DRSC/TRiP Functional Genomics Resources

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Protein Alignment AOX2 and Aox4

DIOPT Version :9

Sequence 1:NP_732047.2 Gene:AOX2 / 41895 FlyBaseID:FBgn0038348 Length:1264 Species:Drosophila melanogaster
Sequence 2:NP_076120.2 Gene:Aox4 / 71872 MGIID:1919122 Length:1336 Species:Mus musculus


Alignment Length:1362 Identity:404/1362 - (29%)
Similarity:633/1362 - (46%) Gaps:180/1362 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 FNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQSRAA 69
            |.|||  .:|...:..|:..|..:.|:.|:||.|||.|..||||:|..::.|.:|.|:::....|
Mouse    12 FFVNG--KKVIEKNPDPEKNLLFYTRKVLNLTGTKYSCGTGGCGACTVMVSRYNPKTRKIHHYPA 74

  Fly    70 NSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQHRGQV 134
            .:||..:.....|.|.|.||:|:.....||:|:|:|:.:|||||:||||.||::|.||..| .:.
Mouse    75 TACLVPICWLHGAAITTVEGVGSIKKRVHPVQERLAKCHGTQCGFCSPGMVMSIYTLLRNH-PEP 138

  Fly   135 SMSQVEDAFGGNLCRCTGYRPILDAMKSFAVDSNVEVPAESVDIEDSFELLCPRTGQSC-----K 194
            :..|:.:|.|||||||||||||:::.|:|:..|.|      ..::.|.: .|....:.|     |
Mouse   139 TPDQITEALGGNLCRCTGYRPIVESGKTFSQKSTV------CQMKGSGK-CCMDPDEKCLESREK 196

  Fly   195 GSCSR------------------PP--LRDHGD------------SQWYWPKTLTELFGALSQVA 227
            ..|::                  ||  :|...|            :.|..|.||.:|   |...|
Mouse   197 KMCTKLYNEDEFQPFDPSQEPIFPPELIRMAEDPNKRRLTFQGKRTTWIIPVTLNDL---LELKA 258

  Fly   228 NGELYMLVAGNTAHGVYRRPRDIRH--FIDVNMVPELRQYSIETDHLLLGGNVTLT---DAMQVF 287
            :.....||.|||..|...:..|..:  ||....||||.......:.:.:|...:|.   |.:...
Mouse   259 SYPEAPLVMGNTTVGPGIKFNDEFYPVFISPLGVPELNLMDTTNNGVTIGAGYSLAQLKDTLDFL 323

  Fly   288 LLAAKRPGFEYCAQLWQHFNLIANVPVRNNGTLAGNINIKKQHFEFPSDVFITFEALDVHVLVYD 352
            :....:...:....|.:|...:|...:||..||.|: ...:.:|...:.:.....| .::|:..:
Mouse   324 VSEQPKEKTKTFHALQKHLRTLAGPQIRNMATLGGH-TASRPNFSDLNPILAAGNA-TINVVSRE 386

  Fly   353 NPSTQRVMN--LLTYLGDTTSK---LVLGGFILKAYPKDRFLFRSYKILPRAQNVHAYVNAGFLI 412
            ....|..:|  .|..|.:...|   ::|..||  .|..........::..|.:|..|.||||..:
Mouse   387 GKDRQLPLNGPFLEKLPEADLKPEEVILSIFI--PYTAQWQFVSGLRLAQRQENAFAIVNAGMSV 449

  Fly   413 EWQDIQHRIVHSARICFGNIRPDYIHDDQVEQLLPGRDLYDPATVAQIFQELPASLQPEERPPEA 477
            |:::..:.| ...::.||::.|..:...|..:.|.||. :|...::...|.:   ||....||:|
Mouse   450 EFEEGTNTI-KDLKMFFGSVAPTVVSASQTCKQLIGRQ-WDDQMLSDACQLV---LQEIRIPPDA 509

  Fly   478 S---PEYRQMLACSLLYKFLLATAP--KERVRERF-----RTGGLLLERPLSS--GSQSFETI-- 528
            .   .|||:.|..|||:||.|....  .|...::|     :....|.:.|:.:  |.|.|:.:  
Mouse   510 EGGMVEYRRTLIISLLFKFYLKVQRWLNEMDPQKFPDIPGKFVSALDDFPIETPQGIQMFQCVDP 574

  Fly   529 --KKNYPVTQPVQKLEGLIQCSGEATYMNDLLTTSNAVHCAFVTAKRVGATIEQIDPSAALQCKG 591
              .:..||..|:....|:...:|||.:::|:......:..|.||:.|..|.|..:|.|.||.|.|
Mouse   575 KQPQKDPVGHPIMHQSGIKHATGEAIFIDDMPPIDQELCLAVVTSTRAHAKITSLDVSEALACPG 639

  Fly   592 VVAFYSAEDIPGSNNF---VLVNQLTPEVDEVFVAGRVKYFDQPLGVIAALTHDAAVYAATLVVV 653
            ||...:|||:||.|:.   :|..|     .||...|::      :..:||.|:..|..||..|.:
Mouse   640 VVDVITAEDVPGENDHNGEILYAQ-----SEVICVGQI------ICTVAADTYIHAKEAAKRVKI 693

  Fly   654 TYARDQRKIFTTMNQVL-------------------AEKQTDRIVSTKKDTVEPLKLPPLAPGDV 699
            .| .|......|:.:.|                   |.|..|:||                    
Mouse   694 AY-DDIEPTIITIEEALEHNSFLSPEKKIEQGNVDYAFKHVDQIV-------------------- 737

  Fly   700 LGRGILELASQYHFTMEPQTTIVVPL--DNILQVYCATQWMDATQGAIAHMLKVSVNSIQLQVRR 762
              .|.:.:..|.||.||.||.:.:|.  |..:.::..||:....|..::..|.|..:.|...::|
Mouse   738 --EGEIHVEGQEHFYMETQTILAIPQTEDKEMVLHLGTQFPTHVQEFVSAALNVPRSRIACHMKR 800

  Fly   763 VGGAYGAKVTRGNIVACATALVASKLRRPARFV-QTIESMMETIGKRWACRSDYEFRARANGSII 826
            .|||:|.|||:..::....|:.|:|..||.||: :..:.|:.|.| |......|:.....||.|.
Mouse   801 AGGAFGGKVTKPALLGAVCAVAANKTGRPIRFILERSDDMLITAG-RHPLLGKYKIGFMNNGEIR 864

  Fly   827 MLSNNYYEDSGCNLNEN--VVDFLTLPILRNVYNLTDANYRTQGSAIRTDAPSSTWCRAPGSAEG 889
            .....||.:.||..:|:  |::|:.|. ..|.|::  .|:|.:|.|.:|:.||:|..|..|..:.
Mouse   865 AADVEYYTNGGCTPDESELVIEFVVLK-SENTYHI--PNFRCRGRACKTNLPSNTAFRGFGFPQA 926

  Fly   890 IAMTETALEHIAFTCQLDPADVRLVNLQPGNKMVQLLPKF------------LASTEYHKRRDQI 942
            ..:.|..:..:|..|.|.|.:||.:|:............|            |..:.:..|:...
Mouse   927 TVVVEAYIAAVASKCNLLPEEVREINMYKKTSKTAYKQTFNPEPLRRCWKECLEKSSFFARKKAA 991

  Fly   943 NLFNSQNRWRKRGLGLALMSFPLNTTVAFNYPVTVAIYH--EDGSVVISHGGIEIGQGVNTKAAQ 1005
            ..||..|.|:||||.:..|.|.:...:|| |....|:.|  .||||:::|||.|:|||::||..|
Mouse   992 EEFNGNNYWKKRGLAVVPMKFSVAVPIAF-YNQAAALVHIFLDGSVLLTHGGCELGQGLHTKMIQ 1055

  Fly  1006 VAAFVLGVPLDQVRVEASNTVNGANSMLTANSMTSEMIGLAVRKACDTLNKRLAPVKERLGPRAS 1070
            ||:..|.||...|....::|....||..||.||.:::.|.||:.||..|..||.|: .|..|:..
Mouse  1056 VASRELNVPKSYVHFSETSTTTVPNSAFTAGSMGADINGKAVQNACQILMDRLRPI-IRKNPKGK 1119

  Fly  1071 WVQVLQAAFLQSVFLIAT---ESYRL--------GDIPNYNIFGLSLTELELDILTGNHLIRRVD 1124
            |.:.::.||.:|:.|.||   :.|:.        ||...|.::|.:.:|:|:|.|||.|.:.|.|
Mouse  1120 WEEWIKMAFEESISLSATGYFKGYQTNMDWKKEEGDPYPYYVYGAACSEVEVDCLTGAHKLLRTD 1184

  Fly  1125 ILEDAGESLSPHIDVGQVEGAFVMGLGYYLTEQLVYDRQTGQILTNRTWNYHPPGAKDIPIDFRI 1189
            |..||..|::|.:|:|||||||:.|:|:|.||:|.|..: |.:.:....:|..|...:||.:|.:
Mouse  1185 IFVDAAFSINPALDIGQVEGAFIQGMGFYTTEELKYSPK-GVLYSRGPEDYKIPTITEIPEEFYV 1248

  Fly  1190 ELLQKSPNPVGFMRSKATGEPALCLAVGALFAMQHAIQSARNDAGLPREWVRLGAPTTPETV 1251
            .|:. |.||:....||..||..:.|....|||:..|:.:||.:.|| .:...|.:|.|||.:
Mouse  1249 TLVH-SRNPIAIYSSKGLGEAGMFLGSSVLFAIYDAVTTARKERGL-SDIFPLNSPATPEVI 1308

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
AOX2NP_732047.2 fer2 3..84 CDD:238126 27/78 (35%)
PLN02906 24..1251 CDD:215491 398/1341 (30%)
Fer2_2 86..159 CDD:280048 39/72 (54%)
FAD_binding_4 206..366 CDD:303082 38/178 (21%)
CO_deh_flav_C 391..497 CDD:281449 33/108 (31%)
Ald_Xan_dh_C 548..655 CDD:214971 36/109 (33%)
Ald_Xan_dh_C2 702..1184 CDD:280834 167/511 (33%)
Aox4NP_076120.2 mam_aldehyde_ox 9..1335 CDD:132014 404/1362 (30%)
Fer2 12..82 CDD:278537 26/71 (37%)
Fer2_2 91..162 CDD:280048 39/71 (55%)
FAD_binding_5 240..420 CDD:279309 42/186 (23%)
CO_deh_flav_C 431..532 CDD:281449 33/105 (31%)
Ald_Xan_dh_C 596..699 CDD:214971 38/114 (33%)
Ald_Xan_dh_C2 713..1243 CDD:280834 172/558 (31%)