DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX3 and xdh

DIOPT Version :9

Sequence 1:	NP_001303439.1	Gene:	AOX3 / 41896	FlyBaseID:	FBgn0038349	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_688983.3	Gene:	xdh / 560486	ZFINID:	ZDB-GENE-070719-9	Length:	1351	Species:	Danio rerio

Alignment Length:	1358	Identity:	414/1358 - (30%)
Similarity:	663/1358 - (48%)	Gaps:	176/1358 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FSINGLPYAVNLTNLPPDITLNTFIREHAQLTATKFMCQEGGCGACICVV------RDGKRSWAV 63
            |.:||  ..:...|..|:|||.|::|....||.||..|.|||||||..:|      ::....:|:
Zfish    21 FFVNG--KKITEKNADPEITLLTYLRRSLGLTGTKLGCAEGGCGACTVMVSKYHPNQNRIIHYAI 83

  Fly    64 NSCLTLLNTCAQLEIVTAEGLGNQRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQNEGKV 128
            |:||..|.:.....:.|.||:|:..:..:|:|:|:||.:|:|||||:||.||:||.|: :|..:.
Zfish    84 NACLAPLCSLHHCAVTTVEGIGSVASKLHPVQERIAKAHGSQCGFCTPGIVMSMYALL-RNNPQP 147

  Fly   129 TMAEVENSFGGNICRCTGYRPILDAMKSFAVDSNIAIPAECGDIEDLKPRNCPKTG---QACSGS 190
            ||.:::.:|.||:||||||||||:..::|..|...     ||.  ..:...|..|.   |....|
Zfish   148 TMHDIQEAFQGNLCRCTGYRPILEGYRTFTKDGGC-----CGG--KSQTNGCCMTNGNTQEHENS 205

  Fly   191 CLPSTLVYE----------------------------------DGVQWHWPKSLSELFDALDKVK 221
            ..|...:|:                                  :.|.|..|.||.||.:......
Zfish   206 AHPVQHLYDQSEFMPLDPTQEIIFPPELVSLSKQTQREMRFVGERVLWIQPCSLKELLELKATYP 270

  Fly   222 DSEEFMLVAGNTAHGVYRRSTDIKH--FIDVQGVEELH--QHSSEGQQLKLGANLSLTQTMEIIR 282
            :::   ||.|||..|:..:..::.:  .:....:.||:  ||:.:|  :::||:::||...::::
Zfish   271 NAK---LVVGNTEVGIEMKFKNLLYPVILAPAYIPELNIIQHTQDG--IEVGASVTLTVLGDVLQ 330

  Fly   283 TTSKQ-PGF--EYLDVLWNHIDLIANVPVRNSGTLAGNISIKKQNPEFP-SDIFISFEALNVKVV 343
            :..|: |.:  |....:...:...|...:||...:.|||....     | ||:...|.|...|:.
Zfish   331 SAVKKLPAYQTEVFKAVLEQLRWFAGQQIRNVAAVGGNIMTAS-----PISDLNPVFMAAGCKLT 390

  Fly   344 ALKNAADEKEMSLAEYLGTNDKKLVLK------TFVLPAYPKDKYIYESYKIMPRAQNAHAYVNA 402
            .: :..:::.:.:.:...|..:|..||      :..:|...|.:| :.::|..||.::..:.|..
Zfish   391 VM-SKGEKRVLEMDDKFFTGYRKTALKPEEILLSIEIPYTKKGQY-FSAFKQSPRKEDDISIVTC 453

  Fly   403 AFLLEL-EADNKVKSARICFGGIRPDFIHASA-IEKLLVGQNPYESSLVEQTFTKLEDLIKPDEV 465
            ...:.. |..|.|:|.||.:||:.|..:.|:| ..|||..|  :...|:|:..:.|.:.:.....
Zfish   454 GMNVYFKEQSNTVQSIRISYGGMAPVTVLATATCNKLLNRQ--WNEDLLEEACSSLAEEMSLSPS 516

  Fly   466 LPDASPAYRSKLACGLFYKFLL--KH----------APVAEVGEKFRSGGQILQRPLSSGLQVFQ 518
            .|.....||..|...|||||.|  :|          ..|.::..:|.:..::.|....|.:|::|
Zfish   517 APGGMVTYRRTLTISLFYKFFLTVQHKLAVSLQMEGVTVEDIQPEFSTATELFQVDTPSSVQLYQ 581

  Fly   519 T----QKKNYPVTQAVEKVEGMIQCSGEATYMNDVLTTSNTLHCAFVGATKVGSTIDSIDASEAL 579
            .    |.::..|...:..:..:.|.:|||.|.:|:....|.||.|.|.:||..:.|.|||.|.|:
Zfish   582 EVPPGQNEDDVVGHPIIHLSALKQATGEAVYCDDMPCYENELHLALVTSTKAHALIKSIDTSSAM 646

  Fly   580 KQPGVIAFYSAKDIPGTN-----TFCEPSFGFEVEEIFCSGLVRHSEQPAGVIVALTADQAHRAA 639
            ..|||:||.|||||||:|     .:.|..|.  .:::.|.|.:      .|.|||.|...|.|||
Zfish   647 SVPGVVAFISAKDIPGSNMTGPVVYDETVFA--DDKVTCVGHI------VGAIVADTQAHAQRAA 703

  Fly   640 KLVRISYSNPSSDFKLQPSLGDV--------FASP--TPDSSRIVPASKSTSKKIKFSEQPDKEV 694
            |:|:|||.      :|:|.:..:        |..|  |.:...:....|.:          |..:
Zfish   704 KVVKISYE------ELKPVIVTIQDAINNKSFFEPVRTIEKGDVAQGFKDS----------DHIL 752

  Fly   695 RGIFQMGLQYHFTMEPQTTVAIP-FEDG-LKIFSATQWMDQTQSVIAHMLQVKAKDVQLQVRRLG 757
            .|...:|.|..|.:|...|:|:| .||| :::|.:||...:||:::|..|.|.|..|..:|:|:|
Zfish   753 HGEMHIGGQEQFYLETNCTLAVPRGEDGEMELFVSTQSASKTQALVAKALGVPANRVVCRVKRMG 817

  Fly   758 GGYGSKITRGNQVACAASLVAYKLNRPVRFVQSLESMMDCNGKRWACRSDYKCHIKDNGKIVGLT 822
            ||:|.|.:|...::...::.|.|:..|||.:...:..|...|.|......||.....||:::.|.
Zfish   818 GGFGGKESRSTILSTVVAVAAQKVKCPVRCMLDRDEDMLVTGGRHPFFGQYKVGFMKNGRVMALE 882

  Fly   823 NDFYEDAGWSPNES-PIEGHSTFTAVNCYDLNGDNFKNNGNAVLTDAPSSTWCRAPGSVEGIAMI 886
            ...|.:||.|.:.| .|...:.|...|.|::  .|....|....|:.||::..|..|..:|:.:.
Zfish   883 VTLYSNAGNSLDLSLSILERALFHMDNSYNI--PNICGTGYMCKTNLPSNSAFRGFGGPQGMMIA 945

  Fly   887 ENIIEHVAFEVQKDPAEVRLANIAAGNKI---SELLPQFLESR---------EYAQRKKEIESHN 939
            |:.:..||........|||..|:.....:   ::.|.||..:|         ::.:||..:|.:|
Zfish   946 ESWMSDVALSCGLPAEEVRRMNMYNEGDLTHFNQRLDQFTIARCWEECMQLSDFNKRKDAVEKYN 1010

  Fly   940 AKNRWTKRGLGLAVMDYPI----FYFGQYPATVAIYHVDGTVVVTHGGIEMGQGMNTKVAQVAAY 1000
            .::|||||||.:....:.|    .:..|..|.|.:|. ||:|::||||.|||||::||:.|||:.
Zfish  1011 RQHRWTKRGLSIIPTKFGISFTAVFLNQAGALVHVYS-DGSVLLTHGGTEMGQGLHTKMVQVASK 1074

  Fly  1001 TLGIDLSFIKVESSDTINGANSMVTGGAVGSESLCYAVRKACETLNSRLEPVKKKD--ASWIETV 1063
            ||.|..:.|.:..:.|....|:..|..:..|:....||..||:|:..||:|.|:|:  ..|.:.|
Zfish  1075 TLEIPCTKIHITETSTSTVPNTSPTAASASSDLNGMAVYNACQTILQRLQPFKEKNPKGCWEDWV 1139

  Fly  1064 EAAYGKSINLIASDHYKKGDMQ-----------NYHIYGLALTEVELDVLTGNSQIKRVDILEDA 1117
            .|||...:||.|:..||..|:.           ||..||:|::|||:|.|||:.:.....|:.|.
Zfish  1140 TAAYFDRVNLSANGFYKTPDLGYDFDTNSGRPFNYFSYGVAVSEVEIDCLTGSHKNLHTSIVMDV 1204

  Fly  1118 GESLSPWIDIGQIEGAFVMCLGYWMSEQLVYDRETGRLLTNRTWNYKPPGAKDIPIDFRIELIQK 1182
            |:||:|.:||||:||.|:..||.:..|:|.|..: |.|.|.....||.|...|||.:.::.|: :
Zfish  1205 GKSLNPALDIGQVEGGFMQGLGLFTLEELRYSPD-GYLYTRGPGMYKIPAFGDIPSELKVSLL-R 1267

  Fly  1183 PNPSGAGFMRSKATGEPPCCLAVSVVFALRQALDSARHDAGLPREWVRLGAPTTPETL 1240
            ..|:......|||.||||..||.||.:|::.|:.:||.::||...: ||.:|.|||.:
Zfish  1268 DAPNDKAIFSSKAVGEPPLFLAASVFYAIKDAITAARAESGLTGPF-RLDSPATPERI 1324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX3	NP_001303439.1	PLN02906	24..1238	CDD:215491	406/1335 (30%)
		Fer2_2	80..153	CDD:280048	38/72 (53%)
		FAD_binding_4	201..360	CDD:303082	37/166 (22%)
		CO_deh_flav_C	386..487	CDD:281449	31/102 (30%)
		Ald_Xan_dh_C	540..646	CDD:214971	47/110 (43%)
		Ald_Xan_dh_C2	688..1172	CDD:280834	170/515 (33%)
xdh	XP_688983.3	fer2	20..92	CDD:238126	28/72 (39%)
		PLN02906	36..1336	CDD:215491	409/1341 (30%)
		Fer2_2	100..171	CDD:280048	37/71 (52%)
		FAD_binding_5	253..428	CDD:279309	40/185 (22%)
		CO_deh_flav_C	436..540	CDD:281449	32/105 (30%)
		Ald_Xan_dh_C	607..714	CDD:279635	49/120 (41%)
		Ald_Xan_dh_C2	734..1258	CDD:280834	172/537 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720