back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX3 and Aox1

DIOPT Version :9

Sequence 1:	NP_001303439.1	Gene:	AOX3 / 41896	FlyBaseID:	FBgn0038349	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_062236.3	Gene:	Aox1 / 54349	RGDID:	620528	Length:	1333	Species:	Rattus norvegicus

Alignment Length:	1364	Identity:	383/1364 - (28%)
Similarity:	623/1364 - (45%)	Gaps:	193/1364 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FSINGLPYAVNLTNLPPDITLNTFIREHAQLTATKFMCQEGGCGACICVV------RDGKRSWAV 63
            |.:||.....|  |:.|::.|..::|::.:||.||:.|..||||||..::      ....|...|
  Rat     8 FYVNGQKVVEN--NVDPEMMLLPYLRKNLRLTGTKYGCGGGGCGACTVMISRYNPSTKSIRHHPV 70

  Fly    64 NSCLTLLNTCAQLEIVTAEGLGNQRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQNEGKV 128
            |:|||.:.:.....:.|.||:||.||..:|:|:|:||.:|||||||:||.||:||.|: :|..:.
  Rat    71 NACLTPICSLYGTAVTTVEGIGNTRTRLHPVQERIAKCHGTQCGFCTPGMVMSMYALL-RNHPEP 134

  Fly   129 TMAEVENSFGGNICRCTGYRPILDAMKSF---------------AVDSNIAIPAECGDIEDLKP- 177
            ::.::.::.|||:|||||||||:||.|:|               .:|..|...||..:.::..|
  Rat   135 SLDQLTDALGGNLCRCTGYRPIIDACKTFCRASGCCESKENGVCCLDQGINGSAEFQEGDETSPE 199

  Fly   178 ---------------------------RNCPKTGQACSGSCLPSTLVYEDGVQWHWPKSLSELFD 215
                                       :..|||           .:.|.:.:.|..|.:|.||.:
  Rat   200 LFSEKEFQPLDPTQELIFPPELMRIAEKQPPKT-----------RVFYSNRMTWISPVTLEELVE 253

  Fly   216 ALDKVKDSEEFMLVAGNTAHGVYRRSTDIKH--FIDVQGVEELHQHSSEGQQLKLGANLSLTQTM 278
            |..|...:.   :|.|.|:.|...:...:.|  .|....:|||...:..|..|.|||.|||.|..
  Rat   254 AKFKYPGAP---IVMGYTSVGPEVKFKGVFHPIIISPDRIEELSIINQTGDGLTLGAGLSLDQVK 315

  Fly   279 EIIR-TTSKQP--GFEYLDVLWNHIDLIANVPVRNSGTLAGNISIKKQNPEFPSDIFISFEALNV 340
            :|:. ...|.|  ..:....|..|:..:|...:||..:|.|:|..:..:.:....:.:....||
  Rat   316 DILTDVVQKLPEETTQTYRALLKHLRTLAGSQIRNMASLGGHIVSRHLDSDLNPLLAVGNCTLN- 379

  Fly   341 KVVALKNAADEKEMSLAEYL----GTNDKK--LVLKTFVLPAYPKDKYIYESYKIMPRAQNAHAY 399
                |.:...::::.|:|..    ..:|.|  .||.:..:|...|.::: .:::...|.|||.|.
  Rat   380 ----LLSKDGKRQIPLSEQFLRKCPDSDLKPQEVLVSVNIPCSRKWEFV-SAFRQAQRQQNALAI 439

  Fly   400 VNAAF-LLELEADNKVKSARICFGGIRPDFIHASAIEKLLVGQNPYESSLVEQTFTKLEDLIKPD 463
            ||:.. :|..|....:|...|.:||:.|..|.|....:.|:|: |:...:::.....:.|.:...
  Rat   440 VNSGMRVLFREGGGVIKELSILYGGVGPTTIGAKNSCQKLIGR-PWNEEMLDTACRLVLDEVTLA 503

  Fly   464 EVLPDASPAYRSKLACGLFYKFLLK-----------HAPVAEVGEKFRSGGQILQ-----RPLSS 512
            ...|.....::..|.....:||.|:           |.|  .:...:.|..:.|.     |.|:.
  Rat   504 GSAPGGKVEFKRTLIISFLFKFYLEVLQGLKREDPGHYP--SLTNNYESALEDLHSKHHWRTLTH 566

  Fly   513 GLQVFQTQKKNYPVTQAVEKVEGMIQCSGEATYMNDVLTTSNTLHCAFVGATKVGSTIDSIDASE 577
             ..|...|....|:.:.:..:.|:...:|||.|.:|:......|...||.:::..:.|.|||.||
  Rat   567 -QNVDSMQLPQDPIGRPIMHLSGIKHATGEAIYCDDMPAVDRELFLTFVTSSRAHAKIVSIDLSE 630

  Fly   578 ALKQPGVIAFYSAKDIPGTNTFCEPSFGFE----VEEIFCSGLVRHSEQPAGVIVALTADQAHRA 638
            ||..|||:...:|..:..|.|     ||.|    .:::.|.|      |....::|.:..:|.:|
  Rat   631 ALSLPGVVDIITADHLQDTTT-----FGTETLLATDKVHCVG------QLVCAVIADSETRAKQA 684

  Fly   639 AKLVRISYSNPSSDFKLQPSLGDVFASPTPDSSRIVPASKSTSKKIKFSEQ-------------- 689
            ||.|::.|.:      |:|              .|:...::...|..|..:
  Rat   685 AKHVKVVYRD------LEP--------------LILTIEEAIQHKSFFESERKLECGNVDEAFKI 729

  Fly   690 PDKEVRGIFQMGLQYHFTMEPQTTVAIP-FEDG-LKIFSATQWMDQTQSVIAHMLQVKAKDVQLQ 752
            .|:.:.|...:|.|.||.||.|:.:.:| .||| :.|:.:||:....|.::|..|::....|...
  Rat   730 ADQILEGEIHIGGQEHFYMETQSMLVVPKGEDGEIDIYVSTQFPKHIQDIVAATLKLSVNKVMCH 794

  Fly   753 VRRLGGGYGSKITRGNQVACAASLVAYKLNRPVRFVQSLESMMDCNGKRWACRSDYKCHIKDNGK 817
            |||:||.:|.|:.:.:.:|...:..|.|..|.||........|...|.|......||.....:|:
  Rat   795 VRRVGGAFGGKVGKTSIMAAITAFAASKHGRAVRCTLERGEDMLITGGRHPYLGKYKVGFMRDGR 859

  Fly   818 IVGLTNDFYEDAGWSPNES--PIEGHSTFTAVNCYDLNGDNFKNNGNAVLTDAPSSTWCRAPGSV 880
            ||.|..:.|.:.|.|.:||  .|| .......|.|..  .|.:..|.|..|:.||:|..|..|..
  Rat   860 IVALDVEHYCNGGSSLDESLWVIE-MGLLKMDNAYKF--PNLRCRGWACRTNLPSNTALRGFGFP 921

  Fly   881 EGIAMIENIIEHVAFEVQKDPAEVRLANI------------AAGNKISELLPQFLESREYAQRKK 933
            :...:.|..:..||......|.:||..|:            .:...:.|...:.:....|::||.
  Rat   922 QAGLVTEACVTEVAIRCGLSPEQVRTINMYKQIDNTHYKQEFSAKTLFECWRECMAKCSYSERKT 986

  Fly   934 EIESHNAKNRWTKRGLGLAVMDYPI----FYFGQYPATVAIYHVDGTVVVTHGGIEMGQGMNTKV 994
            .:...||:|.|.|||:.:..:.:|:    ...||..|.|.|| :||:.:|:|||||||||::||:
  Rat   987 AVGKFNAENSWKKRGMAVIPLKFPVGVGSVAMGQAAALVHIY-LDGSALVSHGGIEMGQGVHTKM 1050

  Fly   995 AQVAAYTLGIDLSFIKVESSDTINGANSMVTGGAVGSESLCYAVRKACETLNSRLEPV--KKKDA 1057
            .||.:..|.:.:|.:.:..:.|....|:..:||:|.::....||:.||:||..||||:  |....
  Rat  1051 IQVVSRELKMPMSSVHLRGTSTETVPNTNASGGSVVADLNGLAVKDACQTLLKRLEPIISKNPQG 1115

  Fly  1058 SWIETVEAAYGKSINLIASDHYK-----------KGDMQNYHIYGLALTEVELDVLTGNSQIKRV 1111
            :|.:..:.|:.:|::|.|..:::           :|....|.:||.|.:|||:|.|||:.:..|.
  Rat  1116 TWKDWAQTAFDQSVSLSAVGYFRGYESNINWEKGEGHPFEYFVYGAACSEVEIDCLTGDHKNIRT 1180

  Fly  1112 DILEDAGESLSPWIDIGQIEGAFVMCLGYWMSEQLVYDRETGRLLTNRTWNYKPPGAKDIPIDFR 1176
            ||:.|.|.|::|.:||||:||||:..:|.:..|:|.|..: |.|.:.....||.|...|||.:..
  Rat  1181 DIVMDVGHSINPALDIGQVEGAFIQGMGLYTIEELSYSPQ-GILYSRGPNQYKIPAICDIPTEMH 1244

  Fly  1177 IELIQKPNPSGAGFMRSKATGEPPCCLAVSVVFALRQALDSARHDAGLPREWVRLGAPTTPETL 1240
            |..: .|:........||..||....|..||.||:..|:.:||.:.|:...| :|.:|.|||.:
  Rat  1245 ISFL-PPSEHSNTLYSSKGLGESGVFLGCSVFFAIHDAVRAARQERGISGPW-KLTSPLTPEKI 1306

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.