Protein Alignment AOX2 and Aox4

DIOPT Version :10

• Sequence 1: NP_732047.2
• Gene: AOX2 / 41895
• FlyBaseID: FBgn0038348
• Length: 1264
• Species: Drosophila melanogaster
• Sequence 2: NP_076120.2
• Gene: Aox4 / 71872
• MGIID: 1919122
• Length: 1336
• Species: Mus musculus
• Alignment Length: 1362
• Identity: 404/1362 - (29%)
• Similarity: 633/1362 - (46%)
• Gaps: 180/1362 - (13%)

  Fly     5 FNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQSRAA 69
            |.|||  .:|...:..|:..|..:.|:.|:||.|||.|..||||:|..::.|.:|.|:::....|
Mouse    12 FFVNG--KKVIEKNPDPEKNLLFYTRKVLNLTGTKYSCGTGGCGACTVMVSRYNPKTRKIHHYPA 74

  Fly    70 NSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQHRGQV 134
            .:||..:.....|.|.|.||:|:.....||:|:|:|:.:|||||:||||.||::|.||..| .:.
Mouse    75 TACLVPICWLHGAAITTVEGVGSIKKRVHPVQERLAKCHGTQCGFCSPGMVMSIYTLLRNH-PEP 138

  Fly   135 SMSQVEDAFGGNLCRCTGYRPILDAMKSFAVDSNVEVPAESVDIEDSFELLCPRTGQSC-----K 194
            :..|:.:|.|||||||||||||:::.|:|:..|.|      ..::.|.: .|....:.|     |
Mouse   139 TPDQITEALGGNLCRCTGYRPIVESGKTFSQKSTV------CQMKGSGK-CCMDPDEKCLESREK 196

  Fly   195 GSCSR------------------PP--LRDHGD------------SQWYWPKTLTELFGALSQVA 227
            ..|::                  ||  :|...|            :.|..|.||.:|   |...|
Mouse   197 KMCTKLYNEDEFQPFDPSQEPIFPPELIRMAEDPNKRRLTFQGKRTTWIIPVTLNDL---LELKA 258

  Fly   228 NGELYMLVAGNTAHGVYRRPRDIRH--FIDVNMVPELRQYSIETDHLLLGGNVTLT---DAMQVF 287
            :.....||.|||..|...:..|..:  ||....||||.......:.:.:|...:|.   |.:...
Mouse   259 SYPEAPLVMGNTTVGPGIKFNDEFYPVFISPLGVPELNLMDTTNNGVTIGAGYSLAQLKDTLDFL 323

  Fly   288 LLAAKRPGFEYCAQLWQHFNLIANVPVRNNGTLAGNINIKKQHFEFPSDVFITFEALDVHVLVYD 352
            :....:...:....|.:|...:|...:||..||.|: ...:.:|...:.:.....| .::|:..:
Mouse   324 VSEQPKEKTKTFHALQKHLRTLAGPQIRNMATLGGH-TASRPNFSDLNPILAAGNA-TINVVSRE 386

  Fly   353 NPSTQRVMN--LLTYLGDTTSK---LVLGGFILKAYPKDRFLFRSYKILPRAQNVHAYVNAGFLI 412
            ....|..:|  .|..|.:...|   ::|..||  .|..........::..|.:|..|.||||..:
Mouse   387 GKDRQLPLNGPFLEKLPEADLKPEEVILSIFI--PYTAQWQFVSGLRLAQRQENAFAIVNAGMSV 449

  Fly   413 EWQDIQHRIVHSARICFGNIRPDYIHDDQVEQLLPGRDLYDPATVAQIFQELPASLQPEERPPEA 477
            |:::..:.| ...::.||::.|..:...|..:.|.||. :|...::...|.:   ||....||:|
Mouse   450 EFEEGTNTI-KDLKMFFGSVAPTVVSASQTCKQLIGRQ-WDDQMLSDACQLV---LQEIRIPPDA 509

  Fly   478 S---PEYRQMLACSLLYKFLLATAP--KERVRERF-----RTGGLLLERPLSS--GSQSFETI-- 528
            .   .|||:.|..|||:||.|....  .|...::|     :....|.:.|:.:  |.|.|:.:
Mouse   510 EGGMVEYRRTLIISLLFKFYLKVQRWLNEMDPQKFPDIPGKFVSALDDFPIETPQGIQMFQCVDP 574

  Fly   529 --KKNYPVTQPVQKLEGLIQCSGEATYMNDLLTTSNAVHCAFVTAKRVGATIEQIDPSAALQCKG 591
              .:..||..|:....|:...:|||.:::|:......:..|.||:.|..|.|..:|.|.||.|.|
Mouse   575 KQPQKDPVGHPIMHQSGIKHATGEAIFIDDMPPIDQELCLAVVTSTRAHAKITSLDVSEALACPG 639

  Fly   592 VVAFYSAEDIPGSNNF---VLVNQLTPEVDEVFVAGRVKYFDQPLGVIAALTHDAAVYAATLVVV 653
            ||...:|||:||.|:.   :|..|     .||...|::      :..:||.|:..|..||..|.:
Mouse   640 VVDVITAEDVPGENDHNGEILYAQ-----SEVICVGQI------ICTVAADTYIHAKEAAKRVKI 693

  Fly   654 TYARDQRKIFTTMNQVL-------------------AEKQTDRIVSTKKDTVEPLKLPPLAPGDV 699
            .| .|......|:.:.|                   |.|..|:||
Mouse   694 AY-DDIEPTIITIEEALEHNSFLSPEKKIEQGNVDYAFKHVDQIV-------------------- 737

  Fly   700 LGRGILELASQYHFTMEPQTTIVVPL--DNILQVYCATQWMDATQGAIAHMLKVSVNSIQLQVRR 762
              .|.:.:..|.||.||.||.:.:|.  |..:.::..||:....|..::..|.|..:.|...::|
Mouse   738 --EGEIHVEGQEHFYMETQTILAIPQTEDKEMVLHLGTQFPTHVQEFVSAALNVPRSRIACHMKR 800

  Fly   763 VGGAYGAKVTRGNIVACATALVASKLRRPARFV-QTIESMMETIGKRWACRSDYEFRARANGSII 826
            .|||:|.|||:..::....|:.|:|..||.||: :..:.|:.|.| |......|:.....||.|.
Mouse   801 AGGAFGGKVTKPALLGAVCAVAANKTGRPIRFILERSDDMLITAG-RHPLLGKYKIGFMNNGEIR 864

  Fly   827 MLSNNYYEDSGCNLNEN--VVDFLTLPILRNVYNLTDANYRTQGSAIRTDAPSSTWCRAPGSAEG 889
            .....||.:.||..:|:  |::|:.|. ..|.|::  .|:|.:|.|.:|:.||:|..|..|..:.
Mouse   865 AADVEYYTNGGCTPDESELVIEFVVLK-SENTYHI--PNFRCRGRACKTNLPSNTAFRGFGFPQA 926

  Fly   890 IAMTETALEHIAFTCQLDPADVRLVNLQPGNKMVQLLPKF------------LASTEYHKRRDQI 942
            ..:.|..:..:|..|.|.|.:||.:|:............|            |..:.:..|:...
Mouse   927 TVVVEAYIAAVASKCNLLPEEVREINMYKKTSKTAYKQTFNPEPLRRCWKECLEKSSFFARKKAA 991

  Fly   943 NLFNSQNRWRKRGLGLALMSFPLNTTVAFNYPVTVAIYH--EDGSVVISHGGIEIGQGVNTKAAQ 1005
            ..||..|.|:||||.:..|.|.:...:|| |....|:.|  .||||:::|||.|:|||::||..|
Mouse   992 EEFNGNNYWKKRGLAVVPMKFSVAVPIAF-YNQAAALVHIFLDGSVLLTHGGCELGQGLHTKMIQ 1055

  Fly  1006 VAAFVLGVPLDQVRVEASNTVNGANSMLTANSMTSEMIGLAVRKACDTLNKRLAPVKERLGPRAS 1070
            ||:..|.||...|....::|....||..||.||.:::.|.||:.||..|..||.|: .|..|:..
Mouse  1056 VASRELNVPKSYVHFSETSTTTVPNSAFTAGSMGADINGKAVQNACQILMDRLRPI-IRKNPKGK 1119

  Fly  1071 WVQVLQAAFLQSVFLIAT---ESYRL--------GDIPNYNIFGLSLTELELDILTGNHLIRRVD 1124
            |.:.::.||.:|:.|.||   :.|:.        ||...|.::|.:.:|:|:|.|||.|.:.|.|
Mouse  1120 WEEWIKMAFEESISLSATGYFKGYQTNMDWKKEEGDPYPYYVYGAACSEVEVDCLTGAHKLLRTD 1184

  Fly  1125 ILEDAGESLSPHIDVGQVEGAFVMGLGYYLTEQLVYDRQTGQILTNRTWNYHPPGAKDIPIDFRI 1189
            |..||..|::|.:|:|||||||:.|:|:|.||:|.|..: |.:.:....:|..|...:||.:|.:
Mouse  1185 IFVDAAFSINPALDIGQVEGAFIQGMGFYTTEELKYSPK-GVLYSRGPEDYKIPTITEIPEEFYV 1248

  Fly  1190 ELLQKSPNPVGFMRSKATGEPALCLAVGALFAMQHAIQSARNDAGLPREWVRLGAPTTPETV 1251
            .|:. |.||:....||..||..:.|....|||:..|:.:||.:.|| .:...|.:|.|||.:
Mouse  1249 TLVH-SRNPIAIYSSKGLGEAGMFLGSSVLFAIYDAVTTARKERGL-SDIFPLNSPATPEVI 1308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AOX2	NP_732047.2	PLN02906	24..1251	CDD:215491	398/1341 (30%)
Aox4	NP_076120.2	mam_aldehyde_ox	9..1335	CDD:132014	404/1362 (30%)