DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX2 and XDH2

DIOPT Version :9

Sequence 1:	NP_732047.2	Gene:	AOX2 / 41895	FlyBaseID:	FBgn0038348	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_195216.2	Gene:	XDH2 / 829642	AraportID:	AT4G34900	Length:	1353	Species:	Arabidopsis thaliana

Alignment Length:	1368	Identity:	382/1368 - (27%)
Similarity:	622/1368 - (45%)	Gaps:	195/1368 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PD----TTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQSRAANSCLTLLNTCDD 81
            ||    .||..:||: |.||.||..|.|||||||..::......::.....|.|:||..|.:.:.
plant    21 PDGLAHMTLLEYLRD-LGLTGTKLGCGEGGCGSCTVMVSSYDRESKTCVHYAVNACLAPLYSVEG 84

  Fly    82 AEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQHRGQVSMSQVEDAFGGN 146
            ..:::.||:|::..|.||:|:.:|..:|:|||:|:|||||:||.||...:...|..::|:...||
plant    85 MHVISIEGVGHRKLGLHPLQESLASSHGSQCGFCTPGFVMSMYALLRSSKNSPSEEEIEECLAGN 149

  Fly   147 LCRCTGYRPILDAMKSFA-VDSNVEVPAESVDIEDSFELLCPRTGQSCK---------GSCSR-- 199
            ||||||||||:||.:.|| .|..:.....|:.::|... :||.||:.|.         .:|:.
plant   150 LCRCTGYRPIIDAFRVFAKSDDALYSGLSSLSLQDGSN-ICPSTGKPCSCGSKTTSEAATCNEDR 213

  Fly   200 ------------------------------PPLRDHGDS--QWYWPKTLTELFGALSQVANGELY 232
                                          .||:..|:.  .||.|.:|..|   |...||....
plant   214 FQSISYSDIDGAKYTDKELIFPPELLLRKLAPLKLGGNEGITWYRPVSLQNL---LELKANFPDA 275

  Fly   233 MLVAGNTAHGVYRRPRDIRH--FIDVNMVPELRQYSIETDHLLLGGNVTLTDAMQVFLLAAK-RP 294
            .|:.|||..|:..|.:.:::  .|....||||...::..:.:.:|..:.|::.:::|....| ||
plant   276 KLLVGNTEVGIEMRLKRLQYPVLISAAQVPELNALNVNDNGIEVGSALRLSELLRLFRKVVKERP 340

  Fly   295 GFE--YCAQLWQHFNLIANVPVRNNGTLAGN-----------------------INIKKQHFEFP 334
            ..|  .|....:.....|...:||...:.||                       ||........|
plant   341 AHETSACKAFIEQLKWFAGTQIRNVACIGGNICTASPISDLNPLWMASRAEFRIINCNGDVRSIP 405

  Fly   335 S-DVFITFEALDVHVLVYDNPSTQRVMNLLTYLGDTTSKLVLGGFILKAYPKDRFLFRSYKILPR 398
            : |.|:.:..:|:                      .:::::|..|:....|.:  ..:.:|...|
plant   406 AKDFFLGYRKVDM----------------------GSNEILLSVFLPWTRPLE--YVKEFKQAHR 446

  Fly   399 AQNVHAYVNAGFLIEWQDI-QHRIVHSARICFGNIRPDYIHDDQVEQLLPGRDLYDPATVAQIFQ 462
            ..:..|.||.|..:..::. |...|..|.|.:|.:.|..:.....|:||.|:: ::...:....:
plant   447 RDDDIAIVNGGMRVFLEEKGQQLFVSDASIVYGGVAPLSLRARNTEELLIGKN-WNKCLLQDALK 510

  Fly   463 ELPASLQPEERPPEASPEYRQMLACSLLYKFLL-ATAPKERVRERFRT-------GGLLLERPLS 519
            .:.:.:..:|..|....|:|:.|..|..:||.| .|.....|.....|       ...|:.|...
plant   511 VIQSDVLIKEGAPGGMVEFRKSLTLSFFFKFFLWVTHHVNNVNPTIETFPPSHMSAVQLVPRFSR 575

  Fly   520 SGSQSFETIKKNYPVTQPVQKLEGLIQCSGEATYMNDLLTTSNAVHCAFVTAKRVGATIEQIDPS 584
            .|.|.:||:|:...|..|...|...:|.:|||.|.:|.......:|.|.|.:|...|.|..:|.|
plant   576 IGKQDYETVKQGTSVGLPEVHLSARMQVTGEAEYTDDTPLPPCTLHAALVLSKVPHARILSVDDS 640

  Fly   585 AALQCKGVVAFYSAEDIPGSNNFVLVNQLTPEVDEVFVAGRVKYFDQPLGVIAALTHDAAVYAAT 649
            ||....|.|..:.|:|:||:|   ::..:..: :|:|....|....|.:||:.|.||:.|..||.
plant   641 AAKSSSGFVGLFLAKDVPGNN---MIGPIVAD-EELFATDVVTCVGQVIGVLVADTHENAKTAAR 701

  Fly   650 LVVVTYARDQRKIFTTMNQVLAEKQTDRIVSTKKDTVEPLKLPPLAPGDV-----------LGRG 703
            .|.|.|..        :..:|:.|:.....|...:|...|:     .|||           :..|
plant   702 KVDVRYQE--------LPAILSIKEAINAKSFHPNTERRLR-----KGDVELCFQSGQCDRIIEG 753

  Fly   704 ILELASQYHFTMEPQTTIVVPLD--NILQVYCATQWMDATQGAIAHMLKVSVNSIQLQVRRVGGA 766
            .:::..|.||.:||..::|..:|  |.:.:..:||.....|..::|:|.:.::.:..:.:|:||.
plant   754 EVQMGGQEHFYLEPNGSLVWTIDGGNEVHMISSTQAPQQHQKYVSHVLGLPMSKVVCKTKRLGGG 818

  Fly   767 YGAKVTRGNIVACATALVASKLRRPARFVQTIESMMETIGKRWACRSDYEFRARANGSIIMLSNN 831
            :|.|.||...:|.|.::.:..|.||.:.:...:..|...|.|.:....|:......|.|:.|...
plant   819 FGGKETRSAFIAAAASVPSYLLNRPVKLILDRDVDMMITGHRHSFVGKYKVGFTNEGKILALDLE 883

  Fly   832 YYEDSGCNLNENVVDFLTLPILR-------NVYNLTDANYRTQGSAIRTDAPSSTWCRAPGSAEG 889
            .|.:.|     |.:| |:|..|.       |||.:  .:.|..|:...|:.||:|..|..|..:|
plant   884 IYNNGG-----NSMD-LSLSNLERAMFHSDNVYEI--PHVRIVGNVCFTNFPSNTAFRGFGGPQG 940

  Fly   890 IAMTETALEHIAFTCQLDPADVRLVNLQPGNKMV------------QLLPKFLASTEYHKRRDQI 942
            :.:||..::.||......|.:::.:|.|....:.            ||..:...|:.:.|.|.:.
plant   941 MLITENWIQRIAAELDKIPEEIKEMNFQVEGSITHYFQSLQHCTLHQLWKELKVSSNFLKTRREA 1005

  Fly   943 NLFNSQNRWRKRGLGLALMSFPLNTTVAF-NYPVTVAIYHEDGSVVISHGGIEIGQGVNTKAAQV 1006
            :.|||.|||:|||:.:....|.::.|..| |....:...:.||:|:::|||:|:|||::||.|||
plant  1006 DEFNSHNRWKKRGVAMVPTKFGISFTTKFMNQAGALVHVYTDGTVLVTHGGVEMGQGLHTKVAQV 1070

  Fly  1007 AAFVLGVPLDQVRVEASNTVNGANSMLTANSMTSEMIGLAVRKACDTLNKRLAPVKERLGPRASW 1071
            ||....:.|..|.|..::|....|:..||.|.:|:|.|.||..||:.:..|:.||..:.... ::
plant  1071 AATAFNILLSSVFVSETSTDKVPNASPTAASASSDMYGAAVLDACEQIIARMEPVASKHNFN-TF 1134

  Fly  1072 VQVLQAAFLQSVFLIATESYRL------------GDIPNYNIFGLSLTELELDILTGNHLIRRVD 1124
            .::..|.:.|.:.|.| ..:.:            |:...|..:|.:..|:|:|.|||:...|:.|
plant  1135 SELASACYFQRIDLSA-HGFHIVPELEFDWVSGKGNAYRYYTYGAAFAEVEIDTLTGDFHTRKAD 1198

  Fly  1125 ILEDAGESLSPHIDVGQVEGAFVMGLGYYLTEQLVYDR------QTGQILTNRTWNYHPPGAKDI 1183
            |:.|.|.||:|.||:||:|||||.|||:...|:|.:..      :.|.:||....:|..|...|:
plant  1199 IMLDLGYSLNPTIDIGQIEGAFVQGLGWVALEELKWGDAAHKWIKPGSLLTCGPGSYKIPSINDM 1263

  Fly  1184 PIDFRIELLQKSPNPVGFMRSKATGEPALCLAVGALFAMQHAIQSARNDAGLPREWVRLGAPTTP 1248
            |....:.||:.:||......|||.|||...||..|.||::.||::||::.|| ..|..|..|.||
plant  1264 PFQLNVSLLKGNPNAKAIHSSKAVGEPPFFLAASAFFAIKEAIKAARSEVGL-TNWFPLETPATP 1327

  Fly  1249 ETV 1251
            |.:
plant  1328 ERI 1330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX2	NP_732047.2	fer2	3..84	CDD:238126	24/66 (36%)
		PLN02906	24..1251	CDD:215491	380/1359 (28%)
		Fer2_2	86..159	CDD:280048	36/72 (50%)
		FAD_binding_4	206..366	CDD:303082	39/190 (21%)
		CO_deh_flav_C	391..497	CDD:281449	25/107 (23%)
		Ald_Xan_dh_C	548..655	CDD:214971	36/106 (34%)
		Ald_Xan_dh_C2	702..1184	CDD:280834	153/521 (29%)
XDH2	NP_195216.2	PLN02906	26..1344	CDD:215491	380/1363 (28%)
		Fer2_2	90..162	CDD:280048	36/71 (51%)
		FAD_binding_5	252..431	CDD:279309	40/203 (20%)
		CO_deh_flav_C	441..545	CDD:281449	25/104 (24%)
		Ald_Xan_dh_C	604..711	CDD:214971	37/118 (31%)
		Ald_Xan_dh_C2	730..1264	CDD:280834	157/548 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820