DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX2 and AAO2

DIOPT Version :9

Sequence 1:	NP_732047.2	Gene:	AOX2 / 41895	FlyBaseID:	FBgn0038348	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_189946.1	Gene:	AAO2 / 823457	AraportID:	AT3G43600	Length:	1321	Species:	Arabidopsis thaliana

Alignment Length:	1352	Identity:	405/1352 - (29%)
Similarity:	639/1352 - (47%)	Gaps:	204/1352 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSIKFNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQ 65
            ||:.|.:||..:|::.:...|.|||..|||......:.|..|.|||||:||.::.:..||.|:|:
plant     1 MSLVFAINGQRFELELSSVDPSTTLLEFLRYQTSFKSVKLSCGEGGCGACVVLLSKFDPVLQKVE 65

  Fly    66 SRAANSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMY-GLLEQ 129
            ....:||||||.:.:...|.|.|||||...|:|||.||::..:.:|||:|:||..:::: .||:.
plant    66 DFTVSSCLTLLCSVNHCNITTSEGLGNSRDGFHPIHKRLSGFHASQCGFCTPGMSVSLFSALLDA 130

  Fly   130 HRGQVS---MSQVEDAFGGNLCRCTGYRPILDAMKSFAVDSNVEVPAESVDIED-SFELLCPRTG 190
            .:.|.|   :.:.|.|..||||||||||||:||.||||.|         ||||| .....| |.|
plant   131 DKSQYSDLTVVEAEKAVSGNLCRCTGYRPIVDACKSFASD---------VDIEDLGLNSFC-RKG 185

  Fly   191 ----------QSCKGSCSRPPLR-------DHGDSQWYWPKTLTELFGALSQV---ANGELYMLV 235
                      .|.|..|:.|...       |.|..:|..|.::.||...|...   :|.....||
plant   186 DKDSSSLTRFDSEKRICTFPEFLKDEIKSVDSGMYRWCSPASVEELSSLLEACKANSNTVSMKLV 250

  Fly   236 AGNTAHGVYRRPRDIRH--FIDVNMVPELRQYSIETDHLLLGGNVTLTDAMQVFLLAAKRPGFE- 297
            ||||:.|.|:..|:..:  :||:..:|.|::.....:.:.:|..||::..:.........||.|
plant   251 AGNTSMGYYKDEREQNYDKYIDITRIPHLKEIRENQNGVEIGSVVTISKVIAALKEIRVSPGVEK 315

  Fly   298 YCAQLWQHFNLIANVPVRNNGTLAGNINIKKQHFEFPSDV------------------------- 337
            ...:|..|..:||...:||.|::.||: :..|..:||||:
plant   316 IFGKLATHMEMIAARFIRNFGSIGGNL-VMAQRKQFPSDMATILLAAGAFVNIMSSSRGLEKLTL 379

  Fly   338 --FITFEALDVHVLVYDNPSTQRVMNLLTYLGDTTSKLVLGGFILKAYPKDRFLFRSYKILPRAQ 400
              |:....|:.|.||..       :.:..:..:|.|:|               .|.:|:..||..
plant   380 EEFLERSPLEAHDLVLS-------IEIPFWHSETNSEL---------------FFETYRAAPRPH 422

  Fly   401 -NVHAYVNAGFLIEWQDIQHRIVHSARICFGNIRPDY-IHDDQVEQLLPG-----RDLYDPATVA 458
             :..||:||.||.|.:|   .:|.:.|:.||.....: |...::|:.|.|     :.||:..|:
plant   423 GSALAYLNAAFLAEVKD---TMVVNCRLAFGAYGTKHAIRCKEIEEFLSGKVITDKVLYEAITL- 483

  Fly   459 QIFQELPASLQPEERPPEASPEYRQMLACSLLYKFL--LATAPKERVRERFRTGGLLLE----RP 517
                 |...:.||:  ..::|.||..||...|:|||  |.|.|....    .:.|..|:    .|
plant   484 -----LGNVVVPED--GTSNPAYRSSLAPGFLFKFLHTLMTHPTTDK----PSNGYHLDPPKPLP 537

  Fly   518 LSSGSQSFETIKKNYPVTQPVQKLEGLIQCSGEATYMNDLLTTSNAVHCAFVTAKRVGATIEQID 582
            :.|.||:.....:..||.|||.|:...:|.||||.|::|:.:.:|.::.||:.:|:..|.|:.|.
plant   538 MLSSSQNVPINNEYNPVGQPVTKVGASLQASGEAVYVDDIPSPTNCLYGAFIYSKKPFARIKGIH 602

  Fly   583 PSAALQCKGVVAFYSAEDIP-GSNNFVLVNQLTPEVDEVFVAGRVKYFDQPLGVIAALTHDAAVY 646
            ....|...||||..|.:|:| |..|..:  ::....|::|                  ..|....
plant   603 FKDDLVPTGVVAVISRKDVPKGGKNIGM--KIGLGSDQLF------------------AEDFTTS 647

  Fly   647 AATLVVVTYARDQRKIFTTMNQVLAEKQTDRI---VSTKKDTVEPLKLPPLAP-------GDVLG 701
            ....:....|..||.....:|..:.|.:|:.:   :.:.:|.|:...|..:.|       ||. .
plant   648 VGECIAFVVADTQRHADAAVNLAVVEYETEDLEPPILSVEDAVKKSSLFDIIPFLYPQQVGDT-S 711

  Fly   702 RGILE-----------LASQYHFTMEPQTTIVV-PLDNILQVYCATQWMDATQGAIAHMLKVSVN 754
            :|:.|           |.|||.|.||.||.:.| ..||.:.||.:||.....|.::|..|.:..|
plant   712 KGMAEADHQILSSEIRLGSQYVFYMETQTALAVGDEDNCIVVYSSTQTPQYVQSSVAACLGIPEN 776

  Fly   755 SIQLQVRRVGGAYGAKVTRGNIVACATALVASKLRRPARFVQTIESMMETIGKRWACRSDYEFRA 819
            :|::..|||||.:|.|..:...||.|.||.|.||:||.|.....::.|...|.|...:..|....
plant   777 NIRVITRRVGGGFGGKSVKSMPVATACALAAKKLQRPVRTYVNRKTDMIMTGGRHPMKITYSVGF 841

  Fly   820 RANGSIIMLSNNYYEDSGCN------LNENVVDFLTLPILRNVYNLTDANYRTQGSAIRTDAPSS 878
            ::.|.|..|......|:|.:      :..|::..|      ..||....::..:  ..:|:..|.
plant   842 KSTGKITALELEILIDAGASYGFSMFIPSNLIGSL------KKYNWGALSFDIK--LCKTNLLSR 898

  Fly   879 TWCRAPGSAEGIAMTETALEHIAFTCQLDPADVRLVNLQPGNKMV----------------QLLP 927
            ...|:||..:|..:.|..:|:||.:..|:...:|.:||.....:.                .:..
plant   899 AIMRSPGDVQGTYIAEAIIENIASSLSLEVDTIRKINLHTHESLALFYKDGAGEPHEYTLSSMWD 963

  Fly   928 KFLASTEYHKRRDQINLFNSQNRWRKRGLGLALMSFPLNTTVAFNYPVTVAIYHEDGSVVISHGG 992
            |...|:::.:|...:..||..|.|||||:....:.:.:   :.|..|..|::. .||::|:..||
plant   964 KVGVSSKFEERVSVVREFNESNMWRKRGISRVPIIYEV---LLFATPGRVSVL-SDGTIVVEIGG 1024

  Fly   993 IEIGQGVNTKAAQVAAFVLGV--------PLDQVRVEASNTVNGANSMLTANSMTSEMIGLAVRK 1049
            ||:|||:.||..|:.::.||:        .|:::||..|::::......|..|.|||....|||.
plant  1025 IELGQGLWTKVKQMTSYALGMLQCDGTEELLEKIRVIQSDSLSMVQGNFTGGSTTSEGSCAAVRL 1089

  Fly  1050 ACDTLNKRLAPVKERLGPRASWVQVLQAAFLQSVFLIATESYRLGDIP-NYNIFGLSLTELELDI 1113
            .|:||.:||.|:.||.....:|.:::..|:.|||.|.|::.|...|.| .|..:|.:::|:|:|:
plant  1090 CCETLVERLKPLMERSDGPITWNELISQAYAQSVNLSASDLYTPKDTPMQYLNYGTAVSEVEVDL 1154

  Fly  1114 LTGNHLIRRVDILEDAGESLSPHIDVGQVEGAFVMGLGYYLTEQLVYDRQTGQILTNRTWNYHPP 1178
            :||...:.:.|||.|.|:||:|.:|:||:||:||.|||:::.|:.:.|.: |.:||:.||.|..|
plant  1155 VTGQTTVLQTDILYDCGKSLNPAVDLGQIEGSFVQGLGFFMLEEYIEDPE-GLLLTDSTWTYKIP 1218

  Fly  1179 GAKDIPIDFRIELLQKSPNPVGFMRSKATGEPALCLAVGALFAMQHAIQSAR 1230
            ....||..|.:|:|....:....:.|||:|||.|.||.....|.:.|::.||
plant  1219 TVDTIPKQFNVEILNGGCHEKRVLSSKASGEPPLLLAASVHCATRQAVKEAR 1270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX2	NP_732047.2	fer2	3..84	CDD:238126	30/80 (38%)
		PLN02906	24..1251	CDD:215491	397/1329 (30%)
		Fer2_2	86..159	CDD:280048	36/76 (47%)
		FAD_binding_4	206..366	CDD:303082	45/192 (23%)
		CO_deh_flav_C	391..497	CDD:281449	35/114 (31%)
		Ald_Xan_dh_C	548..655	CDD:214971	26/107 (24%)
		Ald_Xan_dh_C2	702..1184	CDD:280834	161/524 (31%)
AAO2	NP_189946.1	PLN00192	1..1317	CDD:215096	405/1352 (30%)
		fer2	3..78	CDD:238126	30/74 (41%)
		Fer2_2	86..164	CDD:280048	37/77 (48%)
		FAD_binding_5	218..402	CDD:279309	45/191 (24%)
		CO_deh_flav_C	414..515	CDD:281449	34/111 (31%)
		Ald_Xan_dh_C	568..678	CDD:279635	32/129 (25%)
		Ald_Xan_dh_C2	699..1224	CDD:280834	164/538 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	83	1.000	Domainoid score	I2880
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H98597
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820