back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX3 and Aox4

DIOPT Version :9

Sequence 1:	NP_001303439.1	Gene:	AOX3 / 41896	FlyBaseID:	FBgn0038349	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001008523.2	Gene:	Aox4 / 316424	RGDID:	1311975	Length:	1333	Species:	Rattus norvegicus

Alignment Length:	1364	Identity:	403/1364 - (29%)
Similarity:	649/1364 - (47%)	Gaps:	196/1364 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FSINGLPYAVNLTNLPPDITLNTFIREHAQLTATKFMCQEGGCGACICVVR----DGKR--SWAV 63
            |.:||  ..|...|..|::.|..::|:...||.||:.|..||||||..::.    :.|:  .:..
  Rat    10 FFVNG--KKVIEKNPVPEMNLLFYVRKVLHLTGTKYSCGGGGCGACTVMISRYNPESKKIYHYPA 72

  Fly    64 NSCLTLLNTCAQLEIVTAEGLGNQRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQNEGKV 128
            .:||..:.:.....:.|.||:|:.:...:|:|:||||.:||||||||||.||::|.|: :|..:.
  Rat    73 TACLVPVCSLHGAAVTTVEGVGSIKRRIHPVQERLAKCHGTQCGFCSPGMVMSIYTLL-RNHPEP 136

  Fly   129 TMAEVENSFGGNICRCTGYRPILDAMKSFAVDSNI---------AIPAECGDIEDLKPRNCPKTG 184
            |..::..:.|||:|||||||||:::.|:|:.:|::         .:..:.|..|..|.|.|.|
  Rat   137 TPDQITEALGGNLCRCTGYRPIVESGKTFSPESSVCQMKGSGKCCMDLDEGCSESTKERMCTK-- 199

  Fly   185 QACSGSCLPSTLVYEDGVQ----------------------------------WHWPKSLSELFD 215
                       |..||..|                                  |..|.:|::|.:
  Rat   200 -----------LYNEDEFQPLDPSQEPIFPPELIRMAEDPHKRRLTFQGERTIWIMPVTLNDLLE 253

  Fly   216 ALDKVKDS-EEFMLVAGNTAHGVYRRSTDIKH--FIDVQGVEELHQHSSEGQQLKLGANLSLTQT 277
                :|.| .|..||.||||.|...:..:..|  ||...|:.||:...:....:.:||..||.|.
  Rat   254 ----LKASYPEAPLVMGNTAVGPGMKFNNEFHPVFISPLGLPELNLVDTANSGVTIGARHSLAQM 314

  Fly   278 MEIIRT-TSKQP--GFEYLDVLWNHIDLIANVPVRNSGTLAGNISIKKQNPEFPSDIFISFEALN 339
            .:|:.: |.:||  ..:....|..|:..:|...:||..||.|::   ...|:| ||:.....|.|
  Rat   315 KDILHSLTLEQPKEKTKTHQALLKHLRTLAGPQIRNMATLGGHV---VSRPDF-SDLNPILAAGN 375

  Fly   340 VKVVALKNAADEK------------EMSLAEYLGTNDKKLVLKTFVLPAYPKDKYIYESYKIMPR 392
            ..:..:......:            |.||      ..:::.|..|: |...:.:|: ...::..|
  Rat   376 ATINVISKEGQRQIPLNGPFLERLPEASL------KPEEVALSVFI-PYSGQWQYV-SGLRLAQR 432

  Fly   393 AQNAHAYVNAAFLLEL-EADNKVKSARICFGGIRPDFIHASAIEKLLVGQNPYESSLVEQTFTKL 456
            .:||.|.|||...:|. |..|.:|..::.||.:.|..:.||...|.|:|:...:..|.:.....|
  Rat   433 QENAFAIVNAGMSVEFEEGTNTIKDLQMLFGSVAPTVVSASQTCKQLIGRQWDDQMLSDACQLVL 497

  Fly   457 EDLIKPDEVLPDASPA---YRSKLACGLFYKFLLK---------HAPVAEVGEKFRSGGQILQRP 509
            |::..|    |||...   ||..|...|.:||.||         .....::.|||.|....|...
  Rat   498 EEIRIP----PDAEGGMVEYRRTLIISLLFKFYLKVRRWLSEMDPQKFPDIPEKFVSALDDLPIE 558

  Fly   510 LSSGLQVFQ----TQKKNYPVTQAVEKVEGMIQCSGEATYMNDVLTTSNTLHCAFVGATKVGSTI 570
            ...|:|:||    .|.:..||...:....|:...:|||.:::|:...:..|....|.:|:..:.|
  Rat   559 TPQGIQMFQCVDPNQPEQDPVGHPIMHQSGIKHATGEAKFVDDMPRINQELCLTVVTSTRAHAKI 623

  Fly   571 DSIDASEALKQPGVIAFYSAKDIPGTNTFCEPSFGFEVEEIFCSGLVRHSEQPAGVIVALTAD-- 633
            .|||.||||..|||:...:|:|:||.|......| :...|:.|.|         .:|..:.||
  Rat   624 TSIDVSEALAYPGVVDVITAEDVPGDNNHSGEIF-YAQNEVICVG---------QIICTVAADTY 678

  Fly   634 -QAHRAAKLVRISYSNPSSDFKLQPSLGDVFASPTPDSSRIVPASKSTSKKIKFS------EQPD 691
             .|..|||.|:|:|.:      ::|::..:..:...:|      ..|:.|||:..      :..|
  Rat   679 IHAKEAAKRVKITYDD------IEPAIITIEQALEHNS------FLSSEKKIEQGNVDYAFKHVD 731

  Fly   692 KEVRGIFQMGLQYHFTMEPQTTVAIP-FED-GLKIFSATQWMDQTQSVIAHMLQVKAKDVQLQVR 754
            ..:.|...:..|.||.||.||.:||| .|| .:.:...||:....|..::..|:|....:..|::
  Rat   732 HIIEGEIHVEGQEHFYMETQTILAIPQTEDKEMVLHVGTQFPTHVQEYVSAALKVPRNRIACQMK 796

  Fly   755 RLGGGYGSKITRGNQVACAASLVAYKLNRPVRFVQSLESMMDCNGKRWACRSDYKCHIKDNGKIV 819
            |.||.:|.|:|:...:....::.|:|..||:||:....:.|.....|......||....:||||.
  Rat   797 RTGGAFGGKVTKPALLGAVCAVAAHKTGRPIRFILDRSNDMLITAGRHPLLGKYKIGFMNNGKIK 861

  Fly   820 GLTNDFYEDAGWSPNESP--IEGHSTFTAVNCYDLNGDNFKNNGNAVLTDAPSSTWCRAPGSVEG 882
            ....::|.:.|.:|:||.  || .....:.|.|.:  .||:..|.|..|:.||:|..|..|..:.
  Rat   862 AADVEYYTNGGCTPDESEMVIE-FIVLKSENAYHI--PNFRCRGRACKTNLPSNTAFRGFGFPQA 923

  Fly   883 IAMIENIIEHVAFEVQKDPAEVRLANIAAGNKISELL--------------PQFLESREYAQRKK 933
            ..::|..|..||.:....|.|:|..|:.  .:||:..              .:.|:...:..||:
  Rat   924 TVVVEAYIAAVASKCNLLPEEIREINMY--KQISKTAYKQTFNPEPLRRCWKECLQKSSFFARKQ 986

  Fly   934 EIESHNAKNRWTKRGLGLAVMDY----PIFYFGQYPATVAIYHVDGTVVVTHGGIEMGQGMNTKV 994
            ..|..|..|.|.|:||.:..|.:    |:.::.|..|.|.|: :||:|::||||.|:|||::||:
  Rat   987 AAEEFNKNNYWKKKGLAVVPMKFSVAVPMAFYNQAAALVHIF-LDGSVLLTHGGCELGQGLHTKM 1050

  Fly   995 AQVAAYTLGIDLSFIKVESSDTINGANSMVTGGAVGSESLCYAVRKACETLNSRLEPVKKKD--A 1057
            .|||:..|.|..|::.:..:.|:...|::.|.|::|::....||:.||:||..||:|:.||:  .
  Rat  1051 IQVASRELNIPKSYVHLVETSTVTVPNAVFTAGSMGADINGKAVQNACQTLLDRLQPIIKKNPKG 1115

  Fly  1058 SWIETVEAAYGKSINLIASDHYK-----------KGDMQNYHIYGLALTEVELDVLTGNSQIKRV 1111
            .|.|.|:.|:.:||:|.|:.::|           :||...|::||.|.:|||:|.|||..::.|.
  Rat  1116 KWEEWVKKAFEESISLSATGYFKGYQTNMDWEKEEGDPYPYYVYGAACSEVEVDCLTGAHKLLRT 1180

  Fly  1112 DILEDAGESLSPWIDIGQIEGAFVMCLGYWMSEQLVYDRETGRLLTNRTWNYKPPGAKDIPIDFR 1176
            ||..||..|::|.:||||:||||:..:|::..|:|.|..: |.|.:....:||.|...:||.:|.
  Rat  1181 DIFMDAAFSINPALDIGQVEGAFIQGMGFYTIEELKYSPK-GVLYSRGPDDYKIPTVTEIPEEFY 1244

  Fly  1177 IELIQKPNPSGAGFMRSKATGEPPCCLAVSVVFALRQALDSARHDAGLPREWVRLGAPTTPETL 1240
            :.:::..||  .....||..||....|..||:||:..|:.:||.:.|| .:...|.:|.|||.:
  Rat  1245 VTMVRSRNP--IAIYSSKGLGEAGMFLGSSVLFAIYDAVTTARKERGL-SDIFPLNSPATPEVI 1305

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.