DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX3 and Aox2

DIOPT Version :9

Sequence 1:	NP_001303439.1	Gene:	AOX3 / 41896	FlyBaseID:	FBgn0038349	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_017175142.1	Gene:	Aox2 / 213043	MGIID:	3529596	Length:	1356	Species:	Mus musculus

Alignment Length:	1390	Identity:	399/1390 - (28%)
Similarity:	644/1390 - (46%)	Gaps:	200/1390 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KFSINGLPYAVNLTNLPPDITLNTFIREHAQLTATKFMCQEGGCGACICVVRD------GKRSWA 62
            :|.:||  ..|...|:.|::||..|:|::..||.||..|..||||||..:|..      ..|.::
Mouse    12 EFFVNG--RKVTEKNVDPEVTLLAFLRKNLCLTGTKDACGTGGCGACTVMVSQHDPVCKKTRHFS 74

  Fly    63 VNSCLTLLNTCAQLEIVTAEGLGNQRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQNEGK 127
            |.:||..|.:.....:.|.||:|:.:|..:|:|:|:||.:|||||||:||.||::|.|: :|..:
Mouse    75 VMACLVPLCSLHGAAVTTVEGVGSIKTRLHPVQERIAKSHGTQCGFCTPGMVMSIYTLL-RNHPQ 138

  Fly   128 VTMAEVENSFGGNICRCTGYRPILDAMKSFAVDSNIAIPAECGDIEDLKPRNCPK--TGQAC--- 187
            .:..::..:.|||:||||||||||::.::|.                ::|..||:  |||.|
Mouse   139 PSEEQLMEALGGNLCRCTGYRPILESGRTFC----------------MEPDGCPQKGTGQCCLDQ 187

  Fly   188 -----SGS----C-------------------LPSTLV-------------YEDGVQWHWPKSLS 211
                 |||    |                   .|..|:             |.:.:.|..|.:|.
Mouse   188 KESDSSGSKSDICTKLFVKDEFQPLDPTQELIFPPELLRMAENPEKQTLTFYGERITWIAPGTLQ 252

  Fly   212 ELFDALDKVKDSEEFMLVAGNTAHGVYRRSTDIKHFIDV----QGVEELHQHSSEGQQLKLGANL 272
            ||.....|..::.   |::||||.|...:|..  ||..|    ..:.:|...:.....|.:||..
Mouse   253 ELLVLKAKYPEAP---LISGNTALGPAMKSQG--HFYPVLLSPARIPDLRMVTKTSGGLTIGACC 312

  Fly   273 SLTQTMEIIRTTSK---QPGFEYLDVLWNHIDLIANVPVRNSGTLAGNISIKKQNPEFPSDIFIS 334
            ||.|..:|:..:..   |...:....|..|:..:|...:||..:|.|::..:....:....:.:.
Mouse   313 SLAQVKDILAESISELPQEKTQTYRALLKHLRSLAGQQIRNMASLGGHVISRHCYSDLNPILSVG 377

  Fly   335 FEALNVKVVALKNAADEKEMSLAEY----LGTNDKK--LVLKTFVLPAYPKDKYIYESYKIMPRA 393
            ...||     |.:....:::.|:.:    |.:.|.|  .:|.:..:|...|.::: .:::.....
Mouse   378 NTTLN-----LLSEEGPRQIPLSGHFLAGLASADLKPEEILGSVYIPHSQKREFV-SAFRQAQCH 436

  Fly   394 QNAHAYVNAAF-LLELEADNKVKSARICFGGIRPDFIHASAIEKLLVGQNPYESSLVEQTFTKLE 457
            |||...|||.. :|..|..:.::...|.:||:.|..:.|....:.|:|:......|.|.....|:
Mouse   437 QNALPDVNAGMRVLFREGTDVIEELSIAYGGVGPTTVSAQRSCQQLLGRRWNALMLDEACRLLLD 501

  Fly   458 DLIKPDEVLPDASPAYRSKLACGLFYKFLL----------KHAPVA-------EVGEKFRSGGQI 505
            ::..|...| .....:|..|...||:||.|          |..|.:       |:.::|.|....
Mouse   502 EVSLPGSAL-GGKVEFRRTLIVSLFFKFYLEVLQELKADQKLPPESTDSQRYPEIADRFLSSLGD 565

  Fly   506 LQRPLSSGLQVFQT----QKKNYPVTQAVEKVEGMIQCSGEATYMNDVLTTSNTLHCAFVGATKV 566
            .|..|..|:|.:|.    |....||.:.:..:.|:...:|||.:.:|:......|..|.|.:|:.
Mouse   566 FQVTLPRGVQTYQRVDSHQPLQDPVGRPIMHLSGLKHATGEAVFCDDIPRVDKELFMALVTSTRA 630

  Fly   567 GSTIDSIDASEALKQPGVIAFYSAKDIPGTNTFCEPSFGFE------VEEIFCSGLVRHSEQPAG 625
            .:.|.|||:||.|..|||:...:|:||||.|       |.|      |:::.|.|      |...
Mouse   631 HARIISIDSSEVLDLPGVVDVITAEDIPGNN-------GEEDDKLLAVDKVLCVG------QVIC 682

  Fly   626 VIVALTADQAHRAAKLVRISYSNPSSDFKLQPSLGDVFASPTPDSSRIVPASKSTSKKIKFS-EQ 689
            .:||.|..||.||.:.::|:|.:      |:|.:..: ......:|.:.|..|.....|:.: |.
Mouse   683 AVVAETDVQAKRATEKIKITYED------LKPVIFTI-EDAIKHNSFLCPEKKLEQGNIEEAFEN 740

  Fly   690 PDKEVRGIFQMGLQYHFTMEPQTTVAIP-FED-GLKIFSATQWMDQTQSVIAHMLQVKAKDVQLQ 752
            .|:...|...:|.|.||.||.|..:.|| .|| .|.::.:||.....|..::..|.:....:...
Mouse   741 VDQVAEGTVHVGGQEHFYMETQRVLVIPKTEDKELDMYVSTQDPAHVQKTVSSTLNIPISRITCH 805

  Fly   753 VRRLGGGYGSKITRGNQVACAASLVAYKLNRPVRFVQSLESMMDCNGKRWACRSDYKCHIKDNGK 817
            |:|:|||:|.|:.|.......|::.|.|...|:|.|...|..|...|.|....:.||....::|:
Mouse   806 VKRVGGGFGGKVGRPAVFGAIAAVGAVKTGHPIRLVLDREDDMLITGGRHPLFAKYKVGFMNSGR 870

  Fly   818 IVGLTNDFYEDAGWSPNESPIEGHSTFTAV---NCYDLNGDNFKNNGNAVLTDAPSSTWCRAPGS 879
            |..|..:.|.:.|.:.::|.:.  :.|..:   |.|.:.  |.:..|.|.:|:.||:|..|..|.
Mouse   871 IKALDIECYINGGCTLDDSELV--TEFLVLKLENAYKIR--NLRLRGRACMTNLPSNTAFRGFGF 931

  Fly   880 VEGIAMIENIIEHVAFEVQKDPAEVRLANI----------AAGN--KISELLPQFLESREYAQRK 932
            .:|..:.|:.|..||.:....|.::|..|:          .|.|  .:.....:.|:...:..|:
Mouse   932 PQGALVTESCITAVAAKCGLPPEKIREKNMYKTVDKTIYKQAFNPDPLIRCWNECLDKSSFHIRR 996

  Fly   933 KEIESHNAKNRWTKRGLGLAVMDYPI-FYFGQYPATVAIYHV--DGTVVVTHGGIEMGQGMNTKV 994
            ..::..|.|:.|.|||:.:..|.:.: |....|....|:.|:  ||:|:|.|||.|:|||::||:
Mouse   997 TRVDEFNKKSYWKKRGIAIVPMKFSVGFAATSYHQAAALVHIYTDGSVLVAHGGNELGQGIHTKM 1061

  Fly   995 AQVAAYTLGIDLSFIKVESSDTINGANSMVTGGAVGSESLCYAVRKACETLNSRLEPVKKK--DA 1057
            .|||:..|.|.||::.:..:.|....|::.|..:||::....||:.||:.|..|||||.||  :.
Mouse  1062 LQVASRELKIPLSYLHICETSTTTVPNTIATAASVGADVNGRAVQNACQILLKRLEPVIKKNPEG 1126

  Fly  1058 SWIETVEAAYGKSINLIASDHYK-----------KGDMQNYHIYGLALTEVELDVLTGNSQIKRV 1111
            :|.:.:|||:.|.|:|.|:.:::           :||...|::||.|.:|||:|.|||..:..|.
Mouse  1127 TWRDWIEAAFEKRISLSATGYFRGYKAFMDWEKGEGDPFPYYVYGAACSEVEIDCLTGAHKKIRT 1191

  Fly  1112 DILEDAGESLSPWIDIGQIEGAFVMCLGYWMSEQLVYDRETGRLLTNRTWNYKPPGAKDIPIDFR 1176
            ||:.||..||:|.||||||||||:..:|.:.:|:|:|..| |.|.:.....||.|...|:|..|.
Mouse  1192 DIVMDACCSLNPAIDIGQIEGAFIQGMGLYTTEELLYSPE-GVLYSRSPDKYKIPTVTDVPEQFN 1255

  Fly  1177 IELIQKPNPSG---AGFMRSKATGEPPCCLAVSVVFALRQALDSARHDAGLPR----------EW 1228
            :.|:    ||.   .....||..||....|..||.||:..|:.:||....:..          ||
Mouse  1256 VSLL----PSSQTPLTLYSSKGLGESGMFLGSSVFFAIVDAVAAARRQRDIAEDFTVKSPATPEW 1316

  Fly  1229 VRLGAPTTPETLVVNAGHEAASFRL 1253
            ||:........:|.:....|:|.:|
Mouse  1317 VRMACADRFTDMVGSCSVPASSLQL 1341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX3	NP_001303439.1	PLN02906	24..1238	CDD:215491	389/1353 (29%)
		Fer2_2	80..153	CDD:280048	37/72 (51%)
		FAD_binding_4	201..360	CDD:303082	36/169 (21%)
		CO_deh_flav_C	386..487	CDD:281449	26/101 (26%)
		Ald_Xan_dh_C	540..646	CDD:214971	38/111 (34%)
		Ald_Xan_dh_C2	688..1172	CDD:280834	167/516 (32%)
Aox2	XP_017175142.1	mam_aldehyde_ox	10..1329	CDD:132014	395/1376 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720