DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX3 and aox6

DIOPT Version :9

Sequence 1:	NP_001303439.1	Gene:	AOX3 / 41896	FlyBaseID:	FBgn0038349	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001265746.1	Gene:	aox6 / 570457	ZFINID:	ZDB-GENE-050208-742	Length:	1338	Species:	Danio rerio

Alignment Length:	1370	Identity:	421/1370 - (30%)
Similarity:	651/1370 - (47%)	Gaps:	178/1370 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NGLPYAVN-----LTNLPPDITLNTFIREHAQLTATKFMCQEGGCGAC-ICVVRDGKRS-----W 61
            :||.:.||     ..|..|:..|..::|:..:||.||:.|..|||||| |.|.|...::     .
Zfish     8 DGLIFYVNGKKIVEKNPDPETMLLPYLRKKLRLTGTKYSCGGGGCGACTIMVSRYDPQTKSISHL 72

  Fly    62 AVNSCLTLLNTCAQLEIVTAEGLGNQRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQNEG 126
            :||.||..:.......:.|.||:||.:|..:|:|:|:||.:|:|||||:||.||:||.|: :|..
Zfish    73 SVNGCLFPICHLHGAAVTTVEGIGNTKTKLHPVQERIAKAHGSQCGFCTPGMVMSMYTLL-RNNP 136

  Fly   127 KVTMAEVENSFGGNICRCTGYRPILDAMKSFAVDSNIAI-------------PAECGDIE----- 173
            ..|:.::.....||:|||||||||:|..::|....|..:             .||.|..|
Zfish   137 HPTLDDITECLAGNLCRCTGYRPIIDGYRTFCESENCCLLNGSTCNVLNGNGSAENGHAELFSKD 201

  Fly   174 DLKP--------------RNCPKTGQACSGSCLPSTLVYEDGVQWHWPKSLSELFDALDKVKDSE 224
            ||.|              |......|:....|       .:.:.|..|.||.||   |....|..
Zfish   202 DLLPLDPSQDLIFPPELMRMAEDKDQSIQRFC-------GERMTWISPGSLDEL---LQLKADYP 256

  Fly   225 EFMLVAGNTAHGVYRRSTDIKH--FIDVQGVEELHQ--HSSEGQQLKLGANLSLTQTMEIIRTTS 285
            :..||.|||..|:..:...|.|  .|....|.||.:  |.|||  :.:||..|::....::..|.
Zfish   257 QAPLVMGNTTIGLDMKFKGIFHPIIISPTRVPELFKVNHRSEG--VCVGAGCSMSDLKSVLEKTI 319

  Fly   286 KQ---PGFEYLDVLWNHIDLIANVPVRNSGTLAGNISIKKQNPEFPSDIFISFEALNVKVVAL-K 346
            ..   ........|...|:|:....:||..||.|||:....|    ||:.....|....:||| |
Zfish   320 NDFPPENTHTFRALLQQINLVGGQQIRNVATLGGNIASAYPN----SDLTPVLAAGRCTLVALSK 380

  Fly   347 NAADEKEMSLAEYLG-----TNDKKLVLKTFVLPAYPKDKYIYESYKIMPRAQNAHAYVNAAFLL 406
            :......:....:||     ...::::|..|: ||..:::.:: :::.:||.:||.|.:||...:
Zfish   381 DGRRRLPIDKDFFLGFAKTILKPEEILLSVFI-PATRQNEIVH-AFRHVPRKENALATLNAGMRV 443

  Fly   407 EL-EADNKVKSARICFGGIRPDFIHASAIEKLLVGQNPYESSLVEQTFTKLEDLIKPDEVLPDAS 470
            .| :..|.||...|.:||:....:.|....:.:||: |:|.:.:...::.|.|.:|.|...|...
Zfish   444 WLNDNSNVVKEISIYYGGVGATILSADHACQKIVGR-PWEEATLNDAYSALFDDVKLDPAAPGGK 507

  Fly   471 PAYRSKLACGLFYKF------LLKHAPV--AEVGEKFRSGGQILQRPLSSGLQVFQTQKKNYPVT 527
            ..:|..|...|.:||      .||...|  .||.::.:|..|.|.:.:..|.|.||    |....
Zfish   508 VDFRRSLTLSLLFKFHLLILQYLKEKDVIQMEVPQEMQSAIQPLPKRILPGYQEFQ----NVLED 568

  Fly   528 QAVEKVEG--------MIQCSGEATYMNDVLTTSNTLHCAFVGATKVGSTIDSIDASEALKQPGV 584
            |:.:.:.|        :.|.:|||.|.:|:..|...|..|.|.::|..:.|..||.|||||.|||
Zfish   569 QSAQDLVGRPMMHRSALSQATGEAVYCDDLPYTDGELVLAIVTSSKAHAKITHIDFSEALKLPGV 633

  Fly   585 IAFYSAKDIPGT--NTFCEPSFGFEVE-----EIFCSGLVRHSEQPAGVIVALTAD-QAH--RAA 639
            :...:||||||.  .||.    |::.|     |:.|.|         .:|.|:.|| :||  |.|
Zfish   634 VDVITAKDIPGKKFRTFT----GYDEELLAEDEVSCVG---------QMICAVVADSKAHAKRGA 685

  Fly   640 KLVRISYSN-PSSDFKLQPSL-GDVFASPTPDSSRIVPASKSTSKKIKFSEQPDKEVRGIFQMGL 702
            ..|::||.: ....|.|:.:: .:.|..|.....|     ....|.::.:||   ...|..::|.
Zfish   686 AAVKVSYEDLQDCIFTLEEAIEKESFFLPRRQIER-----GDVEKGLRDAEQ---VYEGEIRIGG 742

  Fly   703 QYHFTMEPQTTVAIPF--EDGLKIFSATQWMDQTQSVIAHMLQVKAKDVQLQVRRLGGGYGSKIT 765
            |.||.||.|:.:.:|.  |..:|::.:||....||..:|..|.:.:..|...|:||||.:|.|:|
Zfish   743 QEHFYMETQSFLVVPVGEEKEMKVYLSTQHPTYTQEAVAETLGIPSNRVTCHVKRLGGAFGGKVT 807

  Fly   766 RGNQVACAASLVAYKLNRPVRFVQSLESMMDCNGKRWACRSDYKCHIKDNGKIVGLTNDFYEDAG 830
            :...:|...:..|:|...|||.|......|...|.|......||.....||:|......:|.::|
Zfish   808 KTAILASITAAAAWKTGLPVRCVLERGEDMLITGGRHPVWGKYKVGFMKNGRITAADFQYYANSG 872

  Fly   831 WSPNESPIEGHSTFTAV-NCYDLNGDNFKNNGNAVLTDAPSSTWCRAPGSVEGIAMIENIIEHVA 894
            ...:||.:........: |.|::  .|.:....|..|:.||:|..|..|..:.:.:||::|:.||
Zfish   873 NKVDESVLVAEKILLHLDNAYNI--PNLRGRSAACRTNLPSNTAFRGFGVPQCMLVIESMIDDVA 935

  Fly   895 FEVQKDPAEVRLANIAAGNKISELLPQF------------LESREYAQRKKEIESHNAKNRWTKR 947
            .::.:.|.|:|..|:.....::....:|            :|..:::.|:|.|:..|.:|::.||
Zfish   936 LQLGRLPEEIREMNMYKQVSLTHYKMEFDPENLVRCWKECMEKSDFSHRRKAIDLFNQQNQFKKR 1000

  Fly   948 GLGLAVMDYPI-FYFGQYPATVAIYHV--DGTVVVTHGGIEMGQGMNTKVAQVAAYTLGIDLSFI 1009
            |:.:..:.|.| |..|......|:.|:  ||:|:|:|||.|||||::||:.|||:..|.|..|.|
Zfish  1001 GISIIPIKYGIGFAEGFLNQAAALVHIYKDGSVLVSHGGAEMGQGLHTKIQQVASRELNIPASLI 1065

  Fly  1010 KVESSDTINGANSMVTGGAVGSESLCYAVRKACETLNSRLEPVKKKD--ASWIETVEAAYGKSIN 1072
            .:..:.|....|:..:..:.|:::...||:.||:.|.:|||||:|||  .:|...:..|:.:.|:
Zfish  1066 HISETSTQCVPNTCPSAASFGTDANGMAVQDACQILYNRLEPVRKKDPKGTWQNWIMKAFLEKIS 1130

  Fly  1073 LIASDHYKKGDMQ-----------NYHIYGLALTEVELDVLTGNSQIKRVDILEDAGESLSPWID 1126
            |.|:.:|:..|:.           .|..|.:..:|||||.|||..:..|.||:.|.|.|::|.||
Zfish  1131 LSATGYYRGHDLDMDWEKQEGRPYAYFTYAVCCSEVELDCLTGEYRTLRTDIVVDIGRSINPSID 1195

  Fly  1127 IGQIEGAFVMCLGYWMSEQLVYDRETGRLLTNRTWNYKPPGAKDIPIDFRIELIQ-KPNPSGAGF 1190
            ||||||||...||.:..|:|.|. .:|.|.|.....||.|...|:|::|.:.|:. ..||.  ..
Zfish  1196 IGQIEGAFTQGLGLYTMEELKYS-PSGVLYTRGPGQYKIPAVCDVPLNFNVYLLAGSSNPH--AI 1257

  Fly  1191 MRSKATGEPPCCLAVSVVFALRQALDSARHDAGLPREWVRLGAPTTPE----------TLVVNAG 1245
            ..||..|||...|..||.||::.|:.:||.||||...: :|.:|.|||          |.:|.|.
Zfish  1258 YSSKGIGEPTLFLGSSVFFAIKDAVTAARKDAGLTGPF-QLNSPATPERACLACATRFTNMVVAQ 1321

  Fly  1246 HEAAS 1250
            :|..|
Zfish  1322 NEPVS 1326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX3	NP_001303439.1	PLN02906	24..1238	CDD:215491	408/1325 (31%)
		Fer2_2	80..153	CDD:280048	37/72 (51%)
		FAD_binding_4	201..360	CDD:303082	46/166 (28%)
		CO_deh_flav_C	386..487	CDD:281449	29/107 (27%)
		Ald_Xan_dh_C	540..646	CDD:214971	43/115 (37%)
		Ald_Xan_dh_C2	688..1172	CDD:280834	165/514 (32%)
aox6	NP_001265746.1	mam_aldehyde_ox	10..1338	CDD:132014	420/1368 (31%)
		Fer2_2	91..162	CDD:280048	37/71 (52%)
		FAD_binding_5	235..414	CDD:279309	50/188 (27%)
		CO_deh_flav_C	422..524	CDD:281449	29/103 (28%)
		Ald_Xan_dh_C	589..695	CDD:214971	45/118 (38%)
		Ald_Xan_dh_C2	708..1240	CDD:280834	169/542 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720