DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX3 and AOX2

DIOPT Version :9

Sequence 1:	NP_001303439.1	Gene:	AOX3 / 41896	FlyBaseID:	FBgn0038349	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_732047.2	Gene:	AOX2 / 41895	FlyBaseID:	FBgn0038348	Length:	1264	Species:	Drosophila melanogaster

Alignment Length:	1277	Identity:	749/1277 - (58%)
Similarity:	961/1277 - (75%)	Gaps:	37/1277 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTKFSINGLPYAVNLTNLPPDITLNTFIREHAQLTATKFMCQEGGCGACICVVR------DGKR 59
            |:.||::||.||.|...:.|||.|||||:|||..|||||:||.|||||:|:||:|      ...:
  Fly     1 MSIKFNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQ 65

  Fly    60 SWAVNSCLTLLNTCAQLEIVTAEGLGNQRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQN 124
            |.|.||||||||||...||:|.||||||.:||:|||||:|:|||||||:||||||||||||:||:
  Fly    66 SRAANSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQH 130

  Fly   125 EGKVTMAEVENSFGGNICRCTGYRPILDAMKSFAVDSNIAIPAECGDIEDLKPRNCPKTGQACSG 189
            .|:|:|::||::||||:|||||||||||||||||||||:.:|||..||||.....||:|||:|.|
  Fly   131 RGQVSMSQVEDAFGGNLCRCTGYRPILDAMKSFAVDSNVEVPAESVDIEDSFELLCPRTGQSCKG 195

  Fly   190 SCLPSTLVYEDGVQWHWPKSLSELFDALDKVKDSEEFMLVAGNTAHGVYRRSTDIKHFIDVQGVE 254
            ||....|......||:|||:|:|||.||.:|.:.|.:||||||||||||||..||:|||||..|.
  Fly   196 SCSRPPLRDHGDSQWYWPKTLTELFGALSQVANGELYMLVAGNTAHGVYRRPRDIRHFIDVNMVP 260

  Fly   255 ELHQHSSEGQQLKLGANLSLTQTMEIIRTTSKQPGFEYLDVLWNHIDLIANVPVRNSGTLAGNIS 319
            ||.|:|.|...|.||.|::||..|::....:|:|||||...||.|.:|||||||||:|||||||:
  Fly   261 ELRQYSIETDHLLLGGNVTLTDAMQVFLLAAKRPGFEYCAQLWQHFNLIANVPVRNNGTLAGNIN 325

  Fly   320 IKKQNPEFPSDIFISFEALNVKVVALKNAADEKEMSLAEYLGTNDKKLVLKTFVLPAYPKDKYIY 384
            ||||:.|||||:||:||||:|.|:...|.:.::.|:|..|||....||||..|:|.|||||::::
  Fly   326 IKKQHFEFPSDVFITFEALDVHVLVYDNPSTQRVMNLLTYLGDTTSKLVLGGFILKAYPKDRFLF 390

  Fly   385 ESYKIMPRAQNAHAYVNAAFLLELE--ADNKVKSARICFGGIRPDFIHASAIEKLLVGQNPYESS 447
            .||||:|||||.||||||.||:|.:  ....|.|||||||.||||:||...:|:||.|::.|:.:
  Fly   391 RSYKILPRAQNVHAYVNAGFLIEWQDIQHRIVHSARICFGNIRPDYIHDDQVEQLLPGRDLYDPA 455

  Fly   448 LVEQTFTKLEDLIKPDEVLPDASPAYRSKLACGLFYKFLLKHAPVAEVGEKFRSGGQILQRPLSS 512
            .|.|.|.:|...::|:|..|:|||.||..|||.|.|||||..||...|.|:||:||.:|:|||||
  Fly   456 TVAQIFQELPASLQPEERPPEASPEYRQMLACSLLYKFLLATAPKERVRERFRTGGLLLERPLSS 520

  Fly   513 GLQVFQTQKKNYPVTQAVEKVEGMIQCSGEATYMNDVLTTSNTLHCAFVGATKVGSTIDSIDASE 577
            |.|.|:|.||||||||.|:|:||:||||||||||||:|||||.:|||||.|.:||:||:.||.|.
  Fly   521 GSQSFETIKKNYPVTQPVQKLEGLIQCSGEATYMNDLLTTSNAVHCAFVTAKRVGATIEQIDPSA 585

  Fly   578 ALKQPGVIAFYSAKDIPGTNTF-----CEPSFGFEVEEIFCSGLVRHSEQPAGVIVALTADQAHR 637
            ||:..||:|||||:||||:|.|     ..|    ||:|:|.:|.|::.:||.|||.|||.|.|..
  Fly   586 ALQCKGVVAFYSAEDIPGSNNFVLVNQLTP----EVDEVFVAGRVKYFDQPLGVIAALTHDAAVY 646

  Fly   638 AAKLVRISYSNPSSDFKLQPSLGDVFASPTPDSSRIVPASKSTSKKIKFSEQPDKEV--RGIFQM 700
            ||.||.::|:....  |:..::..|.|....|  |||...|.|.:.:|.......:|  |||.::
  Fly   647 AATLVVVTYARDQR--KIFTTMNQVLAEKQTD--RIVSTKKDTVEPLKLPPLAPGDVLGRGILEL 707

  Fly   701 GLQYHFTMEPQTTVAIPFEDGLKIFSATQWMDQTQSVIAHMLQVKAKDVQLQVRRLGGGYGSKIT 765
            ..|||||||||||:.:|.::.|:::.||||||.||..|||||:|....:||||||:||.||:|:|
  Fly   708 ASQYHFTMEPQTTIVVPLDNILQVYCATQWMDATQGAIAHMLKVSVNSIQLQVRRVGGAYGAKVT 772

  Fly   766 RGNQVACAASLVAYKLNRPVRFVQSLESMMDCNGKRWACRSDYKCHIKDNGKIVGLTNDFYEDAG 830
            |||.||||.:|||.||.||.||||::||||:..||||||||||:...:.||.|:.|:|::|||:|
  Fly   773 RGNIVACATALVASKLRRPARFVQTIESMMETIGKRWACRSDYEFRARANGSIIMLSNNYYEDSG 837

  Fly   831 WSPNESPIEGHSTFTAVNCYDLNGDNFKNNGNAVLTDAPSSTWCRAPGSVEGIAMIENIIEHVAF 895
            .:.||:.::..:.....|.|:|...|::..|:|:.||||||||||||||.|||||.|..:||:||
  Fly   838 CNLNENVVDFLTLPILRNVYNLTDANYRTQGSAIRTDAPSSTWCRAPGSAEGIAMTETALEHIAF 902

  Fly   896 EVQKDPAEVRLANIAAGNKISELLPQFLESREYAQRKKEIESHNAKNRWTKRGLGLAVMDYPI-- 958
            ..|.|||:|||.|:..|||:.:|||:||.|.||.:|:.:|...|::|||.|||||||:|.:|:
  Fly   903 TCQLDPADVRLVNLQPGNKMVQLLPKFLASTEYHKRRDQINLFNSQNRWRKRGLGLALMSFPLNT 967

  Fly   959 ---FYFGQYPATVAIYHVDGTVVVTHGGIEMGQGMNTKVAQVAAYTLGIDLSFIKVESSDTINGA 1020
               |   .||.||||||.||:||::|||||:|||:|||.|||||:.||:.|..::||:|:|:|||
  Fly   968 TVAF---NYPVTVAIYHEDGSVVISHGGIEIGQGVNTKAAQVAAFVLGVPLDQVRVEASNTVNGA 1029

  Fly  1021 NSMVTGGAVGSESLCYAVRKACETLNSRLEPVKKK---DASWIETVEAAYGKSINLIASDHYKKG 1082
            |||:|..::.||.:..||||||:|||.||.|||::   .|||::.::||:.:|:.|||::.|:.|
  Fly  1030 NSMLTANSMTSEMIGLAVRKACDTLNKRLAPVKERLGPRASWVQVLQAAFLQSVFLIATESYRLG 1094

  Fly  1083 DMQNYHIYGLALTEVELDVLTGNSQIKRVDILEDAGESLSPWIDIGQIEGAFVMCLGYWMSEQLV 1147
            |:.||:|:||:|||:|||:||||..|:||||||||||||||.||:||:||||||.|||:::||||
  Fly  1095 DIPNYNIFGLSLTELELDILTGNHLIRRVDILEDAGESLSPHIDVGQVEGAFVMGLGYYLTEQLV 1159

  Fly  1148 YDRETGRLLTNRTWNYKPPGAKDIPIDFRIELIQK-PNPSGAGFMRSKATGEPPCCLAVSVVFAL 1211
            |||:||::||||||||.|||||||||||||||:|| |||  .|||||||||||..||||..:||:
  Fly  1160 YDRQTGQILTNRTWNYHPPGAKDIPIDFRIELLQKSPNP--VGFMRSKATGEPALCLAVGALFAM 1222

  Fly  1212 RQALDSARHDAGLPREWVRLGAPTTPETLVVNAGHEAASFRL 1253
            :.|:.|||:|||||||||||||||||||:|:|:|.:..:|.|
  Fly  1223 QHAIQSARNDAGLPREWVRLGAPTTPETVVLNSGSQVEAFAL 1264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX3	NP_001303439.1	PLN02906	24..1238	CDD:215491	730/1237 (59%)
		Fer2_2	80..153	CDD:280048	55/72 (76%)
		FAD_binding_4	201..360	CDD:303082	92/158 (58%)
		CO_deh_flav_C	386..487	CDD:281449	56/102 (55%)
		Ald_Xan_dh_C	540..646	CDD:214971	63/110 (57%)
		Ald_Xan_dh_C2	688..1172	CDD:280834	287/493 (58%)
AOX2	NP_732047.2	fer2	3..84	CDD:238126	46/80 (58%)
		PLN02906	24..1251	CDD:215491	732/1239 (59%)
		Fer2_2	86..159	CDD:280048	55/72 (76%)
		FAD_binding_4	206..366	CDD:303082	92/159 (58%)
		CO_deh_flav_C	391..497	CDD:281449	58/105 (55%)
		Ald_Xan_dh_C	548..655	CDD:214971	63/110 (57%)
		Ald_Xan_dh_C2	702..1184	CDD:280834	286/484 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439668
Domainoid	1	1.000	83	1.000	Domainoid score	I2880
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H98597
Inparanoid	1	1.050	1220	1.000	Inparanoid score	I588
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19024at33392
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	1	1.000	-	-		mtm9740
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	1	1.100	-	-	P	PTHR11908
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4296
	11	10.900