DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX2 and XDH1

DIOPT Version :9

Sequence 1:	NP_732047.2	Gene:	AOX2 / 41895	FlyBaseID:	FBgn0038348	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_195215.2	Gene:	XDH1 / 829641	AraportID:	AT4G34890	Length:	1361	Species:	Arabidopsis thaliana

Alignment Length:	1372	Identity:	391/1372 - (28%)
Similarity:	628/1372 - (45%)	Gaps:	203/1372 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PD----TTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQSRAANSCLTLLNTCDD 81
            ||    .||..:||: |.||.||..|.|||||:|..::......::.....|.|:||..|.:.:.
plant    29 PDGLAHMTLLEYLRD-LGLTGTKLGCGEGGCGACTVMVSSYDRKSKTSVHYAVNACLAPLYSVEG 92

  Fly    82 AEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQHRGQVSMSQVEDAFGGN 146
            ..:::.||||::..|.||:|:.:|..:|:|||:|:|||:|:||.||...:...|..::|:...||
plant    93 MHVISIEGLGHRKLGLHPVQESLASSHGSQCGFCTPGFIMSMYSLLRSSKNSPSEEEIEECLAGN 157

  Fly   147 LCRCTGYRPILDAMKSFA-VDSNVEVPAESVDIEDSFELLCPRTGQSCK---------GSCSR-- 199
            ||||||||||:||.:.|| .|..:.....|:.::|. ..:||.||:.|.         .||:.
plant   158 LCRCTGYRPIVDAFRVFAKSDDALYCGVSSLSLQDG-STICPSTGKPCSCGSKTTNEVASCNEDR 221

  Fly   200 ---------------------PP-----------LRDHGDSQWYWPKTLTELFGALSQVANGELY 232
                                 ||           ||.:|...||.|..|..|   |...||....
plant   222 FQSISYSDIDGAKYTDKELIFPPELLLRKLTPLKLRGNGGITWYRPVCLQNL---LELKANYPDA 283

  Fly   233 MLVAGNTAHGVYRRPRDIRH--FIDVNMVPELRQYSIETDHLLLGGNVTLTDAMQVF-LLAAKRP 294
            .|:.|||..|:..|.:.:::  .|.|..||||...::..:.:.:|..:.|::.:::| .:..:||
plant   284 KLLVGNTEVGIEMRLKRLQYQVLISVAQVPELNALNVNDNGIEVGSALRLSELLRLFRKIVKERP 348

  Fly   295 GFE--YCAQLWQHFNLIANVPVRNNGTLAGNI-----------------------NIKKQHFEFP 334
            ..|  .|....:.....|...:||...:.|||                       |........|
plant   349 AHETSACKAFIEQLKWFAGTQIRNVACIGGNICTASPISDLNPLWMASRAEFRITNCNGDVRSIP 413

  Fly   335 S-DVFITFEALDVHVLVYDNPSTQRVMNLLTYLGDTTSKLVLGGFILKAYPKDRFLFRSYKILPR 398
            : |.|:.:..:|:                      .:::::|..|:....|.:  ..:.:|...|
plant   414 AKDFFLGYRKVDM----------------------GSNEILLSVFLPWTRPLE--YVKEFKQAHR 454

  Fly   399 AQNVHAYVNAGFLIEWQDI-QHRIVHSARICFGNIRPDYIHDDQVEQLLPGRD-----LYDPATV 457
            ..:..|.||.|..:..:|. |...|..|.|.:|.:.|..:...:.|:.|.|::     |.|...|
plant   455 RDDDIAIVNGGMRVFLEDKGQQLFVSDASIAYGGVAPLSLCARKTEEFLIGKNWNKDLLQDALKV 519

  Fly   458 AQIFQELPASLQPEERPPEASPEYRQMLACSLLYKFLLATAPK----ERVRERFRTGGLLLERPL 518
            .|      :.:..:|..|....|:|:.|..|..:||.|..:..    ....|.|....:...:|:
plant   520 IQ------SDVVIKEDAPGGMVEFRKSLTLSFFFKFFLWVSHNVNNANSAIETFPPSHMSAVQPV 578

  Fly   519 SS----GSQSFETIKKNYPVTQPVQKLEGLIQCSGEATYMNDLLTTSNAVHCAFVTAKRVGATIE 579
            ..    |.|.:||:|:...|......|...:|.:|||.|.:|.....|.:|.|||.:|...|.|.
plant   579 PRLSRIGKQDYETVKQGTSVGSSEVHLSARMQVTGEAEYTDDTPVPPNTLHAAFVLSKVPHARIL 643

  Fly   580 QIDPSAALQCKGVVAFYSAEDIPGSNNFVLVNQLTPEVDEVFVAGRVKYFDQPLGVIAALTHDAA 644
            .||.|||....|.|..:.|:||||.|   ::..:.|: :|:|....|....|.:||:.|.||:.|
plant   644 SIDDSAAKSSSGFVGLFLAKDIPGDN---MIGPIVPD-EELFATDVVTCVGQVIGVVVADTHENA 704

  Fly   645 VYAATLVVVTYARDQRKIFTTMNQVLAEKQTDRIVSTKKDTVEPLKLPPLAPGDV---------- 699
            ..||..|.|.|..        :..:|:.|:.....|...:|.:.|:     .|||
plant   705 KTAAGKVDVRYEE--------LPAILSIKEAINAKSFHPNTEKRLR-----KGDVELCFQSGQCD 756

  Fly   700 -LGRGILELASQYHFTMEPQTTIVVPLDNILQVY--CATQWMDATQGAIAHMLKVSVNSIQLQVR 761
             :..|.:::..|.||.:||..::|..:|...:|:  .:||.....|..::|:|.:.::.:..:.:
plant   757 RVIEGEVQMGGQEHFYLEPNGSLVWTVDGGSEVHMISSTQAPQKHQKYVSHVLGLPMSKVVCKTK 821

  Fly   762 RVGGAYGAKVTRGNIVACATALVASKLRRPARFVQTIESMMETIGKRWACRSDYEFRARANGSII 826
            |:||.:|.|.||...:|.|.::.:..|.||.:.:...:..|...|.|.:....|:......|.|:
plant   822 RIGGGFGGKETRSAFIAAAASVPSYLLNRPVKLILDRDVDMMITGHRHSFLGKYKVGFTNEGKIL 886

  Fly   827 MLSNNYYEDSGCNLNENVVDFLTLPILR-------NVYNLTDANYRTQGSAIRTDAPSSTWCRAP 884
            .|....|.:.|.:|:      |:|.:|.       |||.:  .:.|..|:...|:.||:|..|..
plant   887 ALDLEIYNNGGNSLD------LSLSVLERAMFHSDNVYEI--PHVRIVGNVCFTNFPSNTAFRGF 943

  Fly   885 GSAEGIAMTETALEHIAFTCQLDPADVRLVNLQPGNKMV------------QLLPKFLASTEYHK 937
            |..:|:.:||..::.||......|.:::.:|.|....:.            ||..:...|..:.|
plant   944 GGPQGMLITENWIQRIAAELNKSPEEIKEMNFQVEGSVTHYCQTLQHCTLHQLWKELKVSCNFLK 1008

  Fly   938 RRDQINLFNSQNRWRKRGLGLALMSFPLNTTVAF-NYPVTVAIYHEDGSVVISHGGIEIGQGVNT 1001
            .|.:.:.|||.|||:|||:.:....|.::.|..| |....:...:.||:|:::|||:|:|||::|
plant  1009 ARREADEFNSHNRWKKRGVAMVPTKFGISFTTKFMNQAGALVHVYTDGTVLVTHGGVEMGQGLHT 1073

  Fly  1002 KAAQVAAFVLGVPLDQVRVEASNTVNGANSMLTANSMTSEMIGLAVRKACDTLNKRLAPVKERLG 1066
            |.|||||....:||..|.|..::|....|:..||.|.:|:|.|.||..||:.:..|:.||..:..
plant  1074 KVAQVAASAFNIPLSSVFVSETSTDKVPNASPTAASASSDMYGAAVLDACEQIIARMEPVASKHN 1138

  Fly  1067 PRASWVQVLQAAFLQSVFLIATESYRLGDIP-----------NYNIFGLSLTELELDILTGNHLI 1120
            .. ::.:::.|.:.|.:.|.|...:.:.|:.           .|..:|.:..|:|:|.|||:...
plant  1139 FN-TFTELVSACYFQRIDLSAHGFHIVPDLGFDWISGKGNAFRYYTYGAAFAEVEIDTLTGDFHT 1202

  Fly  1121 RRVDILEDAGESLSPHIDVGQVEGAFVMGLGYYLTEQLVYDR------QTGQILTNRTWNYHPPG 1179
            |..||:.|.|.||:|.|||||:|||||.|||:...|:|.:..      :.|.:||....||..|.
plant  1203 RAADIMLDLGYSLNPAIDVGQIEGAFVQGLGWVALEELKWGDAAHKWIKPGSLLTCGPGNYKIPS 1267

  Fly  1180 AKDIPIDFRIELLQKSPNPVGFMRSKATGEPALCLAVGALFAMQHAIQSARNDAGLPREWVRLGA 1244
            ..|:|.:..:.||:.:||......|||.|||...||....||::.||::||.:.|| .:|..|.:
plant  1268 INDMPFNLNVSLLKGNPNTKAIHSSKAVGEPPFFLASSVFFAIKEAIKAARTEVGL-TDWFPLES 1331

  Fly  1245 PTTPETV 1251
            |.|||.:
plant  1332 PATPERI 1338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX2	NP_732047.2	fer2	3..84	CDD:238126	23/66 (35%)
		PLN02906	24..1251	CDD:215491	389/1363 (29%)
		Fer2_2	86..159	CDD:280048	36/72 (50%)
		FAD_binding_4	206..366	CDD:303082	39/188 (21%)
		CO_deh_flav_C	391..497	CDD:281449	29/111 (26%)
		Ald_Xan_dh_C	548..655	CDD:214971	41/106 (39%)
		Ald_Xan_dh_C2	702..1184	CDD:280834	155/520 (30%)
XDH1	NP_195215.2	PLN02906	34..1352	CDD:215491	389/1367 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820