DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX3 and F15E6.6

DIOPT Version :9

Sequence 1:	NP_001303439.1	Gene:	AOX3 / 41896	FlyBaseID:	FBgn0038349	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_500531.2	Gene:	F15E6.6 / 177192	WormBaseID:	WBGene00017487	Length:	1256	Species:	Caenorhabditis elegans

Alignment Length:	1329	Identity:	365/1329 - (27%)
Similarity:	612/1329 - (46%)	Gaps:	208/1329 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FSINGLPYAVNLTNLPPDITLNTFIREHAQLTATKFMCQEGGCGACICVVRDGKRSW-------- 61
            |::||..  :...|:.|::||..::|....|..||..|:||.||:|..|:    .:|
Worm     8 FNVNGKD--IKEENVDPELTLAYYLRNKLGLRGTKLGCEEGVCGSCTVVL----GTWDDSLNKAV 66

  Fly    62 --AVNSCLTLLNTCAQLEIVTAEGLGNQRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQN 124
              |||:||..|....:..::|.||:|: |...:|||.|:|:.:..|||||||||||:.|.|: :|
Worm    67 YSAVNACLVPLFHVHKTFVITVEGVGS-RDKIHPIQDRMARGHAVQCGFCSPGFVMSAYALL-RN 129

  Fly   125 EGKVTMAEVENSFGGNICRCTGYRPILDAMKSFAVDSNIAIPAECGDIEDLKPRNCPKTGQACSG 189
            ....|:.::..:...|:||||||||||:|:.||:....    ..||.         .|.|..|..
Worm   130 HPNPTIEQINAAIRANLCRCTGYRPILEALYSFSSSGG----GCCGG---------KKAGAGCCK 181

  Fly   190 SCLPSTLVYEDGVQWH------------WPKSLSELFDALDKV------------KDSEEF---- 226
            ........||....::            :|.||....|:.:.|            |..|:|
Worm   182 DLSSEDEAYEKLTSFNDFPEYDPSQEIIFPPSLRIFVDSENPVTLKGDRIELLLPKSIEQFKEFK 246

  Fly   227 ----MLVAGNTAHGVYRRSTDIKHF----IDVQGVEELHQHSSEGQQLKLGANLSLTQTMEII-R 282
                ::.:|.....:..|:.  |.|    |..:.|:|.::.....:.:.:||.:::.:..:|: |
Worm   247 KDRTVISSGLITRFIATRNP--KEFSQKWITTKYVKEFNEVIENPETVVIGAAVNIQKMSDILSR 309

  Fly   283 TTSKQPGFEYLDVLWNHIDLIANVPVRNSGTLAGNISIKKQNPEFPSDIFISFEALNVKVVALKN 347
            :.|:..|.| :|..   |...::..:.|..|..|.|....::....||:.:.|..||.|:..|.:
Worm   310 SLSQNIGKE-VDAF---IKKFSSPQIANFATWTGGIVSGAKSSISVSDLLLLFNVLNAKLTLLTD 370

  Fly   348 AADEKEMSLAEYLGTNDKKLVLKTFVLPAYPKDKYIYESYKIMPRAQNAHAYVNAAFLLELEADN 412
            :.|..::::.|::   :|||.....::      ..::.|           :.....|.|:|...:
Worm   371 SGDLTQVNIEEFV---EKKLFATNTIV------NTVFSS-----------SITGQLFCLKLGETS 415

  Fly   413 KVKSARICFGGIRPDFIHASAIEKLLVGQN--PYESSLVEQTFTKLEDLIKPDEVLPDASPAYRS 475
            :..|....|..     :..:.|.::.||..  |...:.:|:....|::|..||..........::
Worm   416 EQDSTSFNFAA-----LVGNNISRIFVGLGGPPKRLTSLEEHIFALKNLDVPDLCKTSGMGENKN 475

  Fly   476 -KLACGLFYKFLLKHAPVAEVGEKFRSGGQILQRPLSSGLQVFQ-TQKK-------NYPVTQAVE 531
             |:|.....||:......||..:..            :.||.|: |::|       ||...:|:
Worm   476 IKIALTRLSKFMKNVEKTAETVDGL------------NYLQYFKPTERKSVGRPLANYFNERAI- 527

  Fly   532 KVEGMIQCSGEATYMNDVLTTSNTLHCAFVGATKVGSTIDSIDASEALKQPGVIAFYSAKDIPGT 596
                    :|||.|:||: .|.|.:|..||.:|...:.|.||||:||||..||:.|:.|.|:||.
Worm   528 --------TGEALYVNDI-QTYNPVHLGFVLSTVPHAEILSIDATEALKLEGVVGFFGASDVPGN 583

  Fly   597 NTFCEPSFGFEVEE--------IFCSGLVRHSEQPAGVIVALTADQAHRAAKLVRISYSNPSSDF 653
            |     |.|.::..        ||....|....|..|||.|.....|.||||||::.|....:..
Worm   584 N-----SPGLQISNMNLPDDATIFADKKVESVGQVVGVIAANDVLLARRAAKLVKLEYKELPALV 643

  Fly   654 KLQPSLGDVFASPTPDSSRIVPASKSTSKKIKFSEQPD-----------KEVRGIFQMGLQYHFT 707
            :|:.::                .:||...|::...:.:           |.:.|...:|.|.||.
Worm   644 ELKDAI----------------VAKSLLGKVRHFGKSEYLVNESLVHSYKVLEGESSLGSQEHFY 692

  Fly   708 MEPQTTVAIPFE-DGLKIFSATQWMDQTQSVIAHMLQVKAKDVQLQVRRLGGGYGSKITRGNQVA 771
            :|.|:::.||.| |...:..:||....||.::|..:::.|..:.::.:|:||.:|.|:...:.:|
Worm   693 LETQSSLVIPGEGDESIVHCSTQGTSFTQLMVAETMKIPAHKIIVKTKRMGGAFGGKLNNASWIA 757

  Fly   772 CAASLVAYKLNRPVRFVQSLESMMDCNGKRWACRSDYKCHIKDNGKIVGLTNDFYEDAGWSPNES 836
            |..|:||.|||||.....|.|..:...|||....:.|:..|..:||:.|:.:..:.:.|||.:.:
Worm   758 CICSVVAKKLNRPTYGYLSREEDLAITGKRHGVYTKYRVGINSDGKVQGIHHQAWLNGGWSKDHT 822

  Fly   837 PIEGHSTFTAVNCYDL-NGDNFKNNGNAVLTDAPSSTWCRAPGSVEGIAMIENIIEHVAFEVQKD 900
              ||.:........|: |....:.:|..|.|:..|:|..|..|:.:...:.|.::..:|.||.|.
Worm   823 --EGVTMVMGQFVDDVYNMGTVRYDGYPVKTNTNSNTAFRGYGNPQAKLVSEGVMRRIAREVGKS 885

  Fly   901 PAEVRLANIA--------AGNKISELLPQFLESREYA-------QRKKEIESHNAKNRWTKRGLG 950
            ..||:..|.|        :||..|:   ..:|..||.       :||:.||:.|..::..|||:.
Worm   886 TEEVKKLNFAFEGEKRYLSGNIYSD---AHIECWEYCTRWSDFEKRKETIENFNKTSKIVKRGIA 947

  Fly   951 LAVMDYPIFYFGQYPATVA--IYHVDGTVVVTHGGIEMGQGMNTKVAQVAAYTLGIDLSFIKVES 1013
            ::.:...:.:.|.....||  :.::||::.::.||.|||||:|.|:.||.:..|...:..|.:..
Worm   948 MSSVRLALSHPGPPGHGVASLMINLDGSIQLSIGGTEMGQGLNQKMLQVCSEALKRPIDTITIVD 1012

  Fly  1014 SDTINGANSMVTGGAVGSESLCYAVRKACETLNSRLEP-VKKKDASWIETVEAAYGKSINLIASD 1077
            ..|....|:..||.:..:::...||...||.:.|||:| :.|.|..|.:::..|||..:.|..::
Worm  1013 CSTDKITNAPETGASHNADTNGLAVLACCERIMSRLQPIIDKNDGDWEKSIRDAYGAYVPLQCTE 1077

  Fly  1078 HYKKGDMQN---------YHIYGLALTEVELDVLTGNSQIKRVDILEDAGESLSPWIDIGQIEGA 1133
             |...|.:.         |:..|....|:|:|.:||.:::.||||:.|.||||:|.|||||||||
Worm  1078 -YGSVDREKLSIGEFEYPYNTTGACAVEMEVDTMTGYNRLLRVDIVMDVGESLNPAIDIGQIEGA 1141

  Fly  1134 FVMCLGYWMSEQLVYDRETGRLLTNRTWNYKPPGAKDIPIDFRIELIQKPNPSGAGFMRSKATGE 1198
            |:...|....|::.:::|||:|..|....||.|.:.|:|.|||::|:.....:||....||..||
Worm  1142 FMQGYGLVTCEKITFNKETGQLNQNSAGQYKIPKSSDVPKDFRVKLLGINKANGAKVYSSKGIGE 1206

  Fly  1199 PPCCLAVSVVFA-LRQALDSARHDAGLPR 1226
            ||..::...|.: :...:|..|.:.|:.:
Worm  1207 PPLMMSCGAVHSCIMNCIDDWRKENGIDK 1235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX3	NP_001303439.1	PLN02906	24..1238	CDD:215491	360/1310 (27%)
		Fer2_2	80..153	CDD:280048	36/72 (50%)
		FAD_binding_4	201..360	CDD:303082	37/195 (19%)
		CO_deh_flav_C	386..487	CDD:281449	19/103 (18%)
		Ald_Xan_dh_C	540..646	CDD:214971	46/113 (41%)
		Ald_Xan_dh_C2	688..1172	CDD:280834	157/523 (30%)
F15E6.6	NP_500531.2	fer2	6..77	CDD:238126	24/74 (32%)
		PLN02906	23..1253	CDD:215491	360/1312 (27%)
		Fer2_2	87..158	CDD:280048	36/72 (50%)
		FAD_binding_4	<279..382	CDD:303082	23/106 (22%)
		Ald_Xan_dh_C	528..640	CDD:279635	47/117 (40%)
		Ald_Xan_dh_C2	678..1180	CDD:280834	156/507 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163371
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3132
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.600