DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX3 and Aox3

DIOPT Version :9

Sequence 1:	NP_001303439.1	Gene:	AOX3 / 41896	FlyBaseID:	FBgn0038349	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001008527.2	Gene:	Aox3 / 493909	RGDID:	1359328	Length:	1334	Species:	Rattus norvegicus

Alignment Length:	1340	Identity:	385/1340 - (28%)
Similarity:	649/1340 - (48%)	Gaps:	149/1340 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FSINGLPYAVNLTNLPPDITLNTFIREHAQLTATKFMCQEGGCGACICVVRD----GKR--SWAV 63
            |.:||  ..|...|..|::.|..::|:..|||.||:.|..|.||||..::..    .|:  .::.
  Rat    12 FFVNG--KKVIERNADPEVNLLFYLRKIIQLTGTKYGCGGGDCGACTVMISRYNPISKKISHFSA 74

  Fly    64 NSCLTLLNTCAQLEIVTAEGLGNQRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQNEGKV 128
            .:||..:.:.....:.|.||:|:.:|..:|:|:|:||.:|||||||:||.||::|.|: :|..:.
  Rat    75 AACLVPICSLHGAAVTTVEGIGSTKTRIHPVQERIAKGHGTQCGFCTPGMVMSIYTLL-RNHPEP 138

  Fly   129 TMAEVENSFGGNICRCTGYRPILDAMKSFAVDS----------------------NIAIPAECGD 171
            :..::..:.|||:|||||||||:::.:||:.:|                      ..::..:..:
  Rat   139 STEQIMETLGGNLCRCTGYRPIVESARSFSPNSACCPMNEKWKCCLDEGKNEPERKNSVCTKLYE 203

  Fly   172 IEDLKPRN-------CPKTGQACSGSCLPSTLVYEDGVQWHW--PKSLSELFDALDKVKDSEEFM 227
            .|:.:|.:       .|:..:....|  |:|::...|.:..|  |.:|::|   |:...:.....
  Rat   204 KEEFQPLDPTQELIFPPELMRMAEDS--PNTVLTFRGERTTWIAPGTLNDL---LELKMEYPSAP 263

  Fly   228 LVAGNTAHGVYRRSTDIKH--FIDVQGVEELHQHSSEGQQLKLGANLSLTQTMEIIR-TTSKQP- 288
            ||.|||..|:..:..|:.:  .|....:.||...::..:.|.|||.|||||...|:. ..|:.|
  Rat   264 LVIGNTCLGLDMKFKDVSYPIIISPARILELFVVTNTNEGLTLGAGLSLTQVKNILSDVVSRLPK 328

  Fly   289 -GFEYLDVLWNHIDLIANVPVRNSGTLAGNISIKKQNPEFPSDIFISFEALNVKVVALKNAADE- 351
             ..:....|..|:..:|...:||..:|.|:|..:...    ||:...|...|.|   |..|:.|
  Rat   329 ERTQTYRALLKHLRTLAGQQIRNVASLGGHIISRLPT----SDLNPIFGVGNCK---LNVASTEG 386

  Fly   352 -KEMSLAEYLGTNDKKLVLK------TFVLPAYPKDKYIYESYKIMPRAQNAHAYVNAAFLLELE 409
             :::.|.::......:.:||      :..:|...|.::: .:::..||.|||.|.|||...:..:
  Rat   387 TQQIPLNDHFLAGVPEAILKPEQVLISVFVPLSRKWEFV-SAFRQAPRQQNAFAIVNAGMRVAFK 450

  Fly   410 AD-NKVKSARICFGGIRPDFIHASAIEKLLVGQNPYESSLVEQTFTKLEDLIKPDEVLPDASPAY 473
            .| |.:....|.:|||....:.|.:.:: |:|: .::..:::.....:.:.:......|.....|
  Rat   451 EDTNTITDLSILYGGIGATVVSAKSCQQ-LIGR-CWDEEMLDDAGRMIREEVSLLTAAPGGMVEY 513

  Fly   474 RSKLACGLFYKFLL-------KHAP--VAEVGEKFRSGGQILQR-PLS--SGLQVFQ----TQKK 522
            |..||....:||.|       :..|  ..::.:|..   |:|:. ||:  .|.|.|:    .|..
  Rat   514 RKTLAISFLFKFYLDVLKQLKRRNPHRCPDISQKLL---QVLEDFPLTMPHGTQSFKDVDSQQPL 575

  Fly   523 NYPVTQAVEKVEGMIQCSGEATYMNDVLTTSNTLHCAFVGATKVGSTIDSIDASEALKQPGVIAF 587
            ..||.:.:....|:...:|||.:.:|:...:..|..|.|.::|..:.|.|:||||||..|||:..
  Rat   576 QDPVGRPIMHQSGIKHATGEAVFCDDMSVLAGELFLAVVTSSKPHARIISLDASEALASPGVVDV 640

  Fly   588 YSAKDIPGTNTFCEPSFGFEVEEIFCSGLVRHSEQPAGVIVALTAD---QAHRAAKLVRISYSNP 649
            .:|:|:||.|...|.|. :..:|:.|.|         .::.|:.||   :|.:|.|.|:|.|.:
  Rat   641 ITAQDVPGDNGREEESL-YAQDEVICVG---------QIVCAVAADSYARAKQATKKVKIVYED- 694

  Fly   650 SSDFKLQPSLGDVFASPTPDSSRIVPASKSTSKKIKFS-EQPDKEVRGIFQMGLQYHFTMEPQTT 713
                 ::|.:..| .......|.|.|..|.....::.: :..|:.:.|...:|.|.||.||.|:.
  Rat   695 -----MEPMIVTV-QDALQHESFIGPEKKLEQGNVQLAFQSADQILEGEVHLGGQEHFYMETQSV 753

  Fly   714 VAIPFEDGLK--IFSATQWMDQTQSVIAHMLQVKAKDVQLQVRRLGGGYGSKITRGNQVACAASL 776
            ..||..:.::  |:.::|....||.::|..|.:....:...|:|:||.:|.|.::...:|..|::
  Rat   754 RVIPKGEDMEMDIYVSSQDAAFTQEMVARTLGIPKNRITCHVKRVGGAFGGKTSKPGLLASVAAV 818

  Fly   777 VAYKLNRPVRFVQSLESMMDCNGKRWACRSDYKCHIKDNGKIVGLTNDFYEDAGWSPNESP--IE 839
            .|.|..||:||:......|...|.|......|:....:||||.......|.:.|.:|::|.  ||
  Rat   819 AAQKTGRPIRFILERGDDMLITGGRHPLLGKYRVGFMNNGKIKAADIQLYINGGCTPDDSELVIE 883

  Fly   840 GHSTFTAVNCYDLNGDNFKNNGNAVLTDAPSSTWCRAPGSVEGIAMIENIIEHVAFEVQKDPAEV 904
             ::.....|.|.:  .|.:..|....|:.||:|..|..|..:|..:.|..:..||.:....|.:|
  Rat   884 -YALLKLENAYKI--PNLRVRGRVCKTNLPSNTAFRGFGFPQGAFVTETWVSAVAAKCHLPPEKV 945

  Fly   905 RLANIAA------------GNKISELLPQFLESREYAQRKKEIESHNAKNRWTKRGLGLAVM--- 954
            |..|:..            ...:.:.....:|:..|..|||.::..|.::.|.|||:.:..|
  Rat   946 RELNMYKTIDRTIHKQEFDPTNLIKCWETCMENSSYYSRKKAVDEFNQQSFWKKRGIAIIPMKFS 1010

  Fly   955 -DYPIFYFGQYPATVAIYHVDGTVVVTHGGIEMGQGMNTKVAQVAAYTLGIDLSFIKVESSDTIN 1018
             .:|..::.|..|.|.|| .||:|:|.|||:|:|||:|||:.|||:..|.|.:|:|.::..:|:.
  Rat  1011 VGFPKTFYHQAAALVQIY-TDGSVLVAHGGVELGQGINTKMIQVASRELKIPMSYIHLDEMNTMT 1074

  Fly  1019 GANSMVTGGAVGSESLCYAVRKACETLNSRLEPV--KKKDASWIETVEAAYGKSINLIASDHYK- 1080
            ..|::.|||:.|::....||:.||:.|..||||:  :..:..|.|.:..|:.:||:|.|:.:::
  Rat  1075 VPNTITTGGSTGADVNGRAVQNACQILMKRLEPIISQNPNGDWEEWINEAFIQSISLSATGYFRG 1139

  Fly  1081 ----------KGDMQNYHIYGLALTEVELDVLTGNSQIKRVDILEDAGESLSPWIDIGQIEGAFV 1135
                      :||:..|.::|.|.:|||:|.|||..:..|.||:.|...|::|.:||||||||||
  Rat  1140 YQADMDWEKGEGDIYPYFVFGAACSEVEIDCLTGAHKNIRTDIVMDGSFSINPAVDIGQIEGAFV 1204

  Fly  1136 MCLGYWMSEQLVYDRETGRLLTNRTWNYKPPGAKDIPIDFRIELIQKPNPSGAGFMRSKATGEPP 1200
            ..||.:..|:|.|..| |.|.|.....||.....|||.:|.:.|: .|..:......||..||..
  Rat  1205 QGLGLYTLEELKYSPE-GVLYTRGPHQYKIASVSDIPEEFHVSLL-TPTQNPKAIYSSKGLGEAG 1267

  Fly  1201 CCLAVSVVFALRQALDSARHDAGLPREWVRLGAPTTPETL 1240
            ..|..||.||:..|:.:||.:.|||. .:.:.:|.|.|.:
  Rat  1268 MFLGSSVFFAIAAAVAAARKERGLPL-ILAINSPATAEVI 1306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX3	NP_001303439.1	PLN02906	24..1238	CDD:215491	378/1317 (29%)
		Fer2_2	80..153	CDD:280048	36/72 (50%)
		FAD_binding_4	201..360	CDD:303082	45/167 (27%)
		CO_deh_flav_C	386..487	CDD:281449	25/101 (25%)
		Ald_Xan_dh_C	540..646	CDD:214971	37/108 (34%)
		Ald_Xan_dh_C2	688..1172	CDD:280834	163/516 (32%)
Aox3	NP_001008527.2	mam_aldehyde_ox	9..1333	CDD:132014	385/1340 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820