DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX3 and xdh-1

DIOPT Version :9

Sequence 1:	NP_001303439.1	Gene:	AOX3 / 41896	FlyBaseID:	FBgn0038349	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_502747.1	Gene:	xdh-1 / 178381	WormBaseID:	WBGene00010083	Length:	1358	Species:	Caenorhabditis elegans

Alignment Length:	1363	Identity:	409/1363 - (30%)
Similarity:	657/1363 - (48%)	Gaps:	177/1363 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FSINGLPYAVNLTNLPPDITLNTFIREHAQLTATKFMCQEGGCGAC---ICVVRDGK-RSWAVNS 65
            |.:||  ..|...::.|.:||.|::|:..:||.||..|.|||||||   |..:.:|: :.::.||
Worm    18 FYVNG--KRVEEKDVDPKMTLATYLRDKLKLTGTKIGCNEGGCGACTIMISHIENGEIKHFSANS 80

  Fly    66 CLTLLNTCAQL--EIVTAEGLGN-QRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQNEGK 127
            |  |:..|...  .:.|.||:|: .:...:|:|:||||.:|:|||||:|||||.||.|:..|...
Worm    81 C--LMPVCGVFGKAVTTVEGIGSVAKNRLHPVQERLAKAHGSQCGFCTPGFVMAMYALLRNNPNP 143

  Fly   128 VTMAEVENSFGGNICRCTGYRPILDAMKSFAVDSN--IAIPAE--CGDIEDLKPRNCPKTGQ-AC 187
             |::::.....||:||||||||||:|..|||||.:  :.:..|  ||..|     ||.|..: ||
Worm   144 -TISDINLGLQGNLCRCTGYRPILEAFYSFAVDESGTLKVTEENGCGMGE-----NCCKVKKTAC 202

  Fly   188 SGS-----------------------CLP----STLVYEDGVQWHWPKSLSELF----------- 214
            .||                       |.|    ..|::...::.|..:|:|..:
Worm   203 GGSDETTPGYTGGERKRKIQLSDMSDCKPYDPTQELIFPPELKLHGYESMSFAYDHHHTKWYQPV 267

  Fly   215 ---DALDKVKDSEEFMLVAGNT--AHGVYRRSTDIKHFIDVQGVEELHQHSSEGQQLKLGANLSL 274
               |.|...::.....|::||:  |..:..|..|:...|:.:.|:.||:...|...:.:|..:||
Worm   268 SYDDLLSLKRELPHARLISGNSELAIELKFRFIDLPAVINPRQVKVLHEKHLENDGVYMGTGMSL 332

  Fly   275 TQ----TMEIIRTTSKQPGFEYLDVLWNHIDLI---ANVPVRNSGTLAGNIS----IKKQNPEFP 328
            |.    ::::::...:    |...||.:..:::   |.:.|||..::||||:    |...||
Worm   333 TDMDNYSVQLMKDLPR----EQTAVLKHVHEMLHWFAGIHVRNVASVAGNIATASPISDLNP--- 390

  Fly   329 SDIFISFEALNVKVVALKNAADEKEMSLAE--YLGTNDKKL----VLKTFVLPAYPKDKYIYESY 387
              |:::..||   ||....|..||.:.:.|  :||.....:    ::|..::|...:::: :.:|
Worm   391 --IWMASNAL---VVLDSEARGEKRVHIDEKFFLGYRKTVIQQDEIIKAVIVPLLEENEH-FAAY 449

  Fly   388 KIMPRAQNAHAYVNAAFLLELEADN-KVKSARICFGGIRPDFIHASAIEKLLVGQNPYESSLVEQ 451
            |...|.::..|.|..|||::|:... .|:..||.:||:.|....|....:.|:|:. :..:.:::
Worm   450 KQAQRREDDIAIVTGAFLVKLDPKTLVVEKIRISYGGMAPTTKLALTTMEKLIGEK-WSQTFLDK 513

  Fly   452 TFTKLEDLIKPDEVLPDASPAYRSKLACGLFYKFLLKHAPVAEVGE-KFRSG----GQILQRPLS 511
            ....|.|.:|....:|.....||..||...|:||.|..:...|:.| |:...    ||.:...|.
Worm   514 ALGLLSDELKLPAGVPGGMSQYRLSLALSFFFKFFLGVSKKLELTEIKYVDADVKIGQNVPETLY 578

  Fly   512 SGLQVFQTQKKNY----PVTQAVEKVEGMIQCSGEATYMNDVLTTSNTLHCAFVGATKVGSTIDS 572
            : .|::|..|.|.    |:.:.::.|.|....:|||.|.:|: ..::..|.|||.:.....|::|
Worm   579 A-TQLYQEVKANQPAHDPLGRPIKHVSGDKHTTGEAVYCDDI-NVADCNHIAFVLSPIAHGTLNS 641

  Fly   573 IDASEALKQPGVIAFYSAKDIPGTNTFCEPSFGFEV-----EEIFCSGLVRHSEQPAGVIVALTA 632
            ||.:.||:..||:....|.|:         :.|.::     ..:|....:....||...|||...
Worm   642 IDYTAALEIDGVVGTIDASDV---------TTGAQMGHHSDTPVFVKETITFHGQPIAAIVATDH 697

  Fly   633 DQAHRAAKLVRISYSNPSSDFKLQPSLGD--------VFASPTPDSSRIVPASKSTSKKIKFSEQ 689
            :.|.:||.||::.||.......::.:|..        |..|...|:.:::.:..|     |:
Worm   698 EIARKAASLVKLDYSVEKPIVTIKQALEAESFVFKHFVIHSSLNDNEQVIKSDWS-----KY--- 754

  Fly   690 PDKEVRGIFQMGLQYHFTMEPQTTVAIPFEDG-LKIFSATQWMDQTQSVIAHMLQVKAKDVQLQV 753
             |:.|.|...||.|.||.:|.|..:.||.||. |:|..:.|.::..|..:|..|.:....:..:|
Worm   755 -DRIVEGSIDMGGQEHFYLETQQCIVIPHEDDELEIIISNQCVNDVQIEVAKCLGMAQHKISTKV 818

  Fly   754 RRLGGGYGSKITRGNQVACAASLVAYKLNRPVRFVQSLESMMDCNGKRWACRSDYKCHIKDNGKI 818
            :|:|||:|.|.:.|..:|..|||.|.|..||::|.......|...|.|......||..:.:|||.
Worm   819 KRIGGGFGGKESTGAILAVPASLAAKKFGRPMKFKFERFDDMAITGTRHPFTLQYKLAVDENGKF 883

  Fly   819 VGLTNDFYEDAGWSPNES-PIEGHSTFTAVNCYDLNGDNFKNNGNAVLTDAPSSTWCRAPGSVEG 882
            :.|......::|.:.:.| .:...:...|.|.|..  :|....|....|:..|:|..|..|..:|
Worm   884 LDLDYTALSNSGHTIDLSMGVMQRAMVHADNVYKF--ENADITGKMCKTNLASNTAFRGFGGPQG 946

  Fly   883 IAMIENIIEHVAFEVQKDPAEVRLANI-AAGN-----------KISELLPQFLESREYAQRKKEI 935
            :...|.:::|||.:...:..|||:.|. ..|:           .::....:..::.:|..|.:|:
Worm   947 MFGTEIMVKHVAEKFGFNHDEVRVKNFYKEGDCTPFGMHLNQCNVTRTWDECRKNSDYDNRLEEV 1011

  Fly   936 ESHNAKNRWTKRGLGLAVMDYPIFY----FGQYPATVAIYHVDGTVVVTHGGIEMGQGMNTKVAQ 996
            :..|..|::.|||:.|....:.|.:    ..|..|.|.:| .||:|:|:|||:|||||::||:.|
Worm  1012 KKFNDSNKFRKRGIYLTPTRFGIGFGLKQLNQAGALVLVY-TDGSVLVSHGGMEMGQGLHTKILQ 1075

  Fly   997 VAAYTLGIDLSFIKVESSDTINGANSMVTGGAVGSESLCYAVRKACETLNSRLEPVKKKD--ASW 1059
            :||..|.|.:..|.:..:.|....|:..|..:|||:....||:.||..:|.|||..||.|  .:|
Worm  1076 IAARCLEIPIERIHIHDTSTDKVPNASATAASVGSDMNGLAVQDACRQINERLERFKKLDPNGTW 1140

  Fly  1060 IETVEAAYGKSINLIASD----HYKKGDMQN--------YHIYGLALTEVELDVLTGNSQIKRVD 1112
            .:.|:|||...::|.||.    |::..|..|        |.:||.|..|||:|.|||:..:.|.|
Worm  1141 DDWVKAAYVDRVSLSASGFGIIHHEPVDFFNGKGAELFGYSVYGTACCEVEIDCLTGDHHLLRTD 1205

  Fly  1113 ILEDAGESLSPWIDIGQIEGAFVMCLGYWMSEQLVYDRETGRLLTNRTWNYKPPGAKDIPIDFRI 1177
            |:.|.||||:|.||||||||||:...|.:..|::.. |..|..||....|||.|.|.|.|..|.:
Worm  1206 IVMDVGESLNPAIDIGQIEGAFIQGYGLFTMEEIKI-RPDGIRLTRGPGNYKIPSADDAPRHFNV 1269

  Fly  1178 ELIQKPNPSGAGFMRSKATGEPPCCLAVSVVFALRQALDSARHDAGLPREWVRLGAPTTPETL 1240
            .|:.. :.:..|...|||.||||..|.....||:|:|:.:.|...| ..::....:|.|||.:
Worm  1270 SLLGN-SSNKMGIFSSKAIGEPPLFLGSCAFFAIREAVRAYRIQNG-NADYFVFHSPATPERI 1330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX3	NP_001303439.1	PLN02906	24..1238	CDD:215491	402/1340 (30%)
		Fer2_2	80..153	CDD:280048	38/73 (52%)
		FAD_binding_4	201..360	CDD:303082	43/187 (23%)
		CO_deh_flav_C	386..487	CDD:281449	29/101 (29%)
		Ald_Xan_dh_C	540..646	CDD:214971	31/110 (28%)
		Ald_Xan_dh_C2	688..1172	CDD:280834	172/515 (33%)
xdh-1	NP_502747.1	Fer2	18..86	CDD:278537	27/71 (38%)
		PLN02906	34..1340	CDD:215491	404/1345 (30%)
		Fer2_2	95..168	CDD:280048	38/73 (52%)
		FAD_binding_5	260..440	CDD:279309	44/191 (23%)
		CO_deh_flav_C	447..549	CDD:281449	29/102 (28%)
		Ald_Xan_dh_C	610..715	CDD:279635	33/114 (29%)
		Ald_Xan_dh_C2	755..1264	CDD:280834	172/512 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3132
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.670