DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX2 and AO4

DIOPT Version :9

Sequence 1:	NP_732047.2	Gene:	AOX2 / 41895	FlyBaseID:	FBgn0038348	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_563711.1	Gene:	AO4 / 839488	AraportID:	AT1G04580	Length:	1337	Species:	Arabidopsis thaliana

Alignment Length:	1383	Identity:	410/1383 - (29%)
Similarity:	640/1383 - (46%)	Gaps:	261/1383 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQSRAA 69
            |.|||..:||.:.:  |.|||..|||.:....:.|..|.|||||:|:.::.:..||..:|:..:.
plant     8 FAVNGEKFEVLSVN--PSTTLLEFLRSNTCFKSVKLSCGEGGCGACIVILSKYDPVLDQVEEYSI 70

  Fly    70 NSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQ-HRGQ 133
            |||||||.:.:...|.|.:||||...|:|||.||.|..:.:|||:|:||..:::|..|.: |..|
plant    71 NSCLTLLCSLNGCSITTSDGLGNTEKGFHPIHKRFAGFHASQCGFCTPGMCISLYSALSKAHNSQ 135

  Fly   134 VSMSQV-----EDAFGGNLCRCTGYRPILDAMKSFAVDSNVEVPAESVDIED----SFELLCPRT 189
            .|...:     |.:..||||||||||||.||.||||.|         |||||    ||.    |.
plant   136 SSPDYLTALAAEKSIAGNLCRCTGYRPIADACKSFASD---------VDIEDLGFNSFW----RK 187

  Fly   190 GQSCKGSCSR-PPLRDHGD---------------------SQWYW--PKTLTELFGALSQVANGE 230
            |:|.:....: ||.....|                     ::::|  |.::.||...|:....|:
plant   188 GESREEMLKKLPPYNPEKDLITFPDFLKEKIKCQHNVLDQTRYHWSTPGSVAELQEILATTNPGK 252

  Fly   231 ---LYMLVAGNTAHGVYRRPRDIRHFIDVNMVPELRQYSIETDHLLLGGNVTLTDAMQVFLLAAK 292
               |..||.|||..|.|:..:....:||::.:||:.....:...:.:|..||::..:.. |:...
plant   253 DRGLIKLVVGNTGTGYYKEEKQYGRYIDISHIPEMSMIKKDDREIEIGAVVTISKVIDA-LMEEN 316

  Fly   293 RPGFEYCAQLWQHFNLIANVPVRNNGTLAGNINIKKQHFEFPSDVFITFEALD--VHVLVYDNPS 355
            ...:.: .::..|...:||..:||:|::.||: :..|...||||:.....|.|  ||::   |..
plant   317 TSAYVF-KKIGVHMEKVANHFIRNSGSIGGNL-VMAQSKSFPSDITTLLLAADASVHMI---NAG 376

  Fly   356 TQRVMNLLTYLG-----DTTSKLVLGGFILKAY-PK------DRFLFRSYKILPR-AQNVHAYVN 407
            ....:.:..||.     ||  |.||    ||.: |:      ...||.:|:...| ..:...|:|
plant   377 RHEKLRMGEYLVSPPILDT--KTVL----LKVHIPRWIASSTTGLLFETYRAALRPIGSALPYIN 435

  Fly   408 AGFLIEWQDIQHR------IVHSARICFG------NIRPDYIHDDQVEQLLPGRDLYDPATVAQ- 459
            |.||..   :.|.      ||...|:.||      :||...:.|....::|....||:...:.:
plant   436 AAFLAV---VSHDASSSGIIVDKCRLAFGSYGGYHSIRAREVEDFLTGKILSHSVLYEAVRLLKG 497

  Fly   460 -IFQELPASLQPEERPPEASPEYRQMLACSLLYKFLLATAPKERVRERFRTGGLLLERP------ 517
             |...:..|..          ||::.||...|:.||..                |:|..
plant   498 IIVPSIDTSYS----------EYKKSLAVGFLFDFLYP----------------LIESGSWDSEG 536

  Fly   518 ---------------LSSGSQSFETIKKNYPVTQPVQKLEGLIQCSGEATYMNDLLTTSNAVHCA 567
                           |||..|.||: |:.:||.:.:.|....:|.||||.|::|:.:..:.:|.|
plant   537 KHIDGHIDPTICLPLLSSAQQVFES-KEYHPVGEAIIKFGAEMQASGEAVYVDDIPSLPHCLHGA 600

  Fly   568 FVTAKRVGATIEQIDPSAALQCKGVVAFYSAEDIP--GSNNFVLVNQLTP------EVDEVFV-A 623
            |:.:.:..|.|:.:..|..:...||:|..:.:|||  |.|    :..:|.      ..|||.: |
plant   601 FIYSTKPLAWIKSVGFSGNVTPIGVLAVITFKDIPEVGQN----IGYITMFGTGLLFADEVTISA 661

  Fly   624 GRVKYFDQPLGVIAALTHDAAVYAATLVVVTYARDQRKIFTTMNQVLAEKQTDRIVSTKKDTVE- 687
            |::      :.::.|.|...|..||.|.||.|  |.|.|.|.:..|             :|.|:
plant   662 GQI------IALVVADTQKHADMAAHLAVVEY--DSRNIGTPVLSV-------------EDAVKR 705

  Fly   688 ------PLKLPPLAPGDVLGRGI-----------LELASQYHFTMEPQTTIVVP-LDNILQVYCA 734
                  |.:..|...||: .:|:           |.|.|||.|.||.||.:.:| .||.|.||.:
plant   706 SSLFEVPPEYQPEPVGDI-SKGMAEADRKIRSVELRLGSQYFFYMETQTALALPDEDNCLVVYSS 769

  Fly   735 TQWMDATQGAIAHMLKVSVNSIQLQVRRVGGAYGAKVTRGNIVACATALVASKLRRPARFVQTIE 799
            ||..:.||..||..|.:..:::::..|||||.:|.|..:...||.|.||.|.|::||.|.....:
plant   770 TQAPEFTQTVIATCLGIPEHNVRVITRRVGGGFGGKAIKSMPVATACALAAKKMQRPVRIYVNRK 834

  Fly   800 SMMETIGKRWACRSDYEFRARANGSIIMLSNNYYEDSGCNLNENVVDFLTLPILRNVYN-LTDAN 863
            :.|...|.|...:..|....|::|.:..|..|.:.|:|.:::.::|    :|  :|:.| |...:
plant   835 TDMIMAGGRHPLKITYSVGFRSDGKLTALDLNLFIDAGSDVDVSLV----MP--QNIMNSLRKYD 893

  Fly   864 YRTQGSAI---RTDAPSSTWCRAPGSAEGIAMTETALEHIAFTCQLDPADVRLVNL--------- 916
            :......|   :|:.||.|..||||..:|..:.|:.:|::|.:.::|...||.:||
plant   894 WGALSFDIKVCKTNLPSRTSLRAPGEVQGSYIAESIIENVASSLKMDVDVVRRINLHTYESLRKF 958

  Fly   917 ------QPGNKMVQLL-PKFLASTEYHKRRDQINLFNSQNRWRKRGLGLALMSFPLNTTVAFNYP 974
                  :|....:.|| .|...|.::.:|.:.:..||..|.|||||:.              ..|
plant   959 YKQAAGEPDEYTLPLLWDKLEVSADFRRRAESVKEFNRCNIWRKRGIS--------------RVP 1009

  Fly   975 VTVAIYH----------EDGSVVISHGGIEIGQGVNTKAAQVAAFVLGV--------PLDQVRVE 1021
            :...:.|          .||||.:...|||:|||:.||..|:.|:.||:        .|:::|:.
plant  1010 IIHLVIHRPTPGKVSILNDGSVAVEVAGIEVGQGLWTKVQQMVAYGLGMIKCEGSDDLLERIRLL 1074

  Fly  1022 ASNTVNGANSMLTANSMTSEMIGLAVRKACDTLNKRLAPVKERLGPRA---SWVQVLQAAFLQSV 1083
            .::|::.:.|..||.|.|||....|||..|..|.:||.|...::...|   :|..::|.|..|||
plant  1075 QTDTLSMSQSSYTAGSTTSENCCEAVRLCCGILVERLRPTMNQILENARSVTWDMLIQQANAQSV 1139

  Fly  1084 FLIATESYR-LGDIPNYNIFGLSLTELELDILTGNHLIRRVDILEDAGESLSPHIDVGQVEGAFV 1147
            .|.|...|: ......|..:|:..:|:|:|::||...|.|.||:.|.|:||:|.:|:||:|||||
plant  1140 DLSARTFYKPESSSAEYLNYGVGASEVEVDLVTGRTEIIRSDIIYDCGKSLNPAVDLGQIEGAFV 1204

  Fly  1148 MGLGYYLTEQLVYDRQTGQILTNRTWNYHPPGAKDIPIDFRIELLQKSPNPVGFMRSKATGEPAL 1212
            .|:|:::.|:.. ..:.|.:....||:|..|....||..|.:::|....:....:.|||:|||.|
plant  1205 QGIGFFMYEEYT-TNENGLVNEEGTWDYKIPTIDTIPKQFNVQILNSGHHKNRVLSSKASGEPPL 1268

  Fly  1213 CLAVGALFAMQHAIQSAR 1230
            .:|.....|.:.||:.||
plant  1269 LVAASVHCATRSAIREAR 1286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX2	NP_732047.2	fer2	3..84	CDD:238126	31/78 (40%)
		PLN02906	24..1251	CDD:215491	402/1364 (29%)
		Fer2_2	86..159	CDD:280048	36/78 (46%)
		FAD_binding_4	206..366	CDD:303082	41/187 (22%)
		CO_deh_flav_C	391..497	CDD:281449	28/120 (23%)
		Ald_Xan_dh_C	548..655	CDD:214971	34/115 (30%)
		Ald_Xan_dh_C2	702..1184	CDD:280834	166/535 (31%)
AO4	NP_563711.1	PLN00192	1..1337	CDD:215096	410/1383 (30%)
		fer2	6..86	CDD:238126	31/79 (39%)
		Fer2_2	87..167	CDD:280048	37/79 (47%)
		FAD_binding_5	229..407	CDD:279309	50/189 (26%)
		CO_deh_flav_C	419..526	CDD:281449	28/135 (21%)
		Ald_Xan_dh_C	581..691	CDD:279635	36/121 (30%)
		Ald_Xan_dh_C2	720..1240	CDD:280834	168/541 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	83	1.000	Domainoid score	I2880
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H98597
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820