENIIEHVAFEVQKDPAEVR 905
            ::.....|.|.:  .|.:..|....|:.||:|..|..|..:|..:.|..:..||.:.:..|.:||
Mouse   885 YALLKLENAYKI--PNLRVRGRVCKTNLPSNTAFRGFGFPQGAFVTETCMSAVAAKCRLPPEKVR 947

  Fly   906 LANIAA------------GNKISELLPQFLESREYAQRKKEIESHNAKNRWTKRGLGLAVMDYPI 958
            ..|:..            ...:.:.....:|:..|..|||.::..|.:..|.|||:.:..|.:.:
Mouse   948 ELNMYRTIDRTIHNQEFDPTNLLQCWEACVENSSYYNRKKAVDEFNQQRFWKKRGIAIIPMKFSV 1012

  Fly   959 -----FYFGQYPATVAIYHVDGTVVVTHGGIEMGQGMNTKVAQVAAYTLGIDLSFIKVESSDTIN 1018
                 ||: |..|.|.|| .||:|:|.|||:|:|||:|||:.|||:..|.|.:|:|.::...|:.
Mouse  1013 GFPKTFYY-QAAALVQIY-TDGSVLVAHGGVELGQGINTKMIQVASRELKIPMSYIHLDEMSTVT 1075

  Fly  1019 GANSMVTGGAVGSESLCYAVRKACETLNSRLEPVKKKDAS--WIETVEAAYGKSINLIASDHYK- 1080
            ..|::.||.:.|::....||:.||:.|..||||:.|::.|  |.|.|:.|:.:||:|.|:.:::
Mouse  1076 VPNTVTTGASTGADVNGRAVQNACQILMKRLEPIIKQNPSGTWEEWVKEAFVQSISLSATGYFRG 1140

  Fly  1081 ----------KGDMQNYHIYGLALTEVELDVLTGNSQIKRVDILEDAGESLSPWIDIGQIEGAFV 1135
                      :||:..|.::|.|.:|||:|.|||..:..|.||:.|...|::|.:||||||||||
Mouse  1141 YQADMDWEKGEGDIFPYFVFGAACSEVEIDCLTGAHKNIRTDIVMDGSFSINPAVDIGQIEGAFV 1205

  Fly  1136 MCLGYWMSEQLVYDRETGRLLTNRTWNYKPPGAKDIPIDFRIELIQKPNPSGAGFMRSKATGEPP 1200
            ..||.:..|:|.|..| |.|.|.....||.....|||.:|.:.|: .|.|:......||..||..
Mouse  1206 QGLGLYTLEELKYSPE-GVLYTRGPHQYKIASVTDIPEEFHVSLL-TPTPNPKAIYSSKGLGEAG 1268

  Fly  1201 CCLAVSVVFALRQALDSARHDAGLPREWVRLGAPTTPETL 1240
            ..|..||.||:..|:.:||.:.||...|. :.:|.|.|.:
Mouse  1269 TFLGCSVFFAIAAAVAAAREERGLSPIWA-INSPATAEVI 1307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX3	NP_001303439.1	PLN02906	24..1238	CDD:215491	390/1317 (30%)
		Fer2_2	80..153	CDD:280048	36/72 (50%)
		FAD_binding_4	201..360	CDD:303082	42/165 (25%)
		CO_deh_flav_C	386..487	CDD:281449	26/104 (25%)
		Ald_Xan_dh_C	540..646	CDD:214971	37/108 (34%)
		Ald_Xan_dh_C2	688..1172	CDD:280834	169/518 (33%)
Aox3	NP_076106.2	mam_aldehyde_ox	9..1334	CDD:132014	397/1340 (30%)
		Fer2_2	91..162	CDD:280048	36/71 (51%)
		FAD_binding_5	239..419	CDD:279309	47/190 (25%)
		CO_deh_flav_C	426..530	CDD:281449	26/104 (25%)
		Ald_Xan_dh_C	594..697	CDD:214971	38/118 (32%)
		Ald_Xan_dh_C2	709..1241	CDD:280834	173/537 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720