Protein Alignment AOX3 and AOX1

DIOPT Version :10

• Sequence 1: NP_650477.1
• Gene: AOX3 / 41896
• FlyBaseID: FBgn0038349
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: XP_011509364.1
• Gene: AOX1 / 316
• HGNCID: 553
• Length: 1350
• Species: Homo sapiens
• Alignment Length: 1356
• Identity: 399/1356 - (29%)
• Similarity: 631/1356 - (46%)
• Gaps: 173/1356 - (12%)

  Fly     5 FSINGLPYAVNLTNLPPDITLNTFIREHAQLTATKFMCQEGGCGACICVVRDGK------RSWAV 63
            |.:||  ..|...|:.|:..|..::|:..:||.||:.|..||||||..::....      |....
Human     9 FYVNG--RKVIEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNPITKRIRHHPA 71

  Fly    64 NSCLTLLNTCAQLEIVTAEGLGNQRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQNEGKV 128
            |:||..:.:.....:.|.||:|:..|..:|:|:|:||.:|||||||:||.||::|.|: :|..:.
Human    72 NACLIPICSLYGAAVTTVEGIGSTHTRIHPVQERIAKCHGTQCGFCTPGMVMSIYTLL-RNHPEP 135

  Fly   129 TMAEVENSFGGNICRCTGYRPILDAMKSFAVDSNIAIPAECG------------DIEDLKPRNCP 181
            |:.::.::.|||:|||||||||:||.|:|...|......|.|            :.|: ..:..|
Human   136 TLDQLTDALGGNLCRCTGYRPIIDACKTFCKTSGCCQSKENGVCCLDQGINGLPEFEE-GSKTSP 199

  Fly   182 KTGQACSGSCLP----------------------STLVY-EDGVQWHWPKSLSELFDALDKVKDS 223
            |.  ......||                      .|.|: .:.:.|..|.:|.||.:...|...:
Human   200 KL--FAEEEFLPLDPTQELIFPPELMIMAEKQSQRTRVFGSERMMWFSPVTLKELLEFKFKYPQA 262

  Fly   224 EEFMLVAGNTAHGVYRRSTDIKH--FIDVQGVEELH--QHSSEGQQLKLGANLSLTQTMEIIR-T 283
            .   ::.|||:.|...:...:.|  .|....:|||.  .|:..|  |.|||.|||.|..:|:. .
Human   263 P---VIMGNTSVGPEVKFKGVFHPVIISPDRIEELSVVNHAYNG--LTLGAGLSLAQVKDILADV 322

  Fly   284 TSKQP--GFEYLDVLWNHIDLIANVPVRNSGTLAGNISIKKQNPEFPSDIFISFEALNVKVVALK 346
            ..|.|  ..:....|..|:..:|...:||..:|.|:|..:..:.:....:.:....||:.....|
Human   323 VQKLPEEKTQMYHALLKHLGTLAGSQIRNMASLGGHIISRHPDSDLNPILAVGNCTLNLLSKEGK 387

  Fly   347 NAADEKEMSLAEYLGTNDKKLVLKTFVLPAYPKDKYIYESYKIMPRAQNAHAYVNAAFLLEL-EA 410
            ......|..|::....:.|...:...|...|.:......:::...|.:||.|.||:...:.. |.
Human   388 RQIPLNEQFLSKCPNADLKPQEILVSVNIPYSRKWEFVSAFRQAQRQENALAIVNSGMRVFFGEG 452

  Fly   411 DNKVKSARICFGGIRPDFIHASAIEKLLVGQNPYESSLVEQTFTKLED----LIKPDEVLPDASP 471
            |..::...|.:||:.|..|.|....:.|:|::..|..|         |    ||..:..|..::|
Human   453 DGIIRELCISYGGVGPATICAKNSCQKLIGRHWNEQML---------DIACRLILNEVSLLGSAP 508

  Fly   472 A----YRSKLACGLFYKFLLK-----------HAPVAEVGEKFRSGGQILQRPLSSGLQVFQT-- 519
            .    ::..|.....:||.|:           |.|  .:.:|:.|..:.|..........:|.
Human   509 GGKVEFKRTLIISFLFKFYLEVSQILKKMDPVHYP--SLADKYESALEDLHSKHHCSTLKYQNIG 571

  Fly   520 --QKKNYPVTQAVEKVEGMIQCSGEATYMNDVLTTSNTLHCAFVGATKVGSTIDSIDASEALKQP 582
              |....|:...:..:.|:...:|||.|.:|:......|...||.:::..:.|.|||.||||..|
Human   572 PKQHPEDPIGHPIMHLSGVKHATGEAIYCDDMPLVDQELFLTFVTSSRAHAKIVSIDLSEALSMP 636

  Fly   583 GVIAFYSAKDIPGTNTFC---EPSFGFEVEEIFCSGLVRHSEQPAGVIVALTAD---QAHRAAKL 641
            ||:...:|:.:...|:||   |.......:::||.|         .::.|:.||   ||.||||.
Human   637 GVVDIMTAEHLSDVNSFCFFTEAEKFLATDKVFCVG---------QLVCAVLADSEVQAKRAAKR 692

  Fly   642 VRISYSNPSSDFKLQPSLGDVFASPTPDSSRIVPASKSTSKKIKFS------EQPDKEVRGIFQM 700
            |:|.|.:      |:|.:..:..|...:|      |....:|:::.      :..|:.:.|...|
Human   693 VKIVYQD------LEPLILTIEESIQHNS------SFKPERKLEYGNVDEAFKVVDQILEGEIHM 745

  Fly   701 GLQYHFTMEPQTTVAIP--FEDGLKIFSATQWMDQTQSVIAHMLQVKAKDVQLQVRRLGGGYGSK 763
            |.|.||.||.|:.:.:|  .:..:.::.:||:....|.::|..|::.|..|...|||:||.:|.|
Human   746 GGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKYIQDIVASTLKLPANKVMCHVRRVGGAFGGK 810

  Fly   764 ITRGNQVACAASLVAYKLNRPVRFVQSLESMMDCNGKRWACRSDYKCHIKDNGKIVGLTNDFYED 828
            :.:...:|...:..|.|..|.||.|......|...|.|......||....::|:|:.|..:.|.:
Human   811 VLKTGIIAAVTAFAANKHGRAVRCVLERGEDMLITGGRHPYLGKYKAGFMNDGRILALDMEHYSN 875

  Fly   829 AGWSPNES--PIEGHSTFTAVNCYDLNGDNFKNNGNAVLTDAPSSTWCRAPGSVEGIAMIENIIE 891
            ||.|.:||  .|| .......|.|..  .|.:..|.|..|:.||:|..|..|..:...:.|:.|.
Human   876 AGASLDESLFVIE-MGLLKMDNAYKF--PNLRCRGWACRTNLPSNTAFRGFGFPQAALITESCIT 937

  Fly   892 HVAFEVQKDPAEVRLAN-------------IAAGNKISELLPQFLESREYAQRKKEIESHNAKNR 943
            .||.:....|.:||:.|             |.|.|.| :...:.:....|:.||..:|..||:|.
Human   938 EVAAKCGLSPEKVRIINMYKEIDQTPYKQEINAKNLI-QCWRECMAMSSYSLRKVAVEKFNAENY 1001

  Fly   944 WTKRGLGLAVMDYPIFY----FGQYPATVAIYHVDGTVVVTHGGIEMGQGMNTKVAQVAAYTLGI 1004
            |.|:||.:..:.:|:..    .||..|.|.|| :||:|:|||||||||||::||:.||.:..|.:
Human  1002 WKKKGLAMVPLKFPVGLGSRAAGQAAALVHIY-LDGSVLVTHGGIEMGQGVHTKMIQVVSRELRM 1065

  Fly  1005 DLSFIKVESSDTINGANSMVTGGAVGSESLCYAVRKACETLNSRLEPV--KKKDASWIETVEAAY 1067
            .:|.:.:..:.|....|:.::||:|.::....||:.||:||..||||:  |....:|.:..:.|:
Human  1066 PMSNVHLRGTSTETVPNANISGGSVVADLNGLAVKDACQTLLKRLEPIISKNPKGTWKDWAQTAF 1130

  Fly  1068 GKSINLIA--------SD-HYKKGDMQ--NYHIYGLALTEVELDVLTGNSQIKRVDILEDAGESL 1121
            .:||||.|        || :::||:.|  .|.:||.|.:|||:|.|||:.:..|.||:.|.|.|:
Human  1131 DESINLSAVGYFRGYESDMNWEKGEGQPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGCSI 1195

  Fly  1122 SPWIDIGQIEGAFVMCLGYWMSEQLVYDRETGRLLTNRTWNYKPPGAKDIPIDFRIELIQKPNPS 1186
            :|.||||||||||:..:|.:..|:|.|..: |.|.|.....||.|...|:|.:..|.|: .|:.:
Human  1196 NPAIDIGQIEGAFIQGMGLYTIEELNYSPQ-GILHTRGPDQYKIPAICDMPTELHIALL-PPSQN 1258

  Fly  1187 GAGFMRSKATGEPPCCLAVSVVFALRQALDSARHDAGL--PREWVRLGAPTTPETL 1240
            ......||..||....|..||.||:..|:.:||.:.||  |   :.|.:|.|||.:
Human  1259 SNTLYSSKGLGESGVFLGCSVFFAIHDAVSAARQERGLHGP---LTLNSPLTPEKI 1311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AOX3	NP_650477.1	PLN02906	24..1238	CDD:215491	391/1333 (29%)
AOX1	XP_011509364.1	mam_aldehyde_ox	5..1328	CDD:132014	399/1356 (29%)