DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX3 and Aox2

DIOPT Version :9

Sequence 1:	NP_001303439.1	Gene:	AOX3 / 41896	FlyBaseID:	FBgn0038349	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_038939552.1	Gene:	Aox2 / 316421	RGDID:	1359668	Length:	1347	Species:	Rattus norvegicus

Alignment Length:	1373	Identity:	397/1373 - (28%)
Similarity:	645/1373 - (46%)	Gaps:	205/1373 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KFSINGLPYAVNLTNLPPDITLNTFIREH--AQLTATKFMCQEGGCGACICVVRD------GKRS 60
            :|.:||  ..|...|:.|::||..|:|::  ..||.||:.|..|.||||..:|..      ..|.
  Rat    12 EFFVNG--KKVTEKNVDPEVTLLAFLRKNWTLCLTGTKYACGTGSCGACTVMVSQHDPVCKKTRH 74

  Fly    61 WAVNSCLTLLNTCAQLEIVTAEGLGNQRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQNE 125
            ::|.:||..|.:.....:.|.||:|:.:|..:|:|:||||.:||||||||||.||:||.|: :|.
  Rat    75 FSVMACLVPLCSLHGAAVTTVEGVGSIKTRLHPVQERLAKSHGTQCGFCSPGMVMSMYALL-RNH 138

  Fly   126 GKVTMAEVENSFGGNICRCTGYRPILDAMKSFAVDSNIAIPAECGDIEDLKPRNCPK--TGQAC- 187
            .:.:..::..:.|||:||||||||||::.::|.::|:                .|.:  |||.|
  Rat   139 PQPSEEQLLEALGGNLCRCTGYRPILESGRTFCMESD----------------GCLQKGTGQCCL 187

  Fly   188 -------SGS----C-------------------LPSTLV-------------YEDGVQWHWPKS 209
                   |||    |                   .|..|:             |.:.:.|..|.:
  Rat   188 DQKEGDSSGSKSDICTELFVKDEFQPLDPTQELIFPPELLRMAENPEKQTLTFYGERITWIAPGT 252

  Fly   210 LSELFDALDKVKDSEEFMLVAGNTAHGVYRRSTDIKHFIDV----QGVEELHQHSSEGQQLKLGA 270
            |.||.....|..::.   |::||||.|...:|..  ||..|    ..:.:|...:.....|.:||
  Rat   253 LQELLVLKAKYPEAP---LISGNTALGPAMKSQG--HFYPVLLSPARIPDLRMVTKTSGGLTIGA 312

  Fly   271 NLSLTQTMEII-RTTSKQP--GFEYLDVLWNHIDLIANVPVRNSGTLAGNISIKKQNPEFPSDIF 332
            ..||.|..::: .:.|:.|  ..:....|..|:..:|...:||..:|.|::..:    .:.||:
  Rat   313 CCSLAQVKDVLAESISELPEEKTQTYRALLKHLRSLAGQQIRNMASLGGHVISR----HYYSDL- 372

  Fly   333 ISFEALNVKVVALKNAADE--KEMSLAEY----LGTNDKK--LVLKTFVLPAYPKDKYIYESYKI 389
              ...|:|....|...::|  :::.|..:    |...|.|  .:|.:..:|...|.::: .:::.
  Rat   373 --NPILSVGNATLNLLSEEGLRQIPLNGHFLAGLANEDLKPEEILGSVYIPHSQKREFV-SAFRQ 434

  Fly   390 MPRAQNAHAYVNAAF-LLELEADNKVKSARICFGGIRPDFIHASAIEKLLVGQNPYESSLVEQTF 453
            ....|||...|||.. :|..|..:.::...|.:||:.|..:.|....:.|:|:. :.:.|:::..
  Rat   435 AQCHQNALPDVNAGMRVLFKEGTDIIEELSIAYGGVGPTTVSAHRSCQQLLGRR-WNALLLDEAC 498

  Fly   454 TKLEDLIKPDEVLPDASPA----YRSKLACGLFYKFLLK-----------------HAPVAEVGE 497
            ..|.|.:.    ||.::..    :|..|....|:||.|:                 .....|:.:
  Rat   499 RLLLDEVS----LPGSAVGGKVEFRRTLIVSFFFKFYLEVLQELKADKRLLPESTDSQRYPEIAD 559

  Fly   498 KFRSGGQILQRPLSSGLQVFQT----QKKNYPVTQAVEKVEGMIQCSGEATYMNDVLTTSNTLHC 558
            ..||.....|..|..|:|.:|.    |....||.:.:..:.|:...:|||.:.:|:......|..
  Rat   560 GSRSSLGDFQVTLPQGVQTYQRVNSHQPLQDPVGRPIMHLSGLKHATGEAVFCDDIPRVDKELFM 624

  Fly   559 AFVGATKVGSTIDSIDASEALKQPGVIAFYSAKDIPGTNTFCEPSFGFE------VEEIFCSGLV 617
            |.|.:|:..:.|.|||:||.|..|||:...:|:||||.|       |.|      |:::.|.|
  Rat   625 ALVTSTRAHARIISIDSSEVLDLPGVVDVITAEDIPGNN-------GEEDDKLLAVDKVLCVG-- 680

  Fly   618 RHSEQPAGVIVALTADQAHRAAKLVRISYSNPSSDFKLQPSLGDVFASPTPDSSRIVPASKSTSK 682
                |....:||.|..||.||.|.::|:|.:      |:|.|..: ......:|.:.|..|....
  Rat   681 ----QVVCAVVAETDVQAKRATKKIKITYED------LKPVLFTI-EDAIQHNSFLCPEKKLEQG 734

  Fly   683 KIKFS-EQPDKEVRGIFQMGLQYHFTMEPQTTVAIP-FED-GLKIFSATQWMDQTQSVIAHMLQV 744
            .::.: |..|:.|.|...:|.|.||.||.|..:.|| .|| .|.::.:||.....|..::..|.:
  Rat   735 NMEEAFENVDQIVEGKVHVGGQEHFYMETQRVLVIPKTEDKELDMYVSTQDPAHVQKTVSSALNI 799

  Fly   745 KAKDVQLQVRRLGGGYGSKITRGNQVACAASLVAYKLNRPVRFVQSLESMMDCNGKRWACRSDYK 809
            ....:...|:|:|||:|.|:.|.......|::.|.|..||:|.|...|..|...|.|....:.||
  Rat   800 PLSRITCHVKRVGGGFGGKVGRPAVFGAIAAVGAVKTGRPIRLVLDREDDMLITGGRHPLFAKYK 864

  Fly   810 CHIKDNGKIVGLTNDFYEDAGWSPNESPIEGHSTFTAV---NCYDLNGDNFKNNGNAVLTDAPSS 871
            ....::|:|..|..:.|.:.|.:.::|.:.  :.|..:   |.|.:.  |.:..|.|.:|:.||:
  Rat   865 VGFMNSGRIKALDIECYINGGCTLDDSELV--TEFLVLKLENAYKIR--NLRLRGRACMTNLPSN 925

  Fly   872 TWCRAPGSVEGIAMIENIIEHVAFEVQKDPAEVRLANI----------AAGN--KISELLPQFLE 924
            |..|..|..:|..:.|:.|..||.:....|.::|..|:          .|.|  .:.....:.|:
  Rat   926 TAFRGFGFPQGALVTESCITAVAAKCGLPPEKIREKNMYKTVDKTIYKQAFNPEPLIRCWNECLD 990

  Fly   925 SREYAQRKKEIESHNAKNRWTKRGLGLAVMDYPI-FYFGQYPATVAIYHV--DGTVVVTHGGIEM 986
            ...:|.|:..::..|.|:.|.|||:.:..|.:.: |....|....|:.|:  ||:|:|.|||.|:
  Rat   991 KSSFAIRRTRVDEFNKKSYWRKRGIAVVPMKFSVGFAATSYHQAAALVHIYTDGSVLVAHGGNEL 1055

  Fly   987 GQGMNTKVAQVAAYTLGIDLSFIKVESSDTINGANSMVTGGAVGSESLCYAVRKACETLNSRLEP 1051
            |||::||:.|||:..|.|.:|::....:.|....|::.|..:||::....||:.||:.|..||||
  Rat  1056 GQGIHTKMLQVASRELKIPMSYLHTSETCTAAVPNTIATAASVGADVNGRAVQNACQILLKRLEP 1120

  Fly  1052 VKKK--DASWIETVEAAYGKSINLIASDHYK-----------KGDMQNYHIYGLALTEVELDVLT 1103
            |.||  :.:|.:.:|||:.:.|:|.|:.:::           :||...|::||.|.:|||:|.||
  Rat  1121 VIKKNPEGTWRDWIEAAFEQRISLSATGYFRGYKAFMDWEKGEGDPFPYYVYGAACSEVEIDCLT 1185

  Fly  1104 GNSQIKRVDILEDAGESLSPWIDIGQIEGAFVMCLGYWMSEQLVYDRETGRLLTNRTWNYKPPGA 1168
            |..:..|.||:.||..||:|.||:|||||||:..:|.:.:|:|.|..| |.|.:.....||.|..
  Rat  1186 GAHKKMRTDIVMDACCSLNPAIDVGQIEGAFIQGMGLYTTEELHYSPE-GVLYSRSPDKYKIPTV 1249

  Fly  1169 KDIPIDFRIELI---QKPNPSGAGFMRSKATGEPPCCLAVSVVFALRQALDSARHDAGLPREWVR 1230
            .|:|..|.:.|:   |.|    .....||..||....|..||.||:..|:.:||....:..::.
  Rat  1250 TDVPEQFNVSLLPSSQTP----LTIYSSKGLGESGMFLGSSVFFAIADAVAAARRQRDIAEDFT- 1309

  Fly  1231 LGAPTTPE 1238
            :.:|.|||
  Rat  1310 VKSPATPE 1317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX3	NP_001303439.1	PLN02906	24..1238	CDD:215491	389/1351 (29%)
		Fer2_2	80..153	CDD:280048	40/72 (56%)
		FAD_binding_4	201..360	CDD:303082	39/171 (23%)
		CO_deh_flav_C	386..487	CDD:281449	25/105 (24%)
		Ald_Xan_dh_C	540..646	CDD:214971	39/111 (35%)
		Ald_Xan_dh_C2	688..1172	CDD:280834	167/516 (32%)
Aox2	XP_038939552.1	mam_aldehyde_ox	10..1346	CDD:132014	397/1373 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720